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Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis:A case report

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World Journal of Radiology 2024年第6期16卷 232-240页

作者： Zhan-Rong Zhang feng chen Hui-Juan chen Department of Radiology The Affiliated Hainan Hospital of Hainan Medical University(Hainan General Hospital)Haikou 570311Hainan ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is characterized by diabetes insipidus and is an uncommon *** biopsies still have a certain degree of diagnostic *** present a case in which LCH initially affected the pituitary *** resulted in a misdiagnosis of chronic inflammation upon pathological *** SUMMARY A 25-year-old female exhibited symptoms of diabetes *** resonance imaging revealed an enhanced foci in the pituitary *** surgical resection of the pituitary lesion,the pathological diagnosis was chronic ***,the patient later experienced bone destruction in the skull and lower limb *** the lower limb bone lesion was compared with the initial pituitary lesion,the final diagnosis was modified to *** patient was treated with multiple chemotherapy ***,the patient’s condition gradually worsened,and she eventually passed away at *** LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

关键词： Langerhans cell histiocytosis Pituitary gland Diabetes insipidus Multi-system Misdiagnosis Magnetic resonance imaging Case report

The relationship between compartment models and their stochastic counterparts:A comparative study with examples of the COVID-19 epidemic modeling

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Journal of Biomedical Research 2024年第2期38卷 175-188,I0016-I0018页

作者： Ziyu Zhao Yi Zhou Jinxing Guan Yan Yan Jing Zhao Zhihang Peng feng chen Yang Zhao Fang Shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Nanjing Hanwei Public Health Research Institute Co. LtdNanjingJiangsu 210005China China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic ***,the relationship between CMs and their corresponding stochastic models is not well *** present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling *** demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and *** on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter *** advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of ***,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time ***,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of *** model offered a balance between computational efficiency and *** results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic ***,the results had implications for the development of hybrid models that integrated the strengths of both ***,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.

关键词： compartment models agent-based models compartment-agent mixed models comparative study COVID-19

Glycolysis and gluconeogenesis are involved of glucose metabolism adaptation during fasting and re-feeding in black carp(Mylopharyngodon piceus)

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Aquaculture and Fisheries 2024年第2期9卷 226-233页

作者： Yafan Dai Yubang Shen Jiamin Guo Hao Yang feng chen Wei Zhang Wenhui Wu Xiaoyan Xu Jiale Li Key Laboratory of Freshwater Aquatic Genetic Resources Ministry of Agriculture and Rural AffairsShanghai Ocean UniversityShanghai201306China Shanghai Engineering Research Centre of Aquaculture Shanghai Ocean UniversityShanghai201306China

Both in nature and in aquaculture,fish may experience periods of food scarcity or *** metabolic regulation of fish when nutritional state changes is a complex process that involves many *** study glucose metabolism adaptability during fasting and re-feeding in the black carp(Mylopharyngodon piceus),we measured changes in some biochemical indicators related to glucose *** fish were sampled on days 0,1,3,5,and 10 of fasting(F,S1,S3,S5,and S10,respectively)and days 1,3,and 5 of re-feeding(RF1,RF3,and RF5,respectively).The serum glucose concentration decreased significantly at S1,reached the lowest point at S10,and increased significantly at RF1(P<0.05).The concentration of liver glycogen decreased significantly at S1 and reached the lowest level at S3,whereas the muscle glycogen level decreased significantly at S5 and reached the lowest value at S10(P<0.05).Both liver and muscle glycogen levels returned to the pre-fasting level at RF5(P<0.05).Regarding glycolysis,the concentrations of pyruvate kinase(PK)and hexokinase(HK)decreased significantly at S5 and increased significantly at RF5 and RF1,respectively(P<0.05).The concentrations of glucokinase(GCK)and insulin decreased significantly at S1 and increased significantly at RF1 and RF3,respectively(P<0.05).The mRNA expression levels of liver GCK and glucose transporter 2(GLUT2)decreased significantly at S1 and increased significantly at RF1 and RF5,respectively(P<0.05).As for gluconeogenesis,the concentration of glucose-6-phosphatase(G6PC)increased significantly at S1 and decreased significantly at RF1(P<0.05).The concentrations of glucagon and glucocorticoid(GC)increased significantly at S3 and significantly decreased at RF1 and RF5,respectively(P<0.05).The mRNA expression levels of liver G6PC and phosphoenolpyruvate carboxykinase(PEPCK)increased significantly at S3 and S1,and both decreased significantly at RF1(P<0.05).These results indicate that coordination between glycolysis and gluconeogen

