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Chinese Journal of Chemistry 2016年第2期34卷 210-214页

作者： Lianchao Liu chaojun shen Fangfang Dong Wenjing Wang Daqiang Yuan College of Chemistry Fuzhou University Fuzhou Fujian 350002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China

Two isostructural metal-organic frameworks formulated as [Gd7（L）4（μ3-OH）8（HCOO）（DMF）6（H20）].DMF·H2O （1） and [Tbv（L）4（P3-OH）8（HCOO）（DMF）5（HzO）]·DMFoH2O （2）（H3L=3,5-di（4＇-carboxylphenyl）benzoic acid） have been synthesized and structurally characterized. The building blocks of the structures are the heptanuclear lanthanide clusters of the dicubane-like type [Lnv7（μ3-OH）s]13＋（Ln=Gd, Tb） which are formally assembled into porous three-dimensional networks through the linkage of L. Variable temperature magnetic studies down to 2 K reveal antiferromagnetic interactions in complex 1. Furthermore, the fluorescence property of 2 was also studied.

关键词： MOFs heptanuclear lanthanide cluster magnetic fluorescent

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鼻内镜手术配合

护理研究 2006年第14期20卷 1281-1282页

作者：李荷花王苗峰沈超君浙江省台州医院

随着现代科技的发展,腔镜用于诊断、检查、手术治疗,功能不断扩大完善,并迅速扩展到多学科多病种[1].自2004年5月-2005年5月我院耳鼻咽喉科应用鼻内镜在彩色电视器直视下,对156例鼻咽部疾病病人进行了手术,获得满意效果.现将手术配合介... 详细信息

随着现代科技的发展,腔镜用于诊断、检查、手术治疗,功能不断扩大完善,并迅速扩展到多学科多病种[1].自2004年5月-2005年5月我院耳鼻咽喉科应用鼻内镜在彩色电视器直视下,对156例鼻咽部疾病病人进行了手术,获得满意效果.现将手术配合介绍如下.

关键词：鼻内镜手术病人局部麻醉局麻筛窦筛小房石油蜡凡士林

64排螺旋CT对下腔静脉阻塞布加氏综合征的诊断价值

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中国医疗设备 2017年第9期32卷 78-81页

作者：郭佳沈朝军胡淑敏姜研蚌埠市第一人民医院医学影像科安徽蚌埠233000

目的探讨64排螺旋CT(64-Slice Spiral CT)对下腔静脉阻塞布加氏综合征(Budd-Chiari Syndrom,BCS)的诊断价值。方法选择2012年1月到2016年5月期间,在我院诊治的40例下腔静脉阻塞BCS患者,临床症状为单纯性下腔静脉阻塞及肝静脉与下腔静脉... 详细信息

目的探讨64排螺旋CT(64-Slice Spiral CT)对下腔静脉阻塞布加氏综合征(Budd-Chiari Syndrom,BCS)的诊断价值。方法选择2012年1月到2016年5月期间,在我院诊治的40例下腔静脉阻塞BCS患者,临床症状为单纯性下腔静脉阻塞及肝静脉与下腔静脉混合型阻塞,采用随机表法,将患者分为组1(20例),组2(20例)。组1采取64排螺旋CT平扫及动态增强扫描,观察其在下腔静脉阻塞BCS中的影像表现,组2采取数字减影血管造影(Digital Subtraction Angiography,DSA)检查方式,观察其在下腔静脉阻塞BCS中的影像表现。结果诊断结束后,64排螺旋CT平扫及动态增强扫描对下腔静脉阻塞BCS患者均能做出的明确诊断,并且在肝静脉狭窄(χ~2=0.507,P=0.695)、出现侧枝循环(χ~2=0.008,P=0.618)等征象比较中,均不具有统计学意义(P>0.05)。结论 64排螺旋CT扫描以及DSA的诊断方式均能够准确、直观地反应下腔静脉阻塞BCS的阻塞部位、性质、范围及肝脏内的变化情况,能够从形态学及功能上反映出下腔静脉阻塞程度及肝脏损害程度。因此,64排螺旋CT对于诊断下腔静脉阻塞布加氏综合征具有较大的临床诊断价值。

关键词： 64排螺旋CT 下腔静脉阻塞布加氏综合征数字减影血管造影诊断价值

人工智能在冠状动脉CT血管成像图像后处理和冠状动脉狭窄诊断中的应用

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江苏大学学报（医学版） 2023年第4期33卷 323-327,332页

