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An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review

Food Science and Human Wellness 2024年第4期13卷 1739-1755页

作者： Yuting Su feng chen Jiehua chen Mingfu Wang Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Institution for Innovative Development of Food Industry Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Food Nutrition and Health Shenzhen UniversityShenzhen 518060China

Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of ***,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective ***,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically *** this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various *** on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still *** addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of *** evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and ***,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different

关键词： Atherosclerosis Xanthophylls Antioxidant Anti-inflammation Lipid metabolism

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Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

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Science China Chemistry 2024年第6期67卷 2039-2045页

作者： chen-Hao Guo Wen-Long Zhao Ke-Ke Tan Wei-chen Guo Liheng feng Chuan-feng chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes

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Polyvinyl alcohol fiber cement-stabilized macadam:A review and performance evaluation

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 406-423页

作者： Chaohui Wang Jikang Liu Shaochang chen feng chen Zhiwei Gao School of Highway Chang'an UniversityXi'an 710064China Shaanxi Transportation Technology Consulting Co. Ltd.Xi'an 710068China School of Information Engineering Xizang Minzu UniversityXianyang 712082China

This review evaluated research results on polyvinyl alcohol fiber cement-stabilized macadam(PVA-FCSM)to further improve the long-term durability of road structures and promote its in-depth study and high-quality *** suitable PVA fiber technical indexes for ordinary cement-stabilized macadam(CSM)were *** difference in the mechanical properties between CSM and PVA-FCSM was *** extent to which PVA fibers enhance the durability of CSM were ***,the mechanism of enhancement of CSM by PVA fibers was ***,the performance of each type of fiber cement-stabilized macadam(FCSM)was compared and *** results indicated that the suggested PVA fiber length and content for CSM were 12-30 mm and 0.6-1.2 kg/m^(3),*** different ages,the mean degree of improvement in the unconfined compressive strength was 14%,20%,and 14%,that in the compressive resilience modulus was 8%,11%,and 6%,and that in the splitting strength was 29%,15%,and 22%,*** different ages,the mean degree of decreased in the dry shrinkage coefficient was 21%,16%,and 15%and that in the temperature shrinkage coefficient(20℃-30℃)was 23%,23%,and 18%,*** coefficients increased with extended curing ***,at the same stress level,PVA-FCSM has a higher fatigue life compared to *** bridging effect,high strength,and high modulus of PVA fiber enhance the strength and anti-cracking of *** recommended fiber type for CSM is PVA fiber.

关键词： Highway and railway engineering PVA fiber cement-stabilized macadam Mechanical performance Durability Enhancement mechanism Performance valuation

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Mechanism of selective laser trabeculoplasty:a systemic review

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 963-968页

作者： Yu-feng chen Wen Zeng Department of Ophthalmology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Although selective laser trabeculoplasty(SLT)is a recognized method for the treatment of glaucoma,the exact changes in the target tissue and mechanism for its intraocular pressure lowing effect are still *** purpose of this review is to summarize the potential mechanisms of SLT on trabecular meshwork both in vivo and in vitro,so as to reveal the potential mechanism of *** may induce immune or inflammatory response in trabecular meshwork(TM)induced by possible oxidative damage etc,and remodel extracellular *** may also induce monocytes to aggregate in TM tissue,increase Schlemm’s canal(SC)cell conductivity,disintegrate cell junction and promote permeability through autocrine and paracrine *** provides a theoretical basis for SLT treatment in glaucoma.

关键词： mechanisms selective laser trabeculoplasty glaucoma trabecular meshwork

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Recent advances in heterogeneous hydrosilylation of unsaturated carbon-carbon bonds

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Chinese Chemical Letters 2024年第6期35卷 71-85页

作者： Heng Yang Zhijie Zhou Conghui Tang feng chen School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The hydrosilylation of unsaturated carbon-carbon bonds is one of the most critical reactions in silicone industrial *** homogeneous Speier's catalyst,Karstedt's catalyst,and other noble metal-based catalysts are widely ***,simplifying the separation of the homogeneous catalyst from reaction products and reducing the high cost of precious metals is still *** review describes the recent development of heterogeneous catalysts for alkene,alkyne,and allene hydrosilylations,which can effectively solve problems in homogeneous hydrosilylation.

