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Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China

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World Journal of Gastroenterology 2010年第2期16卷 264-269页

作者： Shi, ming chen, Ji-An Lin, Xiao-Jun Guo, Rong-Ping Yuan, Yun-Fei chen, min-shan Zhang, Ya-Qi Li, Jin-Qing Sun Yat Sen Univ Dept Hepatobiliary Ctr Canc Guangzhou 510060 Guangdong Peoples R China

AIM:To identify prognostic factors from pretreatment variables of the initial transarterial chemoembolization(TACE)procedure in unresectable hepatocellular carcinoma(HCC). METHODS:One thousand and five hundred and sixtynine patients with unresectable HCC underwent TACE as initial treatment were retrospectively *** variables of the initial TACE procedure with a P value less than 0.05 by univariate analysis were subjected to Cox proportional hazards model. RESULTS:The median overall survival time and 1-, 5-,10-year survival rates were 10.37 mo,47%,10%, and 7%,respectively.A Cox proportional hazard model showed that 8 pretreatment factors of regional lymphnodes metastasis,Child-Pugh class,macrovascular invasion,greatest dimension,α-fetoprotein(AFP), Hepatitis virus B,tumor capsule,and nodules were independent prognostic *** with multimodality therapy have better survival than those with TACE treatment only. CONCLUSION:Tumor status,hepatic function reserve,AFP,and hepatitis virus B status were independent prognostic factors for unresectable *** metastasis might not be a contraindication to TACE. Multimodality therapy might improve survival.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Palliative treatment Prognosis

肌肉减少和平衡不良对女性类风湿性关节炎患者并发脊柱骨质疏松性骨折的影响

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颈腰痛杂志 2024年第5期45卷 816-819页

作者：黎淑玲陈敏珊莫晓颖黄玉宁东莞市人民医院风湿科广东东莞523000

目的探讨肌肉减少和平衡不良对女性类风湿性关节炎(RA)患者并发脊柱骨质疏松性骨折的影响。方法选择2021年1月至2024年2月在该院就诊的RA并发脊柱骨质疏松性骨折患者43例作为观察组,按照1:2比例抽取同期在该院就诊的86例RA非脊柱骨质疏... 详细信息

目的探讨肌肉减少和平衡不良对女性类风湿性关节炎(RA)患者并发脊柱骨质疏松性骨折的影响。方法选择2021年1月至2024年2月在该院就诊的RA并发脊柱骨质疏松性骨折患者43例作为观察组,按照1:2比例抽取同期在该院就诊的86例RA非脊柱骨质疏松性骨折患者作为对照组。评估患者的肌肉减少症和平衡控制不良发生率,采用Logistic回归分析观察肌肉减少症和平衡控制不良对脊柱骨质疏松性骨折的影响。结果观察组患者肌肉减少症和平衡控制不良发生率明显高于对照组,差异均有统计学意义(P<0.05)。两组患者年龄、病程、RA疾病活动度(DAS28)、C反应蛋白(CRP)、类风湿因子(RF)、血沉(ESR)、糖皮质激素应用等资料比较,差异存在统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在剔除协变量影响后,肌肉减少症和平衡控制不良均是脊柱骨质疏松性骨折的风险因素(P<0.05)。结论RA女性患者脊柱骨质疏松性骨折受肌肉减少症和平衡控制不良影响,临床工作中应关注RA患者的肌肉质量和平衡能力,以减少脊柱骨质疏松性骨折的发生。

关键词：女性患者类风湿性关节炎脊柱骨质疏松性骨折肌肉减少症平衡控制不良

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Boost VS_(2) electrochemical reactive kinetics by regulating crystallographic planes and coupling carbon matrix for high performance sodium-ion storage

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Rare Metals 2024年第1期43卷 98-112页

作者： min Zeng ming-shan Wang Lin chen En-Zhi Li Zhen-Liang Yang Dan Zhou Hai-Jiao Xie Jun-chen chen Zhi-Yuan Ma Bing-Shu Guo Bo Yu Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Energy Storage Research Institute Southwest Petroleum UniversityChengdu 610500China Institute of Materials China Academy of Engineering PhysicsMianyang 621908China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and TechnologyBeijingBeijing 100083China Hangzhou Yanqu Information Technology Co. Ltd.Hangzhou 310003China

