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CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath

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Asian journal of Andrology 2011年第2期13卷 266-274页

作者： Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz charles j Flickinger john C Herr Department of Urology Daping Hospital Institute of Surgery Research Third Military Medical University Chongqing 400042 China Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing 400038 China Center for Research in Contraceptive and Reproductive Health Department of Cell BiologyUniversity of Virginia Charlottesville VA 22908 USA

Calcium-binding tyrosine phosphorylation-regulated protein （CABYR） is a highly polymorphic calcium-binding tyrosine- and serine-/threonine-phosphorylated fibrous sheath （FS） protein involved in capacitation. A putative domain （amino acids 12-48） homologous to the regulatory subunit of type II cAMP-dependent protein kinase A （RII） dimerisation and A kinase-anchoring protein （AKAP）-binding domains of protein kinase A at the N-terminus suggests that CABYR may self-assemble and bind to AKAPs. Moreover, there is evidence that CABYR has limited interaction with AKAPs. However, further evidence and new relationships between CABYR and other FS proteins, including AKAPs, will be helpful in understanding the basic physiology of FS. In this study, a new strategy for co-immunoprecipitation of insoluble proteins, as well as the standard co-immunoprecipitation method in combination with mass spectrometry and western blot, was employed to explore the relationship between CABYR, AKAP3 and Ropperin. The results showed that AKAP3 was *** with CABYR by the anti-CABYR-A polyclonal antibody, and, conversely, CABYR was also *** with AKAP3 by the anti-AKAP3 polyclonal antibody. Another RIl-like domain containing protein, Ropporin, was also co-immunoprecipitated with CABYR, indicating that Ropporin is one of CABYR＇s binding partners. The interactions between CABYR, AKAP3 and Ropporin were confirmed by yeast two-hybrid assays. Further analysis showed that CABYR not only binds to AKAP3 by its RII domain but binds to Ropporin through other regions besides the RIl-like domain. This is the first demonstration that CABYR variants form a complex not only with the scaffolding protein AKAP3 but also with another Rll-like domain-containing protein in the human sperm FS.

关键词： AKAP3 CABYR fibrous sheath Ropporin sperm tail spermatozoa Western blotting

Performance Evaluation of a Communication Plan Implementation for Behaviour Change in People at Risk of Type 2 Diabetes in the Commune of Tchaourou in Benin

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journal of Diabetes Mellitus 2022年第4期12卷 224-242页

作者： Clémence Germaine Metonnou Colette Sylvie Azandjeme charles jérôme Sossa Moussiliou Noël Paraïso Bio Nigan Victoire Damienne Agueh Department of Promotion Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Laboratory Sports Performance Health and Evaluation National Institute of Youth Physical Education and Sport (INJEPS) University of Abomey-Calavi (UAC) Porto-Novo Benin

Introduction: There are very few programmes to delay or prevent diabetes in Africa. This study aims to evaluate the communication plan implementation to reduce risk factors for Type 2 diabetes in people at risk. Methods: The cross-sectional evaluative study focuses on the resources used for the implementation of the programme, the activities carried out and the beneficiaries of the programme. The non-probabilistic method was used to select. All target populations under study with appropriate sampling techniques. The performance of the communication plan implementation for behaviour change was assessed through the three sub-variables of evaluation of Donabedian health programmes: structure, process and results. The components assessment was based on the Varkevisser scale. The performance of the communication plan implementation for behaviour change was obtained by the sum of the scores of the three sub-variables. Results: The performance of the communication plan implementation for behaviour change was satisfactory in all programme villages at 89%. The establishment of the research team, the management team and the technical team, the availability of financial resources on a timely basis, the follow-up of nutritionists, sports teachers and peer educators, the implementation of the programme package and the home coaching of the targets were effective in all the programme villages of the study. The scores for structure performance, process performance, and results performance were 100%, 95%, and 83.8%, respectively. The involvement of the entire research team, the commitment of local authorities and the motivation of the targets were also important in the obtained result. Conclusion: This study shows that effective T2D preventive communication is possible at community level in Benin and probably in Sub-Saharan Africa.

