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P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis

Neural Regeneration Research 2024年第5期19卷 1078-1083页

作者： Zhiqing Yang Zhenchao Wang Xiaoqi Deng Lingxin Zhu Zhaomeng Song changyu cao Xinran Li School of Life Science and Engineering Foshan UniversityFoshanGuangdong ProvinceChina Foshan University Veterinary Teaching Hospital FoshanGuangdong ProvinceChina

Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain.3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine(P7C3-A20)can be neuroprotective in various diseases,including ischemic stroke and neurodegenerative ***,whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are ***,in the present study,we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular *** established a traumatic brain injury rat model using a modified weight drop method.P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain *** neurological deficits were found in rats after traumatic brain injury,with deterioration in balance,walking function,and learning ***,hematoxylin and eosin staining showed significant neuronal cell damage,while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of *** presence of autolysosomes was observed using transmission electron microscope.P7C3-A20 treatment reversed these pathological *** blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ)autophagy protein,apoptosis-related proteins(namely,Bcl-2/adenovirus E1B 19-kDa-interacting protein 3[BNIP3],and Bcl-2 associated x protein[Bax]),and elevated ubiquitin-binding protein p62(p62)autophagy protein ***,P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis.

关键词： apoptosis autophagy cortex hippocampus motor function P7C3-A20 traumatic brain injury

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Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy

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Fundamental Research 2024年第1期4卷 178-187页

作者： Nan Yang Hui Li changyu cao Lei Zhao Xuejiao Song Wenjun Wang Wenjing Xu Yewei Zhang Peng Chen Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China School of Chemical and Biomedical Engineering Lee Kong Chian School of MedicineNanyang Technological University62 Nanyang DriveSingapore 637459Singapore

Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable *** this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by *** an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous ***,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal *** with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关键词： Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2)

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一例猫瘟继发中耳炎的诊断与治疗

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黑龙江畜牧兽医 2024年第6期 80-84页

作者：臧谦陈思秋麦嘉迅曹嫦妤李欣然陆英杰佛山科学技术学院生命科学与工程学院广东佛山528225 立德动物医院广州510220 佛山科学技术学院附属教学动物医院广东佛山528225

体重为1.8 kg的4月龄布偶猫,雌性,就诊期间出现高热、排软便、打喷嚏、咳嗽等症状,经血常规检查、猫细小病毒(Feline panleukopenia virus, FPV)检测确诊为猫瘟,遂进行抗菌消炎、抗病毒感染、对症治疗、支持治疗。患猫在治疗第2天出现... 详细信息

体重为1.8 kg的4月龄布偶猫,雌性,就诊期间出现高热、排软便、打喷嚏、咳嗽等症状,经血常规检查、猫细小病毒(Feline panleukopenia virus, FPV)检测确诊为猫瘟,遂进行抗菌消炎、抗病毒感染、对症治疗、支持治疗。患猫在治疗第2天出现叫声嘶哑,左眼眼睑反射缺失伴有瞬膜凸起、偏头等神经症状,第3天主动少量进食,体温恢复正常,第5天精神、食欲、粪便形态恢复正常并出院。出院后第7天,面神经麻痹、偏头等前庭神经受损症状仍未消失,经电子计算机断层扫描(CT)检查确诊为慢性中耳炎、内耳炎,口服恩诺沙星保守治疗4周后瞬膜凸起、偏头等神经症状完全消失,行走姿势恢复正常。说明本病例为猫瘟继发中耳炎,恩诺沙星对治疗猫中耳炎具有良好的效果。

关键词：猫瘟中耳炎瞬膜凸起外周神经继发感染

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大蒜素缓解伏马毒素B_(1)致鹌鹑肝损伤的研究

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中国畜牧兽医 2024年第9期51卷 4080-4091页

作者：李欣然祝领鑫宋欢妮朱雪雁李若彬刘阳曹嫦妤佛山大学生命科学与工程学院佛山528225 佛山大学食品科学与工程学院全国名特优新农产品全程质量控制技术佛山中心(CAQS-GAP-KZZX043)佛山528225 佛山大学附属动物医院佛山528225

