Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China
Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China作者机构：Sun Yat Sen Univ Dept Hepatobiliary Ctr Canc Guangzhou 510060 Guangdong Peoples R China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第2期
页 面：264-269页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by The Eleventh Five-Year Key Plan of the China National Science and Technique Foundation,No.2006BAI02A04 the 5010 Foundation of Sun Yat-sen University,No.2007043
主 题：Hepatocellular carcinoma Transarterial chemoembolization Palliative treatment Prognosis
摘 要：AIM:To identify prognostic factors from pretreatment variables of the initial transarterial chemoembolization(TACE)procedure in unresectable hepatocellular carcinoma(HCC). METHODS:One thousand and five hundred and sixtynine patients with unresectable HCC underwent TACE as initial treatment were retrospectively *** variables of the initial TACE procedure with a P value less than 0.05 by univariate analysis were subjected to Cox proportional hazards model. RESULTS:The median overall survival time and 1-, 5-,10-year survival rates were 10.37 mo,47%,10%, and 7%,respectively.A Cox proportional hazard model showed that 8 pretreatment factors of regional lymphnodes metastasis,Child-Pugh class,macrovascular invasion,greatest dimension,α-fetoprotein(AFP), Hepatitis virus B,tumor capsule,and nodules were independent prognostic *** with multimodality therapy have better survival than those with TACE treatment only. CONCLUSION:Tumor status,hepatic function reserve,AFP,and hepatitis virus B status were independent prognostic factors for unresectable *** metastasis might not be a contraindication to TACE. Multimodality therapy might improve survival.
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