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Extracellular vesicles in cancer: golden goose or Trojan horse

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Journal of Molecular Cell Biology 2024年第5期16卷 19-28页

作者： Tao Han Qian Hao Tengfei Chao Qinggang Sun yitian chen Bo Gao Liping Guan Wenjie Ren Xiang Zhou Institutes of Health Central Plains Xinxiang Key Laboratory for Molecular OncologyXinxiang Medical UniversityXinxiang 453003China Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Basic Medical Sciences Xinxiang Medical UniversityXinxiang 453003China Umibio Co.Ltd Shanghai 201210China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines,cytokines,and growth *** vesicles(EVs)have emerged as important mediators of cell-to-cell and cell-to-environment *** from tumor cells,immune cells,and stromal cells can remodel the tumor microenvironment and promote cancer cell survival,proliferation,metastasis,immune evasion,and therapeutic *** importantly,EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer *** can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances,such as chemotherapeutic drugs,nucleic acids,and proteins,for the treatment of *** review provides an overview of the biogenesis and recycling of EVs,discusses their roles in cancer development,and highlights their potential as a delivery system for targeted cancer therapy.

关键词： exosome tumor microenvironment immune response metastasis cancer therapy

Global and national burden of atherosclerosis from 1990 to 2019:trend analysis based on the Global Burden of Disease Study 2019

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Chinese Medical Journal 2023年第20期136卷 2442-2450页

作者： Weihua chen Zeya Li Yu Zhao yitian chen Rongchong Huang Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100053China Department of Cardiology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian 364000China

Background:Atherosclerosis-related diseases represent significant health issues among adults *** their widespread impact,comprehensive data concerning the global and national burden and trends of these diseases remain *** objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national ***:We reported the average annual percentage changes(AAPCs)in prevalence,incidence,mortality,and disabilityadjusted life years(DALYs)of atherosclerosis-related diseases(ischemic heart disease[IHD],ischemic stroke,and peripheral arterial disease[PAD])at the global and national levels among individuals based on a trend analysis of the Global Burden of Diseases Study(GBD)*** further analyzed these global trends as a function of age,gender,and the social development *** also used joinpoint regression analysis to identify the year with the most substantial changes in global ***:Globally,the AAPC of IHD incidence rose from 1990 to 2019(0.20;95%confidence interval[CI],0.12-0.28),with substantial surges in 1995,2001,2005,2010,and ***,AAPC of IHD mortality rates exhibited a different trend until a rise in *** AAPC of incidence rates of ischemic stroke and PAD also escalated during the same period,with respective 0.43(95%CI,0.39-0.48)and 0.13(95%CI,0.06-0.21).For ischemic stroke,both incidence and mortality soared in 2014,while PAD incidence declined in 1994 and 1998,then sharply climbed in ***,the Northern Mariana Islands experienced the steepest increase in IHD and PAD incidence and mortality between 1990 and *** saw a significant rise in ischemic stroke incidence,whereas the highest mortality rate increase occurred in *** sociodemographic index(SDI)quintile,low-middle-,middle-,and high-middle-SDI countries all showed upward trends in IHD,ischemic stroke,and PAD ***,IHD and ischemic stroke mortality rates,as well

关键词： Atherosclerosis Disability-adjusted life years(DALYs) Global Disease Burden 2019 Incidence Mortality

USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ

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Cellular & Molecular Immunology 2023年第3期20卷 252-263页

作者： Xiaotong Zhu Peng Wang Xiaoxia Zhan Yuping Zhang Junli Sheng Shitong He yitian chen Dingnai Nie Xiaolong You Haiyan Mai Qinghong Yu Laisheng Li Ligang Jie Shengfeng Hu Department of Rheumatology and Clinical Immunology Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Emergency Medicine Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Institute of Molecular Immunology School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouGuangdongChina Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouGuangdongChina

The balance between inflammatory T helper type 17(Th17)and immunosuppressive regulatory T(Treg)cells is critical for maintaining immune homeostasis in the human body and is tightly regulated under healthy *** increasing number of studies have reported that deubiquitinases(DUBs)play a vital role in regulating Th17-and Treg-cell ***,the biological functions of only a small fraction of DUBs in Th17-and Treg-cell differentiation are well *** this study,we identified ubiquitin-specific peptidase 1(USP1)as a vital regulator of CD4+T-cell ***1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation,thereby promoting the development of inflammatory ***,USP1 in CD4+T cells enhanced the activity of RORγt but promoted the proteasomal degradation of Foxp3 through deubiquitination and stabilization of TAZ in vitro and in ***,ML323,a specific inhibitor of the USP1/UAF1 deubiquitinase complex,inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo,indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg *** study highlights the critical role of USP1 in regulating adaptive immune responses and suggests that USP1 might be a drug target for the treatment of diseases associated with an imbalance between Th17 and Treg cells.

关键词： USP1 TAZ Th17 Treg

Non-Uniform Sediment Transport Downstream from Reservoir

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Transactions of Tianjin University 2008年第4期14卷 263-270页

作者：李义天陈飞 State Key Laboratory of Water Resources and Hydropower Engineering Sciences Wuhan University

The transport characters of non-uniform sediment before and after the reservoir operation are compared and analyzed. Field data from the Three Gorges Reservoir (TGR), Danjiangkou, and Sanmenxia reservoir indicate that the transport character of coarse particle is various in different reaches. Before the reservoir operation, the dramatic decrease of the hydraulic condition in some reaches is the main reason to cause the coarse particle deposited. After the reservoir operation, almost all grain sized sediment may be eroded, when the reach is eroded seriously. However, the transport character of the coarse particle will be consistent with what it was before, when the reach is not eroded seriously. The deposition amount will be less than its pre-dam value, and it will tend to decrease with the time going on. Erosion of fine particle results from its unsaturation. Longdistance erosion downstream from reservoir is caused by shortage of the supply from riverbed, especially the shortage of fine particle.

