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Journa. of Bioresources a.d Bioproducts 2024年第1期9卷 27-42页

作者： charles Micha.l a.bert Ka.g Chia.g Liew Fa.ulty of Tropica. Forestry Universiti Malaysia SabahKota Kinabalu 88400Kota KinabaluSabah 88400Malaysia

Due to their dura.ility,versa.ility,a.d a.sthetic va.ue,wood a.d wood-ba.ed composites a.e widely used a. building *** fa.t tha. these ma.eria.s a.e fla.ma.le,however,ra.ses a.ma.or worry since they might ca.se fire ha.a.ds a.d significa.t loss of life a.d *** a.ticle investiga.es the va.ia.les tha. a.fect fire performa.ce a. well a. the va.ious fire-reta.da.t trea.ments a.d their *** current developments a.d cha.lenges in improving the fire performa.ce of wood a.d wood-ba.ed composites trea.ed with fire-reta.da.t ma.eria.s a.e summa.ized in this ***,orga.ic chemica.s,a.d densifica.ion a.e some recent developments in fire-reta.da.t trea.ments tha. a.e a.so *** points from the review a.e summa.ized,a.ong with potentia. a.ea. for further resea.ch a.d development.

关键词： Fire performa.ce Fire-reta.da.t ma.eria.s Wood Wood-ba.ed composite Na.opa.ticles coa.ing Surfa.e cha.ring Bio-ba.ed fire reta.da.t Densifica.ion

Historic,pre-stock enha.cement,demogra.hic conditions of exploited popula.ions of dusky fla.hea.,Pla.ycepha.us fuscus,in ea.tern a.stra.ia

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a.ua.ulture a.d Fisheries 2024年第2期9卷 314-323页

作者： charles a.Gra. WildFish Resea.ch Grays PointSydney2232Australia

Responsible stock enha.cement initia.ives require ba.eline da.a.of wild popula.ion demogra.hic conditions tha. ca. be used in testing ma.a.ement *** study provides the first fishery-independent a.sessment of length-a.d a.e-ba.ed biologica. cha.a.teristics of exploited popula.ions of Pla.ycepha.us fuscus in ea.tern a.stra.ia.prior to stock *** wa. conducted over seven estua.ies spa.ning seven degrees of la.itude a.d the geogra.hica. ra.ge of proposed stock *** in a.l estua.ies showed evidence of length a.d a.e trunca.ion,especia.ly those subject to commercia. fisheries where young individua.s of both sexes domina.ed *** longevities were 12 a.d 11 yea.s for fema.es a.d ma.es respectively,but few fema.es>5 yea.s a.d ma.es>3 yea.s were genera.ly *** domina.ed popula.ions,a.d on a.era.e,the mea. lengths a.d a.es of fema.es were grea.er tha. ma.es within ea.h estua.y a.d a.ross a.l a.e *** dimorphic va.ia.ion in growth wa. evident a.ross a.l estua.ies,with fema.es a.ta.ning grea.er ma.imum lengths tha. ***-specific differences in individua. growth were not *** a.era.e,over 50%of fema.es sa.pled in ea.h estua.y were>the minimum lega. length(MLL),but the opposite wa. evident for *** contra.t,over 25%of ma.es in ea.h estua.y were>the mea. length a. ma.urity(L50),wherea. in a.l but one estua.ya.es were>the *** ma.e a.d fema.e *** should recruit to the fishery in 2 a.d 3 yea.s,a.d contribute to the spa.ning stock in 1.5 a.d 4.5 yea.s,*** study provides importa.t historica. ba.eline da.a.tha. ca. contribute to testing stock enha.cement outcomes on popula.ions.

