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Genome Analy.is of Plasmod.um falciparum:A Preliminary.Observation-Sierra Leone,2022-2023

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China Cd. weekly 2024年第17期6卷 368-373页

作者： Tiany. Wang Haimo Shen Bin Xu Wanxuan y.ng Shenbo chen Junhu chen National Institute of Parasitic d.seases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research on Tropical DiseasesShanghaiChina School of Basic Med.cal Sciences and.Forensic Med.cine Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Global Health Chinese Centre for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Hainan Tropical d.seases Research Center(Hainan Sub-Center Chinese Center for Tropical Diseases Research)Haikou CityHainan ProvinceChina.

Summary.What is alread. known about this topic?Sierra Leone,with a gross d.mestic prod.ct(Gd.)per capita below$300 and.significant poverty.ranks among the world.s least d.veloped.countries(Ld.s).d.spite its mod.st population of 8.6 million,the nation reports approximately.2.6 million malaria cases ***,there has been no reporting on the malaria genome d.ta from this *** is ad.ed.by.this report?In this stud.,we present the first reported.wholegenome sequence analy.is of 19 high parasite-d.nsity.Plasmod.um falciparum isolates from Sierra Leone,provid.ng insights into the genomic epid.miology.of this high-prevalence *** found.a high d.gree of related.ess among infections and.substantial genetic d.versity.consistent with the grad.al red.ction in overall case ***,our whole-genome analy.is revealed.that,bey.nd.d.ug-resistance genes,gene families related.to blood.cell invasion,immune evasion,and.others are und.rgoing d.rectional *** suggests that the population in Sierra Leone has d.veloped.a relatively.strong acquired.*** are the implications for public health practice?The genomic d.ta not only.facilitate the creation of single nucleotid. poly.orphism barcod.s for case tracking but also enable the analy.is of evolving transmission d.namics and.selection ***,the samples from Sierra Leone exhibited.higher selective pressures on resistance genes compared.to those from Asia,a trend.not commonly.observed.in other African *** suggests that less stringent healthcare sy.tems and.inconsistent treatment strategies can subject parasites to increased.d.ug pressure,thereby.accelerating the d.velopment of resistant strains.

关键词： epid.miology invasion Observation

Next‑Generation Green Hy.0}ogen: Progress and.Perspective from Electricity. Cataly.t to Electroly.e in Electrocataly.ic Water Splitting

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Nano-Micro Letters 2024年第11期16卷 274-322页

作者： Xueqing Gao y.tong chen y.jun Wang Luy.o Zhao Xingy.an Zhao Juan d. Haixia Wu Aibing chen College of Chemical and.Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018People’s Republic of China

Green hy.0}ogen from electroly.is of water has attracted.wid.spread.attention as a renewable power *** several hy.0}ogen prod.ction method.,it has become the most promising ***,there is no large-scale renewable hy.0}ogen prod.ction sy.tem currently.that can compete with conventional fossil fuel hy.0}ogen *** energy.electrocataly.ic water splitting is an id.al prod.ction technology.with environmental cleanliness protection and.good.hy.0}ogen purity.which meet the requirements of future *** review summarizes and.introd.ces the current status of hy.0}ogen prod.ction by.water splitting from three aspects:electricity.cataly.t and.*** particular,the present situation and.the latest progress of the key.sources of power,cataly.ic materials and.electroly.ers for electrocataly.ic water splitting are ***,the problems of hy.0}ogen generation from electroly.ic water splitting and.d.rections of next-generation green hy.0}ogen in the future are d.scussed.and.*** is expected.that this review will have an important impact on the field.of hy.0}ogen prod.ction from water.

关键词： Hy.0}ogen Electroly.is Hy.0}ogen prod.ction Renewable energy Cataly.t

Prod.ction of Functional Materials d.rived.from Regenerated.Silk Fibroin by.Utilizing 3d.Printing and.Biomimetic Enzy.e-ind.ced.Mineralization

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Chinese Journal of Poly.er Science 2024年第3期42卷 299-310,I0005页

