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Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China

World Journal of Diabetes 2022年第11期13卷 986-1000页

作者： Yuan-Yuan Zhou Tai-Cheng Zhou Nan Chen Guo-Zhong Zhou Hong-Jian Zhou Xing-Dong Li Jin-Rui Wang chao-fang bai Rong Long Yu-Xin Xiong Ying Yang Department of Endocrinology and Metabolism The Sixth Affiliated Hospital of Kunming Medical UniversityThe People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina Department of Endocrinology and Metabolism Affiliated Hospital of Yunnan UniversityThe Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and Metabolism The Frist People’s Hospital of Anning CityAnning City 650300Yunnan ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is the driving force of blindness in patients with type 2 diabetes mellitus(T2DM).DR has a high prevalence and lacks effective therapeutic strategies,underscoring the need for early prevention and *** province,located in the southwest plateau of China,has a high prevalence of DR and an underdeveloped *** To build a clinical prediction model that will enable early prevention and treatment of *** In this cross-sectional study,1654 Han population with T2DM were divided into groups without(n=826)and with DR(n=828)based on fundus *** DR group was further subdivided into non-proliferative DR(n=403)and proliferative DR(n=425)groups.A univariate analysis and logistic regression analysis were conducted and a clinical decision tree model was *** Diabetes duration≥10 years,female sex,standing-or supine systolic blood pressure(SBP)≥140 mmHg,and cholesterol≥6.22 mmol/L were risk factors for DR in logistic regression analysis(odds ratio=2.118,1.520,1.417,1.881,and 1.591,respectively).A greater severity of chronic kidney disease(CKD)or hemoglobin A 1c increased the risk of DR in patients with *** the decision tree model,diabetes duration was the primary risk factor affecting the occurrence of DR in patients with T2DM,followed by CKD stage,supine SBP,standing SBP,and body mass index(BMI).DR classification outcomes were obtained by evaluating standing SBP or BMI according to the CKD stage for diabetes duration<10 years and by evaluating CKD stage according to the supine SBP for diabetes duration≥10 *** Based on the simple and intuitive decision tree model constructed in this study,DR classification outcomes were easily obtained by evaluating diabetes duration,CKD stage,supine or standing SBP,and BMI.

关键词： Diabetic retinopathy Type 2 diabetes Western China Decision tree

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Removal of chromium (Ⅵ) from aqueous solutions using quaternized chitosan microspheres

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Chinese Journal of Chemical Engineering 2017年第2期25卷 153-158页

作者： chao Hua Runhu Zhang fang bai Ping Lu Xiangfeng Liang Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijng 100190China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300130China Department of Chemical Engineering Kunming Metallurgy CollegeKunming 650033China

In this study, quaternized chitosan microspheres （QCMS） were prepared and its Cr （VI） removal potential was investigated. Batch experiments were conducted to examine kinetics, adsorption isotherm, pH effect, and thermodynamic parameters. Equilibrium was attained within 50 rain and maximum removal of 97.34% was achieved under the optimum conditions at pH 5. Adsorption data for Cr （VI） uptake by the QCMS were analyzed according to Langmuir, Freundlich, and Temkin adsorption models. The maximum uptake of Cr （VI） was 39.1 mg.g-a. Thermodynamic parameters for the adsorption system were determinated at 293 K, 303 K, 313 K and 323 K. （AH° = 16.08 ***- 1;AG° = -5.84 to -8.08 ***1-1 and AS° = 74.81 J.K-1 .tool-l）. So the positive values of both A/-F and AS° suggest an endothermic reaction and increase in randomness at the solid-liquid interface during the adsorption. AG° values obtained were negative indicating a spontaneous adsorp- tion process. The kinetic process was described by a pseudo-second-order rate equation very well. The results of the present study indicated that the QCMS could he considered as a potential adsorbent for Cr （V1） in aqueous solutions.

