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手写笔记有益学习

环球科学 2024年第9期 18-18页

作者：夏洛特·胡张宇哲(译) 不详

随着数字科技几乎渗透到学习的方方面面,手写笔记似乎显得有些过时。不过,不断涌现的多项研究却表明,用纸笔,甚至是平板电脑和触控笔来记笔记,仍然是最好的学习方式。对于学龄期的幼儿,这种优势尤为明显。如今,科学家正在探寻这种现象... 详细信息

随着数字科技几乎渗透到学习的方方面面,手写笔记似乎显得有些过时。不过,不断涌现的多项研究却表明,用纸笔,甚至是平板电脑和触控笔来记笔记,仍然是最好的学习方式。对于学龄期的幼儿,这种优势尤为明显。如今,科学家正在探寻这种现象背后的原因。

关键词：平板电脑记笔记学龄期手写学习

Epidemiology and genetics of ventricular fibrillation during acute myocardial infarction

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Journal of Geriatric Cardiology 2016年第9期13卷 789-797页

作者： charlotte Glinge Stefan Sattler Reza Jabbari Jacob Tfelt-Hansen Department of Cardiology Heart Centre Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

从室的纤维性颤动(VF ) 的突然的心脏的死亡(SCD ) 在冠的动脉疾病(CAD ) 期间是全部、心血管的死亡的一个领先的原因，并且在里面多于 SCD 盒子的一半， VF 作为 CAD 的第一症状发生。几流行病学的研究证明了一个家庭成员的突然的死亡... 详细信息

从室的纤维性颤动(VF ) 的突然的心脏的死亡(SCD ) 在冠的动脉疾病(CAD ) 期间是全部、心血管的死亡的一个领先的原因，并且在里面多于 SCD 盒子的一半， VF 作为 CAD 的第一症状发生。几流行病学的研究证明了一个家庭成员的突然的死亡在尖锐心肌的梗塞(MI ) 期间是为 SCD 和 VF 的一个风险因素，独立于包括 MI 的家庭历史的传统的风险因素，在危险性建议一个基因部件到 VF。由于 MI 阻止 SCD 和 VF，我们需要在这张显然健康的人口引起 VF 的基因、分子的机制的更好的理解。尽管新卓见和技术变得可得到，到 VF 的基因倾向在 MI 期间仍然保持糟糕理解。，从许多不同基因研究的调查结果没能到达重制度几基因变体，普通、稀罕的变体，被联系了到 VF 或 SCD。为这评论，我们在 PubMed 找了潜在地相关的文章，用下列网孔术语：突然的心脏的死亡，室的纤维性颤动， out-of-hospital 心脏的拘捕，心肌的梗塞，心肌的局部缺血，冠的动脉疾病，和遗传。这评论由于 MI 为基因危险性描述传染病学和证据到 VF。

关键词：家庭历史遗传心肌的梗塞突然的心脏的死亡室的纤维性颤动

医务人员呼吸防护用品适合性检验和密合性检查有效性的系统综述

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International Journal of Nursing Sciences 2023年第4期10卷 568-578页

作者： charlotte Goko Elizabeth Forster Matthew Mason Peta-Anne Zimmerman School of Nursing&Midwifery Griffith UniversityAustralia Menzies Health Institute Queensland Griffith UniversityAustralia Collaborative for the Advancement of Infection Prevention and Control Australia University of the Sunshine Coast QueenslandAustralia Infection Control Department Gold Coast Hospital and Health ServicesAustralia

目的呼吸防护在医疗卫生工作中至关重要,应使用适当的颗粒过滤呼吸器和等效的呼吸防护用品,以确保良好的佩戴气密性,最大限度地降低医务人员的空气传播感染风险。该文旨在对呼吸防护用品适合性检验和密合性检查有效性研究进行综述和分... 详细信息

目的呼吸防护在医疗卫生工作中至关重要,应使用适当的颗粒过滤呼吸器和等效的呼吸防护用品,以确保良好的佩戴气密性,最大限度地降低医务人员的空气传播感染风险。该文旨在对呼吸防护用品适合性检验和密合性检查有效性研究进行综述和分析。方法系统检索了2003年1月至2022年4月发表的文献,检索范围包括CINAHL、Cochrane图书馆、EMBASE、PubMed、Ovid数据库Medline子库和灰色文献。研究方案已在PROSPERO注册(CRD42020213968)。结果共检索出561篇文献,25篇被纳入该综述,包括22项量性研究和3篇指南文献。在评估呼吸防护用品的有效性方面,适合性检验是更有效且被广泛采用的可靠方法,但呼吸防护程序应该同时包括适合性检验和密合性检查,以最大限度地提高呼吸防护用品的有效性。新型冠状病毒疫情凸显了医务人员相关知识的缺乏,相关教育培训可有效提高呼吸防护用品使用的有效性。结论为确保医务工作者的安全,适合性测试和密合性检查均应采用。建议由专业人员实施全面的呼吸防护项目,包括教育培训、适合性测试和密合性检查,还需要探索适用于实际使用环境的适合性检验方法。

