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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke feng chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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feng chen's work on translational and clinical imaging

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World Journal of Radiology 2011年第4期3卷 120-124页

作者： feng chen, Section of Radiology, Department of Medical Diagnostic Sciences, Faculty of Medicine, University of Leuven, 3000 Leuven, Belgium feng chen, Molecular Small Animal Imaging Center, University of Leuven, 3000 Leuven, Belgium feng chen, Department of Radiology, Zhong Da Hospital, South-east University, Nanjing 210009, Jiangsu Province, China feng chen Section of Radiology Department of Medical Diagnostic Sciences Faculty of Medicine University of Leuven 3000 Leuven Belgium.

Dr. feng chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University, Nanjing, China and a senior researcher in the Department of Radiology at the Catholic University of Leuven, Belgium. His main areas of interest are translational imaging research including stroke, tumor angiogenesis, assessment of therapeutic response in solid tumors, and magnetic resonance contrast media. Dr. feng chen has published 44 scientific papers in peer-reviewed international journals. He and his colleagues have developed an imaging platform which includes animal models, animal preparations and multiparametric magnetic resonance imaging (MRI) protocols for translational animal imaging research using clinical machines. His MRI findings on rodent stroke are considered to "serve as a model for future laboratory investigations of treatment of acutestroke and unify the approaches developed for clinical studies". He and his colleagues have introduced a novel liver tumor model in rodents, in which a series of studies concerning the antitumor activity of vascular disrupting agents have been successively conducted and assessed by in vivo MRI, especially by diffusion weighted imaging as an imaging biomarker. His goal is to provide valuable references for clinical practice and to contribute to the translation of animal imaging research into patient applications.

关键词： Animal study Contrast agent Magnetic res- onance imaging Therapeutic assessment Translational research Tumor angiogenesis Tumor therapy Vascular disrupting agent

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小水电站对赤水河连通性影响评估及恢复对策

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湖泊科学 2025年第1期37卷 253-265页

作者：赵文通贺蔚赵先富陈锋张晶金小伟毛丰李正飞河海大学水利水电学院南京210098 水利部中国科学院水工程生态研究所水利部水工程生态效应与生态修复重点实验室武汉430079 中国水利水电科学研究院水生态环境研究所北京100038 中国环境监测总站北京100012 华威大学全球可持续发展研究所考文垂CV47AL 中国科学院水生生物研究所武汉430072

赤水河作为长江上游珍稀特有鱼类国家级自然保护区的重要组成部分,其生态连通性对于长江上游特有鱼类至关重要。但赤水河流域内广泛分布的小水电站严重影响了该区域的连通性。本研究收集了赤水河流域小水电站的空间位置、建设年份、装... 详细信息

赤水河作为长江上游珍稀特有鱼类国家级自然保护区的重要组成部分,其生态连通性对于长江上游特有鱼类至关重要。但赤水河流域内广泛分布的小水电站严重影响了该区域的连通性。本研究收集了赤水河流域小水电站的空间位置、建设年份、装机容量等详细信息,并采用树状水系连通性指数(DCI)、溪流连续性指数(SCI)、河流破碎化指数(CAFI)和新提出的改进的河流破碎化指数(CAFI M)全面评估小水电站对赤水河流域水系连通性影响的时空变化。研究发现,赤水河流域几乎每条河流都建有小水电站,主要分布在低阶河流。DCI和SCI指数表明,随着电站数量的增加,赤水河流域的连通性显著下降,中下游地区连通性低于上游地区。CAFI和CAFI M指数揭示了类似的趋势,随小水电站的建设河流破碎化程度不断加剧,特别是在习水河、大同河和桐梓河流域表现显著。CAFI M指数将小水电站的装机容量因素纳入考虑,能够更加全面准确地评估小水电站的影响。CAFI M指数相较于传统指标,对装机容量变化更为敏感,能有效反映大型电站的影响。根据CAFI M等指数评估结果,研究评估了赤水河流域内各小水电站障碍物的优先级,提出应优先整改位于高阶河流且装机容量大的电站,以最大程度地改善流域连通性。根据各指数评估结果,研究发现电站的位置和装机容量是决定其优先拆除顺序的关键因素,位于高阶河流且装机容量大的电站(如金阳、圆满贯等)的拆除对改善流域连通性效果最为显著。该研究全面评价了赤水河流域的连通性状况,提出了优化小水电站拆除的策略,为该流域生态修复提供了决策依据,对保护长江上游特有鱼类具有重要意义。本研究为小水电站对流域河网连通性的评估及恢复对策提供了理论基础和方法支持。

