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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： Zhan-Li chen chen xie Wei Zeng Rui-Qi Huang Jin-E Yang Jin-Yu Liu Ya-Jing chen Shi-Mei Zhuang MOE Key Laboratory of Gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China Key Laboratory of Liver Disease of Guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTZ),which inhibits the 20S catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not solid tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTZ treatment,or silencing of PSMC5,a subunit of 19S regulatory particle of proteasome,causes G2-and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/GSDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1/PKMYT1(PD0166285),but not inhibitor of ATR,CHK1 or CHK2,abrogates the BTZ-induced G2-phase arrest,thus exacerbates the BTZ-induced mitotic arrest and *** BTZ and PD0166285 treatment(named BP-Combo)selectively kills various types of solid tumor cells,and significantly lessens the IC50 of both BTZ and PD0166285 compared to BTZ or PD0166285 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD0166285 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.

关键词： proteasome inhibiting catastrophe

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Rational design of biodegradable semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photodynamic therapy

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Nano Research 2024年第6期17卷 5399-5408页

作者： Xuxuan Gu Jinlong Shen Zhiwei Xu Wenqi Wang Ying Wu Wen Zhou chen xie Quli Fan State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China

Semiconducting polymer nanoparticles(SPNs)have shown great promise in second near-infrared window(NIR-II)***,the issue of long metabolic time significantly restricts the clinical application of *** this study,we rationally designed a biodegradable SPN(BSPN50)for NIR-II fluorescence imaging-guided photodynamic therapy(PDT).BSPN50 is prepared by encapsulating a biodegradable SP(BSP50)with an amphiphilic copolymer ***50 is composed of NIR-II fluorescent diketopyrrolopyrrole(DPP)segment and degradable poly(phenylenevinylene)(PPV)segment with the ratio of 50/***50 has both satisfactory degradability under myeloperoxidase(MPO)/hydrogen peroxide(H_(2)O_(2))and NIR-II fluorescence emission upon 808 nm laser ***,BSPN50 shows good photodynamic efficacy under 808 nm laser ***50 shows a faster degradation rate than BSPN100 which has no PPV segment both in vitro and in *** addition,BSPN50 can effectively diagnose tumor via NIR-II fluorescence imaging and inhibit the tumor growth by ***,our study provides a rational approach to construct biodegradable nanoplatforms for efficient tumor NIR-II phototheranostics.

关键词： near-infrared(NIR)-II fluorescence imaging semiconducting polymer nanoparticles photodynamic therapy tumor imaging

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Automated machine learning for rainfall-induced landslide hazard mapping in Luhe County of Guangdong Province,China

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China Geology 2024年第2期7卷 315-329页

作者： Tao Li chen-chen xie Chong Xu Wen-wen Qi Yuan-dong Huang Lei Li National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China Institute of Disaster Prevention Sanhe 065201China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China

Landslide hazard mapping is essential for regional landslide hazard *** main objective of this study is to construct a rainfall-induced landslide hazard map of Luhe County,China based on an automated machine learning framework(AutoGluon).A total of 2241 landslides were identified from satellite images before and after the rainfall event,and 10 impact factors including elevation,slope,aspect,normalized difference vegetation index(NDVI),topographic wetness index(TWI),lithology,land cover,distance to roads,distance to rivers,and rainfall were selected as *** WeightedEnsemble model,which is an ensemble of 13 basic machine learning models weighted together,was used to output the landslide hazard assessment *** results indicate that landslides mainly occurred in the central part of the study area,especially in Hetian and *** 102.44 s were spent to train all the models,and the ensemble model WeightedEnsemble has an Area Under the Curve(AUC)value of92.36%in the test *** addition,14.95%of the study area was determined to be at very high hazard,with a landslide density of 12.02 per square *** study serves as a significant reference for the prevention and mitigation of geological hazards and land use planning in Luhe County.

