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Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

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World Journal of Gastroenterology 2024年第10期30卷 1346-1357页

作者： Jing-feng chen Zhuo-Qing Wu Hao-Shuang Liu Su Yan You-Xiang Wang Miao Xing Xiao-Qin Song Su-Ying Ding Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Institute of Systems Engineering Dalian University of TechnologyDalian 116024Liaoning ProvinceChina College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina

BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD *** A cohort of 3553 participants followed for four consecutive health examinations over 4 years was *** incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were *** proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset *** A total of 83.13%of participants with MAFLD had normal ALT *** incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT *** with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,*** Most participants with MAFLD had normal ALT ***-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Cumulative effect Cox proportional hazards regression Cohort study

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中国典型涉外经营企业竞争情报工作调查研究

情报理论与实践 2024年第1期47卷 6-11,29页

作者：陈峰中国科学技术信息研究所北京100038

[目的/意义]针对中国科学技术情报学会竞争情报分会会员企业之外的中国典型涉外经营企业开展竞争情报工作实态调查,更好展示中国企业竞争情报实际工作全貌,为新时期竞争情报研究与服务工作创新发展提供新的视野、素材和参考。[方法/过程... 详细信息

[目的/意义]针对中国科学技术情报学会竞争情报分会会员企业之外的中国典型涉外经营企业开展竞争情报工作实态调查,更好展示中国企业竞争情报实际工作全貌,为新时期竞争情报研究与服务工作创新发展提供新的视野、素材和参考。[方法/过程]按照透过“名”与“实”分离表象了解新时期中国企业竞争情报工作真实情况的逻辑思路,以企业合规管理为竞争情报“名”与“实”分离的典型场景,基于2018—2023年合规管理主题公开会议,采取对派出报告人的企业统计分析、专家咨询访谈、合规管理标杆企业案例研究、承接企业合规管理体系建设项目的咨询服务机构企业客户名单调查研究、公开资料收集分析相结合的研究方法,对中国典型涉外经营企业进行竞争情报工作实态调查。[结果/结论]调查得到以下主要发现:(1)所有涉外经营企业的合规管理都是无“名”有“实”的竞争情报工作;(2)新时期中国典型涉外经营企业对事实上的竞争情报普遍具有强烈而持久的需求;(3)中国典型涉外经营企业的竞争情报工作专业水平呈现显著的差异性;(4)中国典型涉外经营企业对名为合规管理实为竞争情报的工作有很高的要求;(5)中国典型涉外经营企业对符合企业需要的竞争情报专业人才需求迫切且需求数量巨大;(6)有“实”而无“名”是中国典型涉外经营企业竞争情报工作存在的最大问题。

关键词：竞争情报实态调查合规管理典型涉外经营企业合规管理主题公开会议

Fucoxanthin improves serum lipids， liver metabolism and gut microbiota in hyperlipidemia mice

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Food Science and Human Wellness 2024年

作者： Yonghui Zhou Jingyi Zhang Kun Xu Weihao Zhang feng chen Bin Liu Bingbing Guo Faculty of Environment and Life， Beijing University & Technology Shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Carbon Neutrality， Institute for Advanced Study， Shenzhen University

Fucoxanthin， a kind of exclusively algae-derived carotenoids， could reduce lipid content and regulate gut microbiota composition in obese mice， showing potential in preventing hyperlipidemia. This study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice， as well as investigate the underlying association with gut microbiota changes. Results showed that fucoxanthin significantly reduced body weight gain and body white fat of the mice. In the serum， total triglycerides (TG)， total cholesterol (TC) contents were significantly decreased and high-density-lipoprotein cholesterol levels was significantly upregulated. Moreover， fucoxanthin remarkedly prevented lipid accumulation in the liver. Especially， metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control， indicating the advance of hepatic lipid metabolism. Bile acids profile in the liver was also greatly changed by fucoxanthin. Meanwhile， fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio， Blautia and Clostridia genera. Finally， correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum lipids. Altogether， this study showed great potential of fucoxanthin in improving serum lipids profile， hepatic lipids and bile acids metabolism of hyperlipidemia mice， which was associated with gut microbiota alteration.