作者：祁冬姚传顺胡淑敏何兴义姚木子沈朝军蚌埠市第一人民医院医学影像科安徽蚌埠233000

目的:分析人工智能(artificial intelligence,AI)对冠状动脉CT血管成像(coronary CT angiography,CCTA)图像后处理和诊断冠心病的应用价值。方法:回顾性分析2020年1月至2022年1月40例同时行CCTA和经皮冠状动脉造影(coronary arteriography,CAG)患者的影像学资料。图像后处理及诊断分为人工组和AI组,比较两种方法后处理用时和图像质量主客观评分及评估冠状动脉斑块性质的差异。以CAG结果为金标准,以血管为单位,比较两种方法诊断冠状动脉狭窄的敏感性、特异性、阳性预测值、阴性预测值及准确率的差异,并采用Kappa检验评价其结果的一致性。结果:AI组后处理及诊断用时为(236.57±20.66)s,较人工组[(789.74±63.38)s]缩短了约70.04%(P0.05)。AI组检测斑块总准确率为96.32%(131/136)。人工组与AI组对冠状动脉钙化斑块、非钙化斑块及混合性斑块检出差异无统计学意义(P>0.05),且一致性较好(Kappa=0.901,P<0.001)。以血管为单位,AI组诊断冠状动脉狭窄的敏感性、特异性、阳性预测值、阴性预测值及准确率分别为87.72%(50/57)、94.12%(48/51)、94.34%(50/53)、87.27%(50/53)和90.74%(98/108),与CAG诊断冠状动脉狭窄一致性较好(Kappa=0.815,P<0.001)。结论:AI在CCTA图像后处理效率、斑块性质识别及冠脉狭窄诊断方面具有一定的优势,可作为分析诊断CCTA的有效辅助工具。

关键词：人工智能冠状动脉 CT血管成像图像后处理冠状动脉造影

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

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Science China(Life Sciences) 2015年第4期58卷 328-335页

作者： XU Na shen Ning WANG XiuXing JIANG Shan XUE Bin LI chaojun Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research Center and Medical School of Nanjing University National Resource Center for Mutant Mice

The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate(FPP) or geranylgeranyl pyrophosphate(GGPP) as the substrate, respectively. The prenylation occurs by covalent addition of these two types of isoprenoids to cysteine residues at or near the carboxyl terminus of the proteins that possess Caa X motif, such as Ras small GTPase family. The attachment of hydrophobic prenyl groups can anchor the proteins to intracellular membranes and trigger downstream cell signaling pathway. Geranylgeranyl biphosphate synthase(GGPPS) catalyzes the synthesis of 20-carbon GGPP from 15-carbon FPP. The abnormal expression of this enzyme will affect the relative content of FPP and GGPP, and thus disrupts the balance between protein farnesylation and geranylgeranylation, which participates into various aspects of cellular physiology and pathology. In this paper, we mainly review the property of this important protein post-translational modification and research progress in its regulation of cigarette smoke induced pulmonary disease, adipocyte insulin sensitivity, the inflammation response of Sertoli cells, the hepatic lipogenesis and the cardiac hypertrophy.

关键词： protein prenylation GGPP FPP biological function regulation

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1+3模式在规范皮试药物使用管理中的应用

中国医院 2014年第1期18卷 43-44页

作者：沈超君刘玲芬胡星霞冯常强马宗庆金丽君浙江省台州医院乳甲外科

针对皮试药物使用中存在的问题,通过寻找根本原因,提出整改措施,通过1+3模式对皮试药物使用管理进行持续质量改进,有效地降低了皮试药物使用缺陷率,提高了用药安全。

关键词： 1+3模式皮试药物患者安全

Membrane-targeting amphiphilic AIE photosensitizer for broad-spectrum bacteria imaging and photodynamic killing of bacteria

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Chinese Chemical Letters 2023年第9期34卷 183-187页

作者： Haining Zhang chaojun He Limin shen Wenjun Tao Jianhui Zhu Jinzhao Song Ziyong Li Jun Yin Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyang 471934China Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

An amphiphilic AIE photosensitizer has been successfully developed,which allows for easily inserting into the bacterial *** experiments with phospholipid preliminary demonstrates its membrane *** expected,it is proved to possess a broad-spectrum bacterial staining performance and photodynamic antibacterial activity toward *** and ***.

