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Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson＇s Disease

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Neuroscience Bulletin 2017年第5期33卷 483-492页

作者： Chong-Bin Zhong Qian-Qian chen Caroline Haikal Wen Li Alexander Svanbergssona Meike Diepenbroek jia-Yi Li Institute of Bioengineering Northeastern UniversityShenyang 110819China Institute of Neuroscience College of Life and HealthSciencesNortheastern UniversityShenyang 110819China Neural Plasticity and Repair Unit Wallenberg Neuroscience CenterDepartment of Experimental Medical ScienceLund UniversityBMC A1022184 LundSweden

The enteric nervous system （ENS） controls the function of the gastrointestinal tract and has been impli- cated in various diseases, including Parkinson＇s disease （PD）. PD is a neurodegenerative disease with Lewy bodies （LBs） and Lewy neurites （LNs） as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent mor- phological alterations and aggregation of α-synuclein （α- syn）, the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner＇s and Auerbach＇s plexuses of the gastrointestinal tract with age （from 1 week to 2 years）. In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting patho- logical alterations of the protein over time. Furthermore,α- syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α- Syn-gFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.

关键词： Enteric system · Parkinson's disease · αt-synuclein · Phosphorylation · Protein aggregation

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多形态氮和硝化抑制剂协同供应对土壤氮素转化的影响

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中国土壤与肥料 2024年第7期 69-78页

作者：张如梦李冬佳梁雄英董汶卿唐智萍陈国庆陈骏喻海峰王孝忠刘蕊张卫峰西南大学资源环境学院重庆400716 绿色智能复合肥研究院安徽合肥230001 哈尔滨工业大学环境学院黑龙江哈尔滨150090 中国农业大学资源与环境学院北京100193 西南大学长江经济带农业绿色发展研究中心重庆400716 中国农业大学国家绿色农业发展研究院北京100193 中盐安徽红四方肥业股份有限公司安徽合肥230001

氮养分增效对提高作物产量、品质具有重要意义,其中铵硝协同的养分形态调控策略是手段之一。为探究有机氮无机氮源配施、施用硝化抑制剂两种养分动态调控手段对土壤铵硝动态的影响,采用室内土壤培养试验,设置不同比例的硫硝酸铵和草酰... 详细信息

氮养分增效对提高作物产量、品质具有重要意义,其中铵硝协同的养分形态调控策略是手段之一。为探究有机氮无机氮源配施、施用硝化抑制剂两种养分动态调控手段对土壤铵硝动态的影响,采用室内土壤培养试验,设置不同比例的硫硝酸铵和草酰胺配施处理5个,硫硝酸铵:草酰胺比例分别为100%:0%、0%:100%、25%:75%、50%:50%、75%:25%,每组处理另设置添加硝化抑制剂3,4-二甲基吡唑磷酸盐(DMPP)处理,用以探究不同氮源配施抑制剂DMPP处理对潮土(pH8.25)和水稻土(pH5.48)氮素转化的影响。结果表明,缓释氮肥草酰胺与硫硝酸铵配施显著影响土壤铵硝养分供应形式和速率。直至第10d培养结束,缓释氮肥草酰胺在土壤中的铵、硝态氮仍呈现一个较高水平。抑制剂DMPP的添加可提高所有处理的铵态氮含量,降低硝态氮含量,提高土壤铵硝比,降低土壤表观硝化率。综上所述,草酰胺与硫硝酸铵的不同比例以及配施抑制剂DMPP的方式可以实现对土壤中铵硝比例的改变,提高肥料利用率。

关键词：硝化抑制剂草酰胺硫硝酸铵氮形态铵硝比

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Public key based bidirectional shadow image authentication without pixel expansion in image secret sharing

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Frontiers of Information Technology & Electronic Engineering 2023年第1期24卷 88-103页

作者： Xuehu YAN Longlong LI jia chen Lei SUN National University of Defense Technology Hefei 230037China

Image secret sharing(ISS)is gaining popularity due to the importance of digital images and its wide application to cloud-based distributed storage and multiparty secure *** image authentication generally includes shadow image detection and identification,and plays an important role in ***,traditional dealer-participatory methods,which suffer from significant pixel expansion or storing auxiliary information,authenticate the shadow image mainly during the decoding phase,also known as unidirectional *** authentication of the shadow image in the distributing(encoding)phase is also important for the *** this study,we introduce a public key based bidirectional shadow image authentication method in ISS without pixel expansion for a(k,n)*** the dealer distributes each shadow image to a corresponding participant,the participant can authenticate the received shadow image with his/her private *** the decoding phase,the dealer can authenticate each received shadow image with a secret key;in addition,the dealer can losslessly decode the secret image with any k or more shadow *** proposed method is validated using theoretical analyses,illustrations,and comparisons.

