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改良封闭式负压引流技术在骨外科创伤治疗中的应用

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大医生 2020年第2期5卷 46-48页

作者：郑朝东广东省肇庆市中医院广东肇庆526020

目的分析改良封闭式负压引流技术(VSD)治疗骨外科创伤的临床治疗效果。方法选取广东省肇庆市中医院2017年2月至2018年9月收治的50例骨外科创伤患者为研究对象。依据患者入院时间将其分为对照组(26例)与观察组(24例)。对照组采用常规封... 详细信息

目的分析改良封闭式负压引流技术(VSD)治疗骨外科创伤的临床治疗效果。方法选取广东省肇庆市中医院2017年2月至2018年9月收治的50例骨外科创伤患者为研究对象。依据患者入院时间将其分为对照组(26例)与观察组(24例)。对照组采用常规封闭式负压引流技术治疗,观察组采用改良封闭式负压引流技术治疗。分析2组患者治疗效果、不良反应发生率等指标。结果观察组患者治疗有效率高于对照组,且出现不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论采用改良封闭式负压引流技术治疗骨外科创伤可有效提高临床治疗效果,且患者并发症发生率较低,具有临床推广价值。

关键词：改良封闭式负压引流技术骨外科创伤

An Estimation Method for Multi-channel EEG Data Based on Canonical Correlation Analysis

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Chinese Journal of Electronics 2015年第3期24卷 569-572页

作者： YAN zheng WAN Xiaojiao LING chaodong Department of Information Science and Engineering Huaqiao University

Electroencephalogram(EEG) signal is often contaminated by electronic noise as well as movement artifacts. This paper presented an algorithm based on Canonical correlation analysis(CCA) to estimate multichannel EEG data. Different from previous studies, in which CCA was mainly used to detect the invariant features specific to each brain state, in this paper, the canonical variates computed by CCA were used to reconstruct the multi-channel EEG data. Firstly, two data sets, EEG signals and the reference signals based on prior knowledge were constructed. Next, canonical variates were computed by pro jecting the two data sets onto basis vectors. Finally,a least squares solution was used to estimate the multichannel EEG data. The experiment results suggested that the algorithm is capable of reconstructing the actual specific components with high quality. We also hint future possible application of the algorithm in the estimation of functional connectivity patterns at the end of the paper.

关键词： Electroencephalogram(EEG) Canonical correlation analysis(CCA) Canonical variates

Metformin and metabolic diseases： a focus on hepatic aspects

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Frontiers of Medicine 2015年第2期9卷 173-186页

作者： Juan zheng Shih-Lung Woo Xiang Hu Rachel Botchlett Lulu Chen Yuqing Huo chaodong Wu Department of Nutrition and Food Science Texas A &M University College Station TX 77843 USA Department of Endocrinology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Drug Discovery Center Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen 518055 China

Metformin has been widely used as a diabetes （T2D）. As a drug that primarily targets first-line anti-diabetic medicine for the treatment ot type Z the liver, metformin suppresses hepatic glucose production （HGP）, serving as the main mechanism by which metformin improves hyperglycemia of T2D. BiochemicaUy, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase （AMPK）-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

关键词： metformin diabetes hepatic steatosis inflammatory response insulin resistance

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谈三维坐标法在钢结构异形项目中的应用

山西建筑 2024年第21期50卷 163-167页

作者：李亚博薛韧杨宝杨朝东郑宇中建钢构设计研究院深化设计院四川眉山620000

三维坐标法在异形钢结构项目中的应用,极大地提高了深化设计、制造和安装的精确度与效率。文中主要探讨三维坐标法在钢结构异形项目中的应用,包括其基本原理、应用优势以及实际案例分析。通过三维坐标法在工程中的应用研究,进一步阐明... 详细信息

三维坐标法在异形钢结构项目中的应用,极大地提高了深化设计、制造和安装的精确度与效率。文中主要探讨三维坐标法在钢结构异形项目中的应用,包括其基本原理、应用优势以及实际案例分析。通过三维坐标法在工程中的应用研究,进一步阐明其在现代钢结构工程中的重要性和应用前景,为相关领域的工程师和研究人员提供实用的参考与支持。

关键词：三维坐标法异形钢结构深化设计制造和安装

The complete mitochondrial genome of Parnassius actius(Lepidoptera： Papilionidae： Parnassinae) with the related phylogenetic analysis

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Zoological Systematics 2018年第1期43卷 1-17页