关键词： Chromium (V1)AdsorptionQ uatemized chitosan microspheresIsothermsThermodynamics

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控制方向未知的受限多智能体系统的预设时间模糊控制

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工程科学学报 2025年第1期47卷 121-129页

作者：李菲周超范利蓉王芳燕山大学理学院秦皇岛066004 河北农业大学海洋学院秦皇岛066003

综合考虑受控制方向未知、输入受限和状态时延影响的有领导者多智能体系统的编队控制问题,设计基于模糊逻辑系统的预设时间一致性控制策略.为了保证编队输出误差在预设时间内满足预定的约束范围要求,引入预设时间性能函数,构造Lyapunov-... 详细信息

综合考虑受控制方向未知、输入受限和状态时延影响的有领导者多智能体系统的编队控制问题,设计基于模糊逻辑系统的预设时间一致性控制策略.为了保证编队输出误差在预设时间内满足预定的约束范围要求,引入预设时间性能函数,构造Lyapunov-Krasovskii(L-K)泛函解决状态时延问题,将外界干扰和L-K泛函的导数中的部分项定义为未知非线性函数,并利用模糊逻辑系统对其进行估计,利用Nussbaum函数和均值定理分别处理控制方向未知和输入受限问题,基于以上设计,提出预设时间模糊控制策略,并通过Lyapunov稳定性理论,分析闭环系统的有界稳定性,数值对比仿真和两级化学反应器应用仿真说明控制方法的有效性.

关键词：多智能体系统状态时延输出误差约束输入受限控制方向未知

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Remote,selective,and in situ manipulation of liquid droplets on a femtosecond laser-structured superhydrophobic shape-memory polymer by near-infrared light

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Science China Chemistry 2021年第5期64卷 861-872页

作者： Xue bai Jiale Yong chao Shan Yao fang Xun Hou Feng Chen State Key Laboratory for Manufacturing System Engineering and Shaanxi Key Laboratory of Photonics Technology for Information School of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Droplet manipulation plays a significant role in the fields of biomedical detection,microfluidics,and chemical ***,it still remains a great challenge to simultaneously achieve remote,selective,and in situ droplet manipulation on the same ***,Fe_(3)O_(4)nanoparticles were doped in a shape-memory polymer(SMP)to prepare a photothermal-responsive Fe_(3)O_(4)-SMP composite which showed remarkable near-infrared(NIR)light-triggered shape-memory *** micropillar array was constructed on such Fe_(3)O_(4)-SMP composite through femtosecond laser microfabrication and fluoroalkylsilane *** surface wettability of the as-prepared surface can transform from a low-adhesive sliding state to a high-adhesive pinning state as the micropillars are deformed by ***,the deformed micropillars can stand up and restore to their original morphology under remote NIR light irradiation,resulting in the reversible and repeatable recovery of the ultralow-adhesive *** such light-triggered wettability switching,the droplets pinning on the sample surface can be remotely,selectively,and in situ ***,the superhydrophobic Fe_(3)O_(4)-SMP surface is successfully applied in lossless liquid transfer,selective droplet release,and droplet-based *** as-fabricated superhydrophobic surfaces with NIR light-controlled reversible wettability will hold great promise in the fields of liquid manipulation,lab-on-a-chip,and microfluidics.

关键词： droplet manipulation superhydrophobicity shape-memory polymer femtosecond laser light responsive

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Application of Improved Hybrid Interface Substructural Component Modal Synthesis Method in Vibration Characteristics of Mistuned Blisk

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1219-1231页

作者： bai Bin bai Guangchen LI chao School of Energy and Power Engineering Beihang University

The large and complex structures are divided into hundreds of thousands or millions degrees of freedom（DOF） when they are calculated which will spend a lot of time and the efficiency will be extremely low. The classical component modal synthesis method （CMSM） are used extensively, but for many structures in the engineering of high-rise buildings, aerospace systemic engineerings, marine oil platforms etc, a large amount of calculation is still needed. An improved hybrid interface substructural component modal synthesis method（HISCMSM） is proposed. The parametric model of the mistuned blisk is built by the improved HISCMSM. The double coordinating conditions of the displacement and the force are introduced to ensure the computational accuracy. Compared with the overall structure finite element model method（FEMM）, the computational time is shortened by23.86%–31.56%and the modal deviation is 0.002%–0.157% which meets the requirement of the computational accuracy. It is faster 4.46%–10.57% than the classical HISCMSM. So the improved HISCMSM is better than the classical HISCMSM and the overall structure FEMM. Meanwhile, the frequency and the modal shape are researched, considering the factors including rotational speed, gas temperature and geometry size. The strong localization phenomenon of the modal shape’s the maximum displacement and the maximum stress is observed in the second frequency band and it is the most sensitive in the frequency veering. But the localization phenomenon is relatively weak in 1st and the 3d frequency band. The localization of the modal shape is more serious under the condition of the geometric dimensioning mistuned. An improved HISCMSM is proposed, the computational efficiency of the mistuned blisk can be increased observably by this method.

