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Knockdown of Na,K-ATPase β-subunits in Oncopeltus fasciatus induces molting problems and alterations in tracheal morphology

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Insect Science 2023年第2期30卷 375-397页

作者： Marlena Herbertz Jennifer lohr Christian lohr Susanne Dobler Division of Molecular Evolutionary Biology Department of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany Division of Neurophysiology Department of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany

The ubiquitously expressed transmembrane enzyme Na,K-ATPase(NKA)is vital in maintaining functionality of *** association of α-and β-subunits is believed to be essential for forming a functional *** the large milkweed bug Oncopeltus fasciatus fourα1-paralogs and four β-subunits exist that can associate into NKA *** diversity raises the question of possible tissue-specific distribution and *** the α1-subunits are known to modulate cardenolide-resistance and ion-transport efficiency,the functional importance of the β-subunits needed further *** here characterize all four different β-subunits at the cellular,tissue,and whole organismal scales.A knockdown of different β-subunits heavily interferes with molting success resulting in strongly hampered *** failure of ecdysis might be related to disrupted septate junction(SJ)formation,also reflected in β2-suppression-induced alteration in tracheal *** data further suggest the existence of isolated β-subunits forming homomeric or β-heteromeric *** possible standalone and structure-specific distribution of the β-subunits predicts further,yet unknown pump-independent *** different effects caused byβknockdowns highlight the importance of the various β-subunits to fulfill tissue-specific requirements.

关键词： ecdysis insect Na^(+)/K^(+)-ATPase protein distribution RNAi septate junctions tissue-specific function

Sampling: Design and Analysis 1

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RATIONAL CHEBYSHEV APPROXIMATION WITH VARIOUS DENOMINATOR CONSTRAINTS

1999年

作者： Sharon L. lohr

ISBN: (纸本)9780534353612

Sharon L. lohr's SAMPLING: DESIGN AND ANALYSIS provides a modern introduction to the field of sampling. With a multitude of applications from a variety of disciplines, the book concentrates on the statistical aspects of taking and analyzing a sample. Overall, the book gives guidance on how to tell when a sample is valid or not, and how to design and analyze many different forms of sample surveys

关键词： Sampling (Statistics)

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Analysis in Theory and Applications 1986年第4期 1-19页

作者： charlesb.Dunham Computer Science Department University of Western Ontario London Ontario N6A 5B7 CANADA

Chebyshev approximation by families of generalized rationalfunctions is considered, with various inequality constraints ondenominators being studied. The classical family of rationals R;with denominator>0 is reviewed. Next the family of rationals R;with non-vanishing denominator is *** absence of a charac-terization or uniqueness result is shown. To help in the analysisof R;, the elass of families R;（s） is introduced, where s is a non-zero sign function and denominators take sign s. Such families areshown to have a theory equivalent to that for R;A difficultywith the families R;, R;, R;（s） is that a best approximation may notexist and analytical processes may not have a limit. To remedythis defioiency we add rationals whose denominators have zeros toget the families R;, R, R;（s） respectively. Conventions of Boehmand Goldstein for evaluation at zeros are reviewed. Under statedconditions, existence is guaranteed. Unfortunately, neither astandard characterization nor uniqueness need hold for these largerfamilies. Further, such additions may change the distance fromfunction to approximating family. When a best approximation fromR;is also best in R;is studied. Uniqueness of best approxima-tions from R;, R;（s）, and R;is studied. Existence of best appro-ximations by R;and R;is studied.

关键词： RATIONAL CHEBYSHEV APPROXIMATION WITH VARIOUS DENOMINATOR CONSTRAINTS

Blockchains for constrained edge devices

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Blockchain(Research and Applications) 2020年第1期1卷 37-43页

作者： Antonyo Douglas Richard Holloway Jonathan lohr Elijah Morgan Khaled Harfoush Department of Computer Science North Carolina State University Raleigh NC27606USA Department of Electrical and Computer Engineering North Carolina State University RaleighNC27606USA

Today’s networks are seeing a large influx of Internet connected devices that reside primarily on the edge of the *** of these devices,such as Internet of Things(IoT)devices,are resource constrained both by storage capacity and power requirements that limit a device’s Internet *** interesting architectures have been proposed to address security,device management,configuration,and multi-party interaction concerns using blockchain *** architectures require a trusted intermediary to interact with the blockchain on behalf of the edge *** introduces a single point of failure in trust and *** paper proposes a novel adaptation of blockchain technology to enable these edge devices to interact and participate with a blockchain without requiring a trusted *** proposed architecture provides a flexible and extensible framework that enables multi party interactions to take place at the edge of the *** efficacy of the proposed design is demonstrated through theoretical analysis and by an application to a network of resource constrained IoT devices.

关键词： Blockchains Internet of Things Wireless Communication

Early detection and prevention of pancreatic cancer:Is it really possible today?