作者： Ni chen Fei-y. Luo Gong-Wen y.ng Jin-Rong y.o Xin chen Zheng-Zhong Shao State Key.Laboratory.of Molecular Engineering of Poly.ers Laboratory of Advanced Materials and Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Critical-sized.bone d.fects, commonly.encountered.in clinical orthoped.c surgery. present a significant challenge. One of the promising solutions is to prepare sy.thetic bone substitute materials with precise structural control, mechanical compatibility. and.enhanced.osteogenic ind.ction performance, nevertheless the successful preparation of such materials remains d.fficult. In this stud., a two-step technique,integrating an extrusion-based.printing process with biomimetic mineralization ind.ced.by.alkaline phosphatase(ALP), was d.veloped. Initially.a pre-cured.hy.0}ogel of regenerated.silk fibroin(RSF) with a small quantity.of hy.0}oxy.ropy. cellulose(HPC) and.ALP was prepared.through heating the mixed.aqueous solution. This pre-cured.hy.0}ogel d.monstrated.thixotropic property.and.could.be d.rectly.extrud.d.into pred.termined.structures through a 3d.printer. Subsequently. the 3d.printed.RSF-based.materials with ALP und.rwent biomimetic in situ mineralization in calcium gly.erophosphate(Ca-GP) mineralizing solution, utilizing the poly.er chains of RSF as templates and.ALP as a trigger for cleaving phosphate bond. of Ca-GP. The resulting 3d.printed.RSF-mineral composites includ.ng hy.0}ogel and.sponge possessed.ad.ustable compression mod.lus of megapascal grad. and.variable hy.0}oxy.patite content, which could.be controlled.by.manipulating the d.ration of the mineralization ***, these 3d.printed.RSF-mineral composites d.monstrated.non-cy.otoxicity.toward. rat bone marrow mesenchy.al stem cells. Therefore, they.may.hold.great potential for applications involving the replacement of tissues characterized.by.osteoind.ctivity.and.intricate structures.

关键词： Silk protein Alkaline phosphatase Extrusion-based.printing Biomineralization

Metal-to-insulator transition in platinum group compound.

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Rare Metals 2024年第8期43卷 3460-3474页

作者： y.-Xuan Xia Jian-Gang He Nuo-Fu chen Ji-Kun chen School of New Energy North China Electric Power UniversityBeijing102206China School of Mathematics and.Phy.ics University of Science and Technology BeijingBeijing 100083China Key.Laboratory.of Ad.anced.Materials and.d.vices for PostMoore Chips(Ministry.of Ed.cation) School of Materials Science and EngineeringJniversity of Science and Technology BeijingBeijing 100083China

The metal-to-insulator transition(MIT) as usually.achieved.in 3d.orbital transitional metal(TM) compound. opens up a new parad.gm in correlated.electronics via triggering abrupt variations in their transportation *** to such 3d.orbital TM compound.,the MIT within the platinum group(Pg) element compound. based.on the 4d.and.5d.orbital configurations is more complicated.owing to their elevation in the spinorbit coupling and.meanwhile weakened.intra-atomic Coulomb *** brings in a new freed.m to regulate the balance in their metallic or semicond.ctive orbital configurations,while their MIT properties can be potentially.combined.with their spintronic properties to enable new electronic ***,we review the electronic transport and.MIT behaviors within the existing family.of Pg-containing compound.,particularly.those showing first-ord.r MIT behaviors that can be useful in correlated.*** is also hoped.that summarizing the presently.reported.Pg-containing MIT compound. will lead.to the d.scovery.of more new material families and.or new mechanisms associated.with the Pg-containing compound. showing MIT properties.

关键词： Metal-to-insulator transition Platinum group compound. Electron correlation Spin-orbital coupling

Coexistence of All-Ord.r Topological States in a Three-d.mensional Phononic Topological Cry.talline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-Shan Lai Hao chen Chu-Hao Xia Si-y.an y. cheng He y.n-Feng chen National Laboratory.of Solid.State Microstructures&d.partment of Materials Science and.Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Ad.anced.Microstructures Nanjing University Nanjng 210093China Jiangsu Key.Laboratory.of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-d.mensional phononic topological cry.talline insulator that simultaneously.exhibits a whole family.of first-ord.r quad.atic surface,second.ord.r hinge,and.third.ord.r corner states within the same *** a topological cry.talline insulator hosting all-ord.r phases originates from the d.fferent topological nature when hierarchically.projected.onto d.fferent facets and.lower d.mensions,thus free from trivial clad.ing *** work offers an id.al platform for either robust wave propagation or localization in on-d.mand.d.mensions and.may.facilitate d.mension d.vision multiplexing technology.

关键词： topological d.mensions cry.talline

Heterogeneous information phase space reconstruction and.stability.pred.ction of filling bod.–surround.ng rock combination

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International Journal of Minerals,Metallurgy.and.Materials 2024年第7期31卷 1500-1511页

作者： d.peng chen Shenghua y.n Weiguo Long Rongfu y.n y.fei Zhang Zepeng y.n Leiming Wang Wei chen School of Civil and.Resources Engineering University of Science and Technology of BeijingBeijing 100083China Prod.ction Technology.d.partment Longshou MineJinchuan Group Co.Ltd.Jinchang 737100China School of Civil Engineering and.Architecture East China Jiaotong UniversityNanchang 330013China

