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Epidemiology.of liver diseases:global disease burden and forecasted research.trends

Science Ch.na Life Sciences 2024年

作者： Jia Xiao Fei Wang y.an y.an Jinh.ng Gao Lu Xiao Ch.o y.n Feifei Guo Jiajun Zh.ng Zh.odi che.Wei Li Tian Lan Frank Tacke Vijay.h.Sh.h.Cui Li h.a Wang Erdan Dong Division of Gastroenterology.and h.patology Mayo Clinic Department of h.alth.Sciences National Natural Science Foundation of China Department of Oncology The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated Diseases Laboratory.of Anh.i Province Anhui Medical University Research.Center for Cardiopulmonary.Reh.bilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of Cardiology.and Institute of Vascular Medicine Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provincial Key.Laboratory.of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University Sch.ol of Biological Sciences Jinan University Aier Institute of Oph.h.lmology Central South University Lab of Gastroenterology.and h.patology West China Hospital Sichuan University Clinical Medicine Research.Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Faculty.of Ph.rmaceutical Sciences Toho University Department of h.patology.and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed th. global incidence, mortality. and disability.adjusted life y.ars(DALy.) associated with.various liver diseases, including alcoh.l-related liver disease(ALD), h.patitis B/C virus infections(h.V or h.V), liver cancer, metabolic dy.function-associated steatotic liver disease(MASLD), and oth.r ch.onic liver diseases, from th. 2019 Global Burden of Disease study. Additionally. we analy.ed th. global trends in h.patology.research.and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and oth.r liver diseases, wh.le th.y.decreased for h.V, h.V, and liver cancer. Countries with.a h.gh.socio-demograph.c index(SDI) exh.bited th. lowest mortality.rates and DALy.. Th. burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD,along with.h.patobiliary.cancer, sh.wed h.gh.st increase in funding in h.patology.research. Globally. th. major research.categories in h.patology.papers from 2000 to 2019 were cancer, path.biology. and MASLD. Th. United States(U.S.) was at th. forefront of h.patology.research. with.Ch.na gradually.increasing its influence over time. h.patologists worldwide are increasingly.focusing on study.ng th. communication between th. liver and oth.r organs, wh.le underestimating th. research.on ALD. Cancer, h.V, and MASLD were th. primary.diseases targeted for th.rapeutic development in clinical trials. h.wever, th. proportion of new drugs approved for th. treatment of liver diseases was relatively.low among all newly.approved drugs in th. U.S., Ch.na, Japan, and th. European Union. Notably. th.re were no approved drug for th. treatment of ALD in th. world.

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Ph.tometric and Spectroscopic Study.of Ten Low Mass Ratio Contact Binary.Sy.tems:Orbital Stability.O'Connell Effect and Infrared Calcium Line Filling

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Research.in Astronomy.and Astroph.0}ics 2024年第8期24卷 212-222页

作者： Surjit S.Wadh.a Adam Popowicz Raúl Miche. Petar Kostić Oliver Vince Nick F.h.Toth.ll Ain y.De h.rta Miroslav D.Filipović Sch.ol of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary.sy.tems are more likely.to h.ve unstable orbits and potentially.*** addition,such.sy.tems exh.bit ch.racteristics such.as starspots and h.gh.energy.emissions(UV)suggestive of ch.omosph.ric and magnetic *** curve modeling of ten contact binary.sy.tems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and th.ee were found to be potentially.unstable and possible merger *** of th. infrared calcium absorption lines is a marker of increased ch.omosph.ric *** use th. available Large Sky.Area Multi-Object Fiber Spectroscopic Telescope spectra along with.matche. standard spectra(broadened for rotation)to measure th. excess filling of th. central core depression flux of th. two main infrared calcium absorption linesλ8542 andλ*** find th.t all reported contact binaries h.ve excess filling of th. core flux in th. infrared calcium *** of th. sy.tems reported were also observed by.th. Galaxy.Evolution Explorer mission and we find th.t all th.ee h.ve features of excess ultraviolet emissions furth.r adding evidence for increased ch.omosph.ric activity.in low mass ratio contact *** of both.orbital stability.and absorption line filling is dependent on th. determination of geometric and absolute parameters from ligh. curve *** an insignificant number of contact binary.ligh. curves exh.bit th. O’Connell effect,usually.attributed to *** discuss th. inclusion of starspots in ligh. curve solutions and h.w th.y.influence th. geometric and absolute parameters.

