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汉语连续语音识别之音素声学模型的改进

计算机仿真 2010年第5期27卷 355-358页

作者：吕丹桔 Mei-yuh Huang B Hoffmeister 西南林学院计算机与信息科学系云南昆明650224 微软亚洲研究院雷蒙得华盛顿美国98052 亚琛工业大学计算机第六研究所亚琛德国52056

研究基于主元音音素基元的声学模型的改进。由于汉语语音特点,主元音模型得到了广泛的应用。通过分析主元音音素模型,发现该模型存在词组音节序列字界线有歧义,从而提出主元音的改进方法以明确音节序列中字的分界,减小基元规模,提高语... 详细信息

研究基于主元音音素基元的声学模型的改进。由于汉语语音特点,主元音模型得到了广泛的应用。通过分析主元音音素模型,发现该模型存在词组音节序列字界线有歧义,从而提出主元音的改进方法以明确音节序列中字的分界,减小基元规模,提高语音系统识别率。为了描述连续语意中的协同发音现象,还针对改进后的主元音基元,设计了相应的有调问题集,利用决策树的参数共享策略建立了上下文相关的音素模型。实验结果表明,改进后的有调音素集合在削减了原有基元个数的基础上,字误识率(CER)有0.4%-0.6%的明显改善。

关键词：大词汇量连续汉语语音识别音素主元音决策树

Fenestrated Basilar Artery Associated with Multiple Aneurysms

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第4期23卷 418-419,426页

作者：李文彬李明华 H.Grady Daniel Dee H.Wu Timothy L.Tytle Rifat Karatas Yasemin Karatas William T.C.yuh Department of Radiology the Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200233 Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

No abstract available

关键词： fenestrated basilar artery multiple aneurysm

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粪悬液中肠道细菌的活性检测

基因组学与应用生物学 2020年第12期39卷 5580-5585页

作者：胡赢心陈傲蕾罗倩 Loh yuh Jiun 庞小燕上海交通大学生命科学技术学院微生物代谢国家重点实验室上海200240

近年来,粪菌移植技术在临床上被尝试用于多种疾病的治疗。肠道细菌是粪菌移植中的主要功效成分,粪悬液制备和保存过程中的细菌活性与粪菌移植的临床疗效直接相关。本研究采用SYTO BC-PI双染色与流式细胞术结合的方法检测粪悬液样品中活... 详细信息

近年来,粪菌移植技术在临床上被尝试用于多种疾病的治疗。肠道细菌是粪菌移植中的主要功效成分,粪悬液制备和保存过程中的细菌活性与粪菌移植的临床疗效直接相关。本研究采用SYTO BC-PI双染色与流式细胞术结合的方法检测粪悬液样品中活细菌、死细菌以及受损细菌的比例,藉此反应肠道细菌的活性状态。通过比较了有氧以及厌氧环境下制备粪悬液对肠道细菌活性的影响,并探究了目前粪悬液常用的保存条件(即置于10%甘油溶液中,-80℃冻存)对肠道细菌活性的保护效果。结果表明,有氧条件下制备的粪悬液的细菌活性显著低于厌氧条件下制备的粪悬液,提示粪悬液的制备应在厌氧条件下操作。粪悬液直接冻存会显著降低细菌的活性。添加10%甘油作为保护剂对肠道细菌活性有一定的保护作用,粪悬液中原有活细菌的79%经过冻存后仍保留活性。本研究的结果将为粪菌移植技术的优化和标准化提供依据。

关键词：粪菌移植粪悬液细菌活性流式细胞术

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混合现实技术在口腔颌面部肿瘤手术中的应用

北京大学学报（医学版） 2020年第6期52卷 1124-1129页

作者：唐祖南 Hui yuh Soh 胡耒豪于尧章文博彭歆北京大学口腔医学院·口腔医院口腔颌面外科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081

目的:探讨混合现实技术在口腔颌面部肿瘤手术中的应用价值。方法:选择2018年12月—2020年1月就诊于北京大学口腔医院口腔颌面外科需行手术治疗的肿瘤患者,将患者术前增强CT原始数据导入星图医学影像工作站(维卓致远,中国北京),分别对肿... 详细信息

目的:探讨混合现实技术在口腔颌面部肿瘤手术中的应用价值。方法:选择2018年12月—2020年1月就诊于北京大学口腔医院口腔颌面外科需行手术治疗的肿瘤患者,将患者术前增强CT原始数据导入星图医学影像工作站(维卓致远,中国北京),分别对肿瘤、血管、骨骼等重要解剖结构进行三维模型重构,显示其术前空间关系,对重点结构进行标记,并进行术前规划。通过混合现实技术在术区立体显示三维重建模型,术者利用简单手势在术中保持无菌状态下对眼前的三维重建模型进行调整,观察肿瘤范围、大小、位置及其与周围临近重要解剖结构的关系。应用混合现实技术辅助手术进行,手术开始前进行三维模型配准,肿瘤显露过程中进行术中验证,术后利用Likert量表对混合现实技术的应用效果进行评价。结果:入选的8例患者均顺利实施了混合现实技术辅助下的肿瘤切除手术,手术过程中三维重建模型平均配准时间为12.0 min,术者在所有病例的手术中均都能直观、立体地观看肿物以及周围解剖结构的三维重建模型,并可在术中自行调整图像。Likert量表评价结果显示:在感知准确性、帮助确定解剖部位、术中图像引导作用,以及改善手术安全性的潜力方面均获得较高评分(分别为4.22、4.19、4.16和4.28分)。8例患者术后愈合良好,无手术并发症发生。结论:混合现实技术能通过三维重建模型实时立体可视化,提供术区解剖结构信息,引导和修正手术操作,提高口腔颌面部肿瘤切除手术的准确性和安全性。

关键词：混合现实口腔颌面部肿瘤三维重建

Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin

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World Journal of Gastroenterology 2005年第27期11卷 4241-4245页

作者： Chia-Yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-Po Lee Ming-Yen Hsieh Nei-Jen Hou Zu-Yau Un Ming-yuh Hsieh Liang-Yen Wang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung TaiwanChina Department of Occupational Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Taiwan China

AIM： The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C （CHC） and response of both viruses to combination therapy with high-dose interferon-alfa （IFN） plus ribavirin remain uncertain and are being ***： Total 164 （97 males and 67 females, the mean age 48.1＋11.4 years, range： 20-73 years, 128 histologically proved） naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR *** of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay （COBAS AMPLICOR HCV Test, version 2.0）. HCV genotypes la,lb, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay （Quantiplex HCV RNA 3.0）. There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is ***： Sixty-one （37.2%） patients were positive for SENV-D DNA and had higher mean age than those who were negative （50.7＋ 10.6 years vs 46.6＋ 11.6 years,P = 0.026）. The rate of sustained viral response （SVR） for HCV and SENV-D were 67.3% （105/156） and 56.3% （27/48）, respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b （P〈0.001）, younger ages （P = 0.014）, lower pretreatment levels of HCV RNA （P = 0.019） and higher histological activity index （HAI） score for intralobular regeneration and focal necrosis （P= 0.037）. By multivariate analyses, HCV genotype non-lb, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR （odds ratio （OR）/95% confidence interval （CI）： 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively）. The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy （P = 0.04）.CONCLUSION： Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Resi

关键词： Chronic hepatitis C Combination therapy Interferon Ribavirin SENV-D

Impact of Organic Soil Amendments on the Physical Characteristics and yield Components of Potato （Solanum tuberosurn L.） in the Highlands of Cameroon

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Journal of Agricultural Science and Technology(A) 2013年第4期3卷 257-266页

作者： Takoutsing Bertin Asaah Ebenezar yuh Renata Tchoundjeu Zacharie Degrande Ann Kouodiekong Lazare World Agroforestry Centre (ICRAF) African Humid Tropics Region BP 16317 Yaounde Cameroon Institute of Agrieultural Researeh for Development (IRAD) P.O. Box 80 Bambui NWR Cameroon

A field experiment was conducted in the Western Highlands of Cameroon to study the effects of Calliandra calothyrsus, sterilized compost, non-sterilized compost and mineral fertilizers （NPK 11：11：22） on physical characteristics, yield components and late blight disease severity of potato （Solanum tuberosum）. A two factorial treatment combination made up of fertilization schemes and sanitary measures were laid out in a randomized complete block design （RCBD） with four replicates and 10 treatments. Data collected were subjected to a multivariate ANOVA and means separated with the Dunnett t-test with Calliandra calothyrsus considered as the main treatment. Mineral fertilizers and Calliandra calothyrsus significantly augmented stem diameter, plant height and plant vigor, total and marketable yields, despite the fact that late blight severity was high in the two treatments. The correlation matrix showed that total yield had significant and positive correlation with stem diameter （r = 0.74）, plant height （r = 0.61）, plant vigor （r = 0.61） and marketable yield （r = 0.99） and negative correlation （r = -37） with late blight severity. The increase observed is attributed to the nutrient contents of the treatments applied. Leafy prunings of C. calothyrsus increase soil organic matter which probably improves moisture retention and biological activity. The highest late blight severity recorded between the 45 and 60 coincides with active development of plant canopy which influences disease severity and create a canopy microclimate conducive to disease development. This study suggests that Calliandra calothyrsus has the potential of improving potato production provided appropriate fungicide is used.

关键词： Calliandra calothyrsus late blight severity organic manure mineral fertilizers compost potato (Solanum tuberosum L.).

Bond Characterization of the 3-D Framework Structure of the Copper(Ⅱ) Isonicotinic Acid Complex Formed by Hydrogen Bonding

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Chemical Research in Chinese Universities 2001年第Z1期17卷 212-页

作者： WEN yuh-Sheng Institute of Chemistry Academia Sinic Department of Chemistry National Taiwan University Department of Chemistry National Taiwan University

The crystal of qudra-aquabis(isonicotinato-N)copper(Ⅱ),Cu[(NC5H4COO)]2 . 4H2O was synthesized via hydrothermal method. Single crystal X-ray analysis at 100K (Siemens SmartCCD) and 25K (Nonius KappaCCD) are performed. The results reveal that the Cu atom is octahedrally coordinated by two Nitrogen atoms of pyridine rings in the axial positions and the four Oxygen atoms of the four water molecules in an equatorial orientation. The octahedral Cu(lI) center shows a large Jahn-Teller distortion with the distances of the Cu-N 2.0253(6)A, Cu-O(3)2.0124(6)~, Cu-O(4) 2.4304(7)A. By means of the hydrogen bonding connections, this compound is formed a 3D framework. In addition, the thermal displacement of each atom at 25K is about three-times smaller than that at 100K. Electron density distribution of this compound at 25K and 100K is also analyzed and compared in terms of multipole model. All topological properties based on X-ray diffraction result and theoretical calculation including the bond critical points (BCP), Laplacian of the electron density and electron density at the BCP will be presented.　　……

关键词： electron density theoretical calculation density distribution hydrothermal method hydrogen bonding water molecules critical points

Drosophila Nomp C is a mechano-transduction channel subunit for gentle touch sensation

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Drosophila Nomp C is a mechano-transduction channel subunit ...

Synthesis and Characterization of Hybrid MWCNTs Materials for Direct Formic Fuel Cells

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： yuh Nung Jan 闫致强 Wei Zhang 复旦大学生命科学学院

Touch sensation is essential for behaviors ranging from environmental exploration to social interaction,but the underlying mechanisms are largely *** Drosophila larvae,two types of sensory neurons,class ⅡI and class IV dendritic arborization（da）neurons,tile the body *** mechanotransduction channel Piezo in class IV da neurons is essential for sensing noxious mechanical stimulus but is not involved in gentle *** we report that class ⅡI da neurons are touch sensitive and contribute to gentle touch sensation,based on electrophysiological recording,calcium imaging and behavioral *** further identify Nomp C（no mechanoreceptor potential C）,a member of the transient receptor potential（TRP）family of ion channels,as a mechanotransduction channel for gentle *** C is highly expressed in class ⅡI da neurons and required for their ***,ectopic Nomp C expression confers touch sensitivity to the normally touch insensitive class IV da *** only is Nomp C critical for gentle touch to elicit behavioral responses,Nomp C expression in Drosophila S2cells gives rise to mechanosensitive channels whose ion selectivity can be altered by Nomp C mutation,indicating Nomp C is a pore-forming subunit of a mechanotransduction *** study establishes Nomp C as a bona fide mechanotransduction channel that satisfies all four criteria and mediates gentle touch sensation,and suggests that different mechanosensitive channels might be utilized to sense gentle touch versus noxious mechanical stimulus.

关键词： touch Drosophila ion channel mechanosensation

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Synthesis and Characterization of Hybrid MWCNTs Materials fo...