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PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3120-3133页

作者： Min Luo Yuhui Xia Fang Wang Hong Zhang Danting su chaoyue su Chuan Yang Shaocong Wu Sainan An suxia Lin Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhou 510060China Pharmacy College Guangzhou Medical UniversityGuangzhou 510182China

ERK pathway regulated the programmed death ligand-1(PD-L1)expression which was linked to the response of programmed death-1(PD-1)/PD-L1 blockade *** it is deducible that ERK inhibitor could enhance the efficacy of PD-1 inhibitor in cancer *** this study,PD0325901,an oral potent ERK inhibitor,strongly enhanced the efficacy of PD-1 antibody in vitro and in vivo models in non-small cell lung carcinoma(NSCLC)***,PD0325901 or shRNA-ERK1/2 significantly downregulated the PD-L1 expression in NSCLC cells and increased the CD3+T cells infiltration and functions in tumor *** was a positive correlation between the p-ERK1/2 expression and PD-L1 expression in patients with *** the patients with low p-ERK1/2 expression were observed a high response rate of PD-1/PD-L1 blockage *** results demonstrate that PD0325901,an ERK inhibitor,can enhance the efficacy of PD-1 blockage against NSCLC in vitro and in vivo *** the combination of ERK inhibitor such as PD0325901 and PD-1/PD-L1 blockage is a promising regimen and encouraged to be further confirmed in the treatment of patients with NSCLC.

关键词： ERK1/2 PD-L1 PD-1 PD0325901 NSCLC Immunotherapy Targeted therapy Combination therapy

Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2006-2018页

作者： Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu chaoyue su Hong Bi Jianye Zhang Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical University511436 GuangzhouGuangdongP.R.China Institute of Respiratory and Occupational Diseases Collaborative Innovation Center for CancerMedical CollegeShanxi Datong University037009 DatongP.R.China School of Chinese Medicine Hong Kong Baptist UniversityHong KongP.R.China College of Public Health Guangzhou Medical University511436 GuangzhouGuangdongP.R.China Cancer Center of Datong the Second People’s Hospital of Datong037005 ShanxiP.R.China GZMU-GIBH School of Life Sciences Guangzhou Medical University511436 GuangzhouGuangdongP.R.China Xinjiang Institute of Materia Medica 830004 UrumqiP.R.China Department of Pathology Shanxi Provincial People’s Hospital030012 TaiyuanP.R.China Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical University571199 HaikouP.R.China

Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and *** studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor ***,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well ***,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC *** results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC *** analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in *** shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in *** data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β***-34c-3p can be a diagnostic and prognostic marker for *** expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells.

关键词： invasion Exosomes cancer

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基于生成对抗网络的弹载图像盲去模糊算法

兵工学报 2024年第3期45卷 855-863页

作者：苏迪王少博张成陈志升刘超越北京理工大学宇航学院北京100081 杭州极弱磁场国家重大科技基础设施研究院浙江杭州310051 中国运载火箭技术研究院北京100076

低速旋转弹导引头具有抖动和旋转等运动特性,使得其采集图像存在严重的模糊特点,直接影响了后续图像算法对目标识别的准确性,进而影响制导精度。针对以上问题,提出一种基于生成对抗神经网络的盲去模糊算法。利用复合运动模糊仿真系统,... 详细信息

低速旋转弹导引头具有抖动和旋转等运动特性,使得其采集图像存在严重的模糊特点,直接影响了后续图像算法对目标识别的准确性,进而影响制导精度。针对以上问题,提出一种基于生成对抗神经网络的盲去模糊算法。利用复合运动模糊仿真系统,实现了对弹载图像抖动和旋转等运动模糊的模拟,并制作弹载图像模糊数据集。使用卷积神经网络作为生成器和判别器的基本架构,并设计多个损失函数共同优化网络,以减小图像在修复复原过程中的噪声并保持图像平滑。实现了弹载图像的去模糊,并获得更加稳定、清晰的图像序列。实验结果表明,该算法的去模糊效果在峰值信噪比、结构相似性指标上比现阶段其他算法更好,更符合人类视觉的主观感受,具有工程应用价值。

关键词：低速旋转弹弹载图像生成对抗网络盲去模糊

Light-driven soft actuator based on graphene and WSe2 nanosheets composite for multimodal motion and remote manipulation

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Nano Research 2023年第1期16卷 1313-1319页

作者： Zewen su Yingjie Zhao Youqiang Huang chaoyue Xu Xiaolei Yang Binrui Wang Beibei Xu Shiqing Xu Gongxun Bai College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018China Key laboratory of Modern Optical Instruments Zhejiang UniversityHangzhou 310018China

Remote controlled soft actuators have attracted ever-increasing interest in industrial,medical,robotics,and engineering *** actuators are charming than normal tools in executing dedicate tasks due to small volume and flexible body they ***,it remains a challenge to design soft actuator that can adapt to multi-environments under remote stimuli with promising nano ***,we have developed a kind of near-infrared laser driven soft actuators with multi locomotive modes based on WSe2 and graphene nanosheets *** locomotion modes are driven by photothermal effect induced deformation to adapt to different working ***,the specially designed gripper driven by pulsed laser can lift a heavy load which is four times of its *** work broadens the choice of advanced nanomaterials for photothermal conversion of soft *** is promising to realize applications including photothermal therapy and complex environment detection through the combination of the intelligent robot design and optical fiber system.