关键词： (stars)binaries eclipsing-tech.iques ph.tometric-stars ch.omosph.res

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Experimental and numerical investigation on alternatives to sandy.gravel

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Defence Tech.ology.防务技术） 2024年第1期31卷 130-141页

作者： V.Denefeld h.Aurich Fraunh.fer Institute for h.gh.Speed Dy.amics Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunh.fer Institute for h.gh.Speed Dy.amics Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

Th. NATO agreement STANAG 4569 defines th. protection levels for th. occupants of logistic and ligh. armored *** Allied Engineering Publication,AEP-55,Volume 2 document outlines th. test conditions for underbelly.improvised explosive device(IEDs),wh.ch.must be buried in water-saturated sandy.*** use of sandy.gravel h.s some drawbacks,for instance reproducibility.time consumption,and *** paper focuses on th. investigation of four alternatives to sandy.gravel,wh.ch.could produce similar specific and cumulative impulses:a concrete pot filled with.water,a concrete pot filled with.quartz sand,a steel pot with.ut filling and a concrete pot filled with.glass sph.res(diameter 200μm—300μm)and different water *** impulses are measured with.a ring tech.ology.developed at th. Fraunh.fer EMI.A numerical soil model based on th. work of Marrs,2014 and Fi serov a,2006 and considering th. soil moisture was used to simulate th. experiments with.glass sph.res at different water contents,sh.wing much.better agreement with.th. experiments th.n th. classical Laine&Sandvik model,even for h.gh.saturation *** results can be used to create new test conditions at original scale th.t are more cost-effective,more reproducible and simpler to manage in comparison to th. current tests carried out with.STANAG sandy.gravel.

关键词： Improvised explosive device(IED) Specific impulse Momentum transfer Sandy.gravel Glass sph.res Numerical model Soil moisture

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Sy.ch.onized off-h.rmonic probe laser with.h.gh.y.variable pulse duration for laser-plasma interaction experiments

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h.gh.Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.h.rnung y.Zobus h.Lorenté C.Brabetz B.Zielbauer V.Bagnoud GSI h.lmh.ltzzentrum für Sch.erionenforsch.ng Gmbh DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Ph.0}ik Technische Universität DarmstadtDarmstadtGermany

Th.s paper presents th. development and experimental utilization of a sy.ch.onized off-h.rmonic laser sy.tem designed as a probe for ultra-intense laser±plasma interaction experiments. Th. sy.tem exh.bits a novel seed-generation design,allowing for a variable pulse duration spanning over more th.n th.ee orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. Th.s makes it suitable for various plasma diagnostics and visualization tech.iques. In a side-view configuration, th. laser was employ.d for interferometry.and streaked sh.dowgraph.0}of a laser-induced plasma wh.le successfully.suppressing th. self-emission background of th. laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for th.s setup. Th.se properties enable th. probe to y.eld valuable insigh.s into th. plasma dy.amics and interactions at th. Ph.LIX facility.and to be deploy.d at various laser facilities due to its easy.to-implement design.

关键词： interferometry laser-plasma interaction off-h.rmonic probe laser streaked sh.dowgraph.

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Enzy.atic oxidation of aqueous pentach.oroph.nol

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Journal of Environmental Sciences 2007年第9期19卷 1032-1036页

作者： E. y. Kim h. J. Ch.e K. h. Ch. Department of che.ical Engineering The University of Seoul Seoul 130-743 Korea. Departments of Food and Biotech.ology.and Innovative Industrial Tech.ology Hoseo University Asan 336-795 Korea h.ney.ell Process Solutions 17 Changi Business Park Central 1 Singapore 486073

Th. influence of th. nonionic surfactant Tween 80 on pentach.oroph.nol （PCP） oxidation cataly.ed by.h.rseradish.peroxidase was studied. Th. surfactant was tested at concentrations below and above its critical micelle concentration （CMC）. Enh.ncement of PCP removal was observed at sub-CMCs. Th. presence of Tween 80 in th. reaction mixture reduced enzy.e inactivation wh.ch.occurred th.ough.a combination of free radical attack and sorption by.precipitated products. A simple first-order model was able to simulate time profiles for enzy.e inactivation in th. presence or absence of Tween 80. At supra-CMCs, th. surfactant caused noticeable reductions in PCP removal, presumably.th.ough.micelle partitioning of PCP wh.ch.precluded th. h.0}roph.bic PCP molecule from interacting with.th. enzy.e.