Vanadium disulfide(VS_(2)) as a typical two-dimensional transition metal chalcogenide has excellent competitiveness for sodium-ion storage due to its wide layer spacing(0.575 nm),high theoretical capacity of 932mAh·g^(-1) originating from multi-electron electrochemical ***,continuous sodiation process accompanied by crystal structural evolution and collapse cause rapid capacity ***,novel few-layer VS_(2)nanosheets with open(001) crystal planes are in-situ constructed on reduced graphene oxide to solve these issues mentioned *** indicates that few-layer VS_(2)provides more Na^(+) storage activity due to the low Na^(+)surface migration energy barrier on exposed crystal(001)*** flexible and high electronic conductivity of carbon matrix also effectively builds multi-level buffer structure and electron transport kinetics to boost the Na^(+)insertion/conversion reactive activity on VS_(2) as well as Na^(+) pseudocapacitance storage kinetics on edges and defects of nano *** coupling effects result in high rate capability and long cycling stability as a battery/capacitor *** delivers conspicuous high energy density of 81 and 40 Wh·kg^(-1) at power density of 118 and 10,286W·kg^(-1),as well as 80% energy retention rate after 5000cycles,confirming its great application potential in sodiumbased storage devices.

关键词： Vanadium disulfide Reduced graphene oxide Anode Sodium-ion battery Sodium-ion capacitor

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Current Medical Science 2024年第3期44卷 475-484页

作者： min-shan LI Xiang-hong WANG Heng WANG Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Allergy and Clinical Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Clinical Research Center for Nasal Inflammatory Diseases Wuhan430030China

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various *** receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and ***-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular *** detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune *** this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

关键词： proton-activated G protein-coupled receptors inflammation immunomodulation disease

一种新型义齿材料的体外细胞毒性和家兔皮内反应试验研究

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毒理学杂志 2024年第1期38卷 51-56页

作者：王玉杰陈洁雯潘淑涛范启明区文诗陈敏珊黄红坤张宏涛陈芳李建军佛山科学技术学院广东佛山528000 广东中科英海科技有限公司广东佛山528300

目的通过体外细胞毒性和家兔皮内反应试验,对新型义齿材料的安全性进行初步评价。方法 JSAM-BL材料及2种3D打印试样分别用10%血清培养基、灭菌生理盐水和灭菌棉籽油浸提后,参考国家标准进行体外细胞毒性试验和皮内反应试验。结果体外... 详细信息

目的通过体外细胞毒性和家兔皮内反应试验,对新型义齿材料的安全性进行初步评价。方法 JSAM-BL材料及2种3D打印试样分别用10%血清培养基、灭菌生理盐水和灭菌棉籽油浸提后,参考国家标准进行体外细胞毒性试验和皮内反应试验。结果体外细胞毒性试验用10%血清培养基分别浸提JSAM-BL材料、JSAM-SLASH2-D牙冠和JSAM-TL3-D牙冠,3种试样100%浸提液的细胞生存率分别为2.40%、28.08%和73.92%(F=537.576,F=19.880,F=67.362,P<0.01)。家兔皮内反应试验中JSAM-BL材料、JSAM-SLASH2-D牙冠、JSAM-TL3-D牙冠极性试验组最终评分分别为0.20、0和0,非极性试验组最终评分分别为0、0和0.04。结论体外细胞毒性试验结果表明,JSAM-BL材料、JSAM-SLASH2-D牙冠具有潜在细胞毒性,JSAM-TL3-D牙冠未显示有细胞毒性。家兔皮内反应试验表明,JSAM-BL材料、JSAM-SLASH2-D牙冠及JSAM-TL3-D牙冠的极性和非极性浸提液均无皮内反应。

关键词： 3D打印牙冠体外细胞毒性 MTT 家兔皮内反应

我国高校图书馆社会化研究热点探析——基于网络知识图谱和共词分析

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情报科学 2017年第6期35卷 171-177页

作者：陈善敏宜宾学院图书馆四川宜宾644000

【目的/意义】本文以中国知网(CNKI)中高校图书馆社会化的研究文献为研究对象,分析了我国高校图书馆社会化研究的热点。【方法/过程】采用共词分析方法构建矩阵,利用网络知识图谱分析、SPSS因子分析、聚类分析和多维尺度分析,研究各关... 详细信息

【目的/意义】本文以中国知网(CNKI)中高校图书馆社会化的研究文献为研究对象,分析了我国高校图书馆社会化研究的热点。【方法/过程】采用共词分析方法构建矩阵,利用网络知识图谱分析、SPSS因子分析、聚类分析和多维尺度分析,研究各关键词之间的关系。【结果/结论】综合分析发现当前的研究热点主要包括五个方面:高校图书馆社会化需求、社会化模式、社会化实施中的问题与对策、社会化需求下的情报信息服务以及社会化的趋势。

