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Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

hLife 2023年第1期1卷 26-34页

作者： chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus chee fu yung Wee chee Yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore National Center of Infectious Diseases Singapore Tan Tock Seng Hospital Singapore Lee Kong Chian School of Medicine Nanyang Technology UniversitySingapore Centre Scientifique de Monaco Monaco Direction de I’Action Sanitaire de Monaco Monaco Infectious Disease Service Department of PediatricsKK Women’s and Children’s HospitalSingapore Duke-NUS Medical School Singapore African Health Research Institute DurbanSouth Africa Singapore Immunology Network Agency for ScienceTechnology and ResearchSingapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Infectious Diseases Translational Research Programme National University of SingaporeSingapore 14School of Biological SciencesNanyang Technological UniversitySingapore Singhealth Duke-NUS Global Health Institute Singapore

Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this *** key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding *** raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)***,we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta,Delta,Omicron BA.1,Omicron BA.2 and Omicron *** results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1,ancestral SARS-CoV-2 and SARS-CoV-2 Omicron *** data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.

关键词： SARS-CoV-2 SARS-CoV-1 serotype Omicron primary infection convalescent sera

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Assessing the Performance of a Dynamical Downscaling Simulation Driven by a Bias-Corrected CMIP6 Dataset for Asian Climate

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Advances in Atmospheric Sciences 2024年第5期41卷 974-988页

作者： Zhongfeng XU Ying HAN Meng-Zhuo ZHANG Chi-yung TAM Zong-Liang YANG Ahmed M.EL KENAWY Congbin fu Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China School of Atmospheric Sciences Nanjing UniversityNanjing 210093China Earth System Science Programme The Chinese University of Hong KongHong KongChina Department of Geological Sciences Jackson School of GeosciencesThe University of Texas at AustinAustinTexasUSA Instituto Pirenaico de Ecología Consejo Superior de Investigaciones Científicas(CSIC)Campus de Aula Dei1005Zaragoza 50059Spain Department of Geography Mansoura UniversityMansoura 35516Egypt

In this study,we aim to assess dynamical downscaling simulations by utilizing a novel bias-corrected global climate model(GCM)data to drive a regional climate model(RCM)over the Asia-western North Pacific *** simulations were conducted with a 25-km grid spacing for the period 1980–*** first simulation(WRF_ERA5)was driven by the European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5)dataset and served as the validation *** original GCM dataset(MPI-ESM1-2-HR model)was used to drive the second simulation(WRF_GCM),while the third simulation(WRF_GCMbc)was driven by the bias-corrected GCM *** bias-corrected GCM data has an ERA5-based mean and interannual variance and long-term trends derived from the ensemble mean of 18 CMIP6 *** demonstrate that the WRF_GCMbc significantly reduced the root-mean-square errors(RMSEs)of the climatological mean of downscaled variables,including temperature,precipitation,snow,wind,relative humidity,and planetary boundary layer height by 50%–90%compared to the WRF_***,the RMSEs of interannual-tointerdecadal variances of downscaled variables were reduced by 30%–60%.furthermore,the WRF_GCMbc better captured the annual cycle of the monsoon circulation and intraseasonal and day-to-day *** leading empirical orthogonal function(EOF)shows a monopole precipitation mode in the WRF_*** contrast,the WRF_GCMbc successfully reproduced the observed tri-pole mode of summer precipitation over eastern *** improvement could be attributed to a better-simulated location of the western North Pacific subtropical high in the WRF_GCMbc after GCM bias correction.

关键词： bias correction multi-model ensemble mean dynamical downscaling interannual variability day-to-day variability validation

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fuzzy Logic Controller-based Synchronverter in Grid-connected Solar Power System with Adaptive Damping Factor

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Chinese Journal of Electrical Engineering 2021年第2期7卷 37-49页

作者： Kah yung Yap chee Ming Beh Charles R.Sarimuthu Department of Electrical and Computer Systems Engineering(ECSE) School of EngineeringMonash University MalaysiaSubang Jaya 47500Malaysia

In recent years,renewable energy sources,specifically solar power systems,have developed rapidly owing to their technological maturity and cost ***,its grid integration deteriorates frequency stability because of insufficient rotating masses and inertial ***,a synchronverter,which is an inverter that mimics the operation of a synchronous generator,is crucial to interface solar power in a power *** stabilizes the power grid by emulating a virtual ***,a conventional proportional-integral(PI)-based synchronverter is not equipped with an adaptive damping factor(Dp)or a digitalized smart controller to manage fast-responding solar ***,a novel fuzzy logic controller(FLC)framework is proposed such that the synchronverter can operate in a grid-connected solar power *** this study,Dp is controlled in real time using an FLC to achieve balance between speed and stability for frequency error correction based on frequency *** of four case studies performed in Matlab/Simulink show that the proposed FLC-based synchronverter can stabilize the grid frequency by reducing the frequency deviation by at least 0.2 Hz(0.4%),as compared with the conventional PI-based synchronverter.