作者： Bin zheng Yunliang Wang Chenchen Xia Dunyuan Huang Yan Cao Jiasheng Hao chaodong Zhu Laboratory of Molecular Evolution and Biodiversity College of Life Sciences Anhui Normal University Wuhu 241000 China Key Laboratory of Zoological Systematics and Evolution Institue of Zoology Chinese Academy of Sciences Beijing 100101 China Departmet of Forestry Jiangxi Environmental Engineering College Ganzhou 341002 China

In this study, the complete mitochondrial genome of Parnassius actius（Lepidoptera： Papilionidae： Parnassinae） was reported. Meanwhile, the phylogenetic position of this Apollo species was inferred from this sequence combined with other available related sequence data. The results showed that the whole mitogenome is 15,386 bp in length, containing 13 typical protein-coding genes（PCGs）, 22 transfer RNA genes（t RNAs）, two ribosomal RNA genes（r RNAs） and a noncoding control region（A＋T-rich region）. The mitogenomic gene orientation and arrangement are the same with other sequenced Parnassius species. Thirteen protein coding genes is 11,195 bp in size, encoding 3,720 amino acids totally; the lr RNA and sr RNA genes are 1,351 bp and 779 bp, respectively. Eleven intergenic spacers ranging from 1 to 40 bp（129 bp in total）, 10 overlapping regions from 1 to 8 bp（26 bp in total）, and a 504 bp A＋T-rich region harboring some Parnassius-specific sequences are scattered throughout the whole mitogenome. The maximum likelihood and Bayesian phylogenetic analyses showed that the genus Parnassiusof this study contained five major clades which can be categorized into the eight subgenera reported by the previous molecular studies; additionally, the P. actius was shown to be more closely related to P. nomion than other Parnassius species, suggesting that the P. actius stands as an effective species with its phylogenetic position awaiting further studies.

关键词： Lepidoptera Parnassiinae Parnassius actius mt DNA phylogenetic analysis

Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation

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Liver Research 2020年第3期4卷 136-144页

作者： Xin Guo Bilian Zhu Hang Xu Honggui Li Boxiong Jiang Yina Wang Benrong zheng Shannon Glaser Gianfranco Alpini chaodong Wu Department of Nutrition Texas A&M UniversityCollege StationTXUSA Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Department of VIP Medical Service Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Medical Physiology Texas A&M University College of MedicineBryanTXUSA Hepatology and Gastroenterology MedicineIndiana UniversityIndianapolisINUSA Richard L.Roudebush VA Medical Center IndianapolisINUSA

Background and objectives:Hepatic steatosis and inflammation are key characteristics of non-alcoholic fatty liver disease(NAFLD).However,whether and how hepatic steatosis and liver inflammation are differentially regulated remains to be *** that disruption of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(Pfkfb3/iPfk2)dissociates fat deposition and inflammation,the present study examined a role for Pfkfb3/iPfk2 in hematopoietic cells in regulating hepatic steatosis and inflammation in ***:Pfkfb3-disrupted(Pfkfb3^(+/-))mice and wild-type(WT)littermates were fed a high-fat diet(HFD)and examined for NAFLD ***,bone marrow cells isolated from Pfkfb3^(+/-)mice andWT mice were differentiated into macrophages for analysis of macrophage activation status and for bone marrow transplantation(BMT)to generate chimeric(WT/BMT-Pfkfb3^(+/-))mice in which Pfkfb3 was disrupted only in hematopoietic cells and control chimeric(WT/BMT-WT)*** latter were also fed an HFD and examined for NAFLD *** vitro,hepatocytes were co-cultured with bone marrowderived macrophages and examined for hepatocyte fat deposition and proinflammatory ***:After the feeding period,HFD-fed Pfkfb3^(+/-)mice displayed increased severity of liver inflammation in the absence of hepatic steatosis compared with HFD-fed WT *** inflammatory activation was analyzed,Pfkfb3^(+/-)macrophages revealed increased proinflammatory activation and decreased anti-proinflammatory *** NAFLD phenotype was analyzed in the chimeric mice,WT/BMT-Pfkfb3^(+/-) mice displayed increases in the severity of HFD-induced hepatic steatosis and inflammation compared with WT/BMT-WT *** the cellular level,hepatocytes co-cultured with Pfkfb3^(+/-) macrophages revealed increased fat deposition and proinflammatory responses compared with hepatocytes co-cultured with WT ***:Pfkfb3 disruption only in hematopoietic cells exacerbates HFD-induce