关键词：适合性检验密合性检查医护人员呼吸防护用品个人防护装备佩戴气密性检查

Control systems and data management for high-power laser facilities

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High Power Laser Science and Engineering 2023年第5期11卷 51-75页

作者： Scott Feister Kevin Cassou Stephen Dann Andreas Döpp Philippe Gauron Anthony J.Gonsalves Archis Joglekar Victoria Marshall Olivier Neveu Hans-Peter Schlenvoigt Matthew J.V.Streeter charlotte A.J.Palmer California State University Channel Islands CamarilloCaliforniaUSA UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Ludwig–Maximilians–Universität München GarchingGermany BELLA Center Lawrence Berkeley National LaboratoryBerkeleyCaliforniaUSA Department of Nuclear Engineering and Radiological Sciences University of MichiganAnn ArborMichiganUSA Ergodic LLC San FranciscoCaliforniaUSA Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Queen’s University Belfast BelfastUK

The next generation of high-power lasers enables repetition of experiments at orders of magnitude higher frequency than what was possible using the prior *** requiring human intervention between laser repetitions need to adapt in order to keep pace with the new laser technology.A distributed networked control system can enable laboratory-wide automation and feedback control *** higher-repetition-rate experiments will create enormous quantities of data.A consistent approach to managing data can increase data accessibility,reduce repetitive data-software development and mitigate poorly organized *** opportunity arises to share knowledge of improvements to control and data infrastructure currently being *** compare platforms and approaches to state-of-the-art control systems and data management at high-power laser facilities,and we illustrate these topics with case studies from our community.

关键词： big data community organization control systems data management feedback loops high-power lasers high repetition rate metadata stabilization standards

Plasma metabolomic profiles and immune responses of piglets after weaning and challenge with ***

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Journal of Animal Science and Biotechnology 2014年第3期5卷 291-298页

作者： Sugiharto Sugiharto Mette S Hedemann charlotte Lauridsen Department of Animal Science Faculty of Science and TechnologyAarhus University Faculty of Animal Science and Agriculture Diponegoro UniversitySemarang Central Java 50275Indonesia

Background： The processes of weaning and exposure to pathogenic bacteria induce stress responses, which may alter the metabolism. In this study, we investigated the changes in plasma metabolites and immune responses in piglets in response to the stress induced by weaning and Escherichia coli challenge. Results： Fecal dry matter decreased （P = 0.003） and nearly half （44.4%） the piglets developed diarrhea on day 2 and 3 postweaning. The concentration of plasma immunoglobulin A was higher （P 〈 0.001） on day 11 postweaning than on day 0 or 4 postweaning. The levels of white blood cells increased continuously （P〈 0.001） from day 0 to day 11 postweaning. Differences in the percentages of neutrophils （P = 0.029） and lymphocytes （P = 0.022） were seen, but the neutrophil/lymphocyte ratio did not differ in the period after weaning. A clear separation of the metabolomic profile data for day 0 and day 4 postweaning was observed with a principal components analysis （PCA） scores plot, and the data for day 11 were located between those for day 0 and day 4 postweaning. The plasma levels of proline, taurine, and carnitine were higher, whereas those of betaine, creatine, L-arginine and acetylcarnitine were lower on day 4 postweaning than on day 0. Levels of lysophosphatidylcholine and phosphatidylcholine were either higher or lower after weaning, depending on the chain lengths or characters of these metabolites. Conclusions： Our results show a clear separation in the plasma metabolomic profiles of piglets that corresponded to the fecal responses to stress on the piglets induced by weaning or exposure to a pathogen （E. coli）. These plasma metabolite profiles suggest that the challenges induced proinflammatory responses in the piglets, resulting in postweaning diarrhea, which was associated with higher concentrations of IgA in the plasma.