关键词： nanosheets heterostructure WSe2 graphene photothermal conversion light-driven soft actuator

Comparison of the meat quality and fatty acid profile of muscles in finishing Xiangcun Black pigs fed varied dietary energy levels

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Animal Nutrition 2022年第4期11卷 15-24页

作者： Can Yang Wenlong Wang Xiaowu Tang Ruilin Huang Fengna Li Wenxuan su Yulong Yin chaoyue Wen Jian Liu College of Life Sciences and Environment Hunan Provincial Key Laboratory of Biological Resources Protection and Utilization in Nanyue Mountain AreaHengyang Normal UniversityHengyangHunan 421008China Key Laboratory of Agro-ecological Processes in subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of ScienceChangsh1Hunan 410125China Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Hunan Normal UniversityChangshaHunan 410081China College of Bioengineering Hunan Vocational Technical College of Environment and BiologyHengyangHunan 421005China Key Laboratory of Animal Feed and Nutrition of Zhejiang Province College of Animal SciencesZhejiang UniversityHangzhou 310058China Xiangcun High-technology Agricultural Co.LTD LoudiHunan 417000China

To study the effects of dietary energy level on the meat quality of different muscles in finishing pigs,400Xiangcun Black pigs(BW=79.55±4.77 kg)were randomly assigned to 5 treatments with varied calculated digestive energy(DE)at 3,050,3,100,3,150,3,200 and 3,250 kcal/kg,*** treatment had 8replicates with 10 pigs per *** quality,amino acid and fatty acid composition were tested in this *** differences in average daily gain,average daily feed intake or feed-to-gain ratio(P>0.05)were observed among dietary *** concentrations of longissimus dorsi(LD)muscle in DE3150was higher than those in other groups(P<0.05).The crude fat concentration of biceps femoris(BF)muscle in DE3250 tended to be higher than that in DE3150 and DE3100 groups(P<0.05).Pigs in DE3250 and DE3200 had higher fiber density and smaller cross-sectional area of BF muscle than those in DE3150(P<0.05).Pigs in DE3150 had the highest Cu concentration in LD muscle compared with those in DE3200,DE3250(P<0.05).The C16:1 proportion of LD muscle was lower(P<0.01)and C20:1 was higher(P<0.05)in DE3050 than that in the other dietary *** C18:3n6 and C20:3n6 proportions of BF muscle in DE3150 were higher than those in DE 3050,DE3200 and DE3250(P<0.05).For LD muscle,m RNA expressions of type I and IIa MyHC in group DE3150 were higher than other treatments(P<0.01).The LD muscle in DE3150 expressed higher PPARd than in other groups(P<0.01).Pigs in DE3100 expressed higher FOX1 than in DE3200 and DE3250(P<0.05).Sterol-regulatory element binding proteins(SREBPa)mRNA expression decreased linearly when dietary energy level increased in BF muscle(P<0.01).In conclusion,a200 kcal/kg decrease in digestible energy for 4 consecutive weeks did not affect growth performance of Xiangcun Black ***,LD and BF muscle respond differently to dietary energy level,and meat quality was improved by the medium energy level during the finishing phase.

关键词： Energy Growth performance Fatty acid Myofibrillar morphology Muscle

Bacillus amyloliquefaciens 40 regulates piglet performance,antioxidant capacity,immune status and gut microbiota

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Animal Nutrition 2023年第1期12卷 116-127页

作者： Zipeng Jiang Weifa su Wentao Li chaoyue Wen Shuai Du Huan He Yu Zhang Tao Gong Xinxia Wang Yizhen Wang Mingliang Jin Zeqing Lu National Engineering Research Centre for Green Feed and Healthy Farming Zhejiang UniversityHangzhouChina Key Laboratory of Molecular Nutrition Ministry of EducationZhejiang UniversityHangzhouChina Key Laboratory of Animal Nutrition and Feed Ministry of Agriculture and Rural AffairsZhejiang UniversityHangzhouChina Key Laboratory of Animal Nutrition and Feed Nutrition of Zhejiang Province Zhejiang UniversityHangzhouChina College of Animal Science Institute of Feed ScienceZhejiang UniversityHangzhouChina

Probiotics can improve animal growth performance and intestinal *** species,Lactobacillus species,Bifidobacterium species,yeast *** the common types of ***,understanding the effects of probiotics on the immune status and gut microbiota of weaning piglets and how the probiotics exert their impact are still *** study aimed to investigate the effects of Bacillus amyloliquefaciens 40(BA40)on the performance,immune status and gut microbiota of piglets.A total of 12 litters of newborn piglets were randomly divided into 3 *** in control group were orally dosed with phosphate buffered saline;BA40 group and probiotics group were orally gavaged with resuspension BA40 and a probiotics product,*** results showed that BA40 treatment significantly decreased(Psulfovibrio and reducing the proliferation of pathogens(Streptococcus,Tyzzerella,Vellionella and paraeggerthella).Meanwhile,a metabolic function prediction explained that carbohydrate metabolism and amino acid metabolism enriched in BA40 group in contrast to control group and probiotics *** correlation analysis,the results demonstrated that BA40-enriched Phascolarctobacterium and Desulfovibrio provide insights into strategies for elevating the health status and performance of weaned ***,BA40 exerted stronger ability in decreasing diarrhea incidence and improved antioxidant activity,gut barrier function and immune status of piglets than the other *** study pr