关键词： Mylopharyngodon piceus Fasting Glucose metabolism Glycolysis Gluconeogenesis

The Rule of Law is the Most Important Means of Human Rights Protection

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The Journal of Human Rights 2024年第1期23卷 80-82页

作者：马怀德 chen feng China Society for Human Rights Studies China University of Political Science and Law 不详

Today,we are here to commemorate the 75^(th) anniversary of the adoption of the Universal Declaration of Human *** this Declaration,which consists of only30 articles,seven articles are related to the constitution,law,court,and the rule of law,making it a declaration filled with the rule of ***,today is also the 10^(th) National Constitution Day of *** years ago,“the state respects and protects human rights”was enshrined in the Constitution,becoming a constitutional *** then,human rights protection in China has been based on fundamental law.

关键词： anniversary law Human

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飞秒激光调控晶体材料光学非线性的研究进展

光学学报 2024年第17期44卷 242-257页

作者：张彬陈峰山东大学物理学院晶体材料国家重点实验室

非线性晶体是非线性光学领域中实现波长/频率转换的重要载体。通过周期性地调控非线性晶体的光学非线性，可以按需制备多种非线性光子晶体结构，从而实现特定波长激光高效频率转换和非线性光束整形等应用。飞秒激光直写技术具有精度高... 详细信息

非线性晶体是非线性光学领域中实现波长/频率转换的重要载体。通过周期性地调控非线性晶体的光学非线性，可以按需制备多种非线性光子晶体结构，从而实现特定波长激光高效频率转换和非线性光束整形等应用。飞秒激光直写技术具有精度高、速度快以及真三维加工等特点，在材料微纳加工领域得到了广泛的应用。用透镜或显微物镜将飞秒激光聚焦到非线性晶体内部，可以对激光焦点处的晶体非线性进行调控；通过设置并优化飞秒激光加工参数，能够实现特定三维非线性光子晶体的快速高效制备。本文从非线性晶体的光学非线性调控、飞秒激光直写技术出发，简要介绍了飞秒激光直写非线性光子晶体的最新研究进展，并对几个潜在的研究方向进行了展望。

关键词：超快光学微纳加工飞秒激光直写晶体材料非线性频率转换

Targeted DNA N^(6)-methyladenine editing by dCas9 fused to METTL4 in the lepidopteran model insect Bombyx mori

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Insect Science 2024年第2期31卷 646-650页

作者： feng chen Hao Guo Weiqun Lan Mingyi Zhou Wenjng Geng Guanwang Shen Ping Lin Qingyou Xia Ping Zhao Zhiqing Li Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City Biological Science Research CenterSouthwest UniversityChongqingChina Chongqing Key Laboratory of Sericultural Science Chongqing Engineering and Technology Research Center for Novel Silk MaterialsSouthwest UniversityChongqingChina

Dear Editor,N^(6)-Methyladenine(6mA)DNA modification is an important epigenetic mechanism with roles in regulating gene expression,nucleosome positioning,DNA damage repair,and cell cycle progression(Heyn&Esteller,2015;Luo et al.,2015;Boulias&Greer,2022).Despite progress in understanding the biological functions of 6mA,the contribution of individual 6mA installations on site-specific target genes is largely unknown,and therefore deciphering the molecular mechanism of 6mA in target gene expression has been difficult.