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World Journal of Gastroenterology 2014年第34期20卷 12118-12131页

作者： Marco Del Chiaro Ralf Segersvrd Matthias lohr Caroline Verbeke Division of Surgery Department of Clinical ScienceIntervention and Technology (CLINTEC)Karolinska Institute141 86 StockholmSweden Division of Pathology Department of Laboratory MedicineKarolinska Institute141 86 StockholmSweden

Pancreatic cancer is the 4th leading cause of cancer-related death in Western countries. Considering the low incidence of pancreatic cancer, population-based screening is not feasible. However, the existence of a group of individuals with an increased risk to develop pancreatic cancer has been well established. In particular, individuals suffering from a somatic or genetic condition associated with an increased relative risk of more than 5- to 10-fold seem to be suitable for enrollment in a surveillance program for prevention or early detection of pancreatic cancer. The aim of such a program is to reduce pancreatic cancer mortality through early or preemptive surgery. Considering the risk associated with pancreatic surgery, the concept of preemptive surgery cannot consist of a prophylactic removal of the pancreas in high-risk healthy individuals, but must instead aim at treating precancerous lesions such as intraductal papillary mucinous neoplasms or pancreatic intraepithelial neoplasms, or early cancer. Currently, results from clinical trials do not convincingly demonstrate the efficacy of this approach in terms of identification of precancerous lesions, nor do they define the outcome of the surgical treatment of these lesions. For this reason, surveillance programs for individuals at risk of pancreatic cancer are thus far generally limited to the setting of a clinical trial. However, the acquisition of a deeper understanding of this complex area, together with the increasing request for screening and treatment by individuals at risk, will usher pancreatologists into a new era of preemptive pancreatic surgery. Along with the growing demand to treat individuals with precancerous lesions, the need for low-risk investigation, low-morbidity operation and a minimally invasive approach becomes increasingly pressing. All of these considerations are reasons for preemptive pancreatic surgery programs to be undertaken in specialized centers only.

关键词： Preemptive pancreatic surgery Cystic tumors of the pancreas Familial pancreatic cancer Early detection Pancreas cancer screening

EC-15 proceedings of the 15th Joint Workshop on Electron Cyclotron Emission and Electron Cyclotron Heating Yosemite National Park, California, USA, 10-13 March 2008 editor, John lohr.

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Sampling : :design and analysis / 影印

2009年

作者： editor John lohr.

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Chronic pancreatitis and the heart disease:Still terra incognita?

丛书名：外国优秀统计学教材系列丛书

2002年

作者： lohr Sharon L.

本书以原版英文的方式对抽样进行了详细介绍，具体包括：引言；简单概率抽样；比率和回归估计；分层抽样；等概率整群抽样；不等概率抽样；复杂调查；无响应；在复杂调查中的方差估计；复杂调查的分类数据分析；复杂调查数据回归；抽样... 详细信息

ISBN: (纸本)7503739533

本书以原版英文的方式对抽样进行了详细介绍，具体包括：引言；简单概率抽样；比率和回归估计；分层抽样；等概率整群抽样；不等概率抽样；复杂调查；无响应；在复杂调查中的方差估计；复杂调查的分类数据分析；复杂调查数据回归；抽样中的其他话题；附录。

关键词：抽样调查

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World Journal of Gastroenterology 2019年第44期25卷 6561-6570页

作者： Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias lohr Miroslav Vujasinovic Department of Medicine Huddinge Karolinska InstituteStockholm 14183Sweden Department of Gastroenterology Division of Internal MedicineUniversity Medical Centre MariborMaribor 2000Slovenia Department of Medicine Klinikum BayreuthBayreuth 95445Germany Department for Digestive Diseases Karolinska University HospitalStockholm 14186Sweden Department of Oncology and Pathology Karolinska InstituteStockholm 17176Sweden Cancer Centre Karolinska CCKKarolinska University HospitalStockholm 17176Sweden Unit of Cardiology Heart and Vascular ThemeKarolinska University Hospital HuddingeStockholm 14186Sweden Department of Medicine Solna Karolinska InstituteStockholm 17176Sweden Department of Clinical Science Interventionand Technology(CLINTEC)Karolinska InstituteStockholm 17176Sweden

BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),*** To explore the evidence regarding the association of CP and heart disease,more specifically CVD and *** A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was *** search was limited to articles in the English *** last search was run on the 1st of May *** primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with *** Out of 1166 studies,only 8 were eligible for this *** regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with ***,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was *** the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of *** another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other *** studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary ***,statistically significant higher incidenc

关键词： Chronic Pancreatitis Pancreatic exocrine insufficiency Heart failure Cardiovascular diseases

A Genetic Quest for Better Chocolate

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当代外语研究 2008年第9期 9-11页

作者： Steve lohr 聂丽芳

巧克力的重要原料可可豆的主要产地在非洲。尽管在美洲巧克力的需求十分旺盛,但美洲本土却甚少种植可可树。可可树的产量一直受疫病、虫害、水灾的影响,科学家希望能绘出可可树的基因序列,并加以分析,以便帮助人们选出更强壮的植株,能... 详细信息

巧克力的重要原料可可豆的主要产地在非洲。尽管在美洲巧克力的需求十分旺盛,但美洲本土却甚少种植可可树。可可树的产量一直受疫病、虫害、水灾的影响,科学家希望能绘出可可树的基因序列,并加以分析,以便帮助人们选出更强壮的植株,能够对抗真菌的感染、抵御虫害,并且能够适应全球变暖带来的更为干旱的气候。

关键词：可可树巧克力原料虫害全球变暖美洲基因序列可可豆抗真菌帮助