关键词： Bacillus amyloliquefaciens Piglet Immune status Gut microbiota Metabolic function

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风量对冷库制冷系统性能的影响

低温与超导 2023年第8期51卷 76-81,94页

作者：李海军安彤苏之勇赵超越秦兴铎张逸博中原工学院能源与环境学院郑州450007

针对冷库制冷系统风量设定不合理导致系统制冷性能差的问题,采用准双级压缩补气技术,搭建了基于R404A的冷库制冷系统试验台。通过控制风量对系统总功率、制冷量进行调控,解析风量设定值对系统主要性能参数的影响规律。研究表明:当库内... 详细信息

针对冷库制冷系统风量设定不合理导致系统制冷性能差的问题,采用准双级压缩补气技术,搭建了基于R404A的冷库制冷系统试验台。通过控制风量对系统总功率、制冷量进行调控,解析风量设定值对系统主要性能参数的影响规律。研究表明:当库内风量在3500~7500 m3/h提高过程中,系统制冷量提高了0.23%~3.62%,COP增大了0.93%~16.61%,在风量达到6500 m^(3)/h时系统总功率存在最小值7.85 kW,EER存在最大值2.24,此时为最佳风量;当库外风量在3000~9000 m^(3)/h内提高过程中,系统制冷量提高了0.29%~5.9%,COP增大了2.37%~20.22%,在风量达到6500 m^(3)/h时总功率存在最小值6.31 kW,EER存在最大值2.17,此时为最佳风量。

关键词：风量冷库制冷系统准双级压缩

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安徽某露转井铁矿石工艺矿物学研究

现代矿业 2023年第10期39卷 116-119页

作者：杨召群翟冰艳尚超越苏康安徽马钢矿业资源集团南山矿业有限公司中钢集团马鞍山矿山研究总院股份有限公司

对于某露天转地下开采的矿山,为给高效处理矿石提供理论依据,开展了系统的工艺矿物学研究。结果表明:(1)矿石的有价成分铁含量为36.29%,有害成分硫、磷含量分别为0.07%和0.63%,矿石中的重点可选矿物赤铁矿含量为45.20%。(2)矿石中的赤... 详细信息

对于某露天转地下开采的矿山,为给高效处理矿石提供理论依据,开展了系统的工艺矿物学研究。结果表明:(1)矿石的有价成分铁含量为36.29%,有害成分硫、磷含量分别为0.07%和0.63%,矿石中的重点可选矿物赤铁矿含量为45.20%。(2)矿石中的赤铁矿颗粒粒径极细,94.00%的颗粒粒径小于0.07 mm、38.40%的颗粒粒径小于0.01 mm;石英的颗粒粒径总体较小,但比赤铁矿、褐铁矿粗,粒径小于0.07 mm的颗粒分布率为65.02%。(3)赤铁矿产出形式主要为细粒、微细粒,颗粒形态表现为片状、不规则状、鲕状、斑状颗粒,常与脉石矿物共生,部分与褐铁矿共生;赤铁矿的共生形式包括浸染状、网脉状、斑状、粒状、包裹状互嵌,少量交代磁铁矿形成半假象矿。(4)有价成分铁主要赋存在赤铁矿中,分布率为85.58%,其次赋存在褐铁矿中,分布率为9.80%,硅主要赋存在石英中,磷主要赋存在磷灰石中。

关键词：露天转井下铁矿石赤铁矿工艺矿物学

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安徽某露天矿挂帮矿工艺矿物学研究

现代矿业 2023年第11期39卷 137-140页

作者：杨召群翟冰艳尚超越苏康安徽马钢矿业资源集团南山矿业有限公司安徽省马鞍山243000 中钢集团马鞍山矿山研究总院股份有限公司

为了更好地利用某露天矿场中的挂帮矿,采用工艺矿物学的方法对其矿石性质进行了研究。研究结果表明:矿石铁含量为43.42%,SiO_(2)是主要脉石成分,含量26.89%,有害元素S、P含量分别为0.072%和0.542%;最主要的可选矿物为赤铁矿,但其大部分... 详细信息

为了更好地利用某露天矿场中的挂帮矿,采用工艺矿物学的方法对其矿石性质进行了研究。研究结果表明:矿石铁含量为43.42%,SiO_(2)是主要脉石成分,含量26.89%,有害元素S、P含量分别为0.072%和0.542%;最主要的可选矿物为赤铁矿,但其大部分呈微细粒浸染状分布,极难解离;其次为褐铁矿,常呈斑状与赤铁矿及脉石矿物共生。

关键词：挂帮矿铁矿石赤铁矿工艺矿物学