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Freehand transperineal prostate biopsy with a coaxial needle under local anesthesia:Experience from a single institution in Malaysia

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Cancer Pathogenesis and Therapy 2023年第1期1卷 33-39页

作者： Ing Soon Ngu Ming Soen Ngooi Han Kun Ng Kenny Tang Long Tee chee hoong loo Meng Shi Lim Department of Urology Sarawak General Hospital93586KuchingSarawakMalaysia Department of Urology Sarawak Heart Centre94300Kota SamarahanSarawakMalaysia

Background Freehand transperineal prostate biopsy(TPPBx)using a coaxial needle technique offers an alternative to probe-mounted freehand or template-guided techniques in the diagnosis of prostate cancer(PCa).It only requires the same equipment used for transrectal ultrasound-guided(TRUS)*** study is the first in Malaysia to report this experience and its *** aim to determine PCa detection rate and pain tolerability of freehand TPPBx utilizing a coaxial needle under local anesthesia(LA).Methods Institutional review board approval was obtained from National Medical Research Register(NMRR ID-21-02052-VIL).We retrospectively reviewed the medical records of patients who underwent TPPBx between August 2020 and April *** were reviewed for patients’characteristics,prostate volume,prostate-specific antigen(PSA)results,biopsy results and pain *** was analyzed to determine PCa and clinically significant prostate cancer(csPCa)detection *** was achieved using perineal skin infiltration and a periprostatic nerve *** commonly used standard side-firing transrectal ultrasound with its Prostate Biplane Transducer was used as an imaging *** principles of the Ginsburg protocol were *** tolerability was assessed using a visual analog *** A total of 55 patients with elevated PSA levels underwent freehand TPPBx under *** mean age was 67.3 years,the median PSA was 14.2 ng/mL,and the median PSA density(PSAD)was 0.33 ng/mL/*** optimal PSAD cutoff for predicting csPCa was 0.35 ng/mL/cc(area under the curve[AUC],0.792;sensitivity,87.5%;specificity,69.2%).PCa was detected in 24 patients(43.6%),of whom 16(29.1%)had *** median pain scores during LA infiltration and biopsy were four and two,respectively,which were significant different(P<0.05).TPPBx exhibited an infection rate of *** The PCa detection rate and patient tolerability of freehand TPPBx using a coaxial needle are similar to those of a cont

关键词： Prostate cancer Freehand Transperineal biopsy of prostate Coaxial needle TRUS biopsy PSA density Pain tolerability

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Is the time right for systematically serotyping SARS-related coronaviruses?

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hLife 2024年第1期2卷 4-5页

作者： chee Wah Tan Lin-Fa Wang Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore CitySingapore Duke-NUS Medical School Singapore CitySingapore

IS THERE A NEED FOR SEROTYPING?The emergence and rapid selection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)immune escape variants have exerted significant challenges in many different ways,from public health response to vaccine boosting strategy and monitoring of herd immunity against future variants or related severe acute respiratory syndrome(SARS)related coronaviruses(SARSr-CoVs).The Omicron sub-variants,which differ substantially from the pre-Omicron variants,are circulating worldwide and continuing to evolve extensively through mutations and/or recombination predominantly in the spike protein,mainly due to immune-selective *** their phylogenetically close relationship to ancestral SARS-CoV-2,antigenically,Omicron variants are very different from the original *** is therefore very natural to raise the question whether we need a better way to classify and differentiate those CoVs which are genetically very similar,but antigenically quite *** of viruses is a common practice for many known virus groups,most notably for human papillomavirus(HPV)and dengue virus(DENV)[1,2].The concept of CoV serotypes was not new and has been applied to study the antigenicity of feline CoVs[3].The possibility of establishing distinctive serotypes for the SARS-CoV-2 virus was first raised by Simon-Loriere and Schwartz in 2022[4].Serotyping SARS-CoV-2 is expected to help more scientifically define the differences between variants and facilitate more targeted diagnostics,therapeutics,and vaccine development.

