Metformin and metabolic diseases： a focus on hepatic aspects

作     者：Juan Zheng Shih-Lung Woo Xiang Hu Rachel Botchlett Lulu Chen Yuqing Huo Chaodong Wu 

作者机构：Department of Nutrition and Food Science Texas A &M University College Station TX 77843 USA Department of Endocrinology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Drug Discovery Center Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen 518055 China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2015年第9卷第2期

页      面：173-186页

核心收录：

学科分类：090603[农学-临床兽医学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 10[医学] 

基　　金：by National Natural Science Foundation of China(to J.Z.) National Key Basic Research Program of China (to Y. H.) ADA AHA NIH/NIDDK (to C.W.) 

主　　题：metformin diabetes hepatic steatosis inflammatory response insulin resistance 

摘      要：Metformin has been widely used as a diabetes （T2D）. As a drug that primarily targets first-line anti-diabetic medicine for the treatment ot type Z the liver, metformin suppresses hepatic glucose production （HGP）, serving as the main mechanism by which metformin improves hyperglycemia of T2D. BiochemicaUy, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase （AMPK）-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.