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Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma

Bone Research 2022年第3期10卷 615-626页

作者： Qizhi Qin Mario Gomez-Salazar Masnsen Cherief Chase A.Pagani Seungyong Lee charles hwang Robert J.Tower Sharon Onggo Yuxiao Sun Abhinav Piplani Zhao Li Sowmya Ramesh Thomas L.Clemens Benjamin Levi Aaron W.James Department of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Center for Organogenesis and Trauma Department of SurgeryUniversity of TexasSouthwesternTXUSA Department of Plastic Surgery HarvardCambridgeMA 02138USA Department of Orthopaedics Johns Hopkins UniversityBaltimoreMD 21205USA Baltimore Veterans Administration Medical Center BaltimoreMD 21201USA

The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma model in mice, which results in aberrant cell fate and heterotopic ossification(HO). First, a high spatial degree of neurovascular congruency was observed to exist within extremity injury associated heterotopic ossification. Vascular and perivascular cells demonstrate characteristic responses to injury,as assessed by single cell RNA sequencing. This vascular response to injury was blunted in neurectomized mice, including a decrease in endothelial proliferation and type H vessel formation, and a downregulation of key transcriptional networks associated with angiogenesis. Independent mechanisms to chemically or genetically inhibit axonal ingrowth led to similar deficits in HO site angiogenesis, a reduction in type H vessels, and heterotopic bone formation. Finally, a combination of single cell transcriptomic approaches within the dorsal root ganglia identified key neural-derived angiogenic paracrine factors that may mediate neuron-to-vascular signaling in HO. These data provide further understanding of nerve-to-vessel crosstalk in traumatized soft tissues, which may reflect a key determinant of mesenchymal progenitor cell fate after injury.

关键词： aberrant trauma nerves

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Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

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Bone Research 2019年第4期7卷 371-387页

作者： charles hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi Department of Surgery University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48109USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA Division of Cardiovascular Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biologic and Materials Sciences&Prosthodontics School of DentistryUniversity of MichiganAnn ArborMI 48109USA

Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic *** occurs commonly following orthopedic surgeries,burns,and neurologic *** surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native *** on these clinical observations,we set out to examine the role of vascular signaling in *** endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and *** findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen.

关键词： VEGFA injuries ossification

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Xenos peckii vision inspires an ultrathin digital camera

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Light(Science & Applications) 2018年第1期7卷 272-278页

作者： Dongmin Keum Kyung-Won Jang Daniel S.Jeon charles S.H.hwang Elke K.Buschbeck Min H.Kim Ki-Hun Jeong Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea School of Computing Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea Department of Biological Sciences University of CincinnatiCincinnatiOH 45221-0006USA

Increased demand for compact devices leads to rapid development of miniaturized digital ***,conventional camera modules contain multiple lenses along the optical axis to compensate for optical aberrations that introduce technical challenges in reducing the total thickness of the camera ***,we report an ultrathin digital camera inspired by the vision principle of Xenos peckii,an endoparasite of paper *** male Xenos peckii has an unusual visual system that exhibits distinct benefits for high resolution and high sensitivity,unlike the compound eyes found in most insects and some *** biologically inspired camera features a sandwiched configuration of concave microprisms,microlenses,and pinhole arrays on a flat image *** camera shows a field-of-view(FOV)of 68 degrees with a diameter of 3.4mm and a total track length of *** biologically inspired camera offers a new opportunity for developing ultrathin cameras in medical,industrial,and military fields.

关键词： camera sandwich digital

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Monitoring the effect of heparin in the presence of aprotinin

Monitoring the effect of heparin in the presence of aprotini...

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2006年中华医学会全国麻醉学术年会

作者： hwang Nian Chih Anaesthesia & Surgical Intensive Care Singapore General HospitalSingapore

Heparin and antithrombin III interaction The anticoagulant properties of heparin were first described in 1916i,ii. Heparin is derived from mammalian tissue and was first extracted from dog liver in Baltimore in 1916. Almost two decades later, the University of Toronto team of charles Best, Arthur charles, and David Scott was successful in preparing a pure product, first from beef liver and later from beef lung. Gordon Murray was the first Canadian surgeon to operate on disorders of the arteries and heart. In the

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IC组件的结温计算

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计算机工程与科学 1985年第1期 67-71页

作者： Un Pah hwang ,Vincent W.Antonetti ,charles J.Keeler ,IBM Corp ,Poughkeepsie N.Y. ,滕明生 ,彭心炯

人们发现,用统计参数法确定集成电路IC的结温比用蒙特卡罗法简便。统计参数分析法的一种新的应用是可以予测大型计算机中集成电路的结温分布。这种简明的方法的分析结果可与复杂而昂贵的、处于准高斯分布状态的蒙特卡罗法相并论蒙特卡... 详细信息