关键词： fuzzy logic controller(FLC) synchronverter renewable energy system(RES) grid stability solar power system

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Effects of areca nut consumption on cell differentiation of osteoblasts, myoblasts, and fibroblasts

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BIOCELL 2023年第2期47卷 283-287页

作者： yung-fu CHANG Department of Biomedical Science and Environmental Biology Kaohsiung Medical UniversityKaohsiung807Taiwan Department of Medical Research Kaohsiung Medical University HospitalKaohsiung807Taiwan Translational Research Center of Neuromuscular Diseases Kaohsiung Medical University HospitalKaohsiung807Taiwan

Areca nut is used worldwide as a hallucinogenic addicting drug along the tropical ***,a toxic compound,is the most important alkaloid in areca *** adverse effects of oral uptake and chewing of areca nut are well *** example,the possibility of cancer caused by chewing areca nuts is widely *** areca nut has other adverse effects on other organs,including abnormal cell differentiation,oral cancer,and several other *** use of areca nut is also associated with low *** musculature is the largest organ in the body and is attached to the *** embryo development,the differentiation of bone and muscle cells is *** this article,we reviewed the effects of areca nut and arecoline on embryonic cell differentiation,particularly osteoblasts,myoblasts,and fibroblasts.

关键词： Areca nut Cell differentiation Osteoblast Myoblast Fibroblast

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Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial

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Food Science and Human Wellness 2023年第5期12卷 1917-1923页

作者： Chia-Hua Liang yung-Hsiang Lin yung-Kai Lin Chi-fu Chiang Department of Cosmetic Science and Institute of Cosmetic Science Chia Nan University of Pharmacy and ScienceTainan 71710China Research&Design Center TCI CO.Ltd.Taipei 114722China Institute of Food Safety and Risk Management Department of Food ScienceTaiwan Ocean UniversityKeelung 202301China Graduate Institute of Biomedical Engineering Chung Hsing UniversityTaichung 202301China

Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract(HappyAngel^(■))was used to treat human hair follicle dermal papilla cells(HFDPCs)and the expression of reactive oxygen species(ROS), dihydrotestosterone(DHT), and hair-related genes(SRD5A1, SRD5A2, AR, and KROX20)were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract(HappyAngel^(■))can stimulate hair growth and inhibit the activation of hair loss genes.

关键词： Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells

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Facile design of Au@Pt core-shell nanostructures： Formation of Pt submonolayers with tunable coverage and their applications in electrocatalysis

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Nano Research 2014年第3期7卷 410-417页

作者： fulin Zheng Wing-Tak Wong Ka-fu yung Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong SAR China

A facile design of Pt nanostructures from submonolayer to monolayer has been realized by ion adsorption-in situ electrochemical reduction on Au nanoparticles supported on multiwall carbon nanotubes （CNTs）. The as prepared Au@Pt/CNTs catalysts display coverage-specific electrocatalysis. Au@Pt/CNTs with low Pt coverage is inactive towards methanol oxidation whereas it oxidizes formic acid effectively through a direct pathway with mass specific activity 90 times that of a commercial Pt/C catalyst. Due to its inertness to methanol, it shows high performance in the oxygen reduction reaction （ORR） with high methanol tolerance. In contrast, simply increasing the Pt coverage to above 40% switches the formic acid oxidation process to both direct and indirect catalytic pathways, and also results in high methanol oxidation activity.

关键词： electrocatalysis platinum submonolayer fuel cell

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Relevant Visual Semantic Context-Aware Attention-Based Dialog

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Computers, Materials & Continua 2023年第8期76卷 2337-2354页

作者： Eugene Tan Boon Hong yung-Wey Chong Tat-chee Wan Kok-Lim Alvin Yau National Advanced IPv6 Centre Universiti Sains MalaysiaPenangMalaysia Lee Kong Chian Faculty of Engineering and Science(LKCFES) Universiti Tunku Abdul RahmanSungai LongSelangorMalaysia

