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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

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Neural Regeneration Research 2020年第10期15卷 1807-1813页

作者： Jun-Mou Hong Yi-Da Hu Xiao-Qing Chai Chao-Liang Tang Department of Vascular Surgery Zhongshan HospitalXiamen UniversityXiamenFujian ProvinceChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor superfamily.ALK1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic vascular development.The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells.Indeed,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation.Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral atherosclerosis.In this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular diseases.This review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

关键词： activin receptor-like kinase 1 aneurysm atherosclerotic plaque endoglin extracellular matrix protein intracranial arteriovenous malformation matrix metalloproteinase pericyte transforming growth factor beta 1 pathway vascular development

Mechanisms and status of research on the protective effects of traditional Chinese medicine against ischemic brain injury

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Traditional Medicine Research 2022年第1期7卷 35-43页

作者： Zhe-Tao Zhang Cheng-Yun Hu Fei-Biao Dai Fei tang Chao-Liang Tang Department of Pharmacy The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China Department of Anesthesiology Anhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of Anesthesiology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Ischemic brain injury occurs when the metabolic needs of brain tissue cannot be met due to insufficient blood supply to the brain.It is one of the main causes of death and adult disability worldwide.The recurrence rate of ischemic brain injury is high.It places a heavy economic burden on families and society,and seriously affects human health and quality of life.In traditional Chinese medicine,ischemic stroke belongs to the category of“stroke”.The use of traditional Chinese medicine to treat stroke has a long history.After years of experimental research,a large amount of theoretical knowledge and practical experience have been accumulated.Promoting blood circulation and removing blood stasis is the basis of traditional Chinese medicine theory on the treatment of ischemic stroke.Commonly used single Chinese medicines include Chuangxiong(Ligusticum chuanxiong hort),Danggui(Angelica sinensis),Danshen(Salvia miltiorrhiza Bunge),Honghua(Carthamus tinctorius L.),Mudanpi(Moutan Cortex),and Huangqi(Astragali Radix).Buyang Huanwu decoction,Xinglou Chengqi decoction,Taohong Siwu decoction,and other traditional Chinese medicine prescriptions are believed to have a protective effect against brain damage caused by ischemic stroke.With the development of modern medical technology,the mechanism of traditional Chinese medicine treatments for ischemic brain injury has gradually been explored.This article reviews the mechanisms of traditional Chinese medicine’s protection against ischemic brain injury and its current clinical application.

关键词： traditional Chinese medicine ischemic brain injury stroke brain protection clinical application

Coupling plasma plume of a low-power magnetically shielded Hall thruster with a hollow cathode

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Chinese Journal of Aeronautics 2020年第12期33卷 3018-3026页

作者： Guangchuan ZHANG Junxue REN Wei liang Ning OUYANG chao LU Haibin tang School of Space and Environment Beihang UniversityBeijing 100083China School of Astronautics Beihang UniversityBeijing 100083China Shanghai Institute of Space Propulsion Shanghai 201112China Key Laboratory of Spacecraft Design Optimization&Dynamic Simulation Technologies Ministry of EducationBeijing 100083China Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100083China

The coupling region of a Hall thruster with a hollow cathode is the region between the cathode and the thruster plume.The characteristics of plasma in that region are complicated and strongly associated with the thruster working conditions and the cathode position.In this paper,a laboratory 100 W class magnetically shielded Hall thruster was coupled with a hollow cathode.Optical imaging and electrostatic probe were employed to monitor and scan the plasma plume.Plume characteristics in the coupling region in non-self-sustained mode and self-sustained mode were compared.Evolution of the coupling plume with the cathode position was studied.Experiments show that,when turning the thruster into self-sustained mode or moving the cathode further away axially,the discharge current can be reduced by 6.4–10.6%restraining the electron current and improving ionization.In particular,when the cathode is moved further,the electron conduction near the channel walls is suppressed.The electron current is reduced by 27.4%and the ion beam current is increased by 7%.Overall,this work shows that the working mode of the thruster and the position of the cathode greatly affect the coupling plasma plume.Both play an important role in improving the utilizations of propellant and current.

关键词： Coupling region Electron conduction Hall thruster Hollow cathode Utilizations of propellant and current

Day surgery model: a new path for hospital high-quality development

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Clinical Research Communications 2024年第2期7卷 1-3页

作者： Chao-Liang Tang Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China.

In the current healthcare system,the day surgery model is increasingly valued and has become an important driving force for the high-quality development of hospitals.The day surgery model refers to a medical model where patients can leave the hospital and recover at home on the same day after completing specific treatments or surgeries[1].

关键词： surgery driving hospital

State-of-the-art applications of machine learning in the life cycle of solid waste management

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Frontiers of Environmental Science & Engineering 2023年第4期17卷 53-69页

作者： Rui liang chao Chen Akash Kumar Junyu Tao Yan Kang Dong Han Xianjia Jiang Pei tang Beibei Yan Guanyi Chen School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China Tianjin Key Laboratory of Biomass Wastes Utilization/Tianjin Engineering Research Center of Bio Gas/Oil Technology Tianjin 300072China School of Science Tibet UniversityLhasa 850012China

Due to the superiority of machine learning(ML)data processing,it is widely used in research of solid waste(SW).This study analyzed the research and developmental progress of the applications of ML in the life cycle of SW.Statistical analyses were undertaken on the literature published between 1985 and 2021 in the Science Citation Index Expanded and Social Sciences Citation Index to provide an overview of the progress.Based on the articles considered,a rapid upward trend from 1985 to 2021 was found and international cooperatives were found to have strengthened.The three topics of ML,namely,SW categories,ML algorithms,and specific applications,as applied to the life cycle of SW were discussed.ML has been applied during the entire SW process,thereby affecting its life cycle.ML was used to predict the generation and characteristics of SW,optimize its collection and transportation,and model the processing of its energy utilization.Finally,the current challenges of applying ML to SW and future perspectives were discussed.The goal is to achieve high economic and environmental benefits and carbon reduction during the life cycle of SW.ML plays an important role in the modernization and intellectualization of SW management.It is hoped that this work would be helpful to provide a constructive overview towards the state-of-the-art development of SW disposal.

关键词： Machine learning(ML) Solid waste(SW) Bibliometrics SW management Energy utilization Life cycle

Neuroprotective effect of bispectral index-guided fast-track anesthesia using sevoflurane combined with dexmedetomidine for intracranial aneurysm embolization

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Neural Regeneration Research 2018年第2期13卷 280-288页

作者： Chao-Liang Tang Juan Li Zhe-tao Zhang Bo Zhao Shu-dong Wang Hua-ming Zhang Si Shi Yang Zhang Zhong-yuan Xia Department of Anesthesiology Renmin Hospital of Wuhan University Department of Anesthesiology Anhui Provincial Hospital of Anhui Medical University Department of Pharmacy Anhui Provincial Hospital of Anhui Medical University Department of Neurosurgery Anhui Provincial Hospital of Anhui Medical University

Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//***. cn/）（registration number： ChiCTR-IPR- 16008113）.

关键词： nerve regeneration dexmedetomidine sevoflurane bispectral index fast-track anesthesia embolization of intracranial aneurysm stress response neuroprotection neural regeneration

Microstructure evolution and mechanical properties of high-boron steel with different ratios of boron and carbon

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China Foundry 2022年第2期19卷 169-176页

作者： Ming-chen Ma chao-qing Luo Si-min Chen Hong-qun tang Shan-shan Hu Yu-mei Zhou Jian-lin liang Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured Materials Center of Ecological Collaborative Innovation for Aluminium Industry in GuangxiSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China School of Mechanical Engineering Guangxi UniversityNanning 530004China School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Boron and carbon contents are the main factors influencing the properties of high-boron steel.In this study,experimental samples with different boron-to-carbon ratios(%B/%C)were prepared.The microstructures of the different samples were observed,and their hardness,bending strength,and impact toughness were investigated.Results show that the main microstructures in the investigated high-boron steel samples are the eutectic Fe_(2)B structure with a fishbone shape and the ternary peritectic Fe_(3)(C,B)structure with a chrysanthemum shape.When the boron content is 2.5wt.%and the carbon content is 0.43wt.%(i.e.,%B/%C=5.82),the overall mechanical properties of the alloy are the best.The alloy's hardness,bending strength and impact toughness reach their maximums,which are 67.3 HRC,1,267.36 MPa and 6.19 J·cm^(-2),respectively.The optimized alloy is compared with conventional materials exhibiting excellent wear resistance(namely,high-manganese steel and high-chromium cast iron)through two-body and three-body abrasion tests.The wear resistance of this high-boron steelinvestigated in this work is found to be superior to those of the more common materials.

关键词： high-boron steel boron and carbon contents wear resistance microstructure mechanical properties

Sedimentary architecture and distribution of intra-platform shoal in sequence framework of Permian Changxing Formation in central Sichuan Basin,SW China

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Petroleum Exploration and Development 2023年第2期50卷 388-403页

作者： WANG Dong LIU Hong tang Song BAI Jinhao ZHOU Gang LI Zhengyong liang Feng TAN Xiucheng GENG chao YANG Ying State Key Laboratory of Oil and Gas Reservoir Geology and Exploration Southwest Petroleum UniversityChengdu 610500China Sichuan Natural Gas Geology Key Laboratory Southwest Petroleum UniversityChengdu 610500China Southwest Petroleum University Division of Key Laboratory of Carbonate ReservoirsCNPCChengdu 610500China Central Sichuan Oil and Gas District PetroChina Southwest Oilfield CompanySuining 629000 Research Institute of Petroleum Exploration and Development PetroChina Southwest Oilfield CompanyChengdu 610041China Gas Production Administrative Department of Northern Central Sichuan Gas District PetroChina Southwest Oilfield CompanySuining 629000China Southern Sichuan Gas District PetroChina Southwest Oilfield CompanyLuzhou 646000China

Based on the comprehensive analysis of core, thin section, logging and seismic data, this study carried out the identification and comparison of Permian Changxing Formation sequences, clarified the typical sedimentary architectures of intra-platform shoal, investigated the vertical and horizontal development and distribution of intra-platform shoal in each sequence, and thus established the sedimentary evolution model of shoal body. The study results are reflected in four aspects.First, there are two complete third-order sequences(SQ1 and SQ2) in Changxing Formation in central Sichuan Basin. SQ1 is generally thick in the north and thin in the south, and SQ2 shows a thickness differentiation trend of “two thicknesses and three thinnesses”. Second, the Changxing Formation in central Sichuan Basin mainly develops intra-platform shoal, inter-shoal sea and intra-platform depression subfacies. In the vertical direction, the intra-platform shoal mainly presents two typical sedimentary sequences: stable superposed and high-frequency interbedded. Third, the stable superimposed sedimentary sequence is developed in the shoal belt at the edge of intra-platform depression, which is composed of two shoal-forming periods and located in the highstand systems tracts(HSTs) of SQ1 and SQ2. The high-frequency interbedded sedimentary sequence is developed in the southern shoal belt of intra-platform depression, which is composed of four shoal-forming periods and mainly located in the HST of SQ2. Fourth, during the SQ1 deposition, the intra-platform shoal was mainly developed at the edge of the intra-platform depression on the north side of the study area, and the inter-shoal sea subfacies was mainly developed on the south side. During the SQ2 deposition, the intra-platform shoal was widely developed in the area, forming two nearly parallel intra-platform shoal belts. The study results provide direction and ideas for exploration of Changxing Formation intra-platform shoal reservoirs in central Sichuan Basin.

关键词： Sichuan Basin Permian Changxing Formation intra-platform shoal sequence stratigraphic framework typical sedimentary sequence sedimentary evolution model

Y-shaped block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) synthesized by ATRP

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Chinese Chemical Letters 2009年第11期20卷 1353-1356页

作者： Xin De tang Xiao chao liang Nian Feng Han Institute of New Materials Shandong Jiaotong University Ji'nan 250023 China College of Chemistry & Molecular Engineering Peking University Beijing 100871 China

Novel Y-shaped block copolymers of poly（ethylene glycol） and poly（N-isopropylacrylamide）, PEG-b-（PNIPAM）2, were successfully synthesized through atom transfer radical polymerization （ATRP）. A difunctional macroinitiator was prepared by esterification of 2,2-dichloroacetyl chloride with poly（ethylene glycol） monomethyl ether （PEG）. The copolymers were obtained via the ATRP ofN-isopropylacrylamide （NIPAM） at 30℃ with CuCl/Me6TREN as a catalyst system and DMF/H2O （v/v = 3：1） mixture as solvent. The resulting copolymers were characterized by gel permeation chromatography （GPC） and ^1H NMR. These block copolymers show controllable molecular weights and narrow molecular weight distributions （PDI 〈 1.15）. Their phase transition temperatures and the corresponding enthalpy changes in aqueous solution were measured by differential scanning calorimetry （DSC）. As a result, the phase transition temperature of PEG45-b-（PNIPAM55）2 is higher than that of PNIPAM, however, the corresponding enthalpy change is much lower, indicating the significant influence of the macromolecular composition and architecture on the phase transition.

关键词： Y-shaped Block copolymer Poly（ethylene glycol） Poly（N-isopropylacrylamide） Atom transfer radical polymerization （ATRP）