关键词： modal shape mistuned blisk vibration characteristics computational efficiency computational accuracy

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Design and Study of Virtual Interventional Surgical System with Force Feedback

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第3期36卷 424-431页

作者： ZHANG chao bai Dongming CHEN bai College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

A virtual interventional surgical system with force feedback is designed to provide practice before complicated interventional operation and assistance during *** collision detection,vessel deformation calculating and virtual force computing of the virtual system are implemented by using skeleton spring model as the physical modeling foundation,which is based on the mass spring model and easy to construct with high computing *** order to increase the real time performance,the central plane of the vessel model is extracted and then simplified to complete the skeleton *** initiative bending kinematics of the virtual catheter is analyzed so as to provide the virtual system with higher *** experimental results show that the virtual system can well simulate the vessel deformation and force feedback within an interventional surgery,which gives the virtual system better immersion.

关键词： virtual reality interventional surgery skeleton filling force feedback

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Echo state network based symbol detection in chaotic baseband wireless communication

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Digital Communications and Networks 2023年第6期9卷 1319-1330页

作者： Huiping Yin chao bai Haipeng Ren Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of TechnologyXi'an710048China Xi'an Key Laboratory of Intelligent Equipment Xi'an Technological UniversityXi'an710021China

The chaotic Baseband Wireless Communication System(CBWCS)is expected to eliminate the Inter-Symbol Interference(ISI)caused by multipath propagation by using the optimal decoding threshold that is the sum of the ISI caused by past decoded bits and the ISI caused by future transmitting ***,the current technique is only capable of removing partial effects of the ISI,because only past decoded bits are available for the suboptimal decoding threshold *** unavailability of the future information needed for the optimal decoding threshold is an obstacle to further improve the Bit Error Rate(BER)*** contrast to the previous method using Echo State Network(ESN)to predict one future bit,the proposed method in this paper predicts the optimal decoding threshold directly using *** proposed ESN-based threshold prediction method simplifies the symbol decoding operation by avoiding the iterative prediction of the output waveform points using ESN and accumulated error caused by the iterative *** this approach,the calculation complexity is reduced compared to the previous ESN-based *** proposed method achieves better BER performance compared to the previous *** reason for this superior result is ***,the proposed ESN is capable of using more future symbols information conveyed by the ESN input to obtain more accurate threshold rather than the previous method in which only one future symbol was ***,the proposed method here does not need to estimate the channel information using Least Squared(LS)method,which avoids the extra error caused by inaccurate channel information *** results and experiment based on a wireless open-access research platform under a practical wireless channel show the effectiveness and superiority of the proposed method.

关键词： chaotic baseband wireless communication system(CBWCS) Inter-symbol interference(ISI) Echo state network(ESN) Threshold prediction

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Kernel Estimators of the ROC Curve with Censored Data

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Acta Mathematicae Applicatae Sinica 2013年第1期29卷 43-54页

作者： fang-fang bai Yong Zhou Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Statistics and Management Shanghai University of Finance and Economics

Receiver operating characteristic （ROC） curves are often used to study the two sample problem in medical studies. However, most data in medical studies are censored. Usually a natural estimator is based on the Kaplan-Meier estimator. In this paper we propose a smoothed estimator based on kernel techniques for the ROC curve with censored data. The large sample properties of the smoothed estimator are established. Moreover, deficiency is considered in order to compare the proposed smoothed estimator of the ROC curve with the empirical one based on Kaplan-Meier estimator. It is shown that the smoothed estimator outperforms the direct empirical estimator based on the Kaplan-Meier estimator under the criterion of deficiency. A simulation study is also conducted and a real data is analyzed.

关键词： ROC curve smoothed estimator censored data Kaplan-Meier estimator deficiency

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