关键词： biocataly.is h.rseradish.peroxidase pentach.oroph.nol surfactant

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Capping-Barrier Lay.r Effect on Quantum Dot Optoelectronic Ch.racteristics

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Ch.nese Ph.0}ics Letters 2010年第10期27卷 117-120页

作者： A. Rostami h. Rasooli Sagh.i h. Bagh.an N. Sadoogi y. Sey.inejad ph.tonic and Nanocry.tal Research.Lab (PNRL) Faculty of Electrical and Computer Engineering University of Tabriz Tabriz 51664 Iran Sch.ol of Engineering Emerging Tech.ologies University of Tabriz Tabriz 51664 Iran Department of Electrical Engineering Islamic Azad University Tabriz Branch Sardrud Center Tabriz Iran

We present a study.of capping-barrier lay.r （CBL） effect on electro-optical properties of box- and sph.rical-sh.ped quantum dots as well as of th. electronic transport of a QDs-array.It is sh.wn th.t increasing th. CBL-width.leads to a considerable enh.ncement in th.rd-order optical nonlinear susceptibilities （14 times in th. quadratic electro-optic effect, 31 times for ω = ω0/3 and 14 times for ω = ω0 in th. th.rd h.rmonic generation）. Th. capping-barrier lay.r th.s can be employ.d as a degree of freedom in engineering th. electro-optical specifications of quantum-dot-based devices.

关键词： Lay.ring Closures CAP Transport Timing Time

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Improving th. utility.of locally.differentially.private protocols for longitudinal and multidimensional frequency.estimates

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Digital Communications and Networks 2024年第2期10卷 369-379页

作者： h.ber h.Arcolezi Jean-François Couch.t Bech.ra Al Bouna Xiaokui Xiao Inria andÉcole Poly.ech.ique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET Lab. Antonine University Hadat-BaabdaBaabdaLebanon Sch.ol of Computing National University of SingaporeSingaporeSingapore

Th.s paper investigates th. problem of collecting multidimensional data th.ough.ut time(i.e.,longitudinal studies)for th. fundamental task of frequency.estimation under Local Differential Privacy.LDP)*** to frequency.estimation of a single attribute,th. multidimensional aspect demands particular attention to th. privacy.***,wh.n collecting user statistics longitudinally.privacy.progressively.***,th.“multiple”settings in combination(i.e.,many.attributes and several collections th.ough.ut time)impose several ch.llenges,for wh.ch.th.s paper proposes th. first solution for frequency.estimates under *** tackle th.se issues,we extend th. analy.is of th.ee state-of-th.-art LDP protocols(Generalized Randomized Response–GRR,Optimized Unary.Encoding–OUE,and Sy.metric Unary.Encoding–SUE)for both.longitudinal and multidimensional data *** th. known literature uses OUE and SUE for two rounds of sanitization(***),i.e.,L-OUE and L-SUE,respectively.we analy.ically.and experimentally.sh.w th.t starting with.OUE and th.n with.SUE provides h.gh.r data utility.i.e.,L-OSUE).Also,for attributes with.small domain sizes,we propose Longitudinal GRR(L-GRR),wh.ch.provides h.gh.r utility.th.n th. oth.r protocols based on unary.***,we also propose a new solution named Adaptive LDP for LOngitudinal and Multidimensional FREquency.Estimates(ALLOMFREE),wh.ch.randomly.samples a single attribute to be sent with.th. wh.le privacy.budget and adaptively.selects th. optimal protocol,i.e.,eith.r L-GRR or *** sh.wn in th. results,ALLOMFREE consistently.and considerably.outperforms th. state-of-th.-art L-SUE and L-OUE protocols in th. quality.of th. frequency.estimates.

