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Trends in treatment and overall survival among patients with proximal esophageal cancer

World Journal of Gastroenterology 2019年第47期25卷 6835-6846页

作者： Judith de vos-Geelen Sandra ME Geurts Liselot BJ valkenburg-van Iersel Evelien JM de Jong vivianne CG Tjan-Heijnen Margreet van Putten valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers chantal v hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen Department of Internal Medicine Division of Medical OncologyGROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Research Netherlands Comprehensive Cancer Organization(IKNL)Eindhoven 5612 HZNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Pathology and Data Analytics Leeds Institute of Medical Research at St James”sUniversity of LeedsLeeds LS97TFUnited Kingdom Department of Medical Oncology University Medical Center UtrechtUtrecht 3584 CXNetherlands Department of Radiation Oncology(MAASTRO clinic) GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6229 ETNetherlands Department of Internal Medicine Division of GastroenterologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Radiotherapy RadiotherapiegroepDeventer 7416 SENetherlands Department of Medical Oncology Amsterdam University Medical CentersUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiotherapy Insituut VerbeetenTilburg 5042 SBNetherlands Department of Medical Oncology Leiden University Medical CenterLeiden 2333 ZANetherlands Department of Surgery Catharina Hospital EindhovenEindhoven 5623 EJNetherlands Department of Public Health Erasmus Medical Center RotterdamRotterdam 3015 GDNetherlands

BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital ***-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been *** trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease *** optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life *** To establish trends in treatment and OS in patients with proximal esophageal *** In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer *** proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the *** in radiotherapy,chemotherapy,and surgery,and OS were *** were stratified by presence of distant *** Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment *** In total,2783 patients were *** the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,*** metastatic disease,the use of chemotherapy and radiotherapy increased over *** OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank Pved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank Pvariable regression analysis demonstrated a significant treatment effect over time on ***

关键词： Esophagus Esophageal cancer Proximal Cervical Upper thoracic Trends Treatment Survival Outcome

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Markers of insulin resistance in Polycystic ovary syndrome women:An update

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World Journal of Diabetes 2022年第3期13卷 129-149页

作者： chantal Anifa Amisi Endocrinology and Diabetes Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy

Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders,affecting 5%-10%of women of reproductive *** importance of this syndrome lies in the magnitude of associated comorbidities:infertility,metabolic dysfunction,cardiovascular disease(CvD),plus psychological and oncological *** resistance(IR)is a prominent feature of PCOS with a prevalence of 35%-80%.Without adequate management,IR with compensatory hyperinsulinemia contributes directly to reproductive dysfunction in women with ***,epidemiological data shows compelling evidence that PCOS is associated with an increased risk of impaired glucose tolerance,gestational diabetes mellitus and type 2 *** addition,metabolic dysfunction leads to a risk for CvD that increases with aging in women with ***,the severity of IR in women with PCOS is associated with the amount of abdominal obesity,even in lean women with *** these drastic implications,it is important to diagnose and treat insulin resistance as early as *** markers have been ***,quantitative assessment of IR in clinical practice remains a major *** gold standard method for assessing insulin sensitivity is the hyperinsulinemic euglycemic glucose ***,it is not used routinely because of the complexity of its ***,there has been an urgent need for surrogate markers of IR that are more applicable in large population-based epidemiological *** this,many of them are either difficult to apply in routine clinical practice or useless for women with *** this difficulty,there is still a need for an accurate marker for easy,early detection and assessment of IR in women with *** review highlights markers of IR already used in women with PCOS,including new markers recently reported in literature,and it establishes a new classification for these markers.

关键词： Markers Insulin resistance Polycystic ovary syndrome Emerging markers Impaired glucose tolerance

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Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome

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World Journal of Diabetes 2020年第2期11卷 42-51页

作者： chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli Endocrinology and Diabetes Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy Medical Statistics and Epidemiology Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy

BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS *** has shown that hyperinsulinemia is correlated with increased bone *** that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a ***,increased bone mass could be measured using the wrist circumference *** To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with *** Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were *** nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and *** measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat *** The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16

关键词： Wrist circumference Insulin resistance Polycystic ovary syndrome Congolese women Sub-Saharan African women Marker of insulin resistance Homeostasis Model Assessment of insulin resistance Easy-to-detect marker

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Conserved balance of hepatocyte nuclear DNA content in mononuclear and binuclear hepatocyte populations during the course of chronic viral hepatitis

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World Journal of Gastroenterology 2006年第28期12卷 4546-4548页

作者： Hidenori Toyoda Takashi Kumada Olivier Bregerie Christian Brechot chantal Desdouets Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Inserm U370-Pasteur Institute CHU NeckerParisFrance