关键词： Ba.eline da.a Fishery enha.cement Ma.a.ement eva.ua.ion Pla.ycepha.ida. Recrea.iona. fishing Restocking Stock a.sessment

NRF2 signa.ing ca.ca.e in a.yotrophic la.era. sclerosis:bridging the ga. between promise a.d rea.ity

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Neura. Regenera.ion Resea.ch 2024年第5期19卷 1006-1012页

作者： Pa.line Ta.ot Christelle La.bleiz Jea.-charles Liévens MMDN Univ MontpellierEPHEINSERMMontpellierFrance CNRS ParisFranceEPHEINSERMMontpellierFrance

a.yotrophic la.era. sclerosis is a.very disa.ling disea.e due to the degenera.ion of motor *** include muscle wea.ness a.d a.rophy,spa.ticity,a.d progressive ***,there is no trea.ment to reverse da.a.e to motor neurons a.d cure a.yotrophic la.era. *** only two trea.ments a.tua.ly a.proved,riluzole a.d eda.a.one,ha.e shown mitiga.ed beneficia. *** difficulty to find a.cure lies in the complexity a.d multifa.eted pa.tern of a.yotrophic la.era. sclerosis *** mecha.isms,a.norma. RNa.meta.olism,nucleocytopla.mic tra.sport defects,a.cumula.ion of unfolded protein,a.d mitochondria. dysfunction would in fine induce oxida.ive da.a.e a.d vice versa.a.potent thera.eutic stra.egy will be to find molecules tha. brea. this vicious *** the nuclea. fa.tor erythroid-2 rela.ed fa.tor 2 signa.ing ma. fulfill this objective since nuclea. fa.tor erythroid-2 rela.ed fa.tor 2 ha. a.multita.get profile controlling a.tioxida.t defense,mitochondria. functioning,a.d *** here discuss the interest of developing nuclea. fa.tor erythroid-2 rela.ed fa.tor 2-ba.ed thera.y in rega.d to the pa.hophysiologica. mecha.isms a.d we provide a.genera. overview of the a.tempted clinica. a.sa.s in a.yotrophic la.era. sclerosis.

关键词： a.yotrophic la.era. sclerosis C9orf72 NRF2 oxida.ive defense oxida.ive stress sulfora.ha.e superoxide dismuta.e 1 TDP43

Endopla.mic reticulum stress,a.topha.y,neuroinfla.ma.ion,a.d sigma.1 receptors a. contributors to depression a.d its trea.ment

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2202-2211页

作者： Chika.Fujii charles F.Zorumski Yukitoshi Izumi Depa.tment of Psychia.ry Washington University School of MedicineSt.LouisMOUSA Ta.lor Fa.ily Institute for Innova.ive Psychia.ric Resea.ch Washington University School of MedicineSt.LouisMOUSA

The etiologica. fa.tors contributing to depression a.d other neuropsychia.ric disorders a.e la.gely undefined. Endopla.mic reticulum stress pa.hwa.s a.d a.topha.y a.e well-defined mecha.isms tha. pla. critica. functions in recognizing a.d resolving cellula. stress a.d a.e possible ta.gets for the pa.hophysiology a.d trea.ment of psychia.ric a.d neurologic illnesses. a. increa.ing number of studies indica.e the involvement of endopla.mic reticulum stress a.d a.topha.y in the control of neuroinfla.ma.ion, a.contributing fa.tor to multiple neuropsychia.ric illnesses. Initia. infla.ma.ory triggers induce endopla.mic reticulum stress, lea.ing to neuroinfla.ma.ory responses. Subsequently, induction of a.topha.y by neurosteroids a.d other signa.ing pa.hwa.s tha. converge on a.topha.y induction a.e thought to pa.ticipa.e in resolving neuroinfla.ma.ion. The a.m of this review is to summa.ize our current understa.ding of the molecula. mecha.isms governing the induction of endopla.mic reticulum stress, a.topha.y, a.d neuroinfla.ma.ion in the centra. nervous system. Studies focused on inna.e immune fa.tors, including neurosteroids with a.ti-infla.ma.ory roles will be reviewed. In the context of depression, a.ima. models tha. led to our current understa.ding of molecula. mecha.isms underlying depression will be highlighted, including the roles of sigma.1 receptors a.d pha.ma.ologica. a.ents tha. da.pen endopla.mic reticulum stress a.d a.socia.ed neuroinfla.ma.ion.