人们发现,用统计参数法确定集成电路IC的结温比用蒙特卡罗法简便。统计参数分析法的一种新的应用是可以予测大型计算机中集成电路的结温分布。这种简明的方法的分析结果可与复杂而昂贵的、处于准高斯分布状态的蒙特卡罗法相并论蒙特卡罗法已被Howell用来处理航天设备中热传递分析中的数据误差。Ishimoto

关键词：独立变量结温蒙特卡罗法 Monte-Carlo法数值分析组件 IC

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大众捷运不断电系统可用度及可靠度分析

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都市快轨交通 2010年第5期23卷 92-97页

作者：黄四昌陈振鸿林杰陈信强日立公司铁道交通系统分公司

分析单一组件的历时可用度行为,探讨对数常态分布可靠度(中位数tmed以及误差因子EF)和指数分布维修度(平均维修时间MTTR)对其可用度的影响,得出数值分析结果:在固定稳态可用度ASS以及平均维修时间MTTR的情况下,中位数tmed越小(或是误差... 详细信息

分析单一组件的历时可用度行为,探讨对数常态分布可靠度(中位数tmed以及误差因子EF)和指数分布维修度(平均维修时间MTTR)对其可用度的影响,得出数值分析结果:在固定稳态可用度ASS以及平均维修时间MTTR的情况下,中位数tmed越小(或是误差因子EF越大)的组件历时可用度越早单调下降且下降量越大,越晚回弹至其稳态可用度;在固定稳态可用度ASS以及误差因子EF的情况下,具有越大平均维修时间MTTR的组件历时可用度越晚单调下降但下降量不变,也越晚回弹至其稳态可用度。建立不断电系统可用度以及可靠度的分析模式,探讨正常供电、电池备援以及旁通供电3种不同模式对整体可用度以及可靠度的贡献程度,得出数值分析结果:正常供电模式贡献了绝大部分的整体不断电可用度;不考虑维修作业能力,整体不断电系统的可靠度参数MTTF为1184301h。

关键词：不断电系统可用度稳态可用度可靠度对数常态分布中位数误差因子导致失效之平均时间(MTTF) 指数分布平均维修时间(MTTR)

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Mesenchymal stem cell-based therapy for ischemic stroke

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Chinese Neurosurgical Journal 2016年第4期2卷 233-238页

作者： Johnathon D.Anderson Missy T.Pham Zelenia Contreras Madeline Hoon Kyle D.Fink Henrik J.Johansson Julien Rossignol Department of Internal Medicine Stem Cell Program University of California Davis Davis USAInstitute for Regenerative Cures University of California Davis Medical Center 2921 Stockton Blvd Room 1300 Sacramento CA 95817 USA Department of Internal Medicine Stem Cell Program University of California Davis Davis USA Department of Oncology-Pathology Karolinska InstituteCancer Proteomics Davis USA College of Medicine Central Michigan University Mt PleasantUSA

Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

关键词： Mesenchymal stem cells Exosomes Ischemic stroke

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威利剧院

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建筑技艺 2012年第4期18卷 206-209页

作者： Haviland Argo Steve Chen Dan Choi Robert Donnelly Selva Gurdogan Jonathan Handel Stine Hansen Oke Hauser Andrew Heid Nahyun hwang Ashley Klein Trine Kobbelvedt Natalia Ibanez Lario Soren Sigurd Larsen Mads Kristensen Filip Rem Beatriz Ramo Gro Sarauw Max Schwitalla Rooshad Shroff Gregers Tang Thomsen Lisa Tiedje Angelica Trevino Kristine Wander Monika Wittig Dolly Yarur 方朔 REX/OMA

正达拉斯演艺中心主席兼首席执行官Bill Lively说,"达拉斯演艺中心的创建是我们城市文化产业投资的一部分。演艺中心和表演公园会一道成为激动人心的全天候度假场所,这将会给达拉斯和整个地区带来活力。这个新的演艺中心将会让达拉斯及... 详细信息

正达拉斯演艺中心主席兼首席执行官Bill Lively说,"达拉斯演艺中心的创建是我们城市文化产业投资的一部分。演艺中心和表演公园会一道成为激动人心的全天候度假场所,这将会给达拉斯和整个地区带来活力。这个新的演艺中心将会让达拉斯及本地区的后代享受到来自于全世界的最好的音乐、戏剧、歌剧和舞蹈。"在传统的剧场中,与演出相关的附属空间的激增影响到了观演厅自身的空间。

关键词：演艺中心城市文化外部世界首席执行官产业投资全天候演出空间戏剧观演

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