关键词： Image secret sharing Shadow image authentication Public key Pixel expansion Lossless decoding

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干切9Cr18不锈钢的成型刀具设计及加工工艺

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工具技术 2024年第6期58卷 122-125页

作者：陈姣姣刘松荆惠雯李波唐正文贾喜庆倪叶萍杨万夏成都工具研究所有限公司中国机械工业国际合作有限公司

针对9Cr18不锈钢材料耐磨性好,韧性、强度高,热导率低等难加工特点,结合加工现场干切及成型加工的实际需求,采用刀具材料、刃口参数、涂层协同优化设计的方法进行成型刀具设计。选取耐磨性好、具备干切能力、与铁基元素亲和力小的刀具材... 详细信息

针对9Cr18不锈钢材料耐磨性好,韧性、强度高,热导率低等难加工特点,结合加工现场干切及成型加工的实际需求,采用刀具材料、刃口参数、涂层协同优化设计的方法进行成型刀具设计。选取耐磨性好、具备干切能力、与铁基元素亲和力小的刀具材料,匹配耐高温、耐磨、润滑性良好的涂层涂覆,再兼顾刀具材料、涂层需求、加工工况等实际情况设计合理刀具参数。采取合适的加工工艺制造出成型刀具,使其达到刃形合理、刃口与涂层结合紧密、刃口质量良好、齿形准确、排屑顺畅等指标,满足实际生产要求。

关键词： 9Cr18不锈钢干切成型加工刃口参数涂层协同优化

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依据影像学特征的原发性肺类癌的分型及鉴别意义

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中华肺部疾病杂志（电子版） 2024年第2期17卷 218-222页

作者：谭明超龚明福陈佳张曦孙雅娟陆军(第三)军医大学第二附属医院放射科重庆400037

目的分析原发性肺类癌(primary lung carcinoid,PLC)的分型及临床鉴别诊断,比较典型类癌与不典型类癌影像征象差异,提高肺类癌影像诊断水平。方法回顾性分析54例经组织病理学证实的原发性肺类癌患者的临床及CT资料,其中典型类癌21例,不... 详细信息

目的分析原发性肺类癌(primary lung carcinoid,PLC)的分型及临床鉴别诊断,比较典型类癌与不典型类癌影像征象差异,提高肺类癌影像诊断水平。方法回顾性分析54例经组织病理学证实的原发性肺类癌患者的临床及CT资料,其中典型类癌21例,不典型类癌33例,比较二者包括位置、大小、形态、走行、边缘、钙化、转移、平扫及增强CT值等指标。结果21例典型类癌与33例不典型类癌病灶位置分为中央型/周围型,二者分别为15/6例、4/29例(P0.05)。CT平扫两者CT值分别为(37.32±19.26)Hu、(33.74±13.30)Hu;增强扫描二者平均强化值分别为(61.38±34.72)Hu、(51.87±27.86)Hu。结论典型类癌与不典型类癌的位置、大小、形态、边缘、钙化、强化和转移等CT影像特征部分存在差异,具有统计学意义,影像学征象鉴别二者具有临床意义。

关键词：原发性肺类癌典型肺类癌不典型肺类癌螺旋CT影像学

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Firefly algorithm with division of roles for complex optimal scheduling

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Frontiers of Information Technology & Electronic Engineering 2021年第10期22卷 1311-1333页

作者： jia ZHAO Wenping chen Renbin XIAO Jun YE School of Information Engineering Nanchang Institute of TechnologyNanchang 330099China jiangxi Province Key Laboratory of Water Information Cooperative Sensing and Intelligent Processing Nanchang 330099China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China

A single strategy used in the firefly algorithm(FA)cannot effectively solve the complex optimal scheduling ***,we propose the FA with division of roles(DRFA).Herein,fireflies are divided into leaders,developers,and followers,while a learning strategy is assigned to each role:the leader chooses the greedy Cauchy mutation;the developer chooses two leaders randomly and uses the elite neighborhood search strategy for local development;the follower randomly selects two excellent particles for global *** improve the efficiency of the fixed step size used in FA,a stepped variable step size strategy is proposed to meet different requirements of the algorithm for the step size at different *** division can balance the development and exploration ability of the *** use of multiple strategies can greatly improve the versatility of the algorithm for complex optimization *** optimal performance of the proposed algorithm has been verified by three sets of test functions and a simulation of optimal scheduling of cascade reservoirs.

