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作者： David f.Warner Nicholas K.Schiltz Kurt C.Stange charles W.Given Cynthia Owusu Nathan A.Berger Siran M.Koroukian Department of Sociology 711 Oldfather HallUniversity of Nebraska-Lincoln1400 R St.LincolnNE 68588USA Department of Epidemiology and Biostatistics School of MedicineWood BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA Department of family Medicine and Community Health Bolwell BuildingSchool of MedicineCase Western Reserve University11000 Euclid Ave.ClevelandOH 44106USA Department of family Medicine Clinical CenterMichigan State University788 Service Rd.East LansingMI 48824USA Division of Hematology/Oncology Department of MedicineSchool of MedicineWolstein BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA Case Comprehensive Cancer Center Wearn BuildingCase Western Reserve University11100 Euclid Ave.ClevelandOH 44106USA

Objective:To characterize complex multimorbidity among cancer survivors and evaluate the association between cancer survivorship,time since cancer diagnosis,and self-reported fair/poor health,self-rated worse health in 2 years,and 2-year ***:We used the 2010-2012 Health and Retirement *** survivors were indi-viduals who reported a(nonskin)cancer diagnosis 2 years or more before the *** defined complex multimorbidity as the co-occurrence of chronic conditions,functional limitations,and/or geriatric *** addition to descriptive analyses,we used logistic regression to evaluate the independent association between cancer survivor status and health *** also examined whether cancer survivorship differed by the number of years since ***:Among 15,808 older adults(age≥50 years),11.8%were cancer *** with cancer-free individuals,a greater percentage of cancer survivors had complex multimorbidity:co-occurring chronic conditions,functional limitations,and geriatric *** survivor-ship was significantly associated with self-reported fair/poor health,self-rated worse health in 2 years,and 2-year *** effects declined with the number of years since diagnosis for fair/poor health and mortality but not for self-rated worse ***:Cancer survivor status is independently associated with more complex multi-morbidity,and with worse health *** effects attenuate with time,except for patient perception of being in worse health.

关键词： Comorbidity functional limitations geriatric syndromes multimorbidity health status health decline mortality,cancer survivorship

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Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

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World Journal of Gastroenterology 2021年第14期27卷 1465-1482页

作者： Sarah A Malik Chencan Zhu Jinyu Li Joseph f LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie charles E Robertson Daniel N frank Ellen Li Department of Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794United States Stony Brook Cancer Center Biostatistics and Bioinformatics Shared Resource Stony Brook UniversityStony BrookNY 11794United States Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Surgery Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of family Population and Preventive MedicineStony Brook UniversityStony BrookNY 11794United States Cold Spring Harbor Laboratory Cancer Center Sequencing Technologies and Analysis Shared Resource Cold Spring HarborNY 11724United States Department of Medicine University of Colorado Anschutz Medical CampusAuroraCO 80045United States

BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human ***-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)*** hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk *** To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection *** Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from *** 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on *** sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥*** PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach *** mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level *** confirmed increased fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics *** coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor *** expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race *** Recent adoption of additional preoperative antibiotics as sta

关键词： Colorectal cancer Antibiotics African Continental Ancestry Group Diabetes mellitus 16S rRNA gene RNA-sequencing

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Effect of L-carnitine supplementation during in vitro maturation and in vitro culture on oocyte quality and embryonic development rate of bovines

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Asian pacific Journal of Reproduction 2019年第6期8卷 289-296页

作者： Diego f.Carrillo-González Nélida Rodríguez-Osorio charles R.Long Neil A.Vásquez-Araque Juan G.Maldonado-Estrada One Health and Veterinary Innovative Research and Development Group School of Veterinary MedicineUniversity of Antioquia050034 MedellinColombia faculty of Agricultural Sciences School of ZootechnicsUniversidad de SucreColombia Genomics and Bioinformatics Lab Department of Biological SciencesUniversity of the Republic of UruguaySalto CampusUruguay Department of Veterinary Physiology and Pharmacology College of Veterinary MedicineTexas A&M UniversityCollege StationTexas 77843-4466USA Grupo de investigación Biotecnología Animal Facultad de CienciasUniversidad Nacional de ColombiaSede MedellínMedellínColombia

Objective:To assess the effect of L-carnitine supplementation during in vitro oocyte maturation and in vitro culture process of bovine ***:L-carnitine(3.8 mM)was added to maturation medium and the effect was assessed in the quality(Experiment 1)and in the cleavage and 4-cells stage(Experiment 2).Besides,the effect of L-carnitine addition on maturation medium(3.8 mM)and culture medium(1.5 mM)on embryo rate production was *** Experiment 1,bovine oocytes from abattoir were randomly separated into two groups(the control group and L-carnitine group)forin vitro *** oocytes were examined for cumulus cells expansion as an indicator of maturation,and the content of the mitochondrial activity,the presence of lipid droplets,the reduced glutathione,and the reactive oxygen species were measured by using specific *** Experiment 2,oocytes were matured as performed in Experiment 1,afterward fertilized and cultured until day 3,and cleavage rate and 4-cells stage rate were *** Experiment 3,in vitro maturation and fertilization were done as performed in Experiment 2,but at day 3 of culture,each group of embryos was separated into two new groups,and L-carnitine(1.5 mM)was added in culture media until day *** cleavage and embryo development rate were determined on the basis with the oocytes put on *** rate was calculated from cleaved ***:The cumulus expansion rate at gradeⅢand mitochondrial activity were significantly higher in the L-carnitine group in comparison with the control group(P0.05).In addition,cleavage and the proportion of embryo development and hatching rate were similar for all groups(P>0.05).Conclusions:L-carnitine as a supplement in culture media improves the cumulus expansion and increases the mitochondrial activity during in vitro maturation process but has no apparent effect on the cleavage and development of bovine *** investigations of L-carnitine addition on in vit

关键词： Antioxidants Culture supplement Embryo development Lipid droplets Maturation Mitochondria

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