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“下交群评”:迈向人民主体性的基层治理——以北京市平谷区接诉即办改革为例

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北京工业大学学报（社会科学版） 2024年第3期24卷 29-39页

作者：陈锋北京工业大学文法学部/北京社会管理研究基地北京100124

以人民为中心的发展思想日益成为主导基层治理的逻辑,在北京市接诉即办工作不断深化改革的基础上,以北京市平谷区“下交群评”工作为例,探索党建引领多元主体参与社会治理的机制,并重点关注如何引导群众成为基层治理的主体。研究发现,... 详细信息

以人民为中心的发展思想日益成为主导基层治理的逻辑,在北京市接诉即办工作不断深化改革的基础上,以北京市平谷区“下交群评”工作为例,探索党建引领多元主体参与社会治理的机制,并重点关注如何引导群众成为基层治理的主体。研究发现,“下交群评”通过治理主体的组织嵌入化、治理单元的熟人社会化、治理规则的崇公抑私化、治理机制的交互整体化形塑了新时代“三治融合”的实践机制,为系统治理和源头治理提供了重要保障;从接诉即办的倒逼式治理到主动性治理,再到自主性治理,人民群众真正成为治理问题的发起者、治理过程的参与者、治理成效的获得者、治理情况的监督者。这是全过程人民民主的生动实践,体现了基层正在从被动的市民诉求驱动迈向人民主体性的治理。

关键词：接诉即办 “下交群评” 基层治理三治融合人民主体性全过程人民民主

竞争情报视角的美中经济与安全评估委员会听证会研究

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情报杂志 2024年第6期43卷 54-59,78页

作者：陈峰中国科学技术信息研究所北京100038

[研究目的]从竞争情报专业视角研究美中经济与安全评估委员会(U.S.-China Economic and Security Review Commission,USCC)的听证会,为我国新时期新范式下的竞争情报研究与服务创新发展提供参考。[研究方法]对USCC成立至今已经召开的16... 详细信息

[研究目的]从竞争情报专业视角研究美中经济与安全评估委员会(U.S.-China Economic and Security Review Commission,USCC)的听证会,为我国新时期新范式下的竞争情报研究与服务创新发展提供参考。[研究方法]对USCC成立至今已经召开的168场听证会进行研读分析,围绕USCC主要关注哪些问题、USCC主要邀请哪些人和机构参加听证会、USCC听证会的竞争情报产品形成机理、USCC技术领域听证会特点4个典型问题,从竞争情报专业角度进行研究。[研究结论]研究发现,USCC主要关注美国的安全与发展问题,USCC听证会确定主题和议题的过程也是事实上的关键情报课题识别凝练确定过程;对USCC168场听证会参会作证人和参会机构进行统计分析,发现并展示介绍了高频次参会作证人和参会机构;USCC听证会是一个典型的高质量竞争情报产品生产过程;USCC技术领域听证会具有跳出技术看技术、着眼国家安全与发展全局看技术、从技术要素在经济贸易等领域产生实际影响角度凝练问题、聚焦政策与战略开展技术问题研究的特点。

关键词：竞争情报美中经济与安全评估委员会中美竞争听证会

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晚清财政与国际接轨的路径和范式

江汉论坛 2024年第10期 108-113页

作者：陈锋武汉大学中国传统文化研究中心暨历史学院湖北武汉430072

我在二十多年前首次提出清代财政的“近代转型”或财政的“近代化”以后,陆续有多篇文章探讨相关问题(1)。这些探讨集中在两个时段:一是2000年前后,主要是提出问题和建构框架;二是在近年承担国家社科基金重大项目“清代财政转型与国家... 详细信息

