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折叠结构的PVDF/BTO复合薄膜压电纳米发电机的制备及性能研究

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材料导报 2024年第6期38卷 234-239页

作者：张昌松王向阳魏立柱王如鹏陕西科技大学机电工程学院西安710016

为提高聚偏氟乙烯(PVDF)的压电输出性能,将钛酸钡(BTO)纳米颗粒引入到PVDF溶液中,使用流延法制备PVDF/BTO复合压电薄膜,采用高温拉伸与电极化工艺处理复合薄膜。使用扫描电子显微镜、X射线衍射仪、傅里叶变换红外光谱仪、差示扫描量热... 详细信息

为提高聚偏氟乙烯(PVDF)的压电输出性能,将钛酸钡(BTO)纳米颗粒引入到PVDF溶液中,使用流延法制备PVDF/BTO复合压电薄膜,采用高温拉伸与电极化工艺处理复合薄膜。使用扫描电子显微镜、X射线衍射仪、傅里叶变换红外光谱仪、差示扫描量热仪和准静态压电常数测试仪对复合薄膜的形貌和压电性能进行表征,探究BTO含量对PVDF/BTO复合薄膜的影响,研究BTO诱导PVDF链条偶极子重新排列形成β晶型的机理。结果表明,当BTO含量为10%(质量分数)时,PVDF/BTO复合薄膜的晶体结构中β晶型的含量最多,压电性能最强。最后设计了不同层数的折叠结构并组装制成压电纳米发电机(PENG),发现折叠层数越多,PENG的最大输出电压越高。

关键词：聚偏氟乙烯钛酸钡压电纳米发电机压电性能

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血浆EGFR外显子19和21突变指导进展期肺腺癌的靶向治疗

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中国医药科学 2024年第4期14卷 5-8,46页

作者：马俊房兵张长松江苏省南通市第三人民医院如皋港分院检验科江苏南通226500 江苏省南通市第三人民医院如皋港分院大内科江苏南通226500 南京大学医学院附属苏州医院(苏州科技城医院)检验科江苏苏州215009

目的探讨血浆表皮生长因子受体(EGFR)外显子19和21基因突变指导进展期肺腺癌的靶向治疗。方法选择2022年1月至2023年1月南通市第三人民医院如皋港分院(本院)肿瘤科和南京大学医学院附属苏州医院(苏州科技城医院)肿瘤科采用靶向治疗的60... 详细信息

目的探讨血浆表皮生长因子受体(EGFR)外显子19和21基因突变指导进展期肺腺癌的靶向治疗。方法选择2022年1月至2023年1月南通市第三人民医院如皋港分院(本院)肿瘤科和南京大学医学院附属苏州医院(苏州科技城医院)肿瘤科采用靶向治疗的60例进展期肺腺癌患者作为腺癌组,其中本院20例、南京大学医学院附属苏州医院(苏州科技城医院)40例;另选择同期在南京大学医学院附属苏州医院(苏州科技城医院)体检的60名健康体检者作为健康组。两组患者均进行血浆EGFR基因突变检测。结果血浆EGFR突变检测显示,腺癌组EGFR突变检出率整体(46.67%,28/60)高于健康组(1.67%,1/60);腺癌组EGFR外显子19缺失突变检出率(30.00%,18/60)高于健康组(1.67%,1/60);腺癌组EGFR外显子21缺失突变检出率(16.67%,10/60)高于健康组(0);腺癌组野生型占比(53.33%,32/60)低于健康组(98.33%,59/60),差异有统计学意义(P<0.05)。外显突变患者靶向治疗后肿瘤直径为(2.76±1.03)cm,小于野生型患者的(4.52±1.24)cm,肿瘤体积为(8.96±1.74)cm^(3),小于野生型患者的(14.75±1.93)cm^(3);外显突变患者靶向治疗总有效率(67.86%,19/28)高于野生型患者(50.00%,16/32),疾病控制率(70.00%,21/28)高于野生型患者(56.25%,18/32),差异有统计学意义(P<0.05)。结论血浆EGFR基因突变检测可为进展期肺腺癌患者的靶向治疗提供一定的临床指导。

