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平行盾构开挖离心机模拟试验研究

岩土工程学报 2017年第2期39卷 373-379页

作者：缪林昌王非吴宏伟吕虎东南大学交通学院江苏南京210096 香港科技大学土木学院

通过离心模型试验模拟平行盾构隧道近接开挖施工,研究了盾构隧道近接开挖对既有隧道结构内力、管片变形和地表沉降的变化规律。结果表明:1隧道开挖引起地表沉降的大小与开挖的步骤有关,而沉降槽的范围基本不变;2既有隧道靠近新建隧道一... 详细信息

通过离心模型试验模拟平行盾构隧道近接开挖施工,研究了盾构隧道近接开挖对既有隧道结构内力、管片变形和地表沉降的变化规律。结果表明:1隧道开挖引起地表沉降的大小与开挖的步骤有关,而沉降槽的范围基本不变;2既有隧道靠近新建隧道一侧受拉,这一侧弯矩出现负增量,侧向土压力也有一定的减小,且既有隧道直径水平向变大,而垂向直径基本不受影响;3由于土拱效应,新建隧道已完成开挖部分管片拱顶的土压力随开挖进程先减小后增大;4采用地层结构法可以准确模拟隧道开挖过程的隧道结构力学特性与变形规律。

关键词：平行盾构隧道临近开挖离心模型试验

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.w.eeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify w.en to stop subdividing clusters based on the fundamental principle that cells must differ more betw.en than w.thin *** w. present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering w.th statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as tw.-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynow.ka Bartosz Karaszew.ki Grzegorz w.grzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow.and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and ow.ng to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last tw. decades,the dogma that cell fate is immutable has been increasingly challenged,w.th important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is pow.rful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates w.thout first passing through a stem cell state.

关键词： programming passing proof

Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville ng Michelle New.ery Nicole Miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

The Strategy of Escalation and Negotiation: The Iran Nuclear Dispute

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 434-448页

作者： Tobias w. Langenegger Keith w. Hipel Department of Management Technology and Economics ETH Zurich Zurich Switzerland Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada

The strategic decisions and resulting consequences surrounding the conflict betw.en the United States of America (US) and Iran regarding the Iranian nuclear program are formally investigated using a flexible decision methodology called the Graph Model for Conflict Resolution (GMCR). This highly controversial dispute caught the w.rld's attention as concerns w.re grow.ng that Iran w.uld reach a position w.ere it w.uld be able to build nuclear w.apons, thereby posing a risk to w.rld security. w.ile Iran insisted on its rights for the peaceful use of nuclear technology;the international community;led by the US, tried to discourage the nuclear activities of Iran to ensure its obligations to the non-proliferation of nuclear w.apons. This led to an escalation of tension on both sides, w.th an extension of the nuclear program by Iran and an increase in sanctions by the US, before it w.s possible to arrive at a negotiated agreement. As demonstrated in this paper, a systematic GMCR investigation provides valuable strategic insights into this important conflict. Further, it illustrates w.ys in w.ich the conflict could have evolved, as w.ll as mechanisms for stopping an escalation like this in the future.

关键词： Negotiation Graph Model for Conflict Resolution Iran US nuclear security economic sanctions

Thermodynamic Foundation for High Temperature Electrochemistry

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Chemical Research in Chinese Universities 2004年第4期20卷 494-500页

作者： ZHAng w. E. A. charles J. Congleton Corrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne NE1 7RU UK NE1 7RU UKNE1 7RU UK

Thermodynamic concepts required for the thermodynamic calculation of the potentials of electrodes for high temperature applications are briefly review.d. A thermodynamic approach to the calculation of half cell potentials and the standard chemical potential of an electron at high temperatures w.ich are related to the Standard Hydrogen Electrode(SHE) is discussed. As examples, an external Ag/AgCl reference electrode and a YSZ(Ag|O_2) pH sensor for high temperature applications are analyzed by using the thermodynamic approach to derive a high temperature pH measurement equation. The tw. electrodes are employed to measure high temperature pH and the measured pH w.s compared w.th the calculated pH by using a solution chemistry method. Concepts and principles for electrode kinetics are also briefly introduced and a modification to the Tafel equations is suggested.

关键词： High temperature potential Half cell potential External Ag/AgCl reference electrode Standard chemical potential of an electron High temperature pH sensor.

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing w.th pow.er and w.re

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei w.ng Guijun Bi Youxiang Chew.Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing w.th pow.er(LAAM_(p))and w.re(LAAM_(w.)w.s explored.A process study w.s first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w.,*** the optimized process parameters,robust interfaces w.re achieved betw.en pow.er/w.re deposits and the forged substrate,as w.ll as betw.en pow.er and w.re *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,w.erein the pow.er deposit w.s dominated by a finerα′microstructure and the w.re deposit w.s characterized by lamellar α *** mechanisms of microstructure formation and correlation w.th mechanical behavior w.re analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even w.thout post heat *** fracture occurred w.thin the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w. in the direct manufacturing of Ti-6Al-4V parts in accordance w.th the required dimensional resolution and deposition rate,together w.th sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing pow.er deposition w.re deposition interfacial characteristic mechanical behavior

Tow.rd understanding Cretaceous climate An updated review

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Science China Earth Sciences 2017年第1期60卷 5-19页

作者： w.lliam w. HAY Department of Geological Sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New.data and ideas are changing our view.of conditions during the *** of the continents w.s low.r than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be w.ll below.freezing in *** controversy over the height of Cretaceous sea levels has been resolved by know.edge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of grow.h and decay of ice sheets,but more likely the filling and release of w.ter from groundw.ter reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide w.s not the only significant greenhouse gas;methane contributed significantly to the w.rmer *** of very w.rm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces w.re much w.tter than has been thought,w.th meandering rivers and many oxbow.lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a w.rmer Earth is underw.y,and a new.suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography Sea level Greenhouse Paleohydrology Paleoclimate