关键词：河流连通性小水电站改进的河流破碎化指数CAFI M 连通性指数赤水河流域

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带扇叶形锚固板钢筋机械锚固性能试验研究

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工程力学 2025年第1期42卷 74-82页

作者：吴琛姚鹏飞陈真锋邓芬福建理工大学福建省土木工程新技术与信息化重点实验室福州350118 锦曦控股集团有限公司福州350017

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚... 详细信息

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚固板钢筋可避开抗剪栓钉，具有施工方便的优点，同时拥有良好的锚固性能;当钢筋锚固长度为5d~7d时，发生混凝土劈裂破坏，当锚固长度为8d~12d时，发生钢筋拉断破坏，且钢筋的锚固系数大于1.25，具有良好的锚固性能;带扇叶形锚固板钢筋极限粘结强度随钢筋直径、钢筋锚固长度增大而减小，建议钢筋的锚固长度取为8d;提出了适用于带扇叶形锚固板钢筋极限粘结强度的计算公式，能较准确地反映扇叶形锚固板对混凝土产生的挤压和劈裂作用。

关键词：扇叶型锚固板中心拔出试验机械锚固性能极限粘结强度型钢混凝土节点

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Effect of the Fu Zheng Method Applied by Hong-feng chen on the Quality of Life in TNBC Patients and Empirical Research Based on Data Mining

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Digital Chinese Medicine 2018年第4期1卷 272-279页

作者： Yu-Zhu ZHANG Yue ZHOU Bai-Ling SHI Hong-feng chen Li-Juan CHE Shanghai University of Traditional Chinese Medicine Shanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective To preliminarily evaluate the efficacy of the Fu Zheng method(supporting resistance against pathogenic factors)applied by Professor Hong-feng chen in improving the quality of life in patients with triple-negative breast cancer(TNBC)to collect and organize the traditional Chinese medicine(TCM)formulas applied by Professor Hong-feng chen in the treatment of TNBC in order to explore the patterns in *** The Functional Assessment of Cancer Therapy-Breast scale(FACT-B V4.0)were collected before and after treatment;the database and data mining platform for prescribed TCM formulas were constructed using Microsoft SQL Server 2005,and the patterns in drug pairing and combination were summarized by correlation analysis of data *** The formulas improved the mean scores of the patients’physical well-being,social/family well-being,emotional well-being,physical function well-being and additional concerns(Pfeng chen were *** The TCM formulas applied by Professor Hong-feng chen can alleviate adverse physiological reactions,improve psychological conditions and improve function in *** formulas take spleen invigoration and stomach nourishment as well as blood circulation promotion and stagnation dissipation as the therapeutic principles,with simplicity in prescription and focus on care and protection the foundation of acquired constitution.

关键词： Triple-negative breast cancer Data mining Traditional Chinese medicine formulas Quality of life Hong-feng chen

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快中子诱发蛇纹石混凝土力学性能退化研究

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工程力学 2025年第1期42卷 32-43页

作者：陈凤娟高成琛金浏杜修力北京工业大学城市减灾与防灾防护教育部重点实验室北京100124

基于三维细观数值模拟方法，考虑快中子辐照(MeV>1.0)诱发的温度与骨料膨胀联合作用对混凝土力学行为及破坏形态的影响规律，该文提出了可有效预测辐照混凝土残余力学性能的二阶段数值模型计算方法，开展了蛇纹石骨料混凝土力学性能退... 详细信息

