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Virologica Sinica 2024年第4期39卷 694-698页

作者： Jiayu Wang Wencheng Wu Wei Wang Jingyi Zhang Jianwei Xiao mingyi Cai Jiaying Guo Run Li Shuangli Zhu Wanju Zhang min chen Zheng Teng Microbiology Department Shanghai Municipal Center for Disease Control and PreventionShanghai200336China Microbiology Department Yangpu Municipal Center for Disease Control and PreventionShanghai200090China Microbiology Department Jing’an Municipal Center for Disease Control and PreventionShanghai200070China Microbiology Department Changning Municipal Center for Disease Control and PreventionShanghai200050China WHO WPRO Regional Polio Reference Laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China

Dear Editor,Hand,foot and mouth disease(HFMD)is one of the most common infectious diseases,particularly in the Asia-Pacific *** the past two decades,HFMD rises to prominence for its heavy burden,with over one million cases reported *** 2013,enterovirus A71(EV-A71)and Coxsackievirus A16(CVA16)were the main pathogens leading to HFMD in the mainland of China(Yang et al.,2017).In recent years,non-EV-A71-non-CVA16 other enteroviruses,such as Coxsackievirus A6(CVA6),Coxsackievirus A10(CVA10)and Coxsackievirus A4(CVA4),were frequently reported and replaced EV-A71 and CVA16 becoming the major causative agents of HFMD(Zhou et al.,2021;Wang et al.,2022).

关键词： enterovirus HFMD al.

在继承和借鉴中创新中国演剧--访导演艺术家徐晓钟

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中国文艺评论 2024年第2期 112-124,I0004页

作者：陈敏中央戏剧学院

一、要充分重视和发挥戏剧艺术的本性陈敏(以下简称“陈”):高峰作品难出是当代中国文艺创作的突出问题,您执导的《桑树坪纪事》被学界公认为是中国当代戏剧的高峰作品,具有里程碑意义。曹禺先生以“完美的艺术”评价您的作品,他说,“... 详细信息

一、要充分重视和发挥戏剧艺术的本性陈敏(以下简称“陈”):高峰作品难出是当代中国文艺创作的突出问题,您执导的《桑树坪纪事》被学界公认为是中国当代戏剧的高峰作品,具有里程碑意义。曹禺先生以“完美的艺术”评价您的作品,他说,“戏处理得很精彩很有趣味”,看了您的戏,他的感想是,“海是装不满的,人的路是走不尽的,花是不谢的,感情的长河是流不完的”。[1]您能否结合个人的成长历程,谈谈执导《桑树坪纪事》的感受和体会?

关键词：徐晓钟文艺创作戏剧艺术里程碑意义充分重视成长历程

Adrenaline in pulp capping treatment of reversible pulpitis

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World Journal of Clinical Cases 2024年第22期12卷 5024-5031页

作者： Si-Yun Yang Jin-Zhu Wang Hao Fan min chen Department of Stomatology Anhui Jieshou People's HospitalFuyang 236500Anhui ProvinceChina Department of Stomatology Jiangsu Yancheng Maternal and Child Health HospitalYancheng 224000Jiangsu ProvinceChina

BACKGROUND The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not *** To explore the role of epinephrine in the treatment of pulp capping in patients with reversible *** A total of 100 patients with reversible pulpitis who were treated in Anhui Jieshou People's Hospital from January 2020 to December 2021 were included in the *** were categorized into an observation group(n=50;treatment with adrenaline)and a control group(n=50;treatment with zinc oxide eugenol paste).The 24-h postoperative pain,regression time of gingival congestion and redness,clinical efficacy,and incidence of adverse reactions were compared between the *** were further categorized into the ineffective and effective treatment groups based on clinical *** multiple regression analysis explored factors affecting the efficacy of pulp capping *** A significant difference in 24-h postoperative pain was observed between the groups(P0.05).The proportion of adrenaline usage was lower(P<0.05)and that of anaerobic digestion by Streptococcus and Fusobacterium nucleatum was higher in the ineffective treatment group than in the effective treatment group(P<0.05).Logistic multiple regression analysis revealed adrenaline as a protective factor(P<0.05)and anaerobic digestion by Streptococcus and *** as risk factors for pulp capping in