关键词： downstream from reservoir grain sized sediment hydraulic condition

Analysis of the Relation between Ground Electric Field and the First Lightning Strike

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通讯和计算机（中英文版） 2005年第3期2卷 77-81页

作者： YU Aimin Sill Min LAI Shengli chen yitian College of Electronics and Information South China University of Technology Guang zhou 510640 China Institute of Electronics and Information Guangdong Institute of Science and Technology Guangzhou 510640 China

高质量共建“一带一路”助力构建新时代中塞命运共同体

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当代世界 2024年第10期 70-75页

作者：陈倚天中国银行股份有限公司北京市分行党委宣传部

中国和塞尔维亚传统友谊深厚,彼此交往密切,特别是共建“一带一路”以来,双方合作不断深化且取得一系列丰硕成果,不但实现双边关系的跨越式发展,而且在多边领域协调配合富有成效。但是,在百年变局加速演进的背景下,逆全球化思潮泛起、... 详细信息

中国和塞尔维亚传统友谊深厚,彼此交往密切,特别是共建“一带一路”以来,双方合作不断深化且取得一系列丰硕成果,不但实现双边关系的跨越式发展,而且在多边领域协调配合富有成效。但是,在百年变局加速演进的背景下,逆全球化思潮泛起、地缘政治冲突加剧、外部势力干扰等因素给中塞深化“一带一路”合作带来诸多挑战。在两国元首擘画引领下,双方发展战略对接顺畅、价值理念相融相通、民间社会相知相亲,必将推动新时代中塞命运共同体建设行稳致远。

关键词： “一带一路” 塞尔维亚中塞关系新时代中塞命运共同体

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面向嵌入式系统的功耗管理硬件抽象层

计算机工程 2006年第17期32卷 246-248页

作者：陈虎陈一天奚建清华南理工大学软件工程学院广东科学技术职业学院广州510640

由于缺乏面向嵌入式系统的功耗管理硬件标准接口,嵌入式操作系统在不同硬件平台上的功耗管理功能缺乏可移植性。该文针对嵌入式系统提出了一种功耗管理硬件抽象层模型,同时引入了抽象功耗可管理组件模型,为操作系统提供了统一的功耗状... 详细信息

由于缺乏面向嵌入式系统的功耗管理硬件标准接口,嵌入式操作系统在不同硬件平台上的功耗管理功能缺乏可移植性。该文针对嵌入式系统提出了一种功耗管理硬件抽象层模型,同时引入了抽象功耗可管理组件模型,为操作系统提供了统一的功耗状态转移函数。基于此抽象层,可屏蔽不同硬件结构的功耗管理细节,有效地提高嵌入式操作系统的可移植性。

关键词：嵌入式系统功耗管理硬件抽象层

The acetylation of histone 3 is involved in the neuroprotective effects of artemisinin in PC12 cells

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The acetylation of histone 3 is involved in the neuroprotect...

Artemisia annua extracts improve the cognitive deficits and reverse the pathological changes of Alzheimer's disease via the Hippo pathway

世界中医药学会联合会老年医学专业委员会2021年学术年会暨中国中西医结合学会慢病防治与管理专业委员会第四次学术年会

作者： yitian chen Shuai Li Xia Zhao Lijun Ge Wenhua Zheng Center of Reproduction Development & Aging and Institute of Translation MedicineFaculty of Health Sciences University of Macau

Alzheimer’s disease(AD) is a progressive degenerative disorder of the nervous system with an insidious onset. It is characterized clinically by a comprehensive dementia phenotype consisting of memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavioral changes with hitherto unknown etiology. At present time, there is no specific medicine that can cure or effectively reverse the course of the disease, only the combined use of drug treatment, non drug treatment and attentive care can reduce the symptoms and delay the progression of the disease. In the pre-existing literature, artemisinin has shown promising therapeutic effects on neuronal cells and is capable of pre-venting Alzheimer’s disease. Artemisinin, as an anti-malarial drug, was discovered by Prof. Tu You You. Now, it is widely practiced in a variety of diseases. Because of its ability to protect neuronal cells and its ability to rapidly pass the blood-brain barrier, artemisinin was discovered as a new drug for the treatment of Alzheimer’s disease. However, the mechanism of action of artemisinin is not single. The modification of histones is closely related to the pathogenesis and targeted therapy of many diseases, especially with the acetylation of histones as the most. Therefore, we hypothesized that the artemisinin may protect against Alzheimer’s by regulating the acetylation levels of histones. In this study we found that artemisinin pretreatment followed by addition of aβ1-42 lesioning neural cells PC12 mimics Alzheimer’s disease and determined the pre-protective effect of artemisinin on PC12 cells. Then, accompanied by a certain range of artemisinin’s rising time of action and concentration of action, we found that at the acetylated histone 3 expression level gradually increased. Meanwhile, the dynamic balance of histone acetylation is co regulated by histone acetylases and deacetylases. Use of p300i, an inhibitor of acetylase, in

关键词： Artemisinin Alzheimer’s disease acetylation histone 3

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Artemisia annua extracts improve the cognitive deficits and ...