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On Laminar Flow in Microfabricated Channels with Partial Semi-Circular Profiles

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Open Journal of Applied Sciences 2012年第1期2卷 28-34页

作者： William J. federspiel Isabella Valenti Medical Devices Laboratory McGowan Institute for Regenerative Medicine University of Pittsburgh Medical Devices Laboratory McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh USA

Soft and hard micromachining techniques used to develop microfluidic devices can yield microchannels of many different cross-sectional profiles. For semi-circular microchannels, these techniques often produce only partialsemicircular (PSC) cross-sections. This study investigated fully developed laminar flow in PSC microchannels as a function of a circularity index, κ, defined as the ratio of the radiuses along the curved and flat surfaces of the PSC profile. A correction factor, K, to the Hagen-Poiseuille relation was determined and was well-fitted by the power-law relationship K=5.299/κ2.56. Actual correction factors were compared to estimates based on several hydraulic models for flow in microchannels of arbitrary cross-section, as well as the half-ellipsoid cross-section. The level of wall shear stress, when normalized by the pressure drop per unit length, increased approximately linearly with increase in the circularity index, κ.

关键词： Hagen-Poiseuille Flow Poiseuille Flow Flow Resistance Wall Shear Stress

Risk of pre-stroke antiplatelet therapy

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中华物理医学与康复杂志 2016年第3期38卷 169-169页

作者： Xian Y federspiel JJ Grau-Sepulveda M

BACKGROUND AND OBJECTIVE Intravenous tissue plasminogen activator (tPA) is known to improve outcomes after ischemic stroke. Many patients receive antiplatelet therapy before ischemic stroke, with the concern that those individuals might face an increased risk of bleeding when treated with tPA. This study assessed the risks and benefits associated with pre-stroke antiplatelet therapy among patients with ischemic stroke who received intravenous *** Data were obtained from 85, 072 adult patients with ischemic stroke who received intravenous tPA. Of these, 38, 844 had been receiving antiplatelet therapy before hospital admission. The participants were followed for outcomes including symptomatic intracranial hemorrhage (sICH), in-hospital mortality, discharge ambulatory status and modified Rankin scale score (mRS).RESULTS After risk adjustment, the prior use of antiplatelet agents was found to be associated with a higher onset of sICH (OR 1.18), with a small, absolute increased risk of 0.68%. Prior antiplatelet therapy was not associated with a significantly greater risk of in-hospital mortality. Those receiving antiplatelet therapy had higher ratios of being discharged to home, of independent ambulation and of better mRS scores at *** This study of patients with acute ischemic stroke who received tPA found that those receiving pre-stroke antiplatelet therapy were at increased risk of symptomatic intracranial hemorrhage, but also had better functional outcomes than those who had not received antiplatelet therapy.

关键词：血小板静脉组织缺血性康复医学

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"即连即铸"的奥钢联连铸技术

钢铁 2004年第Z1期39卷 593-600页

作者： H. Wahl K. Herzog C. federspiel P. Juza

　　1前言　　生产率和作业率方面的收益以及可能性调整的灵活性是提高钢铁工业竞争力的关键因素.……

关键词：即连即铸奥钢联关键因素钢铁工业作业率生产率灵活性竞争力收益

Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer

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Open Journal of Applied Sciences 2012年第3期2卷 135-138页

作者： James D. Fisher Morgan V. DiLeo William J. federspiel McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh USA

Cytokines are of chief importance in the pathophysiology of sepsis and other systemic inflammatory response syndromes. We are designing and testing an extracorporeal cytokine adsorption device (CAD) that can remove cytokines via adsorption on biocompatible, microporous beads. The goal of this study was to determine whether a previously reported TNF binding DNA aptamer, 5’-GCGGCCGATA AGGTCTTTCC AAGCGAACGA ATTGAACCGC-3’, could be immobilized our hemoadsorption polymer surface to increase the removal rate of TNF. A reservoir consisting of horse serum spiked with a known concentration of TNF was perfused through our CAD packed with aptamer modified or unmodified (control) polymer beads. The binding affinity of the TNF aptamer was characterized using an enzyme-linked oligonucleotide assay (ELONA). As a positive control a well-established DNA aptamer that binds PDGF BB was also subjected to the same ELONA to validate the assay. TNF capture using the CAD showed no TNF removal over four hours for both the aptamer modified and unmodified control beads. Additionally, the results of the ELONA showed no binding of TNF to the reported aptamer;however the PDGF BB aptamer did bind PDGF BB. Based on these results we are able to conclude that the reported TNF specific aptamer does not bind TNF. These results will be of importance to other studies exploring aptamers for specific binding of TNF.

