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Long noncoding RNAs in hepatitis B virus replication and oncogenesis

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World Journal of Gastroenterology 2022年第25期28卷 2823-2842页

作者： Hui-Chun Li chee-hing yang Shih-Yen Lo Department of Biochemistry Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 97004Taiwan

Several diverse long noncoding RNAs(lncRNAs)have been identified to be involved in hepatitis B virus(HBV)replication and oncogenesis,especially those dysregulated in HBV-related hepatocellular carcinoma(HCC).Most of these dysregulated lncRNAs are modulated by the HBV X *** regulatory mechanisms of some lncRNAs in HBV replication and oncogenesis have been *** polymorphisms of several lncRNAs affecting HBV replication or oncogenesis have also been *** prognosis of HCC remains *** is important to identify novel tumor markers for early diagnosis and find more therapeutic targets for effective treatments of *** dysregulated lncRNAs in HBV-related HCC may become biomarkers for early diagnosis and/or the therapeutic targets of *** mini-review summarizes these findings briefly,focusing on recent developments.

关键词： Hepatitis B virus Hepatocellular carcinoma Long noncoding RNAs Hepatitis B virus X protein Biomarker

Production and pathogenicity of hepatitis C virus core gene products

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World Journal of Gastroenterology 2014年第23期20卷 7104-7122页

作者： Hui-Chun Li Hsin-Chieh Ma chee-hing yang Shih-Yen Lo Department of Biochemistry Tzu Chi University Department of Laboratory Medicine and Biotechnology Tzu Chi University Department of Laboratory Medicine Buddhist Tzu Chi General Hospital

Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes ***,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a *** HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various *** peptide(a.a.178-191)may play a role in the immune *** polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis *** addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron *** this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.

关键词： Hepatitis C virus Core protein Alternative reading frame/core+1 proteins Insulin resistance Steatosis Hepatocellular carcinoma Interferon

Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： chee Ying Tan Cuie Wen Hua Qian Ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability Corrosion Implant applications Laser surface modification Magnesium alloys

Prediction of fracture initiation in cohesive soils based on data mining modelling and large-scale laboratory verification

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Underground Space 2024年第6期19卷 279-300页

作者： Weiping Luo Dajun Yuan Yannick Choy hing Ng Dalong Jin Ping Lu Teng Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of the Ministry of Education for Urban Underground Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Civil and Environmental Engineering National University of SingaporeSingapore 119077Singapore

Many empirical and analytical methods have been proposed to predict fracturing pressure in cohesive *** of them take into account three to four specific influencing factors and rely on the assumption of a failure *** this study,a novel data-mining approach based on the XGBoost algorithm is investigated for predicting fracture initiation in cohesive *** has the advantage of handling multiple influencing factors simultaneously,without pre-determining a failure mode.A dataset of 416 samples consisting of 14 distinct features was herein collected from past studies,and used for developing a regressor and a classifier model for fracturing pressure prediction and failure mode classification *** results show that the intrinsic characteristics of the soil govern the failure mode while the fracturing pressure is more sensitive to the stress *** XGBoost-based model was also tested against conventional approaches,as well as a similar machine learning algorithm namely random forest ***,several large-scale triaxial fracturing tests and an in-situ case study were carried out to further verify the generalization ability and applicability of the proposed data mining approach,and the results indicate a superior performance of the XGBoost model.

关键词： Fracturing pressure Failure mode Cohesive soil Data-mining Large-scale tests

Low-thermal-budget electrically active thick polysilicon for CMOS-First MEMS-last integration

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Microsystems & Nanoengineering 2024年第3期10卷 395-407页

作者： Aron Michael Ian Yao-Hsiang Chuang chee Yee Kwok Kazuo Omaki UNSW SydneyNSW 2052Australia

Low-thermal-budget,electrically active,and thick polysilicon films are necessary for building a microelectromechanical system(MEMS)on top of a complementary metal oxide semiconductor(CMOS).However,the formation of these polysilicon films is a challenge in this ***,for the first time,the development of in situ phosphorus-doped silicon films deposited under ultrahigh-vacuum conditions(~10^(−9)Torr)using electron-beam evaporation(UHVEE)is *** process results in electrically active,fully crystallized,low-stress,smooth,and thick polysilicon films with low thermal *** crystallographic,mechanical,and electrical properties of phosphorus-doped UHVEE polysilicon films are *** films are compared with intrinsic and boron-doped UHVEE silicon *** spectroscopy,X-ray diffraction(XRD),transmission electron microscopy(TEM)and atomic force microscopy(AFM)are used for crystallographic and surface morphological *** curvature,cantilever deflection profile and resonance frequency measurements are employed to study the mechanical properties of the ***,resistivity measurements are conducted to investigate the electrical properties of the *** vertical,high-aspectratio micromachining of UHVEE polysilicon has been developed.A comb-drive structure is designed,simulated,fabricated,and characterized as an actuator and inertial sensor comprising 20-μm-thick in situ phosphorus-doped UHVEE films at a temperature less than 500℃.The results demonstrate for the first time that UHVEE polysilicon uniquely allows the realization of mechanically and electrically functional MEMS devices with low thermal budgets.