关键词： E. coil F18 Immunity Metabolite Piglet Weaning

Distal femur complex fractures in elderly patients treated with megaprosthesis:Results in a case series of 11 patients

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World Journal of Orthopedics 2022年第5期13卷 454-464页

作者： Fabio Zanchini Antonio Piscopo Valerio Cipolloni Federico Fusini Stefano Cacciapuoti Davide Piscopo charlotte Pripp Luigi Aurelio Nasto Enrico Pola Orthopaedics and Traumatology Division Multidisciplinary Department of Medical-Surgical and Dental SpecialtiesUniversity of Campania"Luigi Vanvitelli"School of MedicineNaples 80138Italy Department of Orthopedics and Traumatology Sacro Cuore di GesùFatebenefratelli HospitalBenevento 82100Italy Spine Division Department of Orthopaedics and TraumatologyA.Gemelli IRCCS University HospitalCatholic University of RomeRome 00168Italy Department of Orthopaedic and Traumatology Regina Montis Regalis HospitalMondovì12084Italy Service de Geriatrie et réaaptation HUG H?pital de Bellerive ChemGenève 1205Switzerland

BACKGROUND Surgical treatment of complex fractures of the distal femur in the elderly is *** and pre-existent osteoarthritis are common comorbidities in the elderly which add to the need for early walking and rapid restoration of function and also pose significant obstacles to achievement of satisfactory results with standard fixation ***,several authors have suggested that primary arthroplasty could be a viable alternative option to standard fixation techniques in selected patients with complex distal femur *** To present our experience with 11 cases of distal femur fractures treated with knee arthroplasty and large femoral resection in a population of patients over the age of *** Data from 11 consecutive patients(10 females,1 male)presenting with acute intra-articular supracondylar or intercondylar distal femur fractures and with pre-existent primary osteoarthritis who were treated with primary knee arthroplasty were *** collected standard demographic data,comorbidities and patient reported outcomes including Visual Analogical Scale(VAS),Oxford Knee Score(OKS)and Barthel’s ***-operative joint range of motion(ROM)and standard radiographic data were also *** At a mean follow-up of 23.2 mo,all of the implants were well-positioned and ***,all the patients were alive and walking either independently or with walking *** was a marked improvement in pain(VAS 4.5 postop vs 1.9 at the last follow-up),OKS score(29.5 postop vs 36.81 at the last follow-up),ROM(96.2°postop vs 102°at the last follow-up)and restoration of pre-injury ambulatory status(average Barthel Index 77.3).The radiographic evaluations showed good restoration of the articular *** deaths and no complications were *** In conclusion,we believe that knee megaprosthesis in the case of complex fractures of the distal femur is a valid surgical *** is particularly true in

关键词： Knee Joint replacement Megaprosthesis Elderly Distal femur fracture

Styles and Extent of Volcanism Within the Afar Continental Rift(Ethiopia) and Implications for the Environmental Impact of Large Volcanic Eruptions

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地学前缘 2009年第S1期16卷 61-62页

作者： charlotte Vye Kay Smith British Geological Survey

The Afar region in Ethiopia forms part of the East African Rift and represents the only volcanically and seismically active continental spreading centre on *** unique natural laboratory is the subject of investigation to understand the magmatism and geodynamics during the transition from continental rifting to the generation of new ocean *** the BGS we have applied an integrated

关键词： continental rifting flood basalts Afar

Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence

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Asian Journal of Andrology 2021年第5期23卷 441-449页

作者： Sinda Mahbouli charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy FabLife 104 Avenue Albert lerRueil-Malmaison 92500France Sorbonne University Saint Antoine Research CentreINSERM Genetic and Acquired Lipodystrophies TeamReproductive Biology and CECOSAP-HPTenon HospitalParis F-75020France Reproductive Biology and CECOS AP-HPTenon HospitalParis F-75020France

Infertility affects about 15%of the world's *** 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains *** clinical data show that lifestyle interventions may contribute to male reproductive *** of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male *** analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male *** these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane *** studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been *** review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.

关键词： energy metabolism genetic polymorphisms idiopathic male infertility lifestyle factors nutrition oxidative stress semen quality

The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance

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Cancer Drug Resistance 2020年第1期3卷 38-47页

作者： charlotte Hill Yihua Wang School of Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

Epithelial-mesenchymal transition(EMT)and autophagy are both known to play important roles in the development of ***,these processes are now being utilised as targets for *** is globally one of the leading causes of death,and,despite many advances in treatment options,patients still face many *** resistance in cancer-therapy is a large problem,and both EMT and autophagy have been shown to ***,given the context-dependent role of these processes and the complexity of the interactions between them,elucidating how they both act alone and interact is *** this review,we provide insight into the current landscape of the interactions of autophagy and EMT in the context of malignancy,and how this ultimately may affect drug resistance in cancer therapy.

关键词： Epithelial-mesenchymal transition autophagy cancer drug resistance metastasis therapy