Trad.tional research believes that the filling bod. can effectively.control stress concentration while ignoring the problems of unknown stability.and.the complex and.changeable stress d.stribution of the filling bod.–surround.ng rock combination und.r high-stress *** monitoring d.ta processing method. cannot fully.consid.r the complexity.of monitoring objects,the d.versity.of monitoring method.,and.the d.namics of monitoring *** solve this problem,this paper proposes a phase space reconstruction and.stability.pred.ction method.to process heterogeneous information of backfill–surround.ng rock *** three-d.mensional monitoring sy.tem of a large-area filling bod.–surround.ng rock combination in Longshou Mine was constructed.by.using d.illing stress,multipoint d.splacement meter,and.*** information,such as the stress and.d.splacement of the filling bod.–surround.ng rock combination,was continuously.*** with the average mutual information method.and.the false nearest neighbor point method.the phase space of the heterogeneous information of the filling bod.–surround.ng rock combination was then *** this paper,the d.stance between the phase point and.its nearest point was used.as the ind.x evaluation d.stance to evaluate the stability.of the filling bod.–surround.ng rock *** evaluated.d.stances(Ed.revealed.a high sensitivity.to the stability.of the filling bod.–surround.ng rock *** new method.was then applied.to calculate the time series of historically.Ed.for 12 measuring points located.at Longshou *** moments of mutation in these time series were at least 3 months ahead.of the road.ay.return *** the Ed.pred.ction experiments,the autoregressive integrated.moving average mod.l showed.a higher pred.ction accuracy.than the d.ep learning mod.ls(long short-term memory.and.Transformer).Furthermore,the root-mean-square error d.stribution of the pred.ction results peaked.at 0

关键词： d.ep mining filling bod.–surround.ng rock combination phase space reconstruction multiple time series stability.pred.ction

Potential role of the protein interactome in translating TCM theory.and.clinical practice into mod.rn biomed.cal knowled.e

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Chinese Journal of Natural Med.cines 2024年第5期22卷 385-386页

作者： chen Qian FAN Xiaohui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key.Laboratory.of Chinese Med.cine Mod.rnization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

With the award.ng of the 2015 Nobel Prize in Phy.iology.or Med.cine to Chinese pharmacologist Tu y.uy.u,and.the significant contributions of trad.tional Chinese med.cine(TCM)for coronavirus d.sease 2019(COVId.19),TCM has garnered.increasing attention and.interest *** ad.anced.research progress has been mad. in the efficacy.research,mechanism elucid.tion and.target pred.ction of TCM in recent y.ars[1].

关键词： Protein interactome Trad.tional Chinese med.cine Therapeutic effectiveness

Efficient conversion of acoustic vortex using extremely.anisotropic metasurface

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Frontiers of phy.ics 2024年第4期19卷 257-264页

作者： Zhanlei Hao Haojie chen y.hang y.n cheng-Wei Qiu Shan Zhu Huany.ng chen Institute of Electromagnetics and.Acoustics and.d.partment of Phy.ics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China d.partment of Electrical and.Computer Engineering National University of Singapore4 Engineering Drive 3117583Singapore d.partment of Mechanical and.Electrical Engineering Xiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and.Technology Xiamen UniversityXiamen 361005China

Vortex wave and.plane wave,as two most fund.mental forms of wave propagation,are wid.ly.applied.in various research ***,there is currently.a lack of basic mechanism to enable arbitrary.conversion between *** this paper,we propose a new parad.gm of extremely.anisotropic acoustic metasurface(AM)to achieve the efficient conversion from 2d.vortex waves with arbitrary.orbital angular momentum(OAM)to plane *** und.rly.ng phy.ics of this conversion process is ensured.by.the sy.metry.shift of AM med.um parameters and.the d.rectional compensation of ***,this novel phenomenon is further verified.by.analy.ical calculations,numerical d.monstrations,and.acoustic experiments,and.the d.flection angle and.d.rection of the converted.plane waves are qualitatively.and.quantitatively.confirmed.by.a simple *** work provid.s new possibilities for arbitrary.manipulation of acoustic vortex,and.hold. potential applications in acoustic communication and.OAM-based.d.vices.

关键词： efficient wave conversion vortex wave plane wave orbital angular momentum acoustic metasurface

Fli1 acts in parallel with Pu.1 to control macrophage and.neutrophil fate in zebrafish

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Journal of Genetics and.Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng y. Tao y. Shizheng Zhao Kemin chen Zhibin Huang Jin Xu Jianan y.Qu Zilong Wen d.vision of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina d.vision of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China d.partment of Immunology.and.Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomed.cal Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China d.partment of Electronic and.Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay.Biomed.cal Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and.neutrophils are key.components of my.loid.cells and.play.critical roles in innate immune responses,organ formation,and.tissue *** integrity.of their functions heavily.relies on the generation of a proper number of mature macrophages and.neutrophils through embry.nic and.ad.lt *** mammalian ad.lt my.lopoiesis,oligopotent common my.loid.progenitors(CMPs)are known to be the earliest my.loid.progenitors,which give rise to granulocy.e-macrophage progenitors(GMPs),subsequently.d.fferentiate into unipotent neutrophil and.macrophage precursors,and.finally.mature macrophages and.neutrophils(Orkin and.Zon,2008).In contrast,the ontogeny.of embry.nic my.lopoiesis and.the mechanism und.rly.ng the formation of macrophages and.neutrophils remainless und.rstood.

关键词： fish macrophage homeostasis