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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity vary.ng between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Positron-Lithium Atom and Electron-Lithium Atom Scattering Systems at Intermediate and High Energies

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Chinese Physics Letters 2006年第7期23卷 1753-1756页

作者： K. Ratnavelu S. y. ng Institute of Mathematical Sciences Faculty of Science University of Malaya 50603 Kuala Lumpur Malaysia Department of Physics Faculty of Science National University of Singapore Singapore

The coupled-channel optical method is used to study positron scattering by atomic lithium at energies ranging from the ionization threshold to 60eV, The present method simultaneously treats the target channels and the positronium （Ps） channels in the coupled-channel method together with the continuum effects via an ab-initio optical potential. Ionization, elastic and inelastic cross sections in target channels, and the total cross section are also reported and compared with other theoretical and experimental data. A comparative study with the corresponding electron-lithium data is also reported.

关键词： CLOSE-COUPLIng THEORy HyDROGEN SCATTERIng CROSS-SECTIONS COLLISIONS

On pancreatic cancer screening by magnetic resonance imaging with the recent evidence by Del Chiaro and colleagues

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Chinese Journal of Cancer Research 2015年第4期27卷 417-422页

作者： yì-Xiáng J.Wáng Jing-Shan Gong Romaric Loffroy Department of Imaging and Interventional Radiology Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Department of Radiology Shenzhen People’s Hospital Second Clinical Medicine College of Jinan University Department of Vascular Oncologic and Interventional Radiology Le2i UMR CNRS 6306 University of Dijon School of Medicine Bocage Teaching Hospital

Pancreatic cancer is a lethal disease because incidence and mortality rates are nearly *** 5-year survival rate in Western countries is 4%,the lowest among all types of cancer（1）.In China,pancreatic cancer is the sixth leading cause of death from malignant disease,with an overall cumulative 5-year survival rate of 1%to 3%（2,3）.

关键词： screening mortality intraductal cumulative lethal identical mucinous incidence familial pancreas

Shrinkage Properties of Wool and Acrylic/Wool Plain Knitted Fabrics Treated with DC109

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Journal of China Textile University(English Edition) 1999年第2期16卷 61-67页

作者： Au K.F ng K.y The Hong Kong Polytechnic Univ Hong Kong Hong Kong

This paper examines the effects of shrink - resist treatment, washing cycle and fabric tightness on the shrinkage properties of plain knitted fabrics made from 100% wool, acrylic/wool (50/50) and acrylic/wool (70/30). It was found that shrinkages of both treated and untreated wool fabrics were negatively correlated to fabric tightness and exceeded the IWS shrinkage limits (5% in length and 8 % in area) after 2 - 5A washing cycle. The effect of tightness was not as obvious with acrylic/wool (A/W) fabrics, but the shrinkage was seen to increase with stages of washing cycle for untreated A/W fabrics with some exceeding IWS standard. By apply.ng the DC 109 shrink - resist solvent treatment, it was identified that by with higher percentage of acrylic fibre blended with wool, shrinkage could be reduced considerably and within acceptable limits.

关键词： wool acrylic/wool shrink - resist treatment tightness factor washing cycle .

Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotechnology 2024年第3期19卷 60-79页

作者： yán Wāng yapeng Han De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgNPs),revered for their antimicrobial prowess,have become ubiquitous in a range of products,from biomedical equipment to food ***,amidst their rising popularity,concerns loom over their possible detrimental effects on fetal development and subsequent adult *** review delves into the developmental toxicity of AgNPs across diverse models,from aquatic species like zebrafish and catfish to mammalian rodents and in vitro embryonic stem *** focus encompasses the fate of AgNPs in different contexts,elucidating associated hazardous results such as embryotoxicity and adverse pregnancy ***,we scrutinize the enduring adverse impacts on offspring,spanning impaired neurobehavior function,reproductive disorders,cardiopulmonary lesions,and *** hallmarks of developmental harm are identified,encompassing redox imbalances,inflammatory cascades,DNA damage,and mitochondrial ***,we explore potential explanations,linking immunoregulatory dysfunction and disrupted epigenetic modifications to AgNPsinduced developmental *** substantial progress,our understanding of the developmental risks posed by AgNPs remains incomplete,underscoring the urgency of further research in this critical area.

关键词： Silver nanoparticles(AgNPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitochondrial dysfunction

Computational design of structured chemical products

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1033-1049页

作者： Faheem Mushtaq Xiang Zhang Ka y.Fung Ka M.ng Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina

In chemical product design,the aim is to formulate a product with desired *** and internal product structure are two key drivers of product performance with direct impact on the mechanical,electrical,and thermal ***,there is a keen interest in elucidating the dependence of product performance on ingredients,structure,and the manufacturing process to form the *** of product structure,particularly microstructure,is an intrinsically complex problem that involves different phases of different physicochemical properties,mass fraction,morphology,size distribution,and ***,computational methods have emerged that assist systematic microstructure quantification and *** objective of this paper is to review these computational methods and to show how these methods as well as other developments in product design can work seamlessly in a proposed performance,ingredients,structure,and manufacturing process framework for the design of structured chemical *** begins with the desired target properties and key *** is followed by computation for microstructure and then selection of processing steps to realize this *** framework is illustrated with the design of nanodielectric and die attach adhesive products.

关键词： product design performance ingredients structure manufacturing process framework structured chemical products microstructure design