关键词： immunity SARS establishing

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The Taoism Philosophy within Traditional Chinese Medicine:The Relation between Huang Di Nei Jing(《黄帝内经》Yellow Emperor's Inner Classic)and Dao De Jing(《道德经》Tao Te Jing)

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Chinese Medicine and Culture 2019年第4期2卷 184-188页

作者： chee hoong Lim Seng Keat Lim Guo Lin Wong Linchao Qian Yun Jin Kim School of Traditional Chinese Medicine Xiamen University Malaysia

Taoism refers to an indigenous Chinese philosophical and religious tradition. For more than two and a half millennia, it has had a profound social and intellectual influence on Eastern Asia and since the 19 th century has deeply influenced Western countries. Dao De Jing(《道德经》Tao Te Jing) is still considered to be the primary text of Taoism. The Tao Te Jing is attributed to Laozi, the classical Chinese Philosopher, and describes the major doctrines of Taoism. It is most relevant to Traditional Chinese Medicine(TCM). This article offers a brief introduction to the Taoism within TCM – the relation between Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic) and Dao De Jing(《道德经》Tao Te Jing).

关键词： Dao De Jing (《》 Tao Te Jing) Huang Di Nei Jing (《》 The Yellow Emperorss Inner Classic) Taoism Philosophy

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Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B

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World Journal of Gastroenterology 2021年第14期27卷 1369-1391页

作者： Zhi Yi Goh Ee chee Ren Hui Ling Ko Singapore Immunology Network Agency for ScienceTechnology and ResearchSingapore 138648Singapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119260Singapore

250 million people worldwide continue to be chronically infected with the *** patients may be treated with nucleoside/nucleotide analogues,this only suppresses HBV titre to sub-detection levels without eliminating the persistent HBV covalently closed circular DNA(cccDNA)*** a result,HBV infection cannot be cured,and the virus reactivates when conditions are ***(IFNs)are cytokines known to induce powerful antiviral mechanisms that clear viruses from infected *** have been shown to induce cccDNA clearance,but their use in the treatment of HBV infection is limited as HBVtargeting immune cells are exhausted and HBV has evolved multiple mechanisms to evade and suppress IFN ***,to fully utilize IFN-mediated intracellular mechanisms to effectively eliminate HBV,instead of direct IFN administration,novel strategies to sustain IFN-mediated anti-cccDNA and antiviral mechanisms need to be *** review will consolidate what is known about how IFNs act to achieve its intracellular antiviral effects and highlight the critical interferon-stimulated gene targets and effector mechanisms with potent anti-cccDNA *** include cccDNA degradation by APOBECs and cccDNA silencing and transcription repression by epigenetic *** addition,the mechanisms that HBV employs to disrupt IFN signalling will be *** that have been developed or are in the pipeline for components of the IFN signalling pathway and HBV targets that detract IFN signalling mechanisms will also be identified and discussed for utility in the treatment of HBV ***,these will provide useful insights into design strategies that specifically target cccDNA for the eradication of HBV.

关键词： Covalently closed circular DNA Interferons APOBECs Epigenetic modification Hepatitis B virus therapeutics

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A Case Report of Pemphigoid Nodularis as Masquerader of Neurotic Excoriations

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International Journal of Dermatology and Venereology 2020年第4期3卷 239-241页

作者： Tan chee Hian Tey Hong Liang National Skin Centre 308205Singapore Yong loo Ling School of Medicine National University of Singapore117597Singapore Lee Kong Chian School of Medicine Nanyang Technological University308232Singapore

Introduction:Pemphigoid nodularis is a rare clinical variant of bullous pemphigoid characterized by both prurigo nodularis-like lesions and pemphigoid-like *** presentation:A 72-year-old Chinese man has been on follow-up at an outpatient Dermatology unit for extensive prurigo nodularis for past 4 to 5 years until an inpatient stay when he was admitted for labile mood and erratic behavior due to the intense pruritus and skin *** the admission,the inpatient team noticed tense hemorrhagic blisters on his right thigh for which histological examination confirmed the diagnosis of bullous *** was treated with oral prednisolone,doxycycline,and nicotinamide,which led to clinical ***:Pemphigoid nodularis can be easily misdiagnosed as prurigo *** discuss clinical clues that can raise the suspicion of an underlying immunobullous disorder,including erythematous nodules with a much larger surface area affected by central erosions and *** associated with larger areas of erosions and ulceration is clues that lesions can be more than mere ***:It is important for clinicians to be aware of the presentation of prurigo nodularis in association with bullous pemphigoid such that effective treatment can be promptly *** is especially illustrated in this case,as the treatment of bullous pemphigoid not only improved his skin condition but it also improved his psychological health and behavior with the resolution of itch.