关键词： Implementation People at Risk Type 2 Diabetes Benin

The Cloze Procedure and Proficiency in Enghsh as a Foreign Language

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英语考试研究 2011年第3期 29-34页

作者： j. charles Alderson

Automated Protection Performance Assessment and Enhancement

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journal of Power and Energy Engineering 2014年第4期2卷 525-531页

作者： j. jaeger X.-P. Liang R. krebs T. Bopp FAU University Erlangen Germany Siemens Ltd. Erlangen Beijing China Siemens AG Germany Erlangen Germany

New strategies and methods for assessing the security of protection systems to reduce the risk of unnecessary disturbances and blackouts are the main topic of the present paper. The system behavior of a protection system and network is analyzed and assessed as a whole. Hence, the established algorithms are capable to handle complex network structures with regard to an intelligent data management as well as data validation. Protection security assessment comprised two different aspects: on the one hand the behavior regarding dependability and security in terms of speed and sensitivity, on the other hand the behavior regarding the response on dynamic network phenomena as voltage stability and transient stability. A new automated method for assessing the dependability and security of protection systems is shown. The short-circuit simulation tool is used to provide a simulation system including network and protection devices as a whole. The handling of the large amount of resulting data is done by an intelligent visualization method like a “fingerprint” analysis. Further on the paper is focused on the protection response on dynamic network phenomena and presents innovative strategies for this investigation aspect. The structure of simulation environment will be described. Results of a case study show the application of this method on a real network. The system tool which is concluding these two aspects of protection assessment is called SIGUARD? PSA.

关键词： Protection Security Assessment Dependability Security Protection Coordination Generic Protection Models Dynamic Protection Simulation

CONVEXITY AND BERNSTEIN POLYNOMIALS ON k-SIMPLOIDS

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Acta Mathematicae Applicatae Sinica 1990年第1期6卷 50-66页

作者： WOLFGANG DAHMEN charles A.MICCHELLI Institut fur Mathematik Ⅲ Freie Universitat Berlin Arnimallee 2-61000 Berlin(West)33GermanyIBM T.J.Watson Research CenterP.O.Box 218Yorktown HeightsN.Y.10598U.S.A.

This paper is concerned with Bernstein polynomials on k-simploids by which we mean a crossproduct of k lower dimensional simplices. Specifically, we show that if the Bernstein polynomials ofa given function f on a k-simploid form a decreasing sequence then f+l, where l is any correspondingtensor product of affine functions. achieves its maximum on the boundary of the k-simploid. Thisextends recent results in [1] for bivariate Bernstein polynomials on triangles. Unlike the approachused in [1] our approach is based on semigroup techniques and the maximum principle for secondorder elliptic operators. Furthermore, we derive analogous results for cube spline surfaces.

关键词： Tensor Product Recent Result Maximum Principle Cross Product Analogous Result

OPTICAL MEASUREMENT OF PHOTOSENSITIZER CONCENTRATION IN VIVO

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journal of Innovative Optical Health Sciences 2011年第2期4卷 97-111页

作者： MARTIN R.AUSTWICK jOSEPHINE H.WOODHAMS VADZIM CHALAU charles A.MOSSE CAROLINE ELIOT LAURENCE LOVAT ALEXANDER j.MACROBERT IRVING j.BIGIO STEPHEN G.BOWN National Medical Laser Centre charles Bell House 67-73 Riding House Street University College London London W1W 7EJUK Boston University BME44 Cummington Street BostonMA 02215USA