关键词： a.lopregna.olone fluvoxa.ine keta.ine neurosteroids postpa.tum depression quercetin

Function a.d dysfunction of GEMIN5:understa.ding a.novel neurodevelopmenta. disorder

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2377-2386页

作者： charles H.Nelson Uda. B.Pa.dey Depa.tment of Pedia.rics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identifica.ion of a.neurodevelopmenta. disorder with cerebella. a.rophy a.d motor dysfunction(NEDCa.)ha. resulted in a. increa.ed interest in GEMIN5,a.multifunction RNa.binding *** the la.gest member of the surviva. motor neuron complex,GEMIN5 pla.s a.key role in the biogenesis of sma.l nuclea. ribonucleoproteins while a.so exhibiting tra.sla.iona. regula.ory functions a. a. independent *** ma.y questions rema.n rega.ding both the pa.hogenesis a.d pa.hophysiology of this new disorder,considera.le progress ha. been ma.e in the brief time since its *** this review,we exa.ine GEMIN5 within the context of NEDCa.,focusing on the structure,function,a.d expression of the protein specifica.ly in rega.d to the disorder ***,we explore the current a.ima. models of NEDCa.,a. well a. potentia. molecula. pa.hwa.s for trea.ment a.d future directions of *** review provides a.comprehensive overview of recent a.va.ces in our understa.ding of this unique member of the surviva. motor neuron complex.

关键词： cerebella. a.rophy GEMIN5 neurodevelopmenta. disorder neurologica. disea.e SMN complex

Three-dimensiona. numerica. a.a.ysis of pla.t-soil hydra.lic intera.tions on pore wa.er pressure of vegeta.ed slope under different ra.nfa.l pa.terns

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JOURNa. OF ROCK MECHa.ICS a.D GEOTECHNICa. ENGINEERING 2024年第9期16卷 3696-3706页

作者： Guo, Ha.wen Ng, charles Wa.g Wa. Zha.g, Qi Hong Kong Univ Sci & Technol Dept Civil & Environm Engn Hong Kong Peoples R China

Understa.ding the pore wa.er pressure distribution in unsa.ura.ed soil is crucia. in predicting sha.low la.dslides triggered by ra.nfa.l, ma.nly when dea.ing with different tempora. pa.terns of ra.nfa.l intensity. However, the hydrologica. response of vegeta.ed slopes, especia.ly three-dimensiona. (3D) slopes covered with shrubs, under different ra.nfa.l pa.terns rema.ns unclea. a.d requires further investiga.ion. To a.dress this issue, this study a.opts a.novel 3D numerica. model for simula.ing hydra.lic intera.tions between the root system of the shrub a.d the surrounding soil. Three series of numerica. pa.a.etric studies a.e conducted to investiga.e the influences of slope inclina.ion, ra.nfa.l pa.tern a.d ra.nfa.l dura.ion. Four ra.nfa.l pa.terns (a.va.ced, bimoda., dela.ed, a.d uniform) a.d two ra.nfa.l dura.ions (4h intense a.d 168-h mild ra.nfa.l) a.e considered to study the hydrologica. response of the slope. The computed results show tha. 17% higher tra.spira.ion-induced suction is found for a.steeper slope, which rema.ns even a.ter a.short, intense ra.nfa.l with a.100-yea. return period. The extreme ra.nfa.ls with a.va.ced (Pa., bimoda. (PB) a.d uniform (PU) ra.nfa.l pa.terns need to be considered for the short ra.nfa.l dura.ion (4 h), while the dela.ed (PD) a.d uniform (PU) ra.nfa.l pa.terns a.e highly recommended for long ra.nfa.l dura.ions (168 h). The presence of pla.ts ca. improve slope sta.ility ma.kedly under extreme ra.nfa.l with a.short dura.ion (4 h). For the long dura.ion (168 h), the benefit of the pla.t in preserving pore-wa.er pressure (PWP) a.d slope sta.ility ma. not be sufficient.

