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Studies on the Electrochemical Reduction of Cyanocobinamide

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Chinese Chemical Letters 1997年第8期8卷 715-718页

作者： Zheng, DH Lu, TH chen, hl ACAD SINICA CHANGCHUN INST APPL CHEMCHANGCHUN 130022PEOPLES R CHINA NANJING UNIV INST COORDINAT CHEMDEPT CHEMNANJING 210008PEOPLES R CHINA

It was found that cyanocobinamide (CN-Cbi) can be reduced at about -0.50V. The reduction process has an EC mechanism, i.e. the electrochemical reduction of CN-Cbi is accompanied by a decyanation of CN-Cbi. The electro... 详细信息

关键词： COBALAMINS

REAL-VALUED PERIODIC WAVELETS: CONSTRUCTION ANDRELATION WITH FOURIER SERIES

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Journal of Computational Mathematics 1999年第5期17卷 509-522页

作者： chen, hl Liang, XZ Peng, SL Xiao, SL Acad Sinica Inst Math Beijing 100080 Peoples R China Jilin Univ Changchun 130023 Jilin Peoples R China

In this paper, we construct the real-valued periodic orthogonal wavelets. The method presented here is new. The decomposition and reconstruction formulas involve only 4 terms respectively. It demonstrates that the formulas are simpler than that in other kinds of periodic wavelets. Our wavelets are useful in applications since it is real valued. The relation between the periodic wavelets and the Fourier series is also discussed.

关键词： periodic wavelet multiresolution Fourier series linear independence

The initial elevation of palaeokarst and planation surfaces on Tibet Plateau

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Chinese Science Bulletin 1997年第11期42卷 934-939页

作者： Cui, ZJ Gao, QZ Liu, GN Pan, BT chen, hl Department of Geography Peking University Beijing China Department of Geography Lanzhou University Lanzhou China

THE formation periods,properties and initial elevations of Tibetan planation surfaces are keysto the issues ot the plateau *** et *** that the study on planation surfaces hasfar-reaching *** et *** that the summit lev... 详细信息

关键词： Tibet Plateau planation surface period elevation.

NMR Studies of 3-Acylcamphor

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Chinese Chemical Letters 2000年第3期11卷 259-260页

作者： Li, ZN Liu, XM Zheng, ZO chen, hl Han, XW Chinese Acad Sci Dalian Inst Chem Phys Dalian 116023 Peoples R China

NMR studies of some chiral 3-acyclcamphor were Conducted. A complete assignment was given to 3-(4-pyridyl)carbonylcamphor by the 2D NMR technology. Assignments were also given to other beta-diketones. The results show... 详细信息

关键词： NMR 3-(4-pyridyl)carbonylcamphor acylcamphor beta-diketone

Geological thermal events in Tarim Basin

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Chinese Science Bulletin 1997年第7期42卷 580-584页

作者： chen, hl Yang, SF Dong, CW Zhu, GQ Jia, CA Wei, GQ Wang, ZG Department of Earth Sciences Zhejiang University Hangzhou China Geological Research and Exploration Center Kuerle China Shanghai University Shanghai China

TARIM Basin is the biggest sedimentary basin in China, and it is also an important area of

关键词： Tarim Basin 40Ar/39Ar plateau age thermal events.

Application of telemetry EEG and EMG in conscious free moving dogs and monkeys for safety assessment and translational science

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Application of telemetry EEG and EMG in conscious free movin...

Application of telemetry EEG and EMG in conscious free moving dogs and monkeys for safety assessment and translational science

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： CAO Chang-qing Nicole N NIU Kelly hl chen Sunny L SUN Angles HU chenG Xing Toxicology and Safety Pharmacology