关键词： Firefly algorithm(FA) Division of roles Cauchy mutation Elite neighborhood search Optimal scheduling

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祁连山排露沟流域不同水文过程水体氮素含量特征

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甘肃林业科技 2024年第3期49卷 79-83页

作者：杨鹏王顺利程新平贾鑫刘睿明甘肃省祁连山水源涵养林研究院甘肃张掖734000

为探明祁连山排露沟流域不同水体中全氮、铵态氮和硝态氮的空间分布特征,本研究在祁连山排露沟流域青海云杉林内对大气降水、穿透雨、树干茎流和河川径流水等不同水文过程中的水样进行采集,测定不同水体中全氮、铵态氮和硝态氮含量。结... 详细信息

为探明祁连山排露沟流域不同水体中全氮、铵态氮和硝态氮的空间分布特征,本研究在祁连山排露沟流域青海云杉林内对大气降水、穿透雨、树干茎流和河川径流水等不同水文过程中的水样进行采集,测定不同水体中全氮、铵态氮和硝态氮含量。结果表明,研究区内不同水文过程水体的全氮、铵态氮和硝态氮含量在首次产生树干茎流时,全氮和铵态氮含量均呈现出:树干茎流>穿透雨>大气降水>河川径流,硝态氮含量则呈现出:河川径流>树干茎流>穿透雨>大气降水。其他降水事件中不同水体氮素含量的差异显著性没有明显的变化规律。河川径流中的全氮和铵态氮含量均值明显低于大气降水、穿透雨和树干茎流中的全氮和铵态氮含量,但河川径流的硝态氮含量均值明显高于大气降水、穿透雨和树干茎流中的硝态氮含量。相关性分析表明,有机碳与全氮和铵态氮之间均呈极显著正相关(p0.05)。

关键词：大气降水穿透雨树干茎流河川径流全氮

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Influence of air addition on surface modification of polyethylene terephthalate treated by an atmospheric pressure argon plasma brush

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Plasma Science and Technology 2021年第8期23卷 127-134页

作者： jiacun WU Kaiyue WU Junyu chen Caihong SONg Pengying jia Xuechen LI College of Physics Science and Technology Hebei UniversityBaoding 071002People's Republic of China Institute of Life Science and green Development Hebei UniversityBaoding 071002People's Republic of China

An atmospheric pressure argon plasma brush with air addition is employed to treat polyethylene terephthalate(PET)surface in order to improve its *** indicate that the plasma plume generated by the plasma brush presents periodically pulsed current despite a direct current voltage is ***-current curve reveals that there is a transition from a Townsend discharge regime to a glow one during one discharge *** emission spectrum indicates that more oxygen atoms are produced in the plume with increasing air content,which leads to the better hydrophilicity of PET surface after plasma ***,an aging behavior is also *** hydrophilicity improvement is attributed to the production of oxygen functional groups,which increase in number with increasing air ***,some grain-like structures are observed on the treated PET surface,and its mean roughness increases with increasing air *** results are of great importance for the hydrophilicity improvement of PET surface with a large scale.

关键词： plasma brush water contact angle surface modification plasma treatment hydrophilicity improvement

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Conservation of Traditional Rice Varieties in a globally Important Agricultural Heritage System (gIAHS):Rice-Fish Co-Culture

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Agricultural Sciences in China 2011年第5期10卷 754-761页

作者： XIE jian WU Xuex WU Xue TANg jian-jun ZHANg jia-en LUO Shi-ming chen Xin College of Life Sciences Zhejiang Unmersity Hangzhou 310058 P.R.China Institute of Tropical and Subtropical Ecology South China Agricultural University Guangzhou 510642 P.R.China

The traditional rice-fish farming system is selected as a ＂globally important agricultural heritage system＂（gIAHS） by the Food and Agriculture Organization （FAO）,United Nations Development Programme （UNDP）,and global Environment Facility （gEF）,*** Zhejiang Province of China,where the pilot site for this gIAHS farming system is located,we compared the use of traditional rice varieties in rice-fish co-culture and rice ***,we determined how traditional rice varieties were performed in this rice-fish *** 19% of the farmers who practiced rice monoculture planted traditional varieties while 52% of farmers who practiced rice-fish co-culture planted traditional *** varieties represented 13% of the total land cultivated under rice in the rice-fish system but only 2% in the rice monoculture *** the rice-fish system,yield was lower for traditional rice varieties than hybrid varieties but application of fertilizers and pesticides was also *** a field experiment in the rice-fish system without pesticides,rice planthopper numbers and sheath blight incidence were lower from three traditional varieties than one hybrid variety;yields were 8 to 32% lower from the traditional varieties than the *** results showed that traditional rice varieties can be preserved through conserving gIAHS rice-fish *** study also indicated that traditional rice varieties can survive in the rice-fish system because these varieties are helpful to the whole system and beneficial to the farmers.

关键词： hybrid rice varieties on-farm conservation rice monoculture traditional rice-fish farming

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丝素蛋白-纳米银复合材料在抗菌领域的研究进展

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现代化工 2024年第4期44卷 45-49页

作者：郭文钧杨灵芸柳丁祎陈嘉乐刘雪萍李瑶巨晓洁四川大学化学工程学院四川成都610065

重点总结归纳了丝素蛋白-纳米银复合膜、水凝胶、纤维等多种应用形态在抗菌领域的最新研究进展,阐述了丝素蛋白与纳米银结合的抗菌优势、复合材料目前尚待解决的稳定性与安全性问题,展望了丝素蛋白-纳米银复合材料发展方向。

关键词：伤口愈合细菌感染丝素蛋白纳米银复合材料抗菌性能

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