关键词： Adrenaline Reversible pulpitis Pulp capping Efficacy Safety

Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3798-3819页

作者： Matteo Micucci Bian-Zhao Xiang chen-min Ting Hiu-Yee Kwan Michele Mari Michele Retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli Department of Biomolecular Sciences University of Urbino Carlo BoUrbino 61029Italy Hong Kong Chinese Medicine Clinical Study Centre Chinese EQUATOR CentreSchool of Chinese MedicineChinese Clinical Trial Registry(Hong Kong)Hong Kong Baptist UniversityHong Kong 999077China Centre for Chinese Herbal Medicine Drug Development Hong Kong Baptist UniversityHong Kong 999077China Centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Department of Chemistry College of ScienceSalahaddin University-ErbilErbil 44001Iraq Department of Pharmacognosy Faculty PharmacyTishk International UniversityErbil 44001Iraq Institute of Oncology Research Bellinzona CH6500Switzerland Universitàdella Svizzera Italiana Lugano CH6900Switzerland

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and *** review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer *** advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical *** on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated *** agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive *** convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health *** approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease *** combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关键词： Traditional Chinese medicine Precision medicine Molecular network Phytochemistry Food chemistry Nutraceuticals Gastric cancer

Knockdown of fibrillin-1 suppresses retina-blood barrier dysfunction by inhibiting vascular endothelial apoptosis under diabetic conditions

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1403-1410页

作者： Yue Zhang Xiao-Jing Liu Xin-Ran Zhai Yao Yao Bin Shao Yu-Han Zhen Xin Zhang Zhe Xiao Li-Fang Wang ming-Lian Zhang Zhi-min chen Hebei Eye Hospital Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054001Hebei ProvinceChina Department of Ophthalmology Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

AIM:To investigate the effects of fibrillin-1(FBN1)deletion on the integrity of retina-blood barrier function and the apoptosis of vascular endothelial cells under diabetic ***:Streptozotocin(STZ)-induced diabetic mice were used to simulate the diabetic conditions of diabetic retinopathy(DR)patients,and FBN1 expression was detected in retinas from STZ-diabetic mice and *** the Gene Expression Omnibus(GEO)database,the GSE60436 dataset was selected to analyze FBN1 expressions in fibrovascular membranes from DR *** lentivirus to knock down FBN1 levels,vascular leakage and endothelial barrier integrity were detected by Evans blue vascular permeability assay,fluorescein fundus angiography(FFA)and immunofluorescence labeled with tight junction marker in *** glucose-induced monkey retinal vascular endothelial cells(RF/6A)were used to investigate effects of FBN1 on the cells in *** vascular endothelial barrier integrity and apoptosis were detected by trans-endothelial electrical resistance(TEER)assay and flow cytometry,***:FBN1 mRNA expression was increased in retinas of STZ-induced diabetic mice and fibrovascular membranes of DR patients(GSE60436 datasets)using RNA-seq ***,knocking down of FBN1 by lentivirus intravitreal injection significantly inhibited the vascular leakage compared to STZ-DR group by Evans blue vascular permeability assay and FFA *** of tight junction markers in STZ-DR mouse retinas were lower than those in the control group,and knocking down of FBN1 increased the tight junction *** vitro,30 mmol/L glucose could significantly inhibit viability of RF/6A cells,and FBN1 mRNA expression was increased under 30 mmol/L glucose ***-regulation of FBN1 reduced high glucose(HG)-stimulated retinal microvascular endothelial cell permeability,increased TEER,and inhibited RF/6A cell apoptosis in ***:The expression level of FBN1 increases in reti

关键词： diabetic retinopathy fibrillin-1 retinablood barrier vascular leakage vascular permeability apoptosis retinal vascular endothelial cells

Organic Integration of Traditional Chinese and Western Medicines—Future of Clinical Practice Guidelines of Integrated Traditional Chinese and Western Medicines

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Chinese Journal of Integrative Medicine 2024年第4期30卷 359-365页