The existing dataset for visual dialog comprises multiple rounds of questions and a diverse range of image ***,it faces challenges in overcoming visual semantic limitations,particularly in obtaining sufficient context from visual and textual aspects of *** paper proposes a new visual dialog dataset called Diverse History-Dialog(DS-Dialog)to address the visual semantic limitations faced by the existing ***-Dialog groups relevant histories based on their respective Microsoft Common Objects in Context(MSCOCO)image categories and consolidates them for each ***,each MSCOCO image category consists of top relevant histories extracted based on their semantic relationships between the original image caption and historical *** relevant histories are consolidated for each image,and DS-Dialog enhances the current dataset by adding new context-aware relevant history to provide more visual semantic context for each *** new dataset is generated through several stages,including image semantic feature extraction,keyphrase extraction,relevant question extraction,and relevant history dialog *** DS-Dialog dataset contains about 2.6 million question-answer pairs,where 1.3 million pairs correspond to existing VisDial’s question-answer pairs,and the remaining 1.3 million pairs include a maximum of 5 image features for each VisDial image,with each image comprising 10-round relevant question-answer ***,a novel adaptive relevant history selection is proposed to resolve missing visual semantic information for each ***-Dialog is used to benchmark the performance of previous visual dialog models and achieves better performance than previous ***,the proposed DSDialog model achieves an 8% higher mean reciprocal rank(MRR),11% higher R@1%,6% higher R@5%,5% higher R@10%,and 8% higher normalized discounted cumulative gain(NDCG)compared to ***-Dialog also achieves approximately 1 point improvement o

关键词： Visual dialog context-aware relevant history computer vision natural language processing

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Simultaneous H∞ Control for a Collection of Nonlinear Systems in Canonical Form

Simultaneous H∞ Control for a Collection of Nonlinear Syste...

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第二十九届中国控制会议

作者： WU Jenq-Lang yung chee-Fai Department of Electrical Engineering National Taiwan Ocean University

ISBN: (纸本)9787894631046

A constructive method for designing simultaneous H∞ controllers for a class of nonlinear control systems is *** mild assumptions,it is shown that control storage functions（CSFs） for nonlinear systems in canonical form can be constructed systematically;and,simultaneous H control for such systems can always be *** on the derived CSFs,a universal formula for constructing simultaneous H∞ controllers is proposed *** illustrative example is given to show the validity of the method.

关键词： SimultaneousH $Control State Feedback Nonlinear Control Systems Control Storage function.

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On the adjacent vertex-distinguishing acyclic edge coloring of some graphs

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Applied Mathematics(A Journal of Chinese Universities) 2011年第4期26卷 439-452页

作者： SHIU Wai chee CHAN Wai Hong ZHANG Zhong-fu BIAN Liang （Corresponding author） Department of Mathematics Hong Kong Baptist University 224 Waterloo Road Kowloon Tong Hong Kong. Department of Mathematics Hong Kong Baptist University 224 Waterloo Road Kowloon Tong Hong Kong. Institute of Applied Mathematics Lanzhou Jiaotong University Lanzhou 730070 China.

A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v, where uv∈ E（G）. The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by X＇Aa（G）, is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. If a graph G has an adjacent vertex distinguishing acyclic edge coloring, then G is called adjacent vertex distinguishing acyclic. In this paper, we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures.

关键词： Adjacent strong edge coloring adjacent vertex-distinguishing acyclic edge coloring.

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Optimal location query based on k nearest neighbours

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Frontiers of Computer Science 2021年第2期15卷 105-117页

作者： Yubao LIU Zitong CHEN Ada Wai-chee fu Raymond Chi-Wing WONG Genan DAI School of Data and Computer Science Sun Yat-Sen UniversityGuangzhou510006China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou510006China Department of Computer Science and Engineering Chinese University of Hong KongHong Kong999077China Department of Computer Science and Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Optimal location query in road networks is a basic operation in the location intelligence *** a set of clients and servers on a road network,the purpose of optimal location query is to obtain a location for a new server,so that a certain objective function calculated based on the locations of clients and servers is *** works assume no labels for servers and that a client only visits the nearest *** assumptions are not realistic and it renders the existing work not useful in many *** this paper,we relax these assumptions and consider the k nearest neighbours(KNN)of *** introduce the problem of KNN-based optimal location query(KOLQ)which considers the k nearest servers of clients and labeled *** also introduce a variant problem called relocation KOLQ(RKOLQ)which aims at relocating an existing server to an optimal *** main analysis algorithms are proposed for these *** experiments on the real road networks illustrate the efficiency of our proposed solutions.

关键词： optimal location query k nearest neighbours road network

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