AIM： TO analyze the percentages of hepatocytes with increased nuclear DNA content, i.e., tetraploid （4n） and octoploid （Sn） nuclei, and then compared mononuclear and binuclear hepatocyte populations： METHODS： The percentages of mononuclear diploid （2n）, 4n, and 8n hepatocytes and those of binuclear 2 × 2n, 2 × 4n, and 2 × 8n hepatocytes were determined with a method that can simultaneously measure hepatocyte nuclear DNA content and binuclearity in 62 patients with chronic hepatitis B or C. The percentage of 4n and 8n hepatocytes in the mononuclear hepatocyte population was compared with the percentage of 2 × 4n and 2 × 8n hepatocytes in the binuclear hepatocyte population. RESULTS： The percentages of 4n and 8n hepatocytes in mononuclear hepatocytes and 2 ×4n and 2 × 8n hepatocytes in binuclear hepatocytes were similar, regardless of the activity or fibrosis grade of chronic hepatitis and regardless of the infecting virus. CONCLUSION： The distribution of nuclear DNA content within mononuclear and binuclear hepatocyte populations was conserved during the course of chronic viral hepatitis.

关键词： Chronic viral hepatitis Hepatocyte binuclearity Hepatocyte ploidy Nuclear DNA content

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Effects of age and sex on clinical high-risk for psychosis in the community

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World Journal of Psychiatry 2020年第5期10卷 101-124页

作者： Frauke Schultze-Lutter Benno G Schimmelmann Rahel Fluckiger chantal Michel Department of Psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40692Germany University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of BernBern 3000Switzerland University Hospital of Child and Adolescent Psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND Recent reports of both heightened prevalence rates and limited clinical relevance of clinical high-risk(CHR)criteria and their relevant symptoms in children and adolescents indicate an important role of neurodevelopment in the early detection of ***,sex effects in CHR symptoms have been reported,though studies were *** sex also impacts on neurodevelopment,we expected that sex might have an additional contribution to age in the prevalence and clinical relevance of CHR symptoms and *** To investigate age and sex effects on CHR criteria and symptoms and their association with psychosocial impairment and mental *** In this cross-sectional cohort study,n=29168-to 40-year-olds,randomly drawn from the population register of the Swiss canton Bern,were assessed in semistructured interviews by phone or face-to-face for CHR symptoms and criteria using the Structured Interview for Psychosis-Risk Syndromes and the Schizophrenia Proneness Instrument in its child and youth,and adult version,***,social and occupational functioning and DSM-Iv axis I disorders were *** and interaction effects of age and sex on CHR symptoms and criteria,and interaction effects of age,sex,and CHR symptoms and criteria on presentation of functional impairment and of non-psychotic disorder were investigated using logistic regression *** Altogether,542(18.6%)participants reported any CHR symptom;of these,261(9.0%)participants reported any one of the 11 criteria relevant cognitive and perceptual basic symptoms,and 381(13.1%)any one of the five attenuated or transient psychotic symptoms(attenuated psychotic symptoms/brief intermittent psychotic symptoms).Fewer participants met any one of the CHR criteria(n=82,2.8%)or any one of the three recently recommended CHR criteria(n=38,1.3%).Both age and sex were significantly(P<0.05)associated with CHR symptoms and criteria,mostly by younger age and female se

关键词： Psychosis Clinical high-risk Attenuated psychotic symptoms Basic symptoms Community Age Sex Interview assessment Prevalence

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Rationale for the potential use of mesenchymal stromal cells in liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16418-16432页

作者： Morgan vandermeulen Céline Grégoire Alexandra Briquet chantal Lechanteur Yves Beguin Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege University of Liege Department of Hematology CHU Liege University of Liege Laboratory of Cell and Gene Therapy CHU Liege University of Liege

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success.

关键词： Mesenchymal stem cells Organ transplantation Complication Immunosuppression Tolerance

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Mechanism for Src activation by the CCK2 receptor:Patho-physiological functions of this receptor in pancreas

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World Journal of Gastroenterology 2006年第28期12卷 4498-4503页

作者： Audrey Ferrand Sebastien vatinel Aline Kowalski-Chauvel Claudine Bertrand chantal Escrieut Daniel Fourmy Marlene Dufresne Catherine Seva Dufresne Catherine SevaINSERM U 531IFR 31Institut Louis BugnardBP 8422531432 Toulouse cedex 4France

AIM： TO investigate in vivo, whether CCK2 receptors （CCK2R） regulate proteins known to play a crucial role in cell proliferation and cancer development and analyse in vitro the molecular mechanisms that lead to Src activation; in particular, to identify the domains within the CCK2R sequence that are implicated in this activation. METHODS： The expression and activation of Src and ERK were studied in vivo using immunofluorescence and western-blot techniques. We used pancreatic tissues derived from wild type or Elas-CCK2 mice that expressed the CCK2R in pancreatic acini, displayed an increased pancreatic growth and developed preneoplastic lesions. The pancreatic tumor cell line AR4-2J expressing the endogenous CCK2R or COS-7 cells transiently transfected with wild type or mutant CCK2R were used as in vitro models to study the mechanism of Src activation. Src activation was measured by in vitro kinase assays, ERK activation by western blot using antiphospho-ERK antibodies and the involvement of Src in gastrin-induced cell proliferation by MTT test. RESULTS： We showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, led to the activation of Src and the ERK pathway. Src was activated upstream of the ERK pathway by the CCK2R in pancreatic tumoral cells and contributed to the proliferative effects mediated by this receptor. In vitro results demonstrated that activation of the Src/ERK pathway by the CCK2R required the NPXXY motif, located within the CCK2R sequence at the end of the 7^th transmembrane domain, and suggested the putative role of Gq in this mechanism. CONCLUSION： Deregulation of the Src/ERK pathway by the CCK2R might represent an early step that contributes to cell proliferation, formation of preneoplastic lesions and pancreatic tumor development.

