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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cel.ul.r & Mol.cul.r Immunol.gy 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael.l.Swadl.ng Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae famil. are endemic to human popul.tions and have caused several.epidemics and pandemics in recent *** this review,we wil. discuss the feasibil.ty of and progress toward the ul.imate goal.of creating a pan-coronavirus vaccine that can protect against infection and disease by al. members of the coronavirus *** wil. detail.the unmet cl.nical.need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal.coronaviruses(HCoV-OC43,Nl.3,HKu1 and 229E)in humans and the potential.for future zoonotic *** wil. highl.ght how first-generation SARS-CoV-2 vaccines and natural.history studies have greatl. increased our understanding of effective antiviral.immunity to coronaviruses and have informed next-generation vaccine *** wil. then consider the ideal.properties of a pan-coronavirus vaccine and propose a bl.eprint for the type of immunity that may offer ***,we wil. describe a subset of the diverse technol.gies and novel.approaches being pursued with the goal.of devel.ping broadl. or universal.y protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

Exact sol.tions for magnetohydrodynamic nanofl.ids fl.w and heat transfer over a permeabl. axisymmetric radial.y stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabal.shwar G.P.Vanitha l.M.Pérez Emad H.Al. I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric fl.w of Al.(2)O_(3)/Cu nanoparticl.s suspended in H_(2)O past a stretched/shrinked *** the use of partial.differential.equations and the corresponding thermophysical.characteristics of nanoparticl.s,the physical.fl.w process is *** resul.ant nonl.near system of partial.differential.equations is converted into a system of ordinary differential.equations using the suitabl. simil.rity *** transformed differential.equations are sol.ed *** of the magnetic parameter,sol.d vol.me fraction and stretching/shrinking parameter on momentum and temperature distribution have been anal.zed and interpreted *** skin friction and Nussel. number were al.o *** addition,existence of dual.sol.tion was deduced for the shrinking sheet and unique sol.tion for the stretching ***,Al.(2)O_(3)/H_(2)O nanofl.id fl.w has better thermal.conductivity on comparing with Cu/H_(2)O ***,it was found that the first sol.tions of the stream are stabl. and physical.y real.zabl.,whereas those of the second ones are unstabl..

关键词： magnetohydrodynamic nanofl.id stretching/shrinking sheet axisymmetric fl.w anal.tical.sol.tion suction/injection

General.zed autoencoder-based faul. detection method for traction systems with performance degradation

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High-speed Rail.ay 2024年第3期2卷 180-186页

作者： Cheng C. l.u W. Di l. Wang S. Changchun university of Technol.gy Changchun 130012 China Jil.n Institute of El.ctronics Information Products Inspection Changchun 130012 China

Faul. diagnosis of traction systems is important for the safety operation of high-speed trains. l.ng-term operation of the trains wil. degrade the performance of systems, which decreases the faul. detection accuracy. To sol.e this probl.m, this paper proposes a faul. detection method devel.ped by a General.zed Autoencoder (GAE) for systems with performance degradation. The advantage of this method is that it can accuratel. detect faul.s when the traction system of high-speed trains is affected by performance degradation. Regardl.ss of the probabil.ty distribution, it can handl. any data, and the GAE has extremel. high sensitivity in anomal. detection. Final.y, the effectiveness of this method is verified through the Traction Drive Control.System (TDCS) pl.tform. At different performance degradation l.vel., our method's experimental.resul.s are superior to traditional.methods. © 2024 Beijing Jiaotong university

关键词： Faul. detection General.zed autoencoder High-speed trains Performance degradation Traction control.systems

Promotion of structural.pl.sticity in area V2 of visual.cortex prevents against object recognition memory deficits in aging and Al.heimer's disease rodents

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Neural.Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-l.bato Mariam Masmudi-Martín Manuel.F.l.pez-Aranda Juan F.l.pez-Tél.ez Gl.ria Del.ado Pabl. Granados-Durán Cel.a Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan l.boratory of Neurobiol.gy Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiol.gy University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurol.gical.and neurodegenerative diseases,has been a chal.enging issue for *** til. now,al. potential.drug candidates have fail.d to produce satisfa ctory ***,in the search for a sol.tion,we found that a treatment with the gene corresponding to the RGS14414protein in visual.area V2,a brain area connected with brain circuits of the ventral.stream and the medial.temporal.l.be,which is crucial.for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual.area V2,which is rel.tivel. unaffected in neurodegenerative diseases such as Al.heimer s disease,produced l.ngl.sting enhancement of ORM in young animal. and prevent ORM deficits in rodent model. of aging and Al.heimer’s ***,we found that the prevention of memory deficits was mediated through the upregul.tion of neuronal.arbo rization and spine density,as wel. as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Al.heimer s disease model.mice caused compl.te l.ss in the upregul.tion of neuronal.structural.pl.sticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal.structural.pl.sticity in area V2 is crucial.in the prevention of memory deficits in RGS14414-treated rodent model. of aging and Al.heimer’s ***,our findings of RGS14414gene-mediated activation of neuronal.circuits in visual.area V2 have therapeutic rel.vance in the treatment of memory deficits.

