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Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024年第3期18卷 538-557页

作者： Yue Yuan Jiaxuan Li Xun Lu min chen Huifang Liang Xiao-ping chen Xin Long Bixiang Zhang Song Gong Xiaowei Huang Jianping Zhao Qian chen Division of Gastroenterology Department of Internal Medicine at Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Hepato–Pancreato–Biliary Diseases Wuhan430030China Department of Trauma Surgery Tongji Trauma CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Schistosoma infection is one of the major causes of liver *** roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been ***,the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasis remains *** study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulating exosomal *** activation of HPCs was verified by immunohistochemistry(IHC)and immunofluorescence(IF)staining in fibrotic liver from patients and mice with Schistosoma japonicum *** coculturing HPCs with hepatic stellate cells(HSCs)and assessing the autophagy level in HPCs by proteomic analysis and in vitro phenotypic assays,we found that impaired autophagy degradation in these activated HPCs was mediated by lysosomal *** autophagy by the autophagy inhibitor chloroquine(CQ)significantly diminished liver fibrosis and granuloma formation in ***-infected ***-secreted extracellular vehicles(EVs)were further isolated and studied by miRNA ***-1306-3p,miR-493-3p,and miR-34a-5p were identified,and their distribution into EVs was inhibited due to impaired autophagy in HPCs,which contributed to suppressing HSC *** conclusion,we showed that the altered autophagy process upon HPC activation may prevent liver fibrosis by modulating exosomal miRNA release and inhibiting HSC activation in *** the autophagy degradation process may be a therapeutic strategy for liver fibrosis during Schistosoma infection.

关键词： schistosomiasis hepatic progenitor cell autophagy extracellular vesicle fibrosis miRNA

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Tracking the Confiscated Green Sea Turtles in the South China Sea:Where Did They Come From?Where Will They Go?

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Asian Herpetological Research 2024年第3期15卷 173-182页

作者： min chen Tong HUANG Dayi NIE Liu LIN Fang chen Jing WANG Jinyan YANG Jing ZHANG Tong LIU Yiqiong CUI School of Life Sciences Institute of Eco-ChongmingShanghai Institute of Wildlife EpidemicsEast China Normal UniversityShanghai 200241China Hainan Institute of East China Normal University Sanya 572025HainanChina ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158HainanChina Aquatic Wildlife Conservation Branch of China Wildlife Conservation Association Beijing 100013China Society of Entrepreneurs and Ecology Beijing 100012China Commonwealth Scientific and Industrial Research Organisation Canberra ACT 2601Australia

The population of the green sea turtle(Chelonia mydas)is under decline,threatened by bycatch and illegal acquisition despite worldwide protection ***,the confiscation of illegally acquired sea turtles could aid in tracking their origin and movement patterns,crucial for effective conservation *** satellite tracking and genetic analysis offers an opportunity to investigate the relationship between the origins and migration directions of green sea turtles in the western ***,we applied two methods to investigate the spatial ecology of 18 green turtles caught as bycatch in the South China *** results revealed the genetic origins and diverse movements of the *** Mixed Stock Analysis(MSA)suggested that these turtles originated from the rookery of the Xisha Islands(49.6%),central Ryukyu(24.6%),NE Borneo(8%),and the Sulu Sea(5.2%),with other rookeries in meagre proportions(ming *** results indicate that the South China Sea is likely an important transportation hub and mating spot for green *** findings provided evidence for the rehabilitation of these green turtles in the wild and illustrated the complexity of movement during the green turtle’s life history,and the“mixed backgrounds”of the green turtles also highlight the need for joint conservation efforts of neighbouring countries in the South China Sea.

关键词： conservation genetics green sea turtle(Chelonia mydas) movement rookery satellite tracking

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Protective effects of baffles with different positions,row spacings,heights on debris flow impact

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Journal of Mountain Science 2024年第7期21卷 2352-2367页

作者： SUN Xinpo chen min BI Yuzhang ZHENG Lu CHE Chi XU Ao TIAN Zijian JIANG Zheyuan College of Civil Engineering Sichuan University of Science and EngineeringZigong 643000China College of Resources and Environment Fujian Agriculture and Forestry UniversityFuzhou 350002China School of Civil Engineering Fuzhou UniversityFuzhou 350108China Jiangsu Key Laboratory of Urban Underground Engineering&Environmental Safety Institute of Geotechnical EngineeringSoutheast UniversityNanjing 210096China Beijing Urban Construction Science Technology Promoting Association Beijing 100055China SUSE-BZ Geoenvironmental Engineering Joint Laboratory Sichuan University of Science and EngineeringZigong 643000China