Most techniques for measuring tissue concentrations of drugs are invasive,time-consuming,and often require the removal of tissue or *** pharmacokinetics(OP)is a minimally invasive alternative giving an immediate *** of white light are directed at the tissue of interest using afiber optic *** light is detected by a secondfiber immediately adjacent to thefirst in the same probe(separation 1.7 mm).Using the photosensitizer disulfonated aluminium phthalocyanine(AlS_(2)Pc),OP measurements were made in phantoms and on the mouth,stomach,colon,skin,and liver of normal rats 1 and 24 h after intravenous AlS_(2)Pc ***_(2)Pc concentration was determined by calculating the area under the curve(AUC)in the spectral region around the peak drug absorption or measuring the height of the *** baseline interpolation removed the need for pre-drug,control optical *** measurements correlated well with values from alkali chemical extraction(CE)of the corresponding tissues,(R^(2)0.87=0.97).OP measurements in the mouth also correlated with CE of less accessible internal organs(R^(2)0.77-0.88).In phantoms,the lowest detectable concentration was 0.1μg/*** vivo,results were limited by the lower accuracy in the CE measurements but were almost certainly *** incidentalfinding was a 12-15nm red shifted component in the spectra observed 1 h after drug administration,suggesting partitioning of the drug in different microenvironment compartments,which could prove to be of considerable interest in future *** conclusion,OP shows promise for real-time measurement of concentrations of drugs with suitable absorption peaks.

关键词： Optical pharmacokinetics chemometrics photodynamic therapy noninvasive measurement

Dietary Vitamin K Restriction and Effectiveness of Vitamin K Antagonists Prescribed at the CNHU-HKM University Cardiology Clinic/BENIN

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Food and Nutrition Sciences 2023年第10期14卷 928-940页

作者： Clémence Germaine Metonnou charles jérôme Sossa Lamidhi Salami Rébécca Sabgohan Colette Azandjeme Camelle Mizehoun-Adossoda Virginie Mongbo Health Promotion Department Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Health Policy and Systems Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin School of Nutrition-Dietetics Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Introduction: Their efficacy in preventing thrombotic and embolic events has been proven in numerous studies, but their narrow therapeutic index requires particular vigilance, especially in terms of biology. In addition, treatment-related hemorrhagic complications are not uncommon. This study explores the influence of dietary vitamin K restriction on the efficacy of antivitamin K treatment at the University Cardiology Clinic of CNHU-HKM. Methods: Cross-sectional and descriptive study that took place from 25 April to 29 August 2019. Patients’ dietary behaviors and successive INR values were collected. Information on dietary intake was obtained by 2 non-consecutive 24-hour recalls. The effectiveness of VKA treatment was assessed by the “Time in Therapeutic Range” (TTR) of the INR. VKA treatment was considered effective for a TTR greater than 65%. Results: At the end of this study, 40 patients were surveyed. The mean age of the participants was 58.05 years ± 13.32 years, with a sex ratio of 1.35. Complete arrhythmia due to atrial fibrillation was the main indication for VKA treatment (37.50%) and fluindione was the most commonly prescribed drug (77.50%). The duration of treatment was less than or equal to 2 years in 47.5% of the subjects surveyed. Before starting treatment, 85% of patients received advice on restricting vitamin K-rich foods, and 45% of patients reported “food burnout” after a period of compliance with the restriction. The majority of respondents (97.50%) complied with the restriction on vitamin K-rich foods. All respondents had high energy intakes and a poor distribution of macronutrients, with a predominance of carbohydrates and proteins. 2.5% of respondents were on effective anti-vitamin K therapy with a TTR of over 65%. Conclusion: Restriction of vitamin K-rich foods is not conducive to effective treatment with vitamin K antagonists.