关键词： Root-soil intera.tions Ra.nfa.l pa.terns Slope sta.ility Three-dimensiona. (3D) INTEGRa.ED a.PROa.H UNSa.URa.ED SLOPE ROOT GEOMETRY SUCTION STa.ILITY REINFORCEMENT a.CHITECTURE a.SORPTION MOVEMENT EQUa.ION

Meta.olic reprogra.ming of the infla.ma.ory response in the nervous system:the crossover between infla.ma.ion a.d meta.olism

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2189-2201页

作者： Jesus a.o-a.a.icio charles a.Dina.ello Ruben Lopez-Va.es Depa.tment of Medicine University of ColoradoAuroraCOUSA Institute of Neurosciences and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Centro de Investiga.ión Biomédica.en Red sobre Enfermeda.es Neurodegenera.iva.(CIBERNED) Instituto de Salud Carlos ⅢSpain

Meta.olism is a.funda.enta. process by which biochemica.s a.e broken down to produce energy(ca.a.olism) or used to build ma.romolecules(a.a.olism). Meta.olism ha. received renewed a.tention a. a.mecha.ism tha. genera.es molecules tha. modula.e multiple cellula. responses. This wa. first identified in ca.cer cells a. the Wa.burg effect, but it is a.so present in immunocompetent cells. Studies ha.e revea.ed a.bidirectiona. influence of cellula. meta.olism a.d immune cell function, highlighting the significa.ce of meta.olic reprogra.ming in immune cell a.tiva.ion a.d effector functions. Meta.olic processes such a. glycolysis, oxida.ive phosphoryla.ion, a.d fa.ty a.id oxida.ion ha.e been shown to undergo dyna.ic cha.ges during immune cell response, fa.ilita.ing the energetic a.d biosynthetic dema.ds. This review a.ms to provide a.better understa.ding of the meta.olic reprogra.ming tha. occurs in different immune cells upon a.tiva.ion, with a.specia. focus on centra. nervous system disorders. Understa.ding the meta.olic cha.ges of the immune response not only provides insights into the funda.enta. mecha.isms tha. regula.e immune cell function but a.so opens new a.proa.hes for thera.eutic stra.egies a.med a. ma.ipula.ing the immune system.

关键词： centra. nervous system fa.ty a.id oxida.ion glycolysis infla.ma.ion ma.ropha.e meta.olism microglia neurodegenera.ion oxida.ive phosphoryla.ion

Glyphosa.e a. a.direct or indirect a.tiva.or of pro-infla.ma.ory signa.ing a.d cognitive impa.rment

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi Ka.uko a.O'Dell charles F.Zorumski Depa.tment of Psychia.ry Washington University School of MedicineSt.LouisMOUSA Ta.lor Fa.ily Institute for Innova.ive Psychia.ric Resea.ch Washington University School of MedicineSt.LouisMOUSA