The baffle effectively slowed down debris flow velocity,reduced its kinetic energy,and significantly shortened the distance of debris flow ***,they are widely used for protection against natural hazards such as landslides and *** study,based on the threedimensional DEM(Discrete Element Method),investigated the impact of different baffle positions on debris flow *** flow velocity and kinetic energy variations were studied through single-factor *** baffle positions were preliminarily selected by analyzing the influence of the first-row baffle position on the impact force and accumulation mass of debris ***,based on the selected baffle positions and four factors influencing the effectiveness of baffle protection(baffle position(P),baffle height(h),row spacing(S_(r)),and angle of transit area(α)),an orthogonal design was employed to further explore the optimal arrangement of *** research results indicate that the use of a baffle structure could effectively slow down the motion velocity of debris flows and dissipate their *** the baffle is placed in the transit area,the impact force on the first-row baffle is greater than that when the baffle is placed in the deposition ***,when the baffle is placed in the transit area,the obstruction effect on debris flow mass is also greater than that when the baffle is placed in the deposition *** orthogonal experimental range analysis,when the impact on the first row of baffles is used as the evaluation criterion,the importance of each influencing factor is ranked asα>P>S_(r)>*** the mass of debris flow behind the baffle is regarded as the evaluation criterion,the rank is changed to P>α>S_(r)>*** experimental simulation results show that the optimal baffle arrangement is:P_(5),S_(r)=16,α=35°,h=9.

关键词： Debris flow Baffle Protective effect Discrete element

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A Distributed Ant Colony Optimization Applied in Edge Detection

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Journal of Computer and Communications 2024年第8期12卷 161-173页

作者： min chen Department of Computer Science State University of New York at New Paltz New York USA

With the rise of image data and increased complexity of tasks in edge detection, conventional artificial intelligence techniques have been severely impacted. To be able to solve even greater problems of the future, learning algorithms must maintain high speed and accuracy through economical means. Traditional edge detection approaches cannot detect edges in images in a timely manner due to memory and computational time constraints. In this work, a novel parallelized ant colony optimization technique in a distributed framework provided by the Hadoop/Map-Reduce infrastructure is proposed to improve the edge detection capabilities. Moreover, a filtering technique is applied to reduce the noisy background of images to achieve significant improvement in the accuracy of edge detection. Close examinations of the implementation of the proposed algorithm are discussed and demonstrated through experiments. Results reveal high classification accuracy and significant improvements in speedup, scaleup and sizeup compared to the standard algorithms.

关键词： Distributed System Ant Colony Optimization Edge Detection MapReduce Speedup

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Classification with Convolutional Neural Networks in MapReduce

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Journal of Computer and Communications 2024年第8期12卷 174-190页

作者： min chen Department of Computer Science State University of New York at New Paltz New York USA

Deep learning (DL) techniques, more specifically Convolutional Neural Networks (CNNs), have become increasingly popular in advancing the field of data science and have had great successes in a wide array of applications including computer vision, speech, natural language processing, etc. However, the training process of CNNs is computationally intensive and has high computational cost, especially when the dataset is huge. To overcome these obstacles, this paper takes advantage of distributed frameworks and cloud computing to develop a parallel CNN algorithm. MapReduce is a scalable and fault-tolerant data processing tool that was developed to provide significant improvements in large-scale data-intensive applications in clusters. A MapReduce-based CNN (MCNN) is developed in this work to tackle the task of image classification. In addition, the proposed MCNN adopted the idea of adding dropout layers in the networks to tackle the overfitting problem. Close examination of the implementation of MCNN as well as how the proposed algorithm accelerates learning are discussed and demonstrated through experiments. Results reveal high classification accuracy and significant improvements in speedup, scaleup and sizeup compared to the standard algorithms.

关键词： Distributed System Image Classification CNNs MapReduce Overfitting

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Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2630-2639页

作者： Hai-Hua Shen Yu-Rong Hong Wen Xu Lei chen Jun-min chen Zhi-Gen Yang Cai-Hong chen Department of Ultrasound Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina Department of Ultrasound The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Nursing Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina

BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,the 3-year survival rate is still ***,there are no visual methods to effectively predict their *** To explore the factors influencing the prognosis of HCC after RFA and TACE and develop a nomogram prediction *** Clinical and follow-up information of 150 patients with HCC treated using RFA and TACE in the Hangzhou Linping Hospital of Traditional Chinese Medicine from May 2020 to December 2022 was retrospectively collected and *** examined their prognostic factors using multivariate logistic regression and created a nomogram prognosis prediction model using the R software(version 4.1.2).Internal verification was performed using the bootstrapping *** prognostic efficacy of the nomogram prediction model was evaluated using the concordance index(CI),calibration curve,and receiver operating characteristic RESULTS Of the 150 patients treated with RFA and TACE,92(61.33%)developed recurrence and *** regression analysis identified six variables,and a predictive model was *** internal validation results of the model showed a CI of *** correction curve trend of the prognosis prediction model was always near the diagonal,and the mean absolute error before and after internal validation was *** area under the curve of the prediction model after internal verification was 0.882[95%confidence interval(95%CI):0.820-0.945],with a specificity of 0.828 and sensitivity of *** to the Hosmer-Lemeshow test,χ^(2)=3.552 and P=*** predictive model demonstrated a satisfactory calibration,and the decision curve analysis demonstrated its clinical *** The prognosis of patients with HCC after RFA and TACE is affected by several *** developed prediction model ba

关键词： Nomogram Primary liver cancer Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Influencing factors Decision curve analysis