我在二十多年前首次提出清代财政的“近代转型”或财政的“近代化”以后,陆续有多篇文章探讨相关问题(1)。这些探讨集中在两个时段:一是2000年前后,主要是提出问题和建构框架;二是在近年承担国家社科基金重大项目“清代财政转型与国家财政治理能力研究”前后,主要是对一些问题进行较为深入的揭示。近十年来,晚清财政的转型或近代化已经成为研究热点,学界有不少研究成果,有些成果可以参考。晚清财政的转型或近代化,就其实质而言,是在传统社会内在变化的基础上与国际社会的接轨。

关键词：财政转型晚清财政内在变化近代转型与国际接轨财政治理能力清代财政研究成果

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合规情报的基本问题研究

情报学报 2024年第2期43卷 230-236页

作者：陈峰中国科学技术信息研究所北京100038

使用透过“名”与“实”分离表象的真实情报行为识别、参加合规管理专题会议调研、案例研究、文献资料研究、专家咨询访谈等方法,围绕合规管理的情报属性、合规管理情报行为与现有情报学分支领域的关系、合规情报的概念与学科发展前景... 详细信息

使用透过“名”与“实”分离表象的真实情报行为识别、参加合规管理专题会议调研、案例研究、文献资料研究、专家咨询访谈等方法,围绕合规管理的情报属性、合规管理情报行为与现有情报学分支领域的关系、合规情报的概念与学科发展前景、当前合规情报研究与服务的优先推进领域等问题进行研究。本文认为合规管理属于典型的“情报(intelligence)”行为,合规情报是不同于已有情报学分支领域的新的分支领域和学科方向;提出了合规情报的概念并凝练其含义要点,指出培育合规情报学科方向既有可行性也有必要性,具有重要意义和良好发展前景;指出当前合规情报研究与服务的四个优先推进领域:①合规情报基础理论方法;②合规情报专业人才培养;③合规情报技术工具开发应用;④合规情报的宣传推介。

关键词：合规情报理论方法情报学学科建设合规管理人才培养

Endoscopic features and treatments of gastric cystica profunda

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World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Wei-feng chen Xia Yang Ping-Hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

Comparative Analysis and Legal Reflection on the Boundaries of Human Rights Due Diligence in the Supply Chain

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The Journal of Human Rights 2024年第2期23卷 393-419页

作者：王惠茹 chen feng(Translated) Institute of International Law Chinese Academy of Social Sciences 不详

As global supply chains become increasingly lengthy and complex, human rights due diligence in the supply chain is becoming a controversial focal point in the accountability of multinational corporations. In recent years, legislative practices in the field of human rights due diligence have shown a trend from voluntary soft law toward mandatory hard law, and from corporate due diligence for their own operations towards extended due diligence for the entire supply chain. However, there is a divergence in national practices regarding the extent to which human rights due diligence should extend along the supply chain and the manner in which it should be incorporated into domestic legal policies. International soft law interpretations surrounding the boundaries of human rights due diligence in the supply chain are decentralized, posing risks of interpretation diversification, boundary blurring, and procedural formalization, as well as risks of misinterpretation and misuse. Meanwhile, some countries and regions are vigorously promoting mandatory legislation on human rights due diligence in the supply chain, which has profound implications for the stability of global supply chains and the international economic and trade order. Against this backdrop, it is crucial to explore the reasonable boundaries of human rights due diligence in the supply chain. Instead of applying a one-size-fits-all approach,the rationality of legal factors and the complexity of practical factors should be considered, applying context-specific measures based on the varying degrees of linkage between companies and negative human rights impacts in the supply chain. China should be particularly wary of the “chilling effect” of mandatory legislation on human rights due diligence in the supply chain, attaching great importance to national supply chain security and international supply chain ***,China should actively promote the implementation of voluntary human rights due dilige

关键词： business and human rights human rights due diligence supply chain international soft law mandatory due diligence