关键词： bullous pemphigoid pemphigoid nodularis itch case report

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The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2039-2055页

作者： Kan Xing Wu Thinesshwary Yogarajah Marcus Wing Choy Loe Parveen Kaur Regina Ching Hua Lee chee Keng Mok Yi Hao Wong Patchara Phuektes Li Sze Yeo Vincent T.K.Chow Yong Wah Tan Justin Jang Hann Chu Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University Health SystemNational University of SingaporeSingapore 117597Singapore Department of Pathobiology Faculty of Veterinary MedicineKhonkaen UniversityKhonkaen 40002Thailand Infectious Disease Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A∗STAR)Singapore 138648Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore NUSMed Biosafety Level 3 Core Facility Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore

Positive-sense RNA viruses modify intracellular calcium stores,endoplasmic reticulum and Golgi apparatus(Golgi)to generate membranous replication organelles known as viral *** factories provide a conducive and substantial enclave for essential virus replication via concentrating necessary cellular factors and viral proteins in ***,we identified the vital role of a broadspectrum antiviral,peruvoside in limiting the formation of viral ***,we revealed the pleiotropic cellular effect of Src and PLC kinase signaling via cyclin-dependent kinase 1 signaling leads to Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1(GBF1)phosphorylation and Golgi vesiculation by peruvoside *** ramification of GBF1 phosphorylation fosters GBF1 deprivation consequentially activating downstream antiviral signaling by dampening viral factories *** investigation showed signaling of ERK1/2 pathway via cyclin-dependent kinase 1 activation leading to GBF1 phosphorylation at Threonine 1337(T1337).We also showed 100%of protection in peruvoside-treated mouse model with a significant reduction in viral titre and without measurable cytotoxicity in *** findings highlight the importance of dissecting the broad-spectrum antiviral therapeutics mechanism and pave the way for consideration of peruvoside,host-directed antivirals for positive-sense RNA virus-mediated disease,in the interim where no vaccine is available.

关键词： Positive-sense RNA viruses Peruvoside Antiviral CDKI signaling Viral factories Calcium efflux Broad-spectrum Golgi apparatus

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Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

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Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

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Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

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hLife 2023年第1期1卷 26-34页

作者： chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus chee Fu Yung Wee chee Yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore National Center of Infectious Diseases Singapore Tan Tock Seng Hospital Singapore Lee Kong Chian School of Medicine Nanyang Technology UniversitySingapore Centre Scientifique de Monaco Monaco Direction de I’Action Sanitaire de Monaco Monaco Infectious Disease Service Department of PediatricsKK Women’s and Children’s HospitalSingapore Duke-NUS Medical School Singapore African Health Research Institute DurbanSouth Africa Singapore Immunology Network Agency for ScienceTechnology and ResearchSingapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Infectious Diseases Translational Research Programme National University of SingaporeSingapore 14School of Biological SciencesNanyang Technological UniversitySingapore Singhealth Duke-NUS Global Health Institute Singapore

Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this *** key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding *** raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)***,we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta,Delta,Omicron BA.1,Omicron BA.2 and Omicron *** results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1,ancestral SARS-CoV-2 and SARS-CoV-2 Omicron *** data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.

关键词： SARS-CoV-2 SARS-CoV-1 serotype Omicron primary infection convalescent sera

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SRS27,a semisynthetic diterpenoid lactone,inhibits airway inflammation and hyper-responsiveness via NF-κB pathway in an allergic mouse asthma model

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中国药理学与毒理学杂志 2015年第S1期29卷 53-53页

作者： Jonathan chee Woei LIM Fera Yiqian GOH Sreenivasa Rao SAGINEEDU Audrey chee Hui YONG Shiran Mohd SIDIK Nordin Haji LAJIS Wai-Shiu Fred WONG Johnson STANSLAS Pharmacotherapeutics Unit Department of MedicineFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Department of Pharmacology Yong Loo Lin School of MedicineNational University Health System Laboratory of Natural Products Institute of BioscienceUniversiti Putra Malaysia Faculty of Pharmacy Segi University College 9Jalan Teknologi Histopathology Unit Department of PathologyFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Immunology Program Life Science InstituteNational University of Singapore