关键词： Landslide hazard Heavy rainfall Harzard mapping Hazard assessment Automated machine learning Shallow landslide Visual interpretation Luhe County Geological hazards survey engineering

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Reactive transport modeling constraints on the complex genesis of a lacustrine dolomite reservoir: A case from the Eocene Qaidam Basin,China

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Petroleum Science 2024年第4期21卷 2240-2256页

作者： Ying Xiong Bo Liu Xiu-cheng Tan Zheng-Meng Hou Jia-Shun Luo Ya-chen xie Kai-Bo Shi Kun-Yu Wu School of Earth and Space Sciences Peking University Institute of Oil and Gas Peking University China National Petroleum Corporation Key Laboratory of Carbonate Reservoirs Southwest Petroleum University Institute of Subsurface Energy Systems Clausthal University of Technology Research Institute of Exploration and Development PetroChina Qinghai Oil Field Company

Reactive transport modeling(RTM) is an emerging method used to address geological issues in diagenesis research. However, the extrapolation of RTM results to practical reservoir prediction is not sufficiently understood. This paper presents a case study of the Eocene Qaidam Basin that combines RTM results with petrological and mineralogical evidence. The results show that the Eocene Xiaganchaigou Formation is characterized by mixed siliciclastic-carbonate-evaporite sedimentation in a semiclosed saline lacustrine environment. Periodic evaporation and salinization processes during the syngeneticpenecontemporaneous stage gave rise to the replacive genesis of dolomites and the cyclic enrichment of dolomite in the middle-upper parts of the meter-scale depositional sequences. The successive change in mineral paragenesis from terrigenous clastics to carbonates to evaporites was reconstructed using RTM simulations. Parametric uncertainty analyses further suggest that the evaporation intensity(brine salinity) and particle size of sediments(reactive surface area) were important rate-determining factors in the dolomitization, as shown by the relatively higher reaction rates under conditions of higher brine salinity and fine-grained sediments. Combining the simulation results with measured mineralogical and reservoir physical property data indicates that the preservation of original intergranular pores and the generation of porosity via replacive dolomitization were the major formation mechanisms of the distinctive lacustrine dolomite reservoirs(widespread submicron intercrystalline micropores) in the Eocene Qaidam Basin. The results confirm that RTM can be effectively used in geological studies, can provide a better general understanding of the dolomitizing fluid-rock interactions, and can shed light on the spatiotemporal evolution of mineralogy and porosity during dolomitization and the formation of lacustrine dolomite reservoirs.

关键词： Reactive transport modeling Lacustrine dolomite Mineralogy and porosity evolution Reservoir genesis

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Giant vascular malformations invading the skull:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2869-2875页

作者： Ming-chen xie Fu-Xu Wang Jian Xu Department of Neurosurgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Vascular malformations(VMs)arise as a result of errors in the process of angiogenesis and are usually present at birth,but may not become apparent until after ***,giant VMs of the head and face are uncommon,with few reported cases,and the prognosis for their surgical intervention is *** SUMMARY A 12-year-old girl was admitted to the hospital with findings of an enlarged right temporal *** admission,computed tomography(CT)angiography of cerebral ateries showed a right occlusal gap and a right temporal artery venous ***,cerebral angiography showed a right temporal lobe VM with multiple vessels supplying *** patient underwent surgery to remove the malformed vessels and the eroded *** hours after the surgery,the patient's right pupil was dilated,and an urgent CT scan of the skull showed a right subdural haematoma under the incision,which was urgently removed by a second *** surgery,we gave continuous antibiotic anti-infection treatment,and the patient recovered well and was discharged two weeks *** Surgical removal of giant haemangiomas is risky and adequate preoperative(including interventional embolisation)and intraoperative preparations should be made.

关键词： Giant vascular malformation Early intervention Surgical intervention Interventional embolization Case report

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Toluene Processed All-Polymer Solar Cells with 18% Efficiency and Enhanced Stability Enabled by Solid Additive:Comparison Between Sequential-Processing and Blend-Casting

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Energy & Environmental Materials 2024年第4期7卷 247-254页

作者： Guoping Zhang Chaoyue Zhao Liangxiang Zhu Lihong Wang Wenzhao Xiong Huawei Hu Qing Bai Yaping Wang chen xie Peng You He Yan Dan Wu Tao Yang Mingxia Qiu Shunpu Li Guangye Zhang College of New Materials and New Energies Shenzhen Technology University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Materials Science and Engineering Donghua University Julong College Shenzhen Technology University

The emergence of polymerized small molecule acceptors (PSMAs) has significantly improved the performance of all-polymer solar cells (all-PSCs).However,the pace of device engineering lacks behind that of materials deve... 详细信息

关键词： all-polymers solar cells sequential processing solid additive

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低共熔溶剂预处理对表面矿化木材性能的影响

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北京林业大学学报 2024年第7期46卷 123-132页

作者：谢晨张扬林木资源高效生产全国重点实验室国家林草木质材料循环利用工程技术中心北京林业大学材料学院北京100083

【目的】为了解决木材矿化改性渗透难、矿化位点少等问题,本研究采用低共熔溶剂(DES)预处理速生杨木、打开木材渗透通道、构建活性位点,研究低共熔溶剂预处理对表面矿化木材性能的影响。【方法】本研究使用DES预处理杨木构建矿化位点,诱... 详细信息

【目的】为了解决木材矿化改性渗透难、矿化位点少等问题,本研究采用低共熔溶剂(DES)预处理速生杨木、打开木材渗透通道、构建活性位点,研究低共熔溶剂预处理对表面矿化木材性能的影响。【方法】本研究使用DES预处理杨木构建矿化位点,诱导SiO_(2)在木材表面实现原位矿化,再通过热压制备表面矿化木材,分析DES预处理对表面矿化木材物理力学性能的影响作用;以较优条件制备表面矿化木材,并分析其微观结构形貌和热性能。【结果】(1)表面矿化木材的密度、质量增长率和表面硬度均随DES预处理时间的增加呈先上升后下降的趋势;预处理为2 h时,较未处理材分别提高了35.25%、16.35%和51.53%;表面矿化木材的疏水性大幅提高,预处理0.5 h时初始接触角增大了74.08%。(2)DES预处理可以显著改善表面矿化木材力学性能;当DES预处理时间为2 h时,表面矿化木材的抗弯强度和弹性模量分别提升了20.53%和214.55%。(3)表面矿化处理向木材内引入SiO2形成有机–无机杂化结构,提高木材阻燃性能;DES预处理2 h时,表面矿化木材的质量残余率相较于未处理材提高了70.81%,热释放速率降低了69.9 kW/m^(2),总热释放量降低了27.3 MJ/m^(2)。【结论】速生杨木经DES预处理和表面矿化联合改性后物理力学性能提升,热稳定性和阻燃性能良好。

关键词：木材化学物理力学性能阻燃速生杨木低共熔溶剂表面矿化

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PCCL光束对瑞利粒子作用力的理论研究

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激光技术 2024年第5期48卷 698-704页

作者：谢陈屈军安徽师范大学物理与电子信息学院芜湖241002

为了探究部分相干月牙形光束(PCCL)对瑞利粒子的捕获特性,采用广义惠更斯-菲涅耳原理推导了PCCL光束经过ABCD光学系统传输后的交叉谱密度及对瑞利粒子作用力的表达式,对聚焦PCCL光束在焦平面的归一化光强和对瑞利粒子作用力的分布情况... 详细信息

为了探究部分相干月牙形光束(PCCL)对瑞利粒子的捕获特性,采用广义惠更斯-菲涅耳原理推导了PCCL光束经过ABCD光学系统传输后的交叉谱密度及对瑞利粒子作用力的表达式,对聚焦PCCL光束在焦平面的归一化光强和对瑞利粒子作用力的分布情况进行了软件模拟和理论分析,得到了聚焦PCCL光束的光强和捕获力随光束参量以及焦距变化的规律。结果表明,选取光束阶数n=3、初始腰宽w_(0)=0.1 mm、相干长度d_(0)=6 mm时,经焦距f=12 mm的透镜聚焦后的PCCL光束对高、低折射率粒子均能实现捕获;由于PCCL光束在焦平面处呈现离轴光强分布,峰值光强不在坐标原点,通过调节光束阶数、初始腰宽、相干长度和焦距,可实现对聚焦PCCL光强及瑞利粒子作用力的调控,从而实现聚焦PCCL光束对不同位置处瑞利粒子的灵活捕获。该研究结果为实际聚焦PCCL光束稳定捕获微粒提供了理论依据。

关键词：激光光学聚焦捕获惠更斯-菲涅耳原理部分相干月牙形光束

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噪声鉴别C均值聚类的滁菊花茶品质等级鉴别研究

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光谱学与光谱分析 2024年第8期44卷 2202-2207页