作者： XIE Ying-lan HAN Fei JIN Ying-hui DING Yan-bing GUO Jing JI Dong-xiao ZHANG Teng chenXiao-min SHANG Hong-cai Department of Traditional Chinese Medicine Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan(430074)China Department of Traditional Chinese Medicine Encephalopathy Hubei Province Traditional Chinese Medicine Research InstituteWuhan(430074)China Xuanwu Hospital of Traditional Chinese Medicine Beijing(100000)China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan(430074)China College of Acupuncture and Massage College of Health and RehabilitationNanjing University of Chinese MedicineNanjing(210023)China Department of Ophthalmology Huaihe Hospital of Henan UniversityKaifengHenan Province(475000)China ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese Medicine Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine/Ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese MedicineBeijing(100700)China

The transformation and implementation of clinical practice guidelines for integrated traditional Chinese medicine(TCM)and Western medicine(WM)is crucial to the adoption of medical science and technological findings and is an important way for TCM to be made available to the ***,clinical practice guidelines(CPGs)of TCM and WM integration in recent years was analyzed to clarify the current situation and problems in the existing guidelines according to the following four perspectives:(1)perspective of TCM and WM integration in guidelines,(2)diagnosis Using integrated TCM and WM,(3)integration of TCM and WM treatment,(4)promoting TCM and WM ***,the information and quality evaluation of CPGs for integrated Chinese and Western medicine in 2020–2022 were analyzed to explore the degree and methods of integration of Chinese and Western medicine *** last this study aimed to lay a foundation for the further establishment of Chinese characteristic,repeatable,and calculable clinical practice guidelines of TCM and WM integration.

关键词： clinical practice guidelines integrated traditional Chinese and Western medicine organic integration

A dendritic Cu/Cu_(2)O structure with high curvature enables rapid and efficient reduction of carbon dioxide to C2 in an H-cell

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Chinese Journal of Catalysis 2024年第8期63卷 144-153页

作者： Lei shao Bochen Hu Jinhui Hao Junjie Jin Weidong Shi min chen School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Electrocatalytic reduction of CO_(2)(CO_(2)RR)to multicarbon products is an efficient approach for ad-dressing the energy crisis and achieving carbon *** H-cells,achieving high-current C_(2)products is challenging because of the inefficient mass transfer of the catalyst and the presence of the hydrogen evolution reaction(HER).In this study,dendritic Cu/Cu_(2)O with abundant Cu^(0)/Cu^(+)interfaces and numerous dendritic curves was synthesized in a CO_(2)atmosphere,resulting in the high selectivity and current density of the C_(2)*** Cu/Cu_(2)O achieved a C_(2)Faradaic efficiency of 69.8%and a C_(2)partial current density of 129.5 mA cm^(-2)in an *** element simulations showed that a dendritic structure with a high curvature generates a strong electric field,leading to a localized CO_(2)***,DRT analysis showed that a dendritic struc-ture with a high curvature actively adsorbed the surrounding high concentration of CO_(2),enhancing the mass transfer rate and achieving a high current *** the experiment,the impact of the electronic structure on the performance of the catalyst was investigated by varying the atomic ratio of Cu^(0)/Cu^(+)on the catalyst surface,which resulted in improved ethylene *** the optimal atomic ratio of Cu^(0)/Cu^(+),the charge transfer resistance was minimized,and the desorption rate of the intermediates was low,favoring C_(2)*** functional theory calculations indicated that the Cu^(0)/Cu^(+)interfaces exhibited a lower Gibbs free energy for the rate-determining step,enhancing C_(2)H4 *** Cu/Cu_(2)O catalyst also exhibited a low Cu d-band center,which enhanced the adsorption stability of*CO on the surface and facilitated C_(2)*** observa-tion explained the higher yield of C_(2)products at the Cu^(0)/Cu^(+)interface than that of H_(2)under rapid mass *** results of the net present value model showed that the H-cell holds

关键词： Reduction of CO_(2) High current Dendritic structure Cu/Cu_(2)O H-cell

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肾脏病领域近十年进展

中华内科杂志 2024年第4期63卷 328-332页

作者：陈旻赵明辉北京大学第一医院肾内科北京100034

近十年来, 肾脏病领域有了多方面的重大进展。在慢性肾脏病方面, 我国的病因谱发生了显著的变迁。钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂和新一代高选择性非甾体类盐皮质激素受体拮抗剂(MRA)可改善慢性肾脏病患者的预后。肾小球疾病和... 详细信息