基于三维细观数值模拟方法，考虑快中子辐照(MeV>1.0)诱发的温度与骨料膨胀联合作用对混凝土力学行为及破坏形态的影响规律，该文提出了可有效预测辐照混凝土残余力学性能的二阶段数值模型计算方法，开展了蛇纹石骨料混凝土力学性能退化研究，并借助物理试验进行了模型验证。此外，基于数值模拟结果，提出了蛇纹石骨料膨胀作用下混凝土力学响应及残余力学性能的理论计算公式。该文提出的三维细观数值模型旨在为评估辐照混凝土力学响应及残余力学性能提供有效工具，为揭示辐照混凝土力学性能退化机理提供分析工具，为进行辐照混凝土基准研究提供理论依据，后期可为核反应堆混凝土防护墙延寿评估提供一定的理论指导。

关键词：快中子辐照诱导骨料膨胀力学性能三维细观数值模型蛇纹石骨料混凝土

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三七治疗骨关节炎机制:基于UHPLC-QE-MS、网络药理学及分子动力学模拟

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中国组织工程研究 2025年第8期29卷 1751-1760页

作者：陈跃平陈锋彭清林陈荟伊董盼锋广西中医药大学附属瑞康医院广西壮族自治区南宁市530011 广西中医药大学广西壮族自治区南宁市530200 哈尔滨医科大学黑龙江省哈尔滨市150086

背景:课题组前期研究发现三七能够修复骨细胞的形态结构,对于治疗骨关节炎具有良好的应用前景,但目前对于三七的具体作用机制尚不清楚。目的:采用超高效液相色谱-四极杆-静电场轨道阱串联质谱(ultra-high performance liquid chromatogr... 详细信息

背景:课题组前期研究发现三七能够修复骨细胞的形态结构,对于治疗骨关节炎具有良好的应用前景,但目前对于三七的具体作用机制尚不清楚。目的:采用超高效液相色谱-四极杆-静电场轨道阱串联质谱(ultra-high performance liquid chromatography-Q exactive-mass spectrometry,UHPLC-QE-MS)技术鉴定三七的主要成分,并结合网络药理学、分子对接和分子动力学模拟探究三七治疗骨关节炎的作用机制。方法:利用UHPLC-QE-MS技术鉴定三七的主要成分后,运用TCMSP数据库筛选活性成分,通过TCMSP和Uniprot数据库查找活性成分靶点,通过疾病数据库筛选骨关节炎靶点。在药物靶点与疾病靶点取交集后,导入STRING数据库和Cytoscape软件构建蛋白互作网络筛选关键靶点,通过“活性成分-作用靶点”网络筛选关键活性成分。再对关键靶点进行富集分析,并对关键活性成分和关键靶点进行分子对接验证,最后选取结合能最低的结果进行分子动力学模拟。结果与结论:①在三七溶液中共鉴定出57种活性成分,成分靶点与疾病靶点交集50个,关键活性成分5个(槲皮素、熊脱氧胆酸、山奈酚、柚皮素和红藻氨酸),关键靶点5个(白细胞介素6、基质金属蛋白酶9、白细胞介素1β、白蛋白和趋化因子配体2);②基因本体功能富集642个条目,其中620个条目代表生物过程,21个条目代表分子功能,1个条目代表细胞成分;京都基因与基因组百科全书通路分析63条通路,主要涉及雌激素信号通路、白细胞介素17信号通路和高糖基化终末产物-高糖基化终末产物受体信号通路;③分子对接显示关键活性成分和关键靶点结合活性良好,分子动力学模拟提示槲皮素和基质金属蛋白酶9间的相互作用稳定;④对三七成分进行了较全面研究,初步阐明了其药效物质基础,预测三七可通过多组分、多靶点、多途径和多通路发挥抗炎、软骨保护和免疫调节作用来治疗骨关节炎。

关键词：三七骨关节炎分子动力学模拟质谱分子对接网络药理学

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深挖路基边坡静态爆破布孔参数研究

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价值工程 2025年第1期44卷 78-81页

作者：陈丙锋中国铁建港航局集团有限公司珠海519070

为了提高深挖路基边坡静态爆破效率,基于LS-DYNA数值模拟软件,对深挖路基边坡进行静态爆破数值模拟,从孔间距、临空面距离、孔深、倾角等方面分析布孔参数对静态爆破裂纹扩展的影响;以模拟结果为参考,进行现场静态劈裂施工,获得了良好... 详细信息