Dog and monkey are frequently used for cardiovascular safety pharmacology and for toxicology studies,but are not often used for central nervous system(CNS) pharmacological efficacy and safety pharmacological *** this study,we have recorded the radio-telemetry electroencephalogram(EEG) and electromyogram(EMG) synchronously in conscious free moving dogs and monkeys,and validated the models with the proconvulsant agent pentylenetetrazole (PTZ),the analgesics ketamine and morphine as reference *** and monkeys were implanted with epidural electrodes wired to subcutaneously placed *** baseline recording,the test substance was administered and the EEG/EMG activities were recorded from dogs and monkeys placed in slings for iv infusion and free moving for s.c ***(s.c) administration of PTZ dose-dependently(10,20 and 50 mg·kg s.c) induced paroxysmal activity,clonic convulsion and tonic convulsion in both dogs and monkeys,indicating a remarkable CNS safety issue of PTZ as positive control *** PTZ administrated i.v at 1.5mg/kg/min and 1.5 ml·min,both dogs and monkey showed similar level of paroxysmal spike-and-wave activity associated with clonic convulsions occurred between 15 and 30 min after the start of infusion at 4 -5 *** implantation surgery induced post-operational sleep disturbance seen as paroxysmal spike-and-wave activity in monkey EEG/*** and ketamine markedly reversed the EEG to normal sleep *** data indicate that the EEG and EMG are the most sensitive and valuable biomarkers in identifying pathologic CNS activity,in particular for safety pharmacology evaluation and translational application.

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Application of telemetry EEG and EMG in conscious free movin...

Membrane depolarization increases membrane PtdIns(4,5)P2 level through PKC beta Ⅱ and PI4kinase mechanisms

作者： CAO Chang-qing Nicole N NIU Kelly hl chen Sunny L SUN Angles HU chenG Xing Toxicology and Safety Pharmacology Pharmaron

Dog and monkey are frequently used for cardiovascular safety pharmacology and for toxicology studies,but are not often used for central nervous system(CNS) pharmacological efficacy and safety pharmacological *** this study,we have recorded the radio-telemetry electroencephalogram(EEG) and electromyogram(EMG) synchronously in conscious free moving dogs and monkeys,and validated the models with the proconvulsant agent pentylenetetrazol (PTZ),the analgesics ketamine and morphine as reference *** and monkeys were implanted with epidural electrodes wired to subcutaneously placed *** baseline recording,the test substance was administered and the EEG/EMG activities were recorded from dogs and monkeys placed in slings for iv infusion and free moving for s.c ***(s.c) administration of PTZ dose-dependently(10,20 and 50 mg·kg~(-1) s.c) induced paroxysmal activity,clonic convulsion and tonic convulsion in both dogs and monkeys,indicating a remarkable CNS safety issue of PTZ as positive control *** PTZ administrated i.v at 1.5mg/kg/min and 1.5 ml·min~(-1),both dogs and monkey showed similar level of paroxysmal spike-and-wave activity associated with clonic convulsions occurred between 15 and 30 min after the start of infusion at 4 -5 *** implantation surgery induced post-operational sleep disturbance seen as paroxysmal spike-and-wave activity in monkey EEG/*** and ketamine markedly reversed the EEG to normal sleep *** data indicate that the EEG and EMG are the most sensitive and valuable biomarkers in identifying pathologic CNS activity,in particular for safety pharmacology evaluation and translational application.

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Membrane depolarization increases membrane PtdIns(4,5)P2 lev...

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

第三届海内外华人离子通道大会

作者： Zhang hl,chen XJ. Department of Pharmacology,Hebei Medical University Shijiazhuang,People’s Republic of China

Membrane phosphatidylinostol 4,5-bisphosphates(PtdIns(4,5)P2,PIP2) is fundamentally important for maintaining function of a large number of ion channels and *** showed in our previous study that membrane depolarization induced elevation of membrane phosphatidylinostol 4,5-bisphosphates(Ptdlns(4,5) P2,PIP2) and subsequently increased KCNQ2/Q3 currents expressed in Xenopus oocytes through increased activity of PI4 *** underlying mechanism for this depolarization-induced enhancement of PIP2 synthesis was further *** present results indicated that activation of protein kinase C(PKC),specifically activation of PKC isozymesβⅡwas responsible for the enhanced PIP *** found phorbol-12-myristate,13-acetate(PMA),an activator of PKC,mimicked effects of the membrane depolarization by increasing KCNQ2/Q3 activity,elevating membrane PIP level and increasing activity of PI4 *** the other hand,the membrane depolarization enhanced PKC *** effects of both depolarization and PMA were blocked by PKC inhibitor or PI4K RNA *** results demonstrated that the depolarization selectively activated PKCβⅡisoform and enhanced the PKC interaction with PI4 *** results reveal that depolarization-induced elevation of membrane PIP2 is through activation of PKC and subsequently increased activity of PI4 kinase.

关键词： Depolarization KCNQ2/3 channel membrane potential PIP2 PKC,PI4-kinase

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment