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Dexmedetomidine:chaperone of anesthesia

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Clinical Research Communications 2021年第4期4卷 22-27页

作者： Jun Huang Cheng-Yun Hu Fei-Biao Dai Jia-Wu Wang Ming-Sheng Bao chao-liang tang Department of Anesthesiology The People’s Hospital of ChizhouChizhou 247000China Department of Anesthesiology Anhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Aim:In this review,it will mainly focus on clarifying the pharmacology of dexmedetomidine and discussing the past,present and future clinical applications of dexmedetomidine as an adjunct in anesthesia.Method:We have searched and reviewed the articles about the use of dexmedetomidine in clinical anesthesia,intensive care unit(ICU),painless gastroenteroscopy and painless labor over the past two decades.Recent findings:Dexmedetomidine,a highly selective agonist of alpha2-adrenergic receptors(alpha2-AR),was primarily approved by the U.S.Food and Drug Administration(FDA)for sedation in ICU due to its pharmacological characteristics with sedative,analgesic and sympatholytic effects.These properties make up the limitations of anesthetics,and it produces a“dexmedetomidine assisted”anesthesia mode as an adjuvant combining with other anesthesia methods,which are all termed as“DEX+”.These new methods can reduce the anesthetics requirement but prolong the action period and alleviate the adverse reactions of anesthetics,thus improving the anesthesia more effectively and safely.Summary:Dexmedetomidine possesses the unique properties exerting synergistic effects and alleviating the side effects as an adjuvant in anesthesia through different administration routes.It is beneficial for the patients’long-term outcome and will be bound to be the leading innovator of anesthesia in future.

关键词： dexmedetomidine alpha2-adrenergic receptor anesthesia analgesia sedation

Dynamic Scene Graph Generation of Point Clouds with Structural Representation Learning

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Tsinghua Science and Technology 2024年第1期29卷 232-243页

作者： chao Qi Jianqin Yin Zhicheng Zhang Jin tang School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China Standard and Metrology Research Institute China Academy of Railway Sciences Corporation LimitedBeijing 100081China

Scene graphs of point clouds help to understand object-level relationships in the 3D space.Most graph generation methods work on 2D structured data,which cannot be used for the 3D unstructured point cloud data.Existing point-cloud-based methods generate the scene graph with an additional graph structure that needs labor-intensive manual annotation.To address these problems,we explore a method to convert the point clouds into structured data and generate graphs without given structures.Specifically,we cluster points with similar augmented features into groups and establish their relationships,resulting in an initial structural representation of the point cloud.Besides,we propose a Dynamic Graph Generation Network(DGGN)to judge the semantic labels of targets of different granularity.It dynamically splits and merges point groups,resulting in a scene graph with high precision.Experiments show that our methods outperform other baseline methods.They output reliable graphs describing the object-level relationships without additional manual labeled data.

关键词： scene graph generation structural representation point cloud

Cav3.2 channel regulates cerebral ischemia/reperfusion injury:a promising target for intervention

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Neural Regeneration Research 2024年第11期19卷 2480-2487页

作者： Feibiao Dai Chengyun Hu Xue Li Zhetao Zhang Hongtao Wang Wanjun Zhou Jiawu Wang Qingtian Geng Yongfei Dong chaoliang tang Graduate School Wannan Medical CollegeWuhuAnhui ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Core Facility Center for Medical Sciences The First Affiliated Hospital of USTC(Anhui Provincial Hospital)HefeiAnhui ProvinceChina Department of Pharmacy The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury.Various calcium channels are involved in cerebral ischemia/reperfusion injury.Cav3.2 channel is a main subtype of T-type calcium channels.T-type calcium channel blockers,such as pimozide and mibefradil,have been shown to prevent cerebral ischemia/reperfusion injury-induced brain injury.However,the role of Cav3.2 channels in cerebral ischemia/reperfusion injury remains unclear.Here,in vitro and in vivo models of cerebral ischemia/reperfusion injury were established using middle cerebral artery occlusion in mice and high glucose hypoxia/reoxygenation exposure in primary hippocampal neurons.The results showed that Cav3.2 expression was significantly upregulated in injured hippocampal tissue and primary hippocampal neurons.We further established a Cav3.2 gene-knockout mouse model of cerebral ischemia/reperfusion injury.Cav3.2 knockout markedly reduced infarct volume and brain water content,and alleviated neurological dysfunction after cerebral ischemia/reperfusion injury.Additionally,Cav3.2 knockout attenuated cerebral ischemia/reperfusion injury-induced oxidative stress,inflammatory response,and neuronal apoptosis.In the hippocampus of Cav3.2-knockout mice,calcineurin overexpression offset the beneficial effect of Cav3.2 knockout after cerebral ischemia/reperfusion injury.These findings suggest that the neuroprotective function of Cav3.2 knockout is mediated by calcineurin/nuclear factor of activated T cells 3 signaling.Findings from this study suggest that Cav3.2 could be a promising target for treatment of cerebral ischemia/reperfusion injury.

关键词： calcineurin Cav3.2 channel cerebral ischemia/reperfusion hippocampus hypoxia/reoxygenation inflammatory response nuclear factor of activated T cells 3 oxidative stress primary hippocampal neurons stroke

Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of Materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei tang chao Hou Hao Lu Zhi Zhao Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were described.Based on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been proposed.This study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

Structural uncertainty quantification of Reynolds-Averaged Navier–Stokes closures for various shock-wave/boundary layer interaction flows

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Chinese Journal of Aeronautics 2024年第3期37卷 34-48页

作者： Fanzhi ZENG Tianxin ZHANG Denggao tang Jinping LI chao YAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China School of Aeronautical Engineering Air Force Engineering UniversityXi’an 710038China

Accurate prediction of Shock-Wave/Boundary Layer Interaction(SWBLI)flows has been a persistent challenge for linear eddy viscosity models.A major limitation lies in the isotropic representation of the Reynolds stress,as assumed under the Boussinesq approximation.Recent studies have shown promise in improving the prediction capability for incompressible separation flows by perturbing the Reynolds-stress anisotropy tensor.However,it remains uncertain whether this approach is effective for SWBLI flows,which involve compressibility and discontinuity.To address this issue,this study systematically quantifies the structural uncertainty of the anisotropy for oblique SWBLI flows.The eigenspace perturbation method is applied to perturb the anisotropy tensor predicted by the Menter Shear–Stress Transport(SST)model and reveal the impacts of anisotropy on the prediction of quantities of interest,such as separation and reattachment positions,wall static pressure,skin friction,and heat flux.The results demonstrate the potential and reveal the challenges of eigenspace perturbation in improving the SST model.Furthermore,a detailed analysis of turbulent characteristics is performed to identify the source of uncertainty.The findings indicate that eigenspace perturbation primarily affects turbulent shear stress,while the prediction error of the SST model is more related to turbulent kinetic energy.

关键词： Shock-wave/boundary layer interaction(SWBLI) Turbulence models Uncertainty analysis Eigenspace perturbation Anisotropy

IHVFL: a privacy-enhanced intention-hiding vertical federated learning framework for medical data

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Cybersecurity 2024年第2期7卷 96-112页

作者： Fei tang Shikai liang Guowei Ling Jinyong Shan College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsNo.2Chongwen RoadNan'an DistrictChongqing 400065China School of Cyber Security and Information Law Chongqing University of Posts and TelecommunicationsChongqing 400065China sudo Technology Co. LTD.Beijing 100083China

Vertical Federated Learning(VFL)has many applications in the field of smart healthcare with excellent performance.However,current VFL systems usually primarily focus on the privacy protection during model training,while the preparation of training data receives little attention.In real-world applications,like smart healthcare,the process of the training data preparation may involve some participant's intention which could be privacy information for this partici-pant.To protect the privacy of the model training intention,we describe the idea of Intention-Hiding Vertical Feder-ated Learning(IHVFL)and illustrate a framework to achieve this privacy-preserving goal.First,we construct two secure screening protocols to enhance the privacy protection in feature engineering.Second,we implement the work of sample alignment bases on a novel private set intersection protocol.Finally,we use the logistic regression algorithm to demonstrate the process of IHVFL.Experiments show that our model can perform better efficiency(less than 5min)and accuracy(97%)on Breast Cancer medical dataset while maintaining the intention-hiding goal.

关键词： Medical data Vertical federated learning Privacy-presserving Intention-hiding Logistic regression

Strategy for suppressing abnormal grain growth of ZK60 Mg alloy during solution by pre-compression:A quasi-in-situ study

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Journal of Materials Science & Technology 2024年第4期171卷 115-128页

作者： Zhenxu Wang liang Chen Jianwei tang Cunsheng Zhang Guoqun Zhao Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinanShandong 250061China Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan

Abnormal grain growth(AGG)easily takes place in Mg alloys during high-temperature solutions,result-ing in deterioration of mechanical properties.Hence,the compression prior to solution(pre-compression)was conducted to suppress AGG,and the microstructure evolution as well as suppressing mechanisms was investigated based on quasi-in-situ analysis.After compression along the transverse direction,//ED grains preferentially nucleated and rapidly grew up,and the initial//ED texture was weakened.Two grain growth modes of heat-induced and strain-induced grain boundary migrations were found.The former was attributed to the high interfacial energy of grain boundaries with large curvature.The latter consumed the adjacent grains with high storage energy,forming abnormal grains with irregular shapes.The compression with a reduction>6%could obviously suppress AGG.The suppressing effects were mainly attributed to weakening the size advantage of//ED grains,increasing nucleation,reducing grain boundary character distribution,and redistributing storage energy distribution.After 12%compression along the transverse direction,30°misorientation of//ED grains and high energy grain boundaries were reduced.The{10-12}tensile twins and{10-15}high index twins induced by com-pression increased the nucleation of static recrystallization.Beside,compression introduces high-density dislocations,which also contributed to suppressing AGG behavior during solution.

关键词： Quasi-in-situ analysis Mg alloy Abnormal grain growth Compression Microstructure

Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 364-371页

作者： Ji-Chun tang Jia-Wei Ma Jin-Jin Jian Jie Shen liang-liang Cao Department of Anesthesiology The Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture 843599Xinjiang Uygur Autonomous RegionChina Department of Critical Care Medicine Jiangnan University Medical CenterWuxi 214122Jiangsu ProvinceChina Department of Critical Care Medicine People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture843599Xinjiang Uygur Autonomous RegionChina

BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative pain.The current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and fentanyl.Surgery for colo-rectal cancer typically involves general anesthesia.Therefore,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative recovery.The study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative pain.AIM To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal cancer.METHODS Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research group.After data collection,the effects of postoperative analgesia,sedation,and recovery were compared.RESULTS Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P<0.05).The research group also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(P<0.05).Additionally,interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,general anesthesia coupled with epidural anesthes

关键词： Multimodal analgesia Anesthesia Colorectal cancer Postoperative pain

Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-Yu tang liang Zheng Xiao-Ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first time.The string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final particles.This study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model