关键词： Hydrosilylation Heterogeneous catalysis Alkenes Alkynes Silanes

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Data-driven Anomaly Detection Method Based on Similarities of Multiple Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 803-818页

作者： Xiangjun Zeng Ming Yang chen feng Mingqiang Wang Lingqin Xia the College of Electrical Engineering&New Energy China Three Gorges UniversityYichang 443002China the Key Laboratory of Power System Intelligent Dispatch and Control Shandong UniversityJinan 250061China

The operating conditions of wind turbines(WTs)in the same wind farm(WF)may share similarities due to their shared manufacturing process,control strategy,and operating ***,the similarities of WTs are seldom considered in WT anomaly detection,resulting in the disregard of useful *** paper proposes a method to improve the reliability and accuracy of WT anomaly detection using the supervisory control and data acquisition(SCADA)data of multiple WTs in the same ***,a similarity assessment method based on a comparison of different observation time series is proposed,which objectively quantifies the similarities of WT operating ***,the SCADA data of the target WT and selected WTs that are similar are used to establish several estimation models through a long short-term memory(LSTM)*** models that exhibit good estimation performance are used to construct a combined estimation model that estimates the variations in the monitored variables of the target ***,an anomaly detection method that jointly compares the effective value and information entropy of the residuals is proposed to identify *** effectiveness and accuracy of the proposed method are verified using the data of two actual WFs.

关键词： Anomaly detection information entropy long short-term memory similarity assessment wind farm wind turbines

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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie chen Ya-feng GAO Lei LI Yi-jie feng Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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Effect of Sc on Al_(3)Fe phase and mechanical properties of as-cast AA5052 aluminum alloy

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China Foundry 2024年第3期21卷 257-264页

作者： Yang Li Qing Yu feng-feng chen Jia-wen He Hong-mei Yang Meng-nie Li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical *** studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the *** this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%*** results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc *** ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.

关键词： AA5052 aluminum alloy Al3Fe phase mechanical properties grain boundary

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Efficient ammonia electrosynthesis from nitrate via a three-step relay mechanism

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Science China Chemistry 2024年第1期67卷 319-320页

作者： Haifeng Jiang Gao-feng chen Haihui Wang Beijing Key Laboratory for Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Colloid Chemistry Max-Planck Institute of Colloids and InterfacesPotsdam 14476Germany School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China

Electrocatalytically converting nitrate waste to value-added ammonia(NO3−RR)is beneficial to environmental restoration and an attractive candidate for green ammonia production[1].However,developing NO_(3)^(-)RR in an energy-saving way remains a significant challenge due to the slow kinetics inherent in multi-step electron and proton transfer,making previous investigations for NO_(3)^(-)RR generally operate at a large overpotential(<-0.2 V versus reversible hydrogen electrode(RHE))to achieve optimal efficiency and industrial current for NH3 synthesis[2].

关键词： ammonia nitrate kinetics

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Decreasing productivity of pine forests on the southern edge of the Mongolian Plateau as indicated by tree rings

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Journal of Forestry Research 2024年第5期35卷 171-181页

作者： Zhuolan Shen Shijie Wang feng chen Heli Zhang Xiaoen Zhao Youping chen Mao Hu Yunnan Key Laboratory of International Rivers and Transboundary Eco‑Security Institute of International Rivers and Eco‑SecurityYunnan UniversityKunming 650500People’s Republic of China Southwest United Graduate School Kunming 650500People’s Republic of China Key Laboratory of Tree-Ring Physical and Chemical Research of China Meteorological Administration/Xinjiang Laboratory of Tree-Ring Ecology Institute of Desert MeteorologyChina Meteorological AdministrationÜrümqi 830002People’s Republic of China

Vegetation productivity on the southern edge of the Inner Mongolian Plateau,which plays a vital role in the ecological environment and in the arable and pasto-ral production in this region,can be characterized by the NDVI(normalized difference vegetation index).However,the observed NDVI data span only the last~40 *** growth of Pinus tabulaeformis *** strongly correlated with the NDVI,making it a valuable proxy for extend-ing the length of observed NDVI *** this study,we reconstructed an NDVI series for 1776–2021 for the Daqing Mountains,based on a tree-ring width *** reconstructed data accounted for 55%of the variance in the observed data,and its statistical characteristics and validation indicate that the reconstruction is *** correlation analysis demonstrated the consistency of climate signals in central Inner Mongolia in both the arable and pastoral *** results of superposed epoch analysis revealed a good temporal consistency between drought and flood events and the reconstructed NDVI sequence in this region.

关键词： Drought Semi-arid area Peru current Yinshan Mountains

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