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The Effect and Mechanism of Fructus lycii on Improvement of Exercise Fatigue Using a Network Pharmacological Approach with in vitro Experimental Verification

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Biomedical and Environmental Sciences 2024年第1期37卷 42-53页

作者： JI Xiao Ning LIU Zhao Ping ZHANG Chao Zheng chen min LIANG Jiang LU Jiang ZHANG Lei National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China China National Center for Food Safety Risk Assessment Beijing 100022China Chinese Center for Disease Control and Prevention Beijing 102206China

Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise *** A network pharmacological approach was used to explore potential mechanisms of action of Fructus *** muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological *** Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling *** immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the ***,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin *** Fructus lycii might alleviate exercise fatigue through multiple components and *** these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative *** PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.

关键词： Fructus lycii Exercise fatigue Network pharmacology

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Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives: Construction of C-N Axially Chiral Sulfides

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Chinese Journal of Chemistry 2024年第17期42卷 2005-2009页

作者： Qin Yang Hui-Yun Luo Deng Zhu Xin-Yu Zhang Hua Ke Zhi-min chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Engineering Technooy Rearch Centeror Enviromental Proction Materas Pingxng Universty PingangJiangx355China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGansu 730000China

Chiral BINAM-derived selenide/achiral acid co-catalyzed atroposelective electrophilic sulfenylation of pyrrole derivatives has been realized for the first time.A variety of C-N axially chiral sulfur-containing pyrrole derivatives were readily obtained in moderate to good yields with moderate to excellent *** catalytic system involves sequential desymmetrization and kinetic resolution.

关键词： Electrophilic substitution Desymmetrization Kinetic resolution Atropisomerism Asymmetric catalysis Heterocycles

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Ferroptosis in liver diseases:Fundamental mechanism and clinical implications

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World Journal of Gastroenterology 2024年第32期30卷 3730-3738页

作者： ming-Shuang Lai Xi-Peng Yan Donald R Branch Melika Loriamini Li-min chen The Joint Laboratory on Transfusion-Transmitted Diseases(TTDs)Between Institute of Blood Transfusion Chinese Academy of Medical Sciences and Nanning Blood CenterNanning 530003Guangxi Zhuang Autonomous RegionChina Department of Medicine and Laboratory Medicine and Pathobiology Centre for InnovationCanadian Blood ServicesHamilton 397086Canada Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory for Transfusion-transmitted Infectious Diseases of the Health Commission of Sichuan ProvinceChengdu 610052Sichuan ProvinceChina

This editorial discusses a recently published paper in the World Journal of *** research focuses on p53's regulatory mechanism for controlling ferroptosis,as well as the intricate connection between ferroptosis and liver *** is a specific form of programmed cell death that is dependent on iron and displays unique features in terms of morphology,biology,and genetics,distinguishing it from other forms of cell *** can affect the liver,which is a crucial organ responsible for iron storage and *** evidence indicates a robust correlation between ferroptosis and the advancement of liver disorders.P53 has a dual effect on ferroptosis through various distinct signaling ***,additional investigations are required to clarify the regulatory function of p53 metabolic targets in this complex association with *** the future,researchers should clarify the mechanisms by which ferroptosis and other forms of programmed cell death contribute to the progression of liver *** and controlling important regulatory factors associated with ferroptosis present a promising therapeutic strategy for liver disorders.

关键词： Liver disease P53 Programmed cell death Ferroptosis Therapeutic target

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Compact ultrafast neutron sources via bulk acceleration of deuteron ions in an optical trap

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Matter and Radiation at Extremes 2024年第5期9卷 22-31页

作者： Zhiyu Lei Hanghang Ma Xiaobo Zhang Lin Yu Yihang Zhang Yutong Li Suming Weng min chen Jie Zhang Zhengming Sheng Key Laboratory for Laser Plasmas and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Centre of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 201210China College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

A scheme for a quasi-monoenergetic high-flux neutron source with femtosecond duration and highly anisotropic angular distribution is *** scheme is based on bulk acceleration of deuteron ions in an optical trap or density grating formed by two counter-propagating laser pulses at an intensity of-10^(16)W~cm^(2)in a near-critical-density *** deuterons are first pre-accelerated to an energy of tens of keV in the ambipolar fields formed in the optical *** energy is boosted to the MeV level by another one or two laser pulses at an intensity of-10^(20)W~cm^(2),enabling fusion reactions to be triggered with high *** contrast to previously proposed pitcher–catcher configurations,our scheme can provide spatially periodic acceleration structures and effective collisions between deuterons inside the whole target ***,neutrons are generated directly inside the optical *** simulations show that neutron pulses with energy 2–8 MeV,yield 10^(18)–10^(19)n/s,and total number 106–107 in a duration-400 fs can be obtained with a 25μm ***,the neutron pulses exhibit unique angularly dependent energy spectra and flux distributions,predominantly along the axis of the energy-boosting *** microsize femtosecond neutron pulses may find many applications,such as high-resolution fast neutron imaging and nuclear physics research.

关键词： acceleration scheme angular

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