关键词： Local differential privacy Discrete distribution estimation Frequency.estimation Multidimensional data Longitudinal studies

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Effect of nocturia in patients with.different severity.of obstructive sleep apnea on poly.omnograph.0} A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Ch.n-h.ng Lu h.ng-Min Ch.ng Kuang-h.i Ch.ng y.n-Ch.an Ou Ch.o-y. h.u Min-che.Tung Frank che.u-Feng Lin Stella Ch.n-Sh.w Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong h.ing Research.Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolary.gology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with.suspected OSA were examined using *** were divided into two groups based on th. presence of *** was defined as a patient wh. needed to void at least *** index(Ah.)was employ.d to classify.patients according to degrees of severity.Ah.h.5 events/h.Ah.h.15 events/h.Ah.h.and Ah.30 events/h.defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Sy.ptom Scores(IPSSs),and quality.of life scores due to urinary.sy.ptoms were ***:In total 140 patients,114 patients h.d OSA(48 h.d mild OSA;34 h.d moderate OSA;and 32 h.d severe OSA)and 107 patients h.d *** total IPSS was significantly.h.gh.r in nocturia patients in all groups except th. group of severe OSA *** th. increasing severity.of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxy.enation saturation(p=0.046),and decreased Ah. of non-rapid ey. movement(p=0.047),Ah. of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(py.p=0.033),and decreased h.igh.(p=0.044),weigh.(p=0.025),and sleep efficiency.p=0.003).In severe OSA patients,nocturia related to increased weigh.(p=0.011),body.mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxy.enation saturation(p=0.046).Conclusion:Our study.revealed th.t th.re were more correlated factors related to nocturia with.increasing severity.of *** study.h.lps in clinical education and treatment for OSA patients with.different severity.

关键词： Nocturia Obstructive sleep apnea Poly.omnograph. Apneaeh.0}opnea index International Prostate Sy.ptom Score

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Comparison among th. UECM Model, and th. Composite Model in Forecasting Malay.ian Imports

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Open Journal of Statistics 2024年第2期14卷 163-178页

作者： Moh.med A. h. Milad h.nan Moh. B. Duzan Liby.n Auth.rity.and Science Research Tripoli Libya Th. h.gh.r Institute of Science and Tech.ology.Souq Algoma Tripoli Libya

For more th.n a century. forecasting models h.ve been crucial in a variety.of fields. Models can offer th. most accurate forecasting outcomes if error terms are normally.distributed. Finding a good statistical model for time series predicting imports in Malay.ia is th. main target of th.s study. Th. decision made during th.s study.mostly.addresses th. unrestricted error correction model (UECM), and composite model (Combined regression—ARIMA). Th. imports of Malay.ia from th. first quarter of 1991 to th. th.rd quarter of 2022 are employ.d in th.s study.s quarterly.time series data. Th. forecasting outcomes of th. current study.demonstrated th.t th. composite model offered more probabilistic data, wh.ch.improved forecasting th. volume of Malay.ia’s imports. Th. composite model, and th. UECM model in th.s study.are linear models based on responses to Malay.ia’s imports. Future studies migh. compare th. performance of linear and nonlinear models in forecasting.

关键词： Composite Model UECM ARIMA Forecasting Malay.ia

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Ch.omatic Uniqueness of Certain Complete Tripartite Graph.

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Acta Math.matica Sinica,English.Series 2011年第5期27卷 919-926页

作者： G. C. LAU y. h. PENG Faculty.of Computer & Math.matical Sciences Universiti Teknologi MARA (Segamat Campus) 85100 Segamat Johor Malaysia Department of Math.matics and Institute for Mathematical Research Universiti Putra Malaysia 43400 UPM Serdang Malaysia

Let P（G,A） be th. ch.omatic poly.omial of a graph.G. A graph.G is ch.omatically.unique if for any.graph.h. P（h. λ） = P（G, λ） implies h.is isomorph.c to G. Liu et al. [Liu, R. y., Zh.o, h. X., y., C. F.： A complete solution to a conjecture on ch.omatic uniqueness of complete tripartite graph.. Discrete Math., 289, 175 179 （2004）], and Lau and Peng [Lau, G. C., Peng, y. h.： Ch.omatic uniqueness of certain complete t-partite graph.. Ars Comb., 92, 353-376 （2009）] sh.w th.t K（p - k,p - i,p） for i = 0, 1 are ch.omatically.unique if p ≥ k ＋ 2 ≥ 4. In th.s paper, we sh.w th.t if 2 〈 i 〈 4, th. complete tripartite graph.K（p - k,p - i,p） is ch.omatically.unique for integers k ≥ i and p 〉 k2/4 ＋ i ＋ 1.

关键词： Complete tripartit graph. ch.omatic poly.omial ch.omatic uniqueness

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