关键词： Gastrin, Src Pancreas CCK2 receptor

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Multidimensional assessment of neuro-psychiatric symptoms in patients with low-grade hepatic encephalopathy: A clinical rating scale

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World Journal of Gastroenterology 2005年第37期11卷 5893-5898页

作者： Sergei Mechtcheriakov Ivo W Graziadei André Kugener Julia Wiedemann chantal Galbavy Hartmann Hinterhuber Josef Marksteiner Wolfgang vogel Department of General Psychiatry Medical University Innsbruck Austria Department of Gastroenterology and Hepatology Medical University Innsbruck Anichstrasse 35 AT-6020 Innsbruck Austria

AIM： To evaluate the feasibility of a new clinical rating scale for a standardized assessment of cirrhosis-associated neuro-psychiatric symptoms. METHODS： Forty patients with liver cirrhosis （LC, with or without low-grade hepatic encephalopathy） were investigated using a clinical neuro-psychiatric rating scale based on a comprehensive list of neurological, psychomotor, cognitive, affective, behavioral symptoms, and symptoms of disturbed bioregulation. RESULTS： The analysis revealed that the majodty of cirrhotic patients showed, besides characteristic neurological symptoms of hepatic encephalopathy, various psychomotor, affective and bioregulatory symptoms （disturbed sleep and sexual dysfunction）. Patients were impaired in the following subscales： sleep and biorhythm disorder （75.0% of patients）, Parkinsonoid symptoms （25.0%）, affective symptoms （17.5%）, and psychomotor retardation （12.5%）. The increase of total neuro-psychiatric clinical score was significantly associated with the degree of hepatic encephalopathy. CONCLUSION： This study suggests that a substantial number of patients with LC and low-grade hepatic encephalopathy manifest various clinical neuro-psychiatric symptoms. The use of a rating scale, which explores clinical dimensions of hepatic encephalopathy, would improve the management of patients with LC.

关键词： Liver cirrhosis Hepatic encephalopathy Neuropsychiatric symptoms Clinical neuro-psychiatric rating Bradykinesia

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Gemcitabine in elderly patients with advanced pancreatic cancer

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World Journal of Gastroenterology 2011年第30期17卷 3497-3502页

作者： Olivia Hentic vinciane Rebours Philippe Lévy Philippe Ruszniewski Pascal Hammel Magaly Zappa chantal Dreyer Eric Raymond Ple des maladies de l'Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Ple des maladies de l’Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Service de Radiologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Service de Cancérologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance

AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METHODS： All consecutive patients ≥ 75 years old with advanced pancreatic adenocarcinoma were included in this retrospective study. Necessary criteria to receive chemotherapy were： performance status 0-2, adequate biological parameters and no serious comorbidities. Other patients received best supportive care （BSC）. RESULTS： Thirty-eight patients （53% women, median age 78 years, range 75-84） with pancreatic cancer （metastatic： n = 20, locally advanced： n = 18） were studied. Among them, 30 （79%） were able to receive chemotherapy [median number： 9 infusions （1-45）]. Six patients （23%） had at least one episode of grade 3 neutropenia and one patient developed a grade 3 hemolytic-uremic syndrome. No toxic death occurred. Three patients （11%） had a partial tumor response, 13 （46%） had a stable disease and 12 （43%） had a tumor progression. Median survival was 9.1 mo （metastatic： 6.9 too, locally advanced： 11.4 too）. CONCLUSION： Tolerance and efficacy of gemcitabinebased chemotherapy is acceptable in elderly patients in good condition, with similar results to younger patients.

关键词： Elderly Pancreas Cancer Gemcitabine

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Smoothelin,a new marker to determine the origin of liver fibrogenic cells

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World Journal of Gastroenterology 2013年第48期19卷 9343-9350页

作者： Sébastien Lepreux Christelle Guyot Fabrice Billet chantal Combe Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière CHU Bordeaux Hopital Pellegrin Service d’Anatomie Pathologique F-33076 Bordeaux France U889 and Université victor Segalen Bordeaux 2 F-33076 Bordeaux France Division of Clinical Pharmacology and Toxicology Department of Medicine University Hospital Zurich 8006 Zurich Switzerland Facultés de Médecine et de Pharmacie Université de Limoges EA 6309 F-87025 LimogesFrance

AIM: To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype, we have studied the expression of smoothelin in fibrotic conditions.

关键词： Smooth muscle cells, Myofibroblasts, α -smooth muscle actin, Smoothelin, Fibrosis/cirrhosis, Hepatocellular carcinoma

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