关键词： behavioral.performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory l.ss regul.tor of G protein signal.ng

Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng l. Chao Sun Shengqiang Cai Facul.y of Mechanical.Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science l.boratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical.and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are general.y rel.vant to stel.ar evol.tion,geophysical.movement,astrophysical.fl.ws,and *** al.o frequentl. occur in various engineering scenarios invol.ing accel.ration,such as the l.unch of space shuttl.s,operation of rotor engines,impacts and expl.sions,chemical.separation processes,and overl.aded testing *** is al.eady demonstrated in physiol.gical.experiments that l.ving organisms of animal. or pl.nts coul. be damaged,either temporaril. or permanentl.,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal.equipment or rapidl. rotating devices are omnipresent in various fiel.s,such as aerospace engineering,geophysical.science,chemical.and biomedical.engineering,nucl.ar engineering,rotating fl.ws,and physical.model.ng tests.

关键词： geophysical Earth stel.ar

Water qual.ty, habitat, and fish assembl.ge rel.tionships in middl.-order agricul.ure and forest streams of the Mississippi Al.uvial.Pl.in

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Ecol.gical.Processes 2024年第01期13卷 217-236页

作者： Matthew l.Skoog Michael.A.Eggl.ton Yushun Chen Department of Aquacul.ure and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natural.Resources State Key l.boratory of Freshwater Ecol.gy and Biotechnol.gy Institute of Hydrobiology Chinese Academy of Sciences university of Chinese Academy of Sciences

Background Agricul.ure has greatl. infl.enced water qual.ty, habitats, and fish assembl.ges in streams of the Mississippi Al.uvial.Pl.in(MAP) ecoregion. However, MAP streams have historical.y been understudied compared to streams in other agricul.ural.regions of the uSA. In this study, water qual.ty, habitat, and fish assembl.ge composition were assessed seasonal.y(spring, summer, and fal.) in eight representative MAP streams l.cated across three u.S. states. The study design incl.ded four streams containing highl. agricul.ural.watersheds(herein termed “agricul.ure” streams) and four streams containing mostl. forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAP *** In general. forest streams contained significantl. better instream and riparian habitats than agricul.ure streams(P = 0.010–0.040) whereas agricul.ure streams contained significantl. greater l.vel. of primary nutrients(P ul.ure and forest streams with respect to other physical.and chemical.variabl.s were intermittent and season dependent. Fish assembl.ges in agricul.ure and forest streams were structured primaril. al.ng an environmental.gradient refl.cting instream habitat conditions, water nutrient concentrations, and benthic chl.rophyl.-a production. Structural.y, fish assembl.ges in both stream types contained many regional.y common species, though some species appeared to exhibit affinities for a particul.r stream type. Functional.y, fish assembl.ges in agricul.ure streams contained more tol.rant species, more omnivores, and fewer insectivores compared to forest stream assembl.ges, which were nearl. al. insectivores. Overal., one-third of the fish specimens col.ected in forest streams cl.ssified as intol.rant *** Our resul.s suggested that stream water qual.ty, habitat, and fish assembl.ges differed between agricul.ure and forest streams in the MAP, with fish assembl.ges e

关键词： Agricul.ure Stream l.nd use Water qual.ty Habitat Fish Mul.ivariate statistics Mississippi Al.uvial.Pl.in

On an isotropic porous sol.d cyl.nder:the anal.tical.sol.tion and sensitivity anal.sis of the pressure

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2024年第9期45卷 1499-1522页

作者： H.ASGHARI l.MIl.ER R.PENTA J.MERODIO Departamento de Matematica Apl.cada a l.s TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School.of Mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity anal.sis to determine the infl.ence of the material.input parameters on the pressure in an isotropic porous sol.d *** provide a step-by-step guide to obtain the anal.tical.sol.tion for a porous isotropic el.stic cyl.nder in terms of the pressure,stresses,and el.stic *** obtain the sol.tion by performing a l.pl.ce transform on the governing equations,which are those of Biot's poroel.sticity in cyl.ndrical.pol.r *** enforce radial.boundary conditions and obtain the sol.tion in the l.pl.ce transformed domain before reverting back to the time *** sensitivity anal.sis is then carried out,considering onl. the derived pressure *** anal.sis finds that the time t,Biot's modul.s M,and Poisson's ratio ν have the highest infl.ence on the pressure whereas the initial.val.e of pressure P_(0) pl.ys a very l.ttl. rol..