关键词：血浆 EGFR 基因突变进展期肺腺癌靶向治疗

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Cd污染河道底泥修复植物优选

上海大学学报（自然科学版） 2024年第1期30卷 86-93页

作者：沈佳怡臧学轲章长松高冰洁高铭晶李心怡张新颖上海大学环境与化学工程学院上海200444 上海亚新建设工程有限公司上海200436

选用12种植物对上海市某Cd污染黑臭河道底泥进行了修复试验研究,考察了修复植物对Cd污染底泥的耐受性、富集转运特性和修复效果,以期为实际开展植物修复Cd污染河道底泥研究提供科学依据.结果表明:除移植的灯芯草(Juncus effusus L.)生... 详细信息

选用12种植物对上海市某Cd污染黑臭河道底泥进行了修复试验研究,考察了修复植物对Cd污染底泥的耐受性、富集转运特性和修复效果,以期为实际开展植物修复Cd污染河道底泥研究提供科学依据.结果表明:除移植的灯芯草(Juncus effusus L.)生长情况较差外,其余11种植物对试验底泥均有良好的耐受性;龙葵(Solanum nigrum L.)、灯芯草、金盏菊(Calendula officinalis L.)、八宝景天(Hylotelephium erythrostictum(Miq.)***)以及大吴风草(Farfugrium japonicum(L.f.)Kitam.)地上部分的Cd质量比均高于4.50 mg/kg;苘麻(Abutilon theophrasti Medicus)、灯芯草、金盏菊、八宝景天、大吴风草以及美洲商陆(Phytolacca americana L.)对Cd的富集系数(bioaccumulation factor,BCF)与转运系数(translocation factor,TF)均大于1;龙葵、金盏菊、美洲商陆以及三叶鬼针草(Bidens pilosa L.)对Cd的提取量均高于0.30 kg/hm^(2),具有较好的修复效果,其中龙葵对试验底泥中Cd的提取量为2.84 kg/hm^(2),提取效率可达88.75%,展现出了较大的修复潜力.优选试验结果证明,龙葵可作为该地区Cd污染河道底泥的最佳修复植物.

关键词：河道底泥 Cd 植物修复优选试验龙葵

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汽水换热器管束泄漏原因分析及预防措施

乙烯工业 2024年第1期36卷 24-27+65页

作者：张长松黄超波李文婷杜志奇雷茜中国石油天然气股份有限公司独山子石化分公司

针对制氢装置出现的汽水波纹管换热器泄漏情况，结合具体操作工况，对换热器管束泄漏原因进行成因分析，根据波纹管在含氯介质环境下腐蚀机理，结合实际检验报告，得出可信的分析结果，且根据原因分析制定相应的具体预防措施。通过换热... 详细信息

针对制氢装置出现的汽水波纹管换热器泄漏情况，结合具体操作工况，对换热器管束泄漏原因进行成因分析，根据波纹管在含氯介质环境下腐蚀机理，结合实际检验报告，得出可信的分析结果，且根据原因分析制定相应的具体预防措施。通过换热管改造彻底消除腐蚀隐患，延长换热器运行周期，确保换热器长周期运行。

关键词：汽水换热器腐蚀泄漏改进

Autologous nerve segment-bridging regeneration chambers for the repair of sciatic nerve defects

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Neural Regeneration Research 2011年第4期6卷 262-266页

作者： Jiren zhang changsong Cao Jincheng zhang Department of Hand Surgery First Hospital of Liaoning Medical University Jinzhou 121000 Liaoning Province China

Proximal and distal nerve defects exhibit chemotactic growth over certain distances. Our previous studies demonstrated that Schwann cells survive in autologous nerve segments that are bridged by regeneration chambers and secrete various bioactive substances. However, more data are required to determine the required length of regeneration chambers for chemotaxis and nutrition of neural regeneration, as well as the length of repaired nerve defects to replace the effect of autologous nerve grafting. In the present study, sciatic nerve defects of 12, 16, 20 mm were repaired using a regeneration chamber of 6, 8, and 10 mm in length respectively. These were bridged with autologous nerve segments. Results showed that the bridging of two 6-mm long regeneration chambers to repair a 12-mm nerve defect exhibited similar effects to autologous nerve grafting.

关键词： nerve segment regeneration chamber bridging sciatic nerve defect neural regeneration

Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy

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Biomedical Engineering Frontiers 2023年第1期4卷 31-41页

作者： Anran Zheng Chao Li Shengkai Xu Zhen Guo Chuanyu Li changsong zhang Jia Yao Zhiqi zhang Jinze Li Lutao Du Shasha Zhao Chuanxin Wang Wei zhang Lianqun Zhou CAS Key Lab of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Suzