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New direction for surgery:Super minimally invasive surgery

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World Journal of Gastroenterology 2024年第12期30卷 1676-1679页

作者： en-qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their *** invasive surgery(MIS)has dominated the surgical realm because of its lesser ***,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients ***,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.

关键词： Super minimally invasive surgery Minimally invasive surgery Treatment mode Traditional Surgery New direction for surgery

Prevalence and risk factors of fatty liver disease in chengdu,Southwest China

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 377-382页

作者： Li, Hong Wang, You-Juan Tan, Ke Zeng, Li Liu, Li Liu, Feng-Jun Zhou, Tao-You chen, en-qiang Tang, Hong Sichuan Univ W China Hosp Natl Key Lab Biotherapy Div Mol Biol Infect DisCtr Infect Dis Chengdu 610041 Peoples R China W China Hosp Phys Examinat Ctr Chengdu 610041 Peoples R China Sichuan Univ Dept Hlth Stat W China Coll Publ Hlth Chengdu 610041 Peoples R China

BACKGROUND: Fatty liver disease (FLD) is increasingly recognized as one of the most common chronic liver diseases in China. This study aimed to investigate the prevalence and risk factors of FLD in chengdu, Southwest China, and to provide a relevant basis for the prevention and intervention of FLD. METHODS: Altogether 9094 subjects (4721 men and 4373 women) of over 18 years old who had received a medical checkup in the West China Hospital of Sichuan University between January and December 2007 were evaluated for FLD. FLD was diagnosed by ultrasonography. Body mass index (BMI), height, body weight, blood pressure, fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TCh), alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured using routine laboratory methods. RESULTS: The overall prevalence of FLD was 12.5%, which was more than 3-fold higher in males than in females 2 (18.9% vs. 5.7%, chi(2) =359.624, Pence increased with age in females and males of less than 50 years. The prevalence of alcoholic, suspected alcoholic, and non-alcoholic FLD was 2.6%, 3.6%, and 6.3%, respectively. Multiple logistic regression analyses showed that 10 factors (male sex, age, BMI, FPG, hypertension, TG, TCh, HDL-C, LDL-C, and ALT abnormalities) were closely related to FLD. In heavy drinkers, obesity increased the risk of FLD by 23.78-fold (95% CI, 10.22-55.33), but heavy drinking was only associated with a 2-fold (95% CI, 1.50-2.66) increased risk in obese subjects. CONCLUSIONS: The prevalence of FLD among a health-checkup population in chengdu, Southwest China was lower than the published for other areas of China. FLD in chengdu adults was found to be closely associated with sex, age, BMI, and other metabolic syndrome features.

关键词： fatty liver prevalence risk factors obesity alcohols

Micromechanics of Thermal Conductive Composites:Review,Developments and Applications

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Acta Mechanica Solida Sinica 2024年第2期37卷 215-237页

作者： Guannan Wang Yulin Huang Mengyuan Gao qiang chen Department of Civil engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China School of Mechanical engineering Xi’an Jiaotong UniversityXi’an710049China

Micromechanics investigations of composites with fiber-shaped reinforcement are extensively applied in the engineering design and theoretical analysis of thermal composites in the aerospace engineering and high-tech *** this paper,a critical review of various classical micromechanics approaches is provided based on the classification framework and the development of micromechanics *** numerical micromechanics tools have been developed to overcome limitations through exactly/approximately solving the internal governing equations of *** connections and limitations of those models are also investigated and discussed,based on which three recently developed numerical or semi-analytical models are explained,including finite-element micromechanics,finite-volume direct averaging micromechanics,and locally exact homogenization theory,as well as machine learning *** it is almost inevitable to mention the interfacial effects on thermal behavior of fibrous composites,we review the new mathematical relations that interrupt the original continuity conditions due to the existence of interphase/interface within unit *** speaking,the interphase/interface is demonstrated to play a significant role in influencing the effective coefficients and localized thermal *** present work also briefly reviews the application of micromechanics tools in emerging engineered woven composites,natural fibrous composites,and ablative thermal protection *** is demonstrated that sophisticated micromechanics tools are always demanded for investigating the effective and localized responses of thermal fibrous composites.