关键词： 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(Pfkfb3/iPfk2) Hematopoietic cells Hepatic steatosis Inflammation Macrophages

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玻璃连栋温室正压通风降温系统的设计与试验

中国农业大学学报 2020年第1期25卷 152-162页

作者：刘佳李旭王朝栋郑刚张天柱北京中农富通园艺有限公司北京100083 中国农业大学水利与土木工程学院北京100083

针对我国大型玻璃连栋温室夏季降温难度大、温度分布不均匀的问题,引入荷兰半封闭温室环境控制理念,采用正压通风降温技术,以湿帘蒸发降温提供冷源,对管道风机、送风管等关键机构进行分析计算和设计,建立连栋温室正压通风降温系统,并进... 详细信息

针对我国大型玻璃连栋温室夏季降温难度大、温度分布不均匀的问题,引入荷兰半封闭温室环境控制理念,采用正压通风降温技术,以湿帘蒸发降温提供冷源,对管道风机、送风管等关键机构进行分析计算和设计,建立连栋温室正压通风降温系统,并进行适应性生产试验。试验依托河北南和设施农业产业集群项目,以采用湿帘-风机负压降温系统的温室为对照,对采用正压通风降温系统的温室,进行降温效果对比试验。试验结果表明:1)送风管各侧孔出风风速基本一致,送风均匀性高;2)采用正压通风降温系统的温室室内温度平均高于对照温室3.7℃,极端高温时可高出6.8℃。在河北南和地区,传统湿帘-风机负压通风降温系统的降温效果优于创新设计的正压通风降温系统,正压通风降温系统的实现方式还需改进,在我国的适用性有待进一步研究。

关键词：连栋温室正压通风降温管道风机

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北京首条矩形顶管风险防控设计与沉降分析

地下空间与工程学报 2021年第4期17卷 1281-1290页

作者：郑知斌李名淦闫朝涛郝朝东孟瑞明北京市市政工程设计研究总院有限公司北京100082 北京新航城开发建设有限公司北京102604

北京新机场临空经济区永兴河北路综合管廊需下穿大庆—广州高速路,因管廊设计需规避或降低风险点,经过明挖、暗挖、矩形顶管等工艺比选,认为矩形顶管具有无需降水、控制地层沉降、工期进度较快、道路及管线无需迁改等优势,故采取双孔大... 详细信息

北京新机场临空经济区永兴河北路综合管廊需下穿大庆—广州高速路,因管廊设计需规避或降低风险点,经过明挖、暗挖、矩形顶管等工艺比选,认为矩形顶管具有无需降水、控制地层沉降、工期进度较快、道路及管线无需迁改等优势,故采取双孔大断面矩形顶管穿越高速路。(1)通过受力计算分析,采取合理设置管节中隔墙,增加矩形顶管整体刚度,可减少地层变形,减少板厚、降低配筋率,从而控制投资;(2)通过确定适宜的土仓压力、压注减摩泥浆、地层补充注浆等措施,可有效减少地层扰动。监测结果表明,矩形顶管掘进完成后,高速路面最终沉降仅约为-25 mm。(3)通过沉降监测数据分析,得出矩形顶管掘进最优参数、双孔矩形顶管引起的路面沉降规律及影响范围计算方法。

关键词：大断面矩形顶管沉降控制土压平衡管节内力

一种应用于电容式微机械陀螺的改进型积分器研究

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梧州学院学报 2010年第3期20卷 44-48页

作者：莫冰郑琦凌朝东华侨大学厦门361021

电容式微机械陀螺通常都采用积分器作为前级输入模块,实现高频调制和电容电压转换的功能。传统积分器的转换增益与反馈电容成反比,而反馈电容的值太小,会引起电路自激震荡,因此传统积分器对有用信号的放大倍数有限,系统的信噪比较低。对... 详细信息

电容式微机械陀螺通常都采用积分器作为前级输入模块,实现高频调制和电容电压转换的功能。传统积分器的转换增益与反馈电容成反比,而反馈电容的值太小,会引起电路自激震荡,因此传统积分器对有用信号的放大倍数有限,系统的信噪比较低。对此,提出了一种应用于电容式微机械陀螺的改进型积分器,这种积分器的转换增益可以通过调节电容比值而得到较大值,因此能够提高系统的信噪比。该文在分别分析两种积分器工作原理的基础上,通过理论分析及仿真结果对比,证明了改进型积分器能够提高有用信号的放大倍数。

关键词：电容式微机械陀螺积分器信噪比