关键词： Antivitamin K Dietary Restriction Vitamin K Therapeutic Efficacy

Registry report on prediction by Pocock cardiovascular score of cerebral microemboli acutely following carotid endarterectomy

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Stroke & Vascular Neurology 2018年第3期3卷 147-152页

作者： Mahmud Saedon Athanasios Saratzis Rachel W S Lee charles E Hutchinson Christopher H E Imray Donald R j Singer Nottingham University Hospitals NHS Trust NottinghamUK University Hospitals Coventry and Warwickshire NHS Trust CoventryUK Leicester Royal Infirmary LeicesterUK Yale School of Medicine New HavenConnecticutUSA Fellowship of Postgraduate Medicine LondonUK

background Cerebral microemboli may lead to ischaemic neurological complications after carotid endarterectomy(CEA).The association between classical cardiovascular risk factors and acute cerebral microemboli following carotid surgery has not been *** aim of this study was to explore whether an established cardiovascular risk score(Pocock score)predicts the presence of cerebral microemboli acutely after *** and methods Pocock scores were assessed for the 670 patients from the Carotid Surgery Registry(age 71±1(SEM)years,474(71%)male,652(97%)Caucasian)managed from january 2002 to December 2012 in the Regional Vascular Centre at University Hospitals Coventry and Warwickshire NHS Trust,which serves a population of *** was undertaken in 474(71%)patients for symptomatic carotid stenosis and in 196(25%)asymptomatic patients during the same period.74% of patients were hypertensive,71%were smokers and 49% had *** A high Pocock score(≥2.3%)was significantly associated with evidence of cerebral microemboli acutely following CEA(P=0.039,Mann-Whitney(MW)test).A Pocock score(≥2.3%)did not predict patients who required additional antiplatelet therapy(microemboli signal(MES)rate>50 hour-1:P=0.164,MW test).Receiver operating characteristic analysis also showed that the Pocock score predicts acute postoperative microemboli(area under the curve(AUC)0.546,95%CI 0.502 to 0.590,P=0.039)but not a high rate of postoperative microemboli(MES>50 hour−1:AUC 0.546,95% CI 0.482 to 0.610,P=0.164).A Pocock score≥2.3% showed a sensitivity of 74% for the presence of acute postoperative cerebral microemboli.A Pocock score≥2.3% also showed a sensitivity of 77% and a negative predictive value of 90% for patients who developed a high microembolic rate>50 hour−1 after carotid *** These findings demonstrate that the Pocock score could be used as a clinical tool to identify patients at high risk of developing acute postoperative microemboli.

关键词： cerebral Surgery Registry

Cardiorespiratory and muscular fitness associations with older adolescent cognitive control

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journal of Sport and Health Science 2021年第1期10卷 82-90,I0001页

作者： Tatsuya T.Shigeta Angus A.Leahy jordan j.Smith Narelle Eather David R.Lubans charles H.Hillman Department of Psychology Northeastern UniversityBostonMA 02115USA Priority Research Centre for Physical Activity and Nutrition School of EducationUniversity of NewcastleCallaghanNSW 2308Australia Department of Physical Therapy Movement&Rehabilitation SciencesNortheastern UniversityBostonMA 02131USA

Background:Participation in physical activity supports greater cardiorespiratory fitness(CRF),a correlate of cognitive ***,the relationship between muscular fitness(MF)and cognitive control is less *** present study investigated the differential relationship of CRF and MF with cognitive control in older ***:This cross-sectional study involved students(1517 years old,n=541,43%female)from 20 secondary schools who completed tests of inhibition(modified flanker task),working memory(n-back task),CRF(Progressive Aerobic Cardiovascular Endurance Run),and MF(standing long jump and push-up test).Multilevel analyses tested the association between CRF or MF and cognitive outcomes while accounting for the influence of the other fitness variable and relevant demographic ***:CRF predicted response accuracy during incongruent flanker trials,the condition requiring greater *** the working memory task,CRF predicted greater target accuracy and greater d’scores on the 1-back task,requiring lesser amounts of working *** the 2-back task,which requires greater amounts of working memory,CRF also predicted greater target and non-target accuracy and d’***,MF did not predict any cognitive outcomes after adjustment for ***:CRF was selectively related to better performance during task conditions that require greater amounts of inhibition and working *** finding suggests that CRF,but not MF,may benefit cognitive control in older *** selective influence of CRF on older adolescents’cognition highlights the value of aerobic physical activity.

关键词： Adolescence Cognition Physical activity Physical fitness