关键词： Micromechanics models Thermal fibrous composites Microstructural detail-free models Semi-analytical and numerical methods Interfacial effects Woven composites Natural composites

Fe-N_(x) sites coupled with core-shell FeS@C nanoparticles to boost the oxygen catalysis for rechargeable Zn-air batteries

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Journal of energy Chemistry 2024年第3期90卷 565-577,I0013页

作者： Katam Srinivas Zhuo chen Anran chen Fei Ma Ming-qiang Zhu Yuanfu chen School of Integrated Circuit Science and engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina College of Mechanical and Electronic engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Materials and energy Yunnan UniversityKunming 650091YunnanChina

The development of efficient single-atom catalysts(SACs) for the oxygen reduction reaction(ORR)remains a formidable challenge,primarily due to the symmetric charge distribution of metal singleatom sites(M-N_(4)).To address such issue,herein,Fe-N_(x) sites coupled synergistic catalysts fabrication strategy is presented to break the uniform electronic distribution,thus enhancing the intrinsic catalytic ***,atomically dispersed Fe-N_(x) sites supported on N/S-doped mesoporous carbon(NSC)coupled with FeS@C core-shell nanoparticles(FAS-NSC@950) is synthesized by a facile hydrothermal reaction and subsequent *** to the presence of an in situ-grown conductive graphitic layer(shell),the FeS nanoparticles(core) effectively adjust the electronic structure of single-atom Fe sites and facilitate the ORR kinetics via short/long-range coupling ***,FAS-NSC@950displays a more positive half-wave potential(E_(1/2)) of 0.871 V with a significantly boosted ORR kinetics(Tafel slope=52.2 mV dec^(-1)),outpacing the commercial Pt/C(E_(1/2)=0.84 V and Tafel slope=54.6 mV dec^(-1)).As a bifunctional electrocatalyst,it displays a smaller bifunctional activity parameter(ΔE) of 0.673 V,surpassing the Pt/C-RuO_(2) combination(ΔE=0.724 V).Besides,the FAS-NSC@950-based zincair battery(ZAB) displays superior power density,specific capacity,and long-term cycling performance to the Pt/C-Ir/C-based *** work significantly contributes to the field by offering a promising strategy to enhance the catalytic activity of SACs for ORR,with potential implications for energy conversion and storage technologies.

关键词： Fe-N_(x)sites Core-shell FeS@C Synergistic interactions Oxygen reduction reaction Zn-air battery

Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： Bo-Zong Shao Wen-Gang Zhang Zhen-Yu Liu en-qiang Linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,Crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by Chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation Cancer Inflammatory bowel disease Pancreatitis

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乙型肝炎病毒转录复制调控与乙型肝炎重症化

中华肝脏病杂志 2010年第4期18卷 243-245页

作者：唐红陈恩强四川大学华西医院感染性疾病中心成都610041

乙型肝炎是一种严重危害人类健康的全球性传染病。我国是乙型肝炎高发区，每年有1％的乙型肝炎患者发生重型肝炎，其病情严重；由于乙型肝炎从轻症发展至重症之重症化过程的分子机制目前尚不甚清楚，缺乏特异、有效的治疗手段，故病死... 详细信息

乙型肝炎是一种严重危害人类健康的全球性传染病。我国是乙型肝炎高发区，每年有1％的乙型肝炎患者发生重型肝炎，其病情严重；由于乙型肝炎从轻症发展至重症之重症化过程的分子机制目前尚不甚清楚，缺乏特异、有效的治疗手段，故病死率极高。因此，HBV引起的重型肝炎是目前和今后相当长时间内临床乙型肝炎防治工作所面临的巨大挑战。

关键词：肝炎病毒乙型转录因子基因调节肝炎重型

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乙型肝炎病毒基因变异及其临床意义

中华肝脏病杂志 2009年第3期17卷 161-163页

作者：唐红陈恩强四川大学华西医院感染性疾病中心成都610041

HBV变异不仅可在慢性感染过程中自然发生，亦可于应用药物或接种疫苗后出现。病毒发生变异后常引起其生物学特征的改变，不仅其自身复制能力可能受到影响，同时可引发对抗病毒药物的耐药及导致严重的不良后果，这给乙型肝炎的预防、诊... 详细信息

HBV变异不仅可在慢性感染过程中自然发生，亦可于应用药物或接种疫苗后出现。病毒发生变异后常引起其生物学特征的改变，不仅其自身复制能力可能受到影响，同时可引发对抗病毒药物的耐药及导致严重的不良后果，这给乙型肝炎的预防、诊断和治疗等带来一系列新的问题。因此，加强对HBV变异特征的研究，具有重要的生物学和临床意义。

关键词：肝炎病毒,乙型突变药物耐受,病毒预后

Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： Guang-Xiang Gu Shu-Ting Pan Yi-chen Fan chen chen qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric end-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

Charge transfer complex enabled photoreduction of ether phosphonium salts for the selective oxyalkylation of enamides

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Chinese Chemical Letters 2024年第2期35卷 411-414页

作者： Sen Qiao Kunquan chen qiang Liu Zhixiang Wang Xiangyu chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100049China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou 256606China

A charge transfer complex(CTC)-enabled photoreduction of ether phosphonium salts for the generation of oxyalkyl radicals was *** photoreduction provides a convenient method to achieve selective oxyalkylation of enamid... 详细信息

关键词： enamides Phosphonium salts Ethers Charge transfer complex Visible light