关键词： Aptamers Sepsis Hemoadsorption TNF

SMART~/ASTC技术的冶金、操作和经济效果

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钢铁 2003年第11期38卷 21-25页

作者： K.Mrwald M.Thalhammer C.federspiel L.Gould 奥钢联工程技术公司

铸坯锥度自动控制 (ASTC)技术与 SMART○R智能扇形段联合实施 ,通过减轻中心偏析而显著改善连铸坯内部质量。辊缝锥度可以远程调节 ,借助动态轻压下能够满足在过渡浇铸条件下的特殊要求。

关键词：连铸铸坯锥度自动控制轻压下自动化 ASTC技术智能扇形段

Brain Processing of Fearful Facial Expression in Mentally Disordered Offenders

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Journal of Behavioral and Brain Science 2011年第3期1卷 115-123页

作者： Katarina Howner Hakan Fischer Thomas Dierks Andrea federspiel Lars-Olof Wahlund Tomas Jonsson Maria Kristoffersen Wiberg Marianne Kristiansson Department of Clinical Neuroscience Karolinska InstituteStockholmSweden NVS-Department Karolinska InstituteStockholmSweden Department of Psychology Stockholm UniversityStockholmSweden Department of Psychiatric Neurophysiology University Hospital for PsychiatryBernSwitzerland Department of Clinical Science Intervention and TechnologyKarolinska InstituteStockholmSweden

Emotional facial expressions are important cues for interaction between people. The aim of the present study was to investigate brain function when processing fearful facial expressions in offenders with two psychiatric disorders which include impaired emotional facial perception;autism spectrum disorder (ASD) and psychopathy (PSY). Fourteen offenders undergoing forensic psychiatric assessment (7 with ASD, and 7 psychopathic offenders) and 12 healthy controls (HC) viewed fearful and neutral faces while undergoing functional magnetic resonance imaging (fMRI). Brain activity (fearful versus neutral faces) was compared both between HC and offenders and between the two offender groups (PSY and ASD). Functional co-activation was also investigated. The offenders had increased activity bilaterally in amygdala and medial cingulate cortex as well as the left hippocampus during processing fearful facial expressions compared to HC. The two subgroups of offenders differed in five regions compared with each other. Results from functional co-activation analysis suggested a strong correlation between the amygdala and anterior cingulate cortex (ACC) in the left hemisphere only in the PSY group. These findings suggest enhanced neural processing of fearful faces in the amygdala as well as in other facial processing brain areas in offenders compared to HC. Moreover, the co-activation between amygdala and ACC in the PSY but not the ASD group suggested qualitative differences in amygdala activity in the two groups. Since the sample size is small the study should be regarded as a pilot study.

关键词： Psychopathy Autism Spectrum Disorder Offenders fMRI Emotional Facial Processing

连铸中SMART/ASTC技术的冶金、操作及经济优势

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连铸中SMART/ASTC技术的冶金、操作及经济优势

采用奥钢联DYNAGAP轻压下技术的6流大方坯连铸机

中国金属学会2003中国钢铁年会

作者： KarlMerwald Manfred Thalhammer Christian federspiel 奥钢联工程技术公司（VAI）奥钢联工程技术公司（VAI）奥钢联工程技术公司（VAI）

ASTC（自动铸流锥度控制）的开发和应用与SMART扇形段相结合通过降低中心偏析,而大大改进了连浇时的内部铸流质量。辊缝锥度远程调整,采用动态轻压下也可以满足过渡浇铸条件下的一些特殊要求。到2003年5月,在芬兰、美国、意大利、奥地... 详细信息

ASTC（自动铸流锥度控制）的开发和应用与SMART扇形段相结合通过降低中心偏析,而大大改进了连浇时的内部铸流质量。辊缝锥度远程调整,采用动态轻压下也可以满足过渡浇铸条件下的一些特殊要求。到2003年5月,在芬兰、美国、意大利、奥地利、韩国和中国共有9台连铸机11流采用了SMART /ASTC技术。另外还有7台连铸机也采用了这一技术,共计18流。SMART /ASTC方案可用于板坯连铸机和大方坯连铸机浇铸各种钢种,其中中国攀枝花钢厂的六流大方坯连铸机的如期试车就是一例。

关键词：板坯连铸动态轻压下质量中心偏析

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钢铁 2004年第Z1期39卷 115-119页

作者：张大德李再友李建全陈小平 M Thalhammer H Wahl C federspiel K Hauser H-P Kogler 攀枝花钢铁集团公司攀枝花钢铁集团公司攀枝花钢铁集团公司攀枝花钢铁集团公司奥钢联工程技术公司奥钢联工程技术公司奥钢联工程技术公司奥钢联工程技术公司奥钢联工程技术公司

　　1前言　　2001年9月奥钢联赢得了中华人民共和国攀枝花钢铁公司(攀钢)6流大方坯连铸机供货合同.　　……

关键词：奥钢联轻压下技术攀枝花钢铁公司大方坯连铸机人民共和国供货合同攀钢

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“即连即铸”的奥钢联(VAI)连铸技术

连铸 2004年第6期29卷 8-13页

作者： H.Wahl K.Herzog C.federspiel P.Juza 奥钢联

生产率和作业率方面的收益以及灵活调整的可能性是提高钢铁工业竞争力的关键因素。对于新建尤其是改造项目，用极短的工期和停产时间是使投资在经济上获得成功的关键。

关键词：钢铁工业收益奥钢联停产技术竞争力投资连铸作业率新建