关键词： adenine fused Bombyx

Acupoint Selection Standards of Auricular Therapy in the Treatment of Maintenance Hemodialysis Insomnia Based on Data Mining

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 53-64页

作者： Jun-Xin Wang Bing-Qian Zou Yu-feng chen cheng-Long Wang Wei-Hong Li Xue-Ling Ma Xiang-Di Liu Department of TCM Nursing School of NursingBeijing University of Chinese MedicineBeijingChina Department of Healthcare Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesP.R.China Pharmacology of Integrated Chinese and Western Medicine School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Beijing Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineMinistry of EducationBeijingChina

Background:Insomnia is a high-incidence complication in patients undergoing maintenance hemodialysis(MHD).Auricular therapy can effectively improve sleep with few adverse *** selection affects the impact of auricular ***,there is currently a lack of analysis on the standards of acupoint *** study used data mining technology to investigate the acupoint selection principles and characteristics of auricular therapy for the treatment of MHD-related ***:The objective of the study is to explore the standards of acupoint selection in auricular therapy for the treatment of MHD-related insomnia through data mining *** and Methods:We searched three English(PubMed,WOS,and Embase)and four Chinese(CNKI,VIP,Wangfang,and CBM)databases for studies on auricular therapy for MHD-related insomnia from self-establishment to November 14,***:Eighty-one publications were involved,which included 33 *** most common auricular points in patients with MHD-related insomnia were the Shenmen,heart,and kidney *** applications involved the visceral,nervous system,and specific *** effective clusters and two clusters were obtained through cluster analysis,including specific auricular points for insomnia,such as the multi-dream area,neurasthenia area,deep sleep point,and anterior ear *** network analysis showed that the core auricular acupoint combinations for the intervention of MHD-related insomnia were Shenmen with kidney,Shenmen with heart,heart with kidney,heart with Shenmen,and heart and Shenmen with ***:The selection of auricular points for the treatment of MHD-related insomnia was guided by the heart theory of traditional Chinese *** treatment attaches importance to the use of the multi-dream area,neurasthenia area,and other acupoints.

关键词： Acupoint selection standards auricular therapy data mining insomnia maintenance hemodialysis

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殷周之际天命转换对“德”的促成

哲学研究 2024年第3期 44-51页

作者：冯晨中共山东省委党校哲学教研部

殷周天命转换给予“德”以现实确立的机会和条件。尽管“德”与“至上神”的信仰有关,但“德”能够形成的条件则是周人的“天”而非般人的“帝”。周人的天命既有自然神的法则,也有人文的规则,二者通过周人的主体意识表达出来,形成周人... 详细信息

殷周天命转换给予“德”以现实确立的机会和条件。尽管“德”与“至上神”的信仰有关,但“德”能够形成的条件则是周人的“天”而非般人的“帝”。周人的天命既有自然神的法则,也有人文的规则,二者通过周人的主体意识表达出来,形成周人的价值目标和行为原则,对此价值目标的追求和行为原则的遵循称为“德”。在周人与天的互动过程中,“德”逐步深化为周人对自我的规定性和应然性的要求。最终,“德”成为周人以天命信仰为形式的人文精神。

关键词：殷周之际德天命

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论孔子仁的实现方式

孔子研究 2024年第4期 116-125,159,160页

作者：冯晨中共山东省委党校山东省政德与廉洁文化研究中心济南250000

孔子的仁没有先天的善性作为生成与实现的基础,只有“性相近”之“性”所提供的“性灵”以为发生前提和发展基础。就个体生命而言,仁发端于道德情感,完成于礼的规范。但在社会现实中,个体的情感和礼之间还需要义的介入。义是道德主体在... 详细信息

孔子的仁没有先天的善性作为生成与实现的基础,只有“性相近”之“性”所提供的“性灵”以为发生前提和发展基础。就个体生命而言,仁发端于道德情感,完成于礼的规范。但在社会现实中,个体的情感和礼之间还需要义的介入。义是道德主体在具体的伦理情境中的恰当反应,也是情感和礼在实践中的即时表达,体现着道德主体的自由和创造。仁是生命在伦理生活中以情、义、礼为互动方式的实践活动,这一活动决定了仁无法被概念确切定义,仁的所有意义会在个体的生命活动中被领会并在此过程中得以实现。

关键词：孔子仁情、义、礼道德主体