关键词： budget thick thermal

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

Vibration properties of Paulownia wood for Ruan sound quality using machine learning methods

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Journal of Forestry Research 2024年第5期35卷 216-222页

作者： yang yang College of Art and Design Harbin UniversityHarbin 150076People’s Republic of China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin 150040People’s Republic of China

As an important material for manufacturing resonant components of musical instruments,Paulownia has an important influence on the sound quality of *** this paper,a model for evaluating the sound quality of Ruan based on the vibration characteristics of wood is developed using machine learning ***,the selection of materials for Ruan manufacturing relies primarily on manually weighing,observing,striking,and listening by the instrument *** in scientific theory have hindered the quality of the finished *** this study,nine Ruans were manufactured,and a prediction model of Ruan sound quality was proposed based on the raw material information of *** of a total of 180 data sets,145 and 45 sets were chosen for training and validation,*** this paper,typical correlation analysis was used to determine the correlation between two single indicators in two adjacent pairwise combinations of the measured objects in each stage of the production process in *** vibra-tion characteristics of the wood were tested,and a model for predicting the evaluation of Ruan’s acoustic qualities was developed by measuring the vibration characteristics of the resonating plate *** acoustic quality of the Ruan sound board wood was evaluated and predicted using machine learning model generalized regression neural *** results show that the prediction of Ruan sound quality can be achieved using Matlab simulation based on the vibration characteristics of the soundboard *** the model-predicted values were compared with the tradi-tional predicted results,it was found that the generalized regression neural network had good performance,achieving an accuracy of 93.8%which was highly consistent with the experimental *** was concluded that the model can accurately predict the acoustic quality of the Ruan based on the vibration performance of the soundboards.

关键词： Sound quality Wood vibration performance Paulownia wood Machine learning methods

Overview of radar detection methods for low altitude targets in marine environments

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Journal of Systems Engineering and Electronics 2024年第1期35卷 1-13页

作者： yang Yong yang Boyu School of Electronic Science National University of Defense TechnologyChangsha 410073China

In this paper,a comprehensive overview of radar detection methods for low-altitude targets in maritime environments is presented,focusing on the challenges posed by sea clutter and multipath *** performance of the radar detection methods under sea clutter,multipath,and combined conditions is categorized and summarized,and future research directions are outlined to enhance radar detection performance for low-altitude targets in maritime environments.

关键词： radar sea clutter multipath scattering detection low altitude target

Fresh-Keeping Decision and Coordination of Fresh Agricultural Product Supply Chain Considering Carbon Cap-and-Trade under Different Dominance

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 30-51页

作者： yang yang Guanxin Yao China Institute for Agricultural Equipment Industrial Development Jiangsu UniversityZhenjiang212013China Jiangsu Modern Logistics Research Base Yangzhou UniversityYangzhou225009China

In the context of low carbon,this paper discussed the impact of the carbon cap-and-trade policy on the fresh-keeping decision-making of two-echelon fresh agricultural product supply chains under different dominance,and designed cost-sharing contracts to coordinate the supply chain of fresh agricultural products dominated by suppliers and retailers *** results showed that:dominance has no effect on the fresh-keeping decision and total revenue of fresh agricultural product supply chain,but it affects the internal income distribution,and dominance does not always bring more benefits;the implementation of carbon cap-and-trade reduces the fresh-keeping decision-making of fresh agricultural products supply chain and reduces the free-rider income of followers;the role of higher carbon trading price is twofold,which not only brings about the speculation of leading enterprises,but also promotes the application of low-carbon technologies;consumers’high preference for freshness,low-cost and high-efficiency low-carbon technology are all conducive to improving the fresh-keeping efforts and benefits of the supply chain;cost-sharing contracts can coordinate the supply chain of fresh agricultural products.

关键词： Dominant power carbon cap-and-trade policy fresh agricultural product supply chain fresh-keeping decision-making