Andrographis paniculata contains two main diterpenoid constituents,andrographolide(AGP)and 14-deoxy-11,12-didehydroandrographolide(DDAG),which were found to exhibit antiasthma effects in a mouse asthma ***,due to inadequacies of both compounds in terms of drug-likeness,DDAG analogues were semisynthesised to tackle these *** objective of the study was to investigate the potential of DDAG analogues as new antiasthma *** the analogues,(SRS27)was proven to inhibit cysteinyl leukotrienes(CysLT)and nitric oxide(NO)synthesis in mouse macrophages,like ***,on the other hand,failed to exhibit such ***27 is less cytotoxic than AGP,suggests that a simple chemical modification of DDAG produces a compound with CysLT and NO inhibitory activites similar to AGP while maintaining toxicity profile similar to *** is interesting to note that other analogues such as SRS28,SRS49,SRS76 and SRS83 with chemical modifications on the same carbon numbers 3 and 19 of DDAG were unable to show inhibition of CysLT and NO ***,the potential anti-inflammatory effect of SRS27 was investigated in ovalbumin(OVA)-induced mouse asthma *** compound was administered in a prophylactic manner and showed a substantial decrease in mouse asthma model ***27 at 3mg·kg-1 significantly reduced OVA-induced total cell such as macrophages,eosinophils,lymphocytes and neutrophils,as well as inflammatory cytokines such as IL-4,IL-5,IL-13 and eotaxin in bronchoalveolar lavage BAL *** compound also suppressed serum IgE *** addition,SRS27 suppressed mucus hyper-secretion and expression of inflammatory mediators such as TNF-α,MCP-1,Muc5 ac,RANTES,IL-33 and ***27 is the first known DDAG derivative tested positive in mouse asthma model and as such SRS27 could serve as a prototype prophylactic agent.

关键词： NF-κB A549cell line andrographolide analogues nitr

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中国儿童孤独症谱系障碍患病率的系统综述(英文)

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上海精神医学 2013年第2期25卷 70-80页

作者：万玉美胡强李婷姜丽娟杜亚松 Lei FENG John chee-Meng WONG 李春波上海交通大学医学院附属精神卫生中心 Department of Psychological Medicine Yong Loo Lin School of MedicineNational University of Singapore Department of Psychological Medicine National University Hospital

背景中国孤独症和孤独症谱系障碍(autism spectrum disorders,ASD)的患病率缺乏可靠的估计。目的运用Meta分析综合评价中国18岁以下人群孤独症和ASD患病情况,并分析其在性别、民族、城乡等不同因素间的差异。方法检索中国知识资源总库... 详细信息

背景中国孤独症和孤独症谱系障碍(autism spectrum disorders,ASD)的患病率缺乏可靠的估计。目的运用Meta分析综合评价中国18岁以下人群孤独症和ASD患病情况,并分析其在性别、民族、城乡等不同因素间的差异。方法检索中国知识资源总库、中国科技期刊数据库、万方数据检索系统、中国生物医学文摘数据库、PubMed和Web of Science等数据库,收集关于中国孤独症谱系障碍患病率的文献,按照预先制定的纳入及排除标准筛选相关研究。采用R-2.1 5.2软件对资料进行统计学分析。结果共纳入24项研究,其中5项来自香港和台湾的注册研究(涉及14,570,369名儿童),19项来自大陆以人群为基础的筛查和诊断研究(合并样本量为771,413名儿童)。港台注册研究报道的孤独症年患病率为1.8～424.6/10,000。中国大陆的18项研究(剔除一个患病率最低的全国性研究)报道孤独症患病率为2.8～30.4/10,000,合并后孤独症患病率为12.8/10,000(95%CI,9.4～17.5)。5项研究报道ASD(患病率为7.3～75.3/10,000)合并后患病率24.5/10,000(95%CI,10.4～57.4)。不同性别、居住地点、发表时间和抽样来源之间报道的患病率存在明显差异。结论港台注册研究报道的孤独症患病率存着巨大差异(达200倍),大陆以人群为基础的筛查诊断研究报道的患病率存在较大差异(10～15倍),凸显迫切需要建立标准的方法来估计孤独症和ASD的患病率。只有方法学质量得到改善,才有可能为这些不常见但严重致残的疾病提供循证的防治策略。

关键词：中国大陆患病率自闭儿童国家知识基础设施医学文献数据库系统谱系

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