近十年来, 肾脏病领域有了多方面的重大进展。在慢性肾脏病方面, 我国的病因谱发生了显著的变迁。钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂和新一代高选择性非甾体类盐皮质激素受体拮抗剂(MRA)可改善慢性肾脏病患者的预后。肾小球疾病和遗传性肾脏病的病因与诊疗研究亦有了突破性进展。异种器官移植术显示了基因和生物工程学进展对肾脏病领域产生的深远影响。急性肾损伤流行病学和肾脏替代治疗时机的研究, 为急性肾损伤标准化诊疗增添了新的证据。

关键词：肾脏病慢性肾脏病肾小球疾病遗传性肾脏病肾移植急性肾损伤

随机激励下带滞变阻尼的调谐质量阻尼器减振性能研究

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工程力学 2024年第1期41卷 171-181页

作者：向越谭平贺辉陈倩敏广州大学土木工程学院广州510006 广州大学工程抗震减震与结构安全教育部重点实验室广州510006 湖南工学院土木与建筑工程学院衡阳421002

近年来,阻尼力与位移呈线性关系的新型调谐质量阻尼器(Tuned mass damper, TMD)相继出现,其参数分析优化原理大部分属于动力数值分析缺乏理论参数优化指导。该文对白噪声作用下具有上述特性的TMD,即滞变阻尼调谐质量阻尼器(Hysteretic d... 详细信息

近年来,阻尼力与位移呈线性关系的新型调谐质量阻尼器(Tuned mass damper, TMD)相继出现,其参数分析优化原理大部分属于动力数值分析缺乏理论参数优化指导。该文对白噪声作用下具有上述特性的TMD,即滞变阻尼调谐质量阻尼器(Hysteretic damping tuned mass damper, HD-TMD)进行减振优化研究。总结了HD-TMD的力学机理并推导出相应的结构-HD-TMD系统运动方程;提出适用于HD-TMD的H_(2)优化和性能平衡设计,并通过数值拟合技术得到了最优参数公式和基于容忍度的性能平衡设计流程;以真实可用的变摩擦摆式调谐质量阻尼器(VFP-TMD)为HD-TMD的实际算例,检验所提出的优化方法对风振激励的减振性能影响。结果表明:H_(2)优化和性能平衡设计下的HD-TMD可以提供略优于传统黏滞阻尼TMD的控制效果。H_(2)优化的最优参数能使HD-TMD发挥最大的潜能从而实现最好的减振率,但面临VFP-TMD行程过大导致的摆动非线性问题。性能平衡设计下的最优参数可以控制VFP-TMD行程在线性范围内,同时发挥出良好且稳定的减振控制效果实现双赢。与最优参数公式结果相比,性能平衡设计的峰值减振率和均方差峰值减振率仅损失3.19%和0.74%。

关键词：结构减振控制调谐质量阻尼器滞变阻尼 H_(2)优化性能平衡设计

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L-theanine/α-Ketoglutarate/Nrf2 axis promotes exercise-mediated amelioration of NASH in mice

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Food Science and Human Wellness 2024年

作者： Wang-Jing Mu min chen Jie-Ying Zhu Hong-Yang Luo Yang Li Shan Li Lin-jing Yan Ruo-ying Li Liang Guo School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health， Shanghai University of Sport Shanghai Frontiers Science Research Base of Exercise and Metabolic Health， Shanghai University of Sport Key Laboratory of Exercise and Health Sciences of the ministry of Education， Shanghai University of Sport

L-Theanine (LTA) is a non-protein amino acid mainly found in tea plants with many beneficial effects. Exercise exerts a wide range of benefits in metabolic health. Here， we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced NASH in mice. Meanwhile， combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes， including hepatic steatosis， inflammation， cell death and oxidative stress. In vivo studies indicate that LTA inhibits free fatty acid (FFA)-induced hepatocyte injury， including steatosis， oxidative stress and apoptosis. Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction. Mechanistically， LTA increases the α-ketoglutarate (α-KG) level in hepatocytes， which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter. Moreover， LTA promote the above α-KG/Nrf2 axis in synergy with exercise， thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice. Our results suggest that， through promoting the α-KG/Nrf2 axis-mediated anti-oxidative pathway， the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.

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