关键词：高校图书馆社会化网络知识图谱共词分析

我国图书情报领域特色资源论文研究态势——基于文献计量和多元统计

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情报科学 2017年第8期35卷 170-176页

作者：陈善敏宜宾学院图书馆四川宜宾644000

【目的/意义】以中国知网(CNKI)中国学术期刊网络出版总库的图书情报领域特色资源研究的论文为研究对象,分析了我国高校图书馆图书情报领域特色资源研究的发展态势。【方法/过程】采用文献计量法和共词分析法,利用网络知识图谱、因子分... 详细信息

【目的/意义】以中国知网(CNKI)中国学术期刊网络出版总库的图书情报领域特色资源研究的论文为研究对象,分析了我国高校图书馆图书情报领域特色资源研究的发展态势。【方法/过程】采用文献计量法和共词分析法,利用网络知识图谱、因子分析、聚类分析和多维尺度分析,研究各关键词之间的关系。【结果/结论】综合分析发现当前的研究热点主要包括五个方面:特色资源建设、地方特色文献、共享特色资源、数字特色资源、特色资源服务模式和策略。

关键词：特色资源图书情报文献计量网络知识图谱共词分析

Assembling S-scheme heterojunction between basic bismuth nitrate and bismuth tungstate with promoting charges’separation for accelerated photocatalytic sulfamethazine degradation

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Journal of Materials Science & Technology 2024年第4期171卷 185-197页

作者： Wenhan chen Meng Dai Li Xiang shan Zhao Shuguang Wang Zuoli He shandong Key Laboratory of Water Pollution Control and Resource Reuse Shandong Key Laboratory of Environmental Processes and HealthSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China CEDAR Knight Cancer InstituteSchool of MedicineOregon Health and Science UniversityPortlandOR 97201United States Weihai Research Institute of Industrial Technology of shandong University Shandong UniversityWeihai 264209China

The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated *** this study,a one-pot glycerol-assisted hydrothermal process was utilized to successfully synthesize S-scheme heterojunction photocatalysts comprising basic bismuth nitrate(BBN)and bismuth tungstate(BWO).Interestingly,the BBN/BWO heterogeneous photo-catalysts exhibited the highest photocatalytic *** optimized product achieved the degradation of sulfamethazine(SMZ)within 1 h,with a kinetic constant(k)value of 0.05818 min^(−1).The degradation process was influenced significantly by·O^(2)−and h^(+)*** determine the degradation pathway of SMZ in the presence of BBN/BWO-0.6,liquid chromatography-mass spectrometry(LC-MS)analysis was performed,which revealed a decrease in the toxicity of intermediates and *** enhanced pho-tocatalytic activity can be attributed to the internal electric field(IEF)of the S-scheme heterojunction between BBN and BWO,effectively promoting the separation of photogenerated *** research presents a viable approach for developing S-scheme heterojunctions in SMZ photodegradation and other environmental applications.

关键词： Photocatalysis S-scheme Heterojunction Bi_(2)WO_(6) Sulfamethazine

Experimental and numerical simulation study on the erosion behavior of the elbow of gathering pipeline in shale gas field

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Petroleum Science 2024年第2期21卷 1257-1274页

作者： En-Bin Liu Shen Huang Ding-Chao Tian Lai-min Shi shan-Bi Peng He Zheng Petroleum Engineering School Southwest Petroleum UniversityChengdu 610500SichuanChina Chongqing Natural Gas Sales Center Natural Gas BranchSinopecChongqing400023China Zhejiang Zheneng Natural Gas Operation Co. Ltd.Hangzhou 310000ZhejiangChina School of Civil Engineering and Architecture Southwest Petroleum UniversityChengdu 610500SichuanChina Louisiana Tech Univ Trenchless Technol Ctr599 Dan Reneau DrRustonLA71270USA Southwest Oil and Gas Field Branch Natural Gas Research Institute Chengdu 610213SichuanChina

During the production period of shale gas, proppant particles and rock debris are produced together,which will seriously erode the elbows of gathering pipelines. In response to this problem, this paper takes the elbow of the gathering pipeline in the Changning Shale Gas Field as an example to test the erosion rate and material removal mechanism of the test piece at different angles of the elbow through experiments and compares the four erosion models with the experimental results. Through analysis, it is found that the best prediction model for quartz sand-carbon steel erosion is the Oka model. Based on the Oka model, FLUENT software was used to simulate and analyze the law of erosion of the elbow of the gas gathering pipeline under different gas flow velocities, gas gathering pressure, particle size, length of L1,and bending directions of the elbow. And a spiral pipeline structure is proposed to reduce the erosion rate of the elbow under the same working conditions. The results show that this structure can reduce erosion by 34%.

关键词： Shale gas Gas gathering pipeline Elbow Erosion CFD