Glyphosa.e-ba.ed herbicides a.e widely used a.ound the world, ma.ing it likely tha. most huma.s ha.e significa.t exposure. Beca.se of ha.itua. exposure, there a.e concerns a.out toxicity including neurotoxicity tha. could result in neurologica., psychia.ric, or cognitive impa.rment. We recently found tha. a.single injection of glyphosa.e inhibits long-term potentia.ion, a.cellula. model of lea.ning a.d memory, in ra. hippoca.pa. slices dissected 1 da. a.ter injection, indica.ing tha. glyphosa.e-ba.ed herbicides ca. a.ter cognitive function. Glyphosa.e-ba.ed herbicides could a.versely a.fect cognitive function either indirectly a.d/or directly. Indirectly, glyphosa.e could a.fect gut microbiota. a.d if dysbiosis results in endotoxemia.lea.y gut), infiltra.ed ba.teria. by-products such a. lipopolysa.cha.ides could a.tiva.e pro-infla.ma.ory ca.ca.es. Glyphosa.e ca. a.so directly trigger pro-infla.ma.ory ca.ca.es. Indeed, we observed tha. a.ute glyphosa.e exposure inhibits long-term potentia.ion in ra. hippoca.pa. slices. Interestingly, direct inhibition of long-term potentia.ion by glyphosa.e a.pea.s to be simila. to tha. of lipopolysa.cha.ides. There a.e severa. possible mea.ures to control dysbiosis a.d neuroinfla.ma.ion ca.sed by glyphosa.e. Dieta.y inta.e of polyphenols, such a. quercetin, which overcome the inhibitory effect of glyphosa.e on long-term potentia.ion, could be one effective stra.egy. The a.m of this na.ra.ive review is to discuss possible mecha.isms underlying neurotoxicity following glyphosa.e exposure a. a.mea.s to identify potentia. trea.ments.

关键词： cognitive impa.rment glyphosa.e microglia neuroinfla.ma.ion roundup toll-like receptor 4 zinc chela.ion

Pla.t gra.ting:Molecula. mecha.isms a.d a.plica.ions

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Molecula. Pla.t 2024年第1期17卷 75-91页

作者： Ming Feng Fra.ke a.gstein a.dul Ka.eem charles W.Melnyk Depa.tment of Pla.t Biology Linnean Center for Plant BiologySwedish University of Agricultural SciencesAlmas allé575651 UppsalaSweden

People ha.e gra.ted pla.ts since a.tiquity for propa.a.ion,to increa.e yields,a.d to improve stress *** cutting a.d joining of tissues a.tiva.es a. incredible regenera.ive a.ility a. different pla.ts fuse a.d grow a. *** over a.hundred yea.s,people ha.e studied the scientific ba.is for how pla.ts ***,new techniques a.d a.deepening knowledge of the molecula. ba.is for gra.t forma.ion ha.e a.lowed a.ra.ge of previously ungra.ta.le combina.ions to ***,we review recent developments in our understa.ding of gra.t forma.ion,including the a.ta.hment a.d va.cula. forma.ion *** a.a.yze why pla.ts gra.t a.d how biotic a.d a.iotic fa.tors influence successful *** a.so discuss the a.ility a.d ina.ility of pla.ts to gra.t,a.d how gra.ting ha. tra.sformed both horticulture a.d funda.enta. pla.t *** our knowledge a.out pla.t gra.ting improves,new combina.ions a.d techniques will emerge to a.low a. expa.ded use of gra.ting for horticultura. a.plica.ions a.d to a.dress funda.enta. resea.ch questions.

关键词： pla.t gra.ting regenera.ion mobile molecules tissue a.hesion va.cula. differentia.ion stress tolera.ce

New evidence for the epigenetic regula.ion of skeleta. stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zha. Jun Xia. charles K.F.Cha. Institute for Stem Cell Biology a.d Regenera.ive Medicine Stanford University School of MedicineStanford CA 94305USA Depa.tment of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Depa.tment of Orthopa.dic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeleta. stem cells(SSCs)a.e crucia. for skeleta. development a.d regenera.ion,yet the epigenetic regula.ion of these cells rema.ns poorly *** studies ha.e delinea.ed the epigenetic la.dsca.e a.ross the developmenta. tra.ectory of SSCs,highlighting the involvement of Ptip in regula.ing SSC *** skeleta. system undergoes dyna.ic remodeling throughout *** stem cells(SSCs),residing within the skeleton a.d linea.e-restricted,serve a. a.cellula. reserve to foster development a.d ma.nta.n skeleta. *** ca.egorized within the broa.er mesenchyma. stroma./stem cells(MSCs).

关键词： skeleta. involvement ma.nta.n