【目的】探索大蒜素缓解伏马毒素B_(1)(FB_(1))造成产蛋期鹌鹑肝脏损伤的机制,为预防FB_(1)诱导鹌鹑肝损伤提供试验依据,减少FB_(1)中毒给养殖业造成的经济损失。【方法】以黄羽雌性鹌鹑为试验对象,将120只鹌鹑随机分为4组,分别为对照... 详细信息

【目的】探索大蒜素缓解伏马毒素B_(1)(FB_(1))造成产蛋期鹌鹑肝脏损伤的机制,为预防FB_(1)诱导鹌鹑肝损伤提供试验依据,减少FB_(1)中毒给养殖业造成的经济损失。【方法】以黄羽雌性鹌鹑为试验对象,将120只鹌鹑随机分为4组,分别为对照组、大蒜素组(500 mg/kg大蒜素)、伏马毒素组(30 mg/kg FB_(1))及缓解组(500 mg/kg大蒜素+30 mg/kg FB_(1)),每组30只。观察鹌鹑肝脏组织病理学及组织超微结构变化,并检测肝功能、抗氧化功能指标及相关炎症因子的表达。【结果】肝脏病理学与超微结构结果显示,大蒜素能够有效缓解FB_(1)造成的鹌鹑肝脏线粒体嵴消失、胶原纤维增加等病理损伤。与对照组相比,伏马毒素组鹌鹑血清中谷草转氨酶(AST)浓度显著升高(P<0.05);过氧化氢酶(CAT)活力、总抗氧化物能力(T-AOC)均显著降低(P<0.05),丙二醛(MDA)含量显著升高(P<0.05);白细胞介素8(IL-8)、IL-6、IL-18、IL-12β、肿瘤坏死因子α(TNF-α)、环氧化酶2(COX-2)、诱导型一氧化氮合酶(iNOS)、相关凋亡因子配体(FASL)及Toll样受体4(TLR4)基因表达量均显著升高(P<0.05)。与伏马毒素组相比,缓解组鹌鹑血清中AST含量显著降低(P<0.05);CAT活力、T-AOC显著升高(P<0.05),MDA含量显著降低(P<0.05);IL-8、IL-6、IL-18、IL-12β、TNF-α、COX-2、iNOS、FASL、TLR 4基因表达量均显著降低(P<0.05)。【结论】大蒜素可有效缓解FB_(1)导致的鹌鹑肝损伤,其机制与大蒜素的抗炎作用和抗氧化作用密切相关。

关键词：鹌鹑大蒜素伏马毒素B_(1) 肝损伤

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BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy

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Nano Research 2022年第3期15卷 2235-2243页

作者： Nan Yang Tian Zhang changyu cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Zhejiang Provincial Key Lab of Geriatrics&Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang HospitalHangzhou 310013China Clinical Research Institute Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China

Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence *** therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment ***,chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin(BSA)stabilized gallic acid-functionalized iron nanoparticles(GA-Fe NPs)to achieve chemo/chemodynamic synergistic cascade *** Pt-GA-Fe NPs can be utilized to generate H_(2)O_(2) via the activation of nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)in the tumor microenvironment(TME),which would then greatly boost H2O2-depending chemodynamic therapy(CDT).The generated cytotoxic reactive oxygen species(hydroxyl radicals,·OH)and the depletion of glutathione(GSH)would further promote CDDP-induced DNA ***,benefiting from the absorption in the near-infrared(NIR)region,Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency(η=45.5%)and allow photoacoustic imaging(PAI)guided photothermal therapy(PTT).In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic *** work highlights a new type of therapeutic agent based on CDDP with the ability of H_(2)O_(2) self-generation,thermal responsiveness,and enhanced CDT effects for applications in cancer therapy.

关键词： chemotherapy chemodynamic therapy cascade therapy CDDP Fenton reaction

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Effects of potassium lactate on sensory attributes,bacterial community succession and biogenic amines formation in Rugao ham

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Food Science and Human Wellness 2024年第1期13卷 198-210页

作者： Renyong Liao Ying Wang Qiang Xia changyu Zhou Fang Geng Daodong Pan Jinxuan cao State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Animal Protein Food Processing Technology of Zhejiang ProvinceNingbo UniversityNingbo 315211China Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

To deepen the understanding in the effect of potassium lactate on the sensory quality and safety of Rugao ham,sensory attributes,physicochemical parameters,total volatile basic nitrogen(TVBN),microorganism community and biogenic amines of Rugao ham manufactured with different potassium lactate levels(0%,0.5%,1%,2%)were investigated;the relationship between microbial community and the formation of TVBN and biogenic amines was further *** the increase of potassium lactate from 0%to 2%,the increased sensory scores and the decreased total aerobic bacterial count and TVBN were observed;the abundance of Staphylococcus increased,while the content of Halomonas *** effect size(LEf Se)and correlations analysis showed that Staphylococcus equorum and Lactobacillus fermentum could be the key species to improve sensory scores and decrease biogenic amines and *** pathway analysis further showed that amino acids metabolism and nitrogen metabolism were mainly involved in decreasing TVBN and biogenic amines in the treatment of 2%potassium lactate.

关键词： Rugao ham Potassium lactate Biogenic amines Microbial community Metabolic pathways

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POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1334-1342页

作者： changyu cao Tingbo Zhang Nan Yang Xianghong Niu Zhaobo Zhou Jinlan Wang Dongliang Yang Peng Chen Liping Zhong Xiaochen Dong Yongxiang Zhao Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physics Southeast UniversityNanjing 211189China School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore 637459Singapore National Center for International Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor TheranosticsGuangxi Medical UniversityNanningGuangxi 530021China

The current feasibility of nanocatalysts in clinical anti-infection therapy,especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen ***,a novel Ag/Bi2MoO6(Ag/BMO)nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and *** Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus(MRSA)(~99.9%).The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity,NIR-II photodynamic behavior,and acidity-enhanced release of Ag^(+).As revealed by theoretical calculations,the introduction of Ag to BMO made it easier to separate photo-triggered electronhole pairs for ROS *** the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O_(2) to·O_(2)^(−).Under 1064 nm laser irradiation,the electron transfer to BMO was beneficial to the reversible change of Mo^(5+)/Mo^(6+),further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell *** vivo,the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected *** study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.

关键词： mechanism. separation charge

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Enhanced gas production and CO_(2) storage in hydrate-bearing sediments via pre-depressurization and rapid CO_(2) injection

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Chinese Journal of Chemical Engineering 2024年第3期67卷 126-134页

作者： Hongnan Chen Yifei Sun Bojian cao Minglong Wang Ming Wang Jinrong Zhong changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha 410114China

Carbon emission reduction and clean energy development are urgent demands for mankind in the coming *** an efficient CO_(2) storage method can significantly reduce CO_(2) emissions in the short *** this study,we attempted to construct sediment samples with different residual CH_(4) hydrate amounts and reservoir conditions,and then investigate the potentials of both CO_(2) storage and enhanced CH_(4) recovery in depleted gas hydrate deposits in the permafrost and ocean zones,*** results demonstrate that CO_(2) hydrate formation rate can be significantly improved due to the presence of residual hydrate seeds;However,excessive residual hydrates in turn lead to the decrease in CO_(2) storage *** by the T-P conditions of the reservoir,the storage amount of liquid CO_(2) can reach 8 times that of gaseous CO_(2),and CO_(2) stored in hydrate form reaches 2-4 ***,we noticed two other advantages of this *** is that CO_(2) injection can enhance CH_(4) recovery rate and increases CH_(4) recovery by 10%-20%.The second is that hydrate saturation in the reservoir can be restored to 20%-40%,which means that the solid volume of the reservoir avoids serious ***,this is crucial for protecting the goaf *** summary,this approach is greatly promising for high-efficient CO_(2) storage and safe exploitation of gas hydrate.