为了提高深挖路基边坡静态爆破效率,基于LS-DYNA数值模拟软件,对深挖路基边坡进行静态爆破数值模拟,从孔间距、临空面距离、孔深、倾角等方面分析布孔参数对静态爆破裂纹扩展的影响;以模拟结果为参考,进行现场静态劈裂施工,获得了良好的破岩效果。结果表明:随孔间距、临空面距离的减小,岩石裂纹发育更加充分,且临空面距离对裂纹扩展影响相较于孔间距对裂纹扩展的影响更为明显;随着孔深的增加,静态爆破对岩石的致裂效果减弱;钻孔倾角对边坡致裂、损伤影响较小;边坡裂隙对静态爆破两孔连线裂纹扩展起导向作用;此类模拟方法与现场施工吻合度很高,具有较广泛的适用性和经济性,为静态爆破现场工程提供了良好的科学指导。

关键词：公路路基 LS-DYNA 数值计算现场施工边坡

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Efficient Leave-One-Out Strategy for Supervised Feature Selection

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Tsinghua Science and Technology 2013年第6期18卷 629-635页

作者： Dingcheng feng feng chen Wenli Xu National Laboratory for Information Science and Technology Tsinghua University

Feature selection is a key task in statistical pattern recognition. Most feature selection algorithms have been proposed based on specific objective functions which are usually intuitively reasonable but can sometimes be far from the more basic objectives of the feature selection. This paper describes how to select features such that the basic objectives, e.g., classification or clustering accuracies, can be optimized in a more direct way. The analysis requires that the contribution of each feature to the evaluation metrics can be quantitatively described by some score function. Motivated by the conditional independence structure in probabilistic distributions, the analysis uses a leave-one-out feature selection algorithm which provides an approximate solution. The leave-one- out algorithm improves the conventional greedy backward elimination algorithm by preserving more interactions among features in the selection process, so that the various feature selection objectives can be optimized in a unified way. Experiments on six real-world datasets with different feature evaluation metrics have shown that this algorithm outperforms popular feature selection algorithms in most situations.

关键词： leave-one-out feature selection objectives evaluation metrics

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Ni_(x)Co_(1-x)S as an effective noble metal-free cocatalyst for enhanced photocatalytic activity of g-C_(3)N_(4)

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Journal of Materials Science & Technology 2020年第21期56卷 227-235页

作者： Yuting Gao feng chen Zhe chen Hongfei Shi School of Material Science and Technology Jilin Institute of Chemical TechnologyJilin132022China Jinlin Petrochemical Company Organic Synthetic Plants Jinlin132021China

Solar photocatalysis,as a method of green energy production and sustainable technology,has been regarded as one of the most effective strategies to resolve environmental issues and the current energy *** this work,intimate contact hollow Ni_(x)Co_(1-x)S polyhedron/g-C3N4 nanosheet composites were prepared in-situ through a facile one-step hydrothermal *** as-prepared Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composites showed superior photocatalytic activity and high stability for H2 generation and methyl orange(MO)degradation under visible light *** optimized 4 wt.%Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite attained a maximum H2 evolution rate of 1420μmol g^–1 h^–1,which was about 157 times higher than that of pure *** addition,the Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite also exhibited greatly improved photocatalytic activity for dye degradation,which for MO was at 98.14%in 9 *** outstanding photocatalytic performance was predominantly attributed to the unique architecture of hollow Ni_(x)Co_(1-x)S polyhedrons,which not only provided more active sites at the edges and surface as convenient charge transfer channels,but also promoted the separation and transport of electron-hole *** work provides some novel ideas for the design and development of highly efficient noble metal-free cocatalyst/semiconductor systems for photocatalytic H2 generation and dye degradation.

关键词： Non-noble metal cocatalyst Ni_(x)Co_(1-x)S g-C_(3)N_(4) Photocatalytic hydrogen production Dye degradation

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