Mechanisms and status of research on the protective effects of traditional Chinese medicine against ischemic brain injury
作者机构：Department of PharmacyThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China Department of AnesthesiologyAnhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of AnesthesiologyThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China
出 版 物：《Traditional Medicine Research》 (TMR传统医学研究)
年 卷 期：2022年第7卷第1期
页 面：35-43页
基 金：supported by the National Natural Science Foundation of China(No.81801175) the China Postdoctoral Science Foundation(No.2019M662179) the Anhui Province Postdoctoral Science Foundation(No.2019B324) the Fundamental Research Funds for the Central Universities(No.WK9110000044).
主 题：traditional Chinese medicine ischemic brain injury stroke brain protection clinical application
摘 要：Ischemic brain injury occurs when the metabolic needs of brain tissue cannot be met due to insufficient blood supply to the brain.It is one of the main causes of death and adult disability worldwide.The recurrence rate of ischemic brain injury is high.It places a heavy economic burden on families and society,and seriously affects human health and quality of life.In traditional Chinese medicine,ischemic stroke belongs to the category of“stroke.The use of traditional Chinese medicine to treat stroke has a long history.After years of experimental research,a large amount of theoretical knowledge and practical experience have been accumulated.Promoting blood circulation and removing blood stasis is the basis of traditional Chinese medicine theory on the treatment of ischemic stroke.Commonly used single Chinese medicines include Chuangxiong(Ligusticum chuanxiong hort),Danggui(Angelica sinensis),Danshen(Salvia miltiorrhiza Bunge),Honghua(Carthamus tinctorius L.),Mudanpi(Moutan Cortex),and Huangqi(Astragali Radix).Buyang Huanwu decoction,Xinglou Chengqi decoction,Taohong Siwu decoction,and other traditional Chinese medicine prescriptions are believed to have a protective effect against brain damage caused by ischemic stroke.With the development of modern medical technology,the mechanism of traditional Chinese medicine treatments for ischemic brain injury has gradually been explored.This article reviews the mechanisms of traditional Chinese medicine’s protection against ischemic brain injury and its current clinical application.
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