作者：武斌谢晨傲陈勇武小红贾红雯滁州职业技术学院信息工程学院安徽滁州239000 江苏大学电气信息工程学院江苏镇江212013

近红外光谱检测技术可以通过探测近红外区域的光谱特征,反映所测样品内部有机物化学成分和结构信息。在分析物质成分时,近红外光谱通常会涉及到大量的波长数据,因此其维数往往比较高。同时,光谱会出现重叠和冗余等现象,会影响模型的性... 详细信息

近红外光谱检测技术可以通过探测近红外区域的光谱特征,反映所测样品内部有机物化学成分和结构信息。在分析物质成分时,近红外光谱通常会涉及到大量的波长数据,因此其维数往往比较高。同时,光谱会出现重叠和冗余等现象,会影响模型的性能。提出一种噪声鉴别C均值聚类(NDCM)算法。NDCM将一种快速广义噪声聚类(FGNC)和模糊线性判别分析(FLDA)相结合,可实现模糊聚类过程中进行数据鉴别信息的提取和数据空间维度的压缩,以达到更高的聚类准确率。对滁菊花茶近红外光谱数据进行模糊C均值聚类(FCM)得到的模糊隶属度和聚类中心作为噪声鉴别C均值聚类(NDCM)的初始模糊隶属度和初始聚类中心,使NDCM具有聚类速度快,准确率高等优点。FCM算法对光谱噪声数据敏感,而NDCM算法在处理含噪声的光谱数据时能够表现出较好的性能。该研究选取特级滁菊、一级滁菊、二级滁菊三种品质等级的滁菊花茶作为实验样本,共计240个样本。实验使用便携式近红外光谱仪(NIR-M-F1-C)采集滁菊花茶的近红外光谱数据。用Savitzky-Golay滤波和多元散射校正(MSC)对滁菊花茶近红外光谱进行预处理,以减少光谱中掺杂的噪声和重叠信息。通过主成分分析(PCA)对采集到的400维光谱数据进行维度压缩降至6维。该研究使用线性判别分析(LDA)提取滁菊花茶光谱数据中的鉴别信息,并将数据空间维度进一步转换为2维。分别用FCM,FGNC和NDCM三种算法对处理后的数据进行聚类分析,以实现对滁菊花茶的准确分类。实验结果显示:当权重指数m=2.5时,FCM,FGNC,NDCM的聚类准确率分别为92.42%,98.48%,100%。NDCM聚类时间略长于FGNC。FCM算法需要进行27次迭代才能收敛,而FGNC算法和NDCM算法分别只需要13次和10次迭代就能达到收敛。采用近红外光谱技术结合MSC、Savitzky-Golay滤波、PCA、LDA和NDCM算法,建立了一种精准鉴别滁菊花茶品质等级的聚类模型。

关键词：噪声鉴别C均值聚类近红外光谱无损检测线性判别分析

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19世纪末至20世纪初苏格兰的中国艺术品收藏

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国际汉学 2024年第1期 88-95,153页

作者：谢琛伦敦邦瀚斯拍卖行

2017年开始,苏格兰国家博物馆与苏格兰境内的36家机构合作,调查了整个区域内的东亚藏品状况,该项目在2020年初以调查报告的形式公布了成果。本研究以该调查报告为线索,锁定中国物品大量流入的19世纪末至20世纪初这一时间段,以不同身份... 详细信息

2017年开始,苏格兰国家博物馆与苏格兰境内的36家机构合作,调查了整个区域内的东亚藏品状况,该项目在2020年初以调查报告的形式公布了成果。本研究以该调查报告为线索,锁定中国物品大量流入的19世纪末至20世纪初这一时间段,以不同身份的藏家为切入点,将这个时期从中国历经迁转来到苏格兰的“藏品”放置于收藏者个体的生命历程以及宏观的历史背景中去考察。重构“藏品”和“收藏者”在历史现场中的身份对于揭示中国和苏格兰这两个地域间的互动,探析中国器物在异域的接受史及其背后的动因,以及描绘苏格兰的历史图景都有重要意义。

关键词：苏格兰中国藏品藏家跨文化研究

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