关键词： Photodynamic therapy Aggregation-induced emission Photosensitizer Membrane-targeting Singlet oxygen Broad-spectrum Bacteria imaging

Human activity and climate change triggered the expansion of rocky desertification in the karst areas of Southwestern China

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Science China Earth Sciences 2021年第10期64卷 1761-1773页

作者： chaojun CHEN Daoxian YUAN Hai CHENG Tsailuen YU Chuanchou shen RLawrence EDWARDS Yao WU Siya XIAO Jian ZHANG Tao WANG Ran HUANG Ziqi LIU Tingyong LI Junyun LI Chongqing Key Laboratory of Karst Environment School of Geographical SciencesSouthwest UniversityChongqing 400715China Key Laboratory of Karst Dynamics MNRGuangxiInstitute of Karst GeologyChinese Academy of Geological SciencesGuilin 541004China Yunnan Key Laboratory of Plateau Geographical Processes&Environmental Changes Faculty of GeographyYunnan Normal UniversityKunming 650500China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710049China High-precision Mass Spectrometry and Environment Change Laboratory(HISPEC) Department of GeosciencesTaiwan UniversityTaipei 10617China Research Center for Future Earth Taiwan UniversityTaipei 10617China Global Change Research Center Taiwan UniversityTaipei 10617China Department of Earth Sciences University of MinnesotaMinneapolisMN 55455USA Environnements et Paléoenvironnements Océaniques et Continentaux(EPOC) UMR CNRS 5805Universitéde BordeauxPessac 33600France School of Karst Science Guizhou Normal UniversityGuiyang 550001China

It is conducive to the sustainable development of human beings in karst regions to research the mechanism of karst rocky desertification(KRD)*** the large-scale KRD in southwestern China is caused by climate change or human activities is still *** this study,the evolution of the KRD in southwestern China over the past 2000 years was reconstructed through the high-precisionδ^(13)C record of stalagmites from Shijiangjun(SJJ)Cave,Guizhou Province,***δ^(13)C of the stalagmites from SJJ Cave exhibited heavy values from the Medieval Warm Period(MWP)to the Little Ice Age(LIA).Furthermore,theδ^(13)C records of other stalagmites and tufa from southwestern China also showed the same significant heavy *** the stalagmiteδ^(13)C could record the change of ecological environment,it indicated that the consistent change of the stalagmitesδ^(13)C may record the process of KRD expansion in the karst regions of southwestern *** the MWP,the stronger Asian summer monsoon and the northward movement of the rain belt led to a dry period in southwestern China and a wet period in northern *** contrast,it was wet in southwestern China and dry in northern China during the *** addition,after the Jing-Kang event(JK event,AD1127)occurred at the end of the Northern Song dynasty,the political and economic center of China migrated to southern China for the first time,which changed the population distribution pattern of larger population in the north and smaller population in the ***,the expansion of KRD in southwestern China was exacerbated in the MWP due to the change of climate in southwestern China,the migration of a large number of people,wars,the large-scale reclamation of arable land,and the cultivation of large areas of crops.

关键词： Karst rocky desertification Jing-Kang event Stalagmiteδ13C record Medieval Warm Period Little Ice Age

Resolving controversies surrounding carbon sinks from carbonate weathering

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Science China Earth Sciences 2024年第9期67卷 2705-2717页

作者： Xiaoyong BAI Sirui ZHANG Pete SMITH chaojun LI Lian XIONG Chaochao DU Yingying XUE Zilin LI Mingkang LONG Minghui LI Xiaoyun ZHANG Shu YANG Qing LUO Xiaoqian shen State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243UUUK College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550025China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

The importance of carbonate weathering carbon sinks(CCSs)is almost equal to that of vegetation photosynthesis in the global carbon ***,CCSs have become controversial in formulating carbon neutral policies to deal with global climate problems in various countries,since the carbonate dissolution is *** order to address these controversies,we reviewed recent advances in understanding CCSs and examined the outstanding controversies surrounding *** have analyzed the five controversies,revealing the existence of CCSs,quantifying their magnitude,clarifying their spatiotemporal pattern,and documenting how they have increased and how they evolved under the background of global *** addressing these five controversies,we help to bring clarity to the role of CCSs in the carbon cycle of global terrestrial ecosystems.

关键词： Carbon sink Carbonate weathering Carbon cycle Climate change Anthropogenic driver

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HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation

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Molecular Plant 2020年第3期13卷 515-531页

作者： Chao Yang Wenjin shen Lianming Yang Yun Sun Xibao Li Minyi Lai Juan Wei chaojun Wang Yingchao Xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenCore Botanical GardensChinese Academy of SciencesGuangzhou 510650China College of Life Sciences Leshan Normal UniversityLeshan 614004China College of Life Sciences South China Agricultural UniversityGuangzhou 510642China School of Advanced Agricultural Sciences and School of Life Sciences Peking University100871 BeijingChina Center of Economic Botany Core Botanical GardensChinese Academy of SciencesGuangzhou 510650China These authors contributed equally to this article

Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in *** this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression ***5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone ***,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated *** analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy ***,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants.

关键词： autophagy histone acetylation HY5 HDA9 light-to-dark shift nitrogen starvation