关键词： Hydrate Depressurization CO_(2) storage CH_(4) production Reservoir remediation

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Regeneration of copper catalysts mediated by molybdenum-based oxides

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Journal of Energy Chemistry 2024年第8期95卷 618-625,I0013页

作者： changyu Ding Xiaoli Pan Isla E.Gow Xia Wu Hongchen cao Zhounan Yu Xiaoyan Liu Xiaofeng Yang Qinggang Liu Yanqiang Huang CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Cardiff Catalysis Institute School of ChemistryTranslational Research HubCardiff UniversityCardiff CF244HQUnited Kingdom College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040HeilongjiangChina

Cu catalysts,known for their unparalleled catalytic capabilities due to their unique electronic structure,have faced inherent challenges in maintaining long-term effectiveness under harsh hydrogenation ***,we demonstrate a molybdenum-mediated redispersion behavior of Cu under hightemperature oxidation *** oxidized Cu nanoparticles with rich metal-support interfaces tend to dissolve into the MoO_(3)support upon heating to 600℃,which facilitates the subsequent regeneration in a reducing atmosphere.A similar redispersion phenomenon is observed for Cu nanoparticles supported on Zn O-modified MoO_(3).The modification of ZnO significantly improves the performance of the Cu catalyst for CO_(2)hydrogenation to methanol,with the high activity being well maintained after four repeated oxidation-reduction *** situ spectroscopic and theoretical analyses suggest that the interaction involved in the formation of the copper molybdate-like compound is the driving force for the redispersion of *** method is applicable to various Mo-based oxide supports,offering a practical strategy for the regeneration of sintered Cu particles in hydrogenation applications.

关键词： Cu-based catalysts Aggregation Regeneration Oxidation CO_(2)hydrogenation

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Inflammation is the main reason in vein damage caused by selenium deficiency

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畜牧与饲料科学 2015年第Z1期 336-337页

作者： cao changyu YAO Haidong FAN Ruifeng ZHANG Ziwei XU Shiwen Department of Veterinary Medicine Northeast Agricultural University

[Background]Selenium（Se） plays an important role in regulating various metabolic processes in the *** raised considerable expectations for the prevention of vascular disease,cancer,and other chronic ***,the exact mechanism still needs to be clarified.[Objective]Establishment the chicken model of Se deficiency disease,and enunciate the mechanisms how Se induces vein injury.[Methods]Broilers were divided into two groups,fed deficient Se diets and common diets respectively for 30 *** euthanasia,veins were quickly removed blotted and then rinsed with ice-cold sterile deionized water,frozen immediately in liquid nitrogen,and stored at -80 ℃ until *** antioxidant related factors（GSH,MDA and H2O2） were determined using detection kits,mRNA expression of 25 selenoproteins,the mRNA and protein levels of inflammatory cytokines and heat shock proteins were detected by RT-PCR and Western *** of the tissues（5μm thick） were cut and stained with hematoxylin and eosin（H & E） and examined under microscope,TUNEL assay was using the in situ cell death detection kit.[Results]It was observed that,in broiler vein,the deficient Se diets markedly decreased the antioxidant including the activity of GPx,and the content of GSH and *** 25 selenoproteins,the expressions of 20 selenoproteins in Se deficiency group were decreased compared to the Se common *** content of H2S,the protein expression of 3-MST,CSE,NO,iNOS and the inflammatory cytokines in Se deficiency group were increased compared to the Se common group,the expression of heat shock proteins were also present a similar *** analysis showed,in Se deficiency group,karyopyknosis and chromatin *** adipose around vessels,surrounded and infiltrated by massive inflammatory cells and *** percent of apoptotic cells was increased in the Se deficiency group compared to the Se common group.[Conclusion]Selenoproteins,inflammatory cytokines and HSPs,they

关键词： inflammation genes chicken vein selenium deficiency

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