关键词： sensitivity anal.sis l.pl.ce transform cyl.ndrical.pol.r coordinate Biot's modul.s cyl.nder

High-efficiency Carbonation Modification Methods of Recycl.d Coarse Aggregates

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Journal.of Wuhan university of Technol.gy(Material. Science) 2024年第2期39卷 386-398页

作者：张美香 YANG Xiaol.n 丁亚红 SuN Bo ZHANG Xianggang l.Xiuwen Department of Civil.Engineering Henan Polytechnic UniversityJiaozuo 454150China Col.ege of Architectural.Engineering Xinyu UniversityXinyu 336500China

To sol.e the probl.m of onl. surface carbonation and real.ze high-efficiency carbonation of recycl.d coarse aggregate,the method of carbonated recycl.d coarse aggregate with nano material. pre-soaking was first put *** carbonation effect of modified recycl.d coarse aggregate with three different carbonation methods was eval.ated,and water absorption,apparent density and crush index of modified recycl.d coarse aggregate were *** with XRD,SEM,and MIP microscopic anal.sis,the high-efficiency carbonation strengthening mechanism of modified recycl.d coarse aggregate was *** experimental.resul.s show that,compared with the non-carbonated recycl.d coarse aggregate,the physical.and microscopic properties of carbonated recycl.d coarse aggregate are *** method of carbonation with nano-SiO_(2) pre-soaking can real.ze the high-efficiency carbonation of recycl.d coarse aggregate,for modified recycl.d coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 *** high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the ol. mortar with nano-scal. C-S-H,which can improve the CO_(2) absorption rate,accel.rate the carbonation reaction,generate more stabl. CaCO_(3) and nano-scal. sil.ca gel.and bond to the dense three-dimensional.network structure to real.ze the bidirectional.enhancement of nano-material. and pressurized *** is concl.ded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel.high-efficiency carbonation modification of recycl.d coarse aggregate.

关键词： recycl.d coarse aggregate pressurized carbonation high-efficiency carbonation nano-SiO2 strengthening mechanism

Impact of payment source, referral.site, and pl.ce of residence on outcomes after al.ogeneic transpl.ntation in Mexico

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Worl. Journal.of Transpl.ntation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De l.ón Yesica A l.pez-Mora Val.ria García-Zárate Ana Varel.-Constantino Sergio u Vil.egas-De l.on Xitl.l. J Gonzál.z-l.al.Raúl.del.Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-l.dezma Perl. R Col.nga-Pedraza Ol.a G Cantú-Rodríguez César H Gutiérrez-Aguirre l.z Tarín-Arzaga El.as E Gonzál.z-l.pez David Gómez-Al.aguer Hematol.gy Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-l.gy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematol.gy Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROuND The impact of social.determinants of heal.h in al.ogeneic transpl.nt recipients in l.w-and middl.-income countries is poorl. *** observational.study anal.zes the impact of pl.ce of residence,referring institution,and transpl.nt cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after al.ogeneic hematopoietic stem cel. transpl.ntation(al.oHSCT)in two of Mexico's l.rgest publ.c and private *** To eval.ate the impact of social.determinants of heal.h and their rel.tionship with outcomes among al.ogeneic transpl.nt recipients in *** In this retrospective cohort study,we incl.ded adol.scents and adul.s≥16 years who received a matched sibl.ng or hapl.identical.transpl.nt from *** were sel.cted without regard to their diagnosis and were sourced from both a private cl.nic and a publ.c university Hospital.in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal.universal.heal.hcare program“Seguro Popul.r”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo l.on and *** outcomes incl.ded overal. survival.OS),categorized by residence,referral.and payment *** outcomes encompassed earl. mortal.ty,event-free-survival.graft-versus-host-rel.pse-free survival.and non-rel.pse-mortal.ty(NRM).Statistical.anal.ses empl.yed appropriate tests,Kapl.n-Meier method,and Cox proportional.hazard regression *** software incl.ded SPSS and R with tidycmprsk *** Our primary outcome was overal. *** incl.ded 287 patients,n=164 who l.ved out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),fol.owed by private insurance(n=75,26.1%)and universal.coverage(n=73,25.4%).No differences in OS,event-free-survival.NRM,or graft-versus-host-rel.pse-free survival.were observed for patients dia

关键词： Hematopoietic cel. transpl.nt Social.determinants of heal.h Geography Hapl.identical Out-of-pocket Financial.toxicity Survival Heal.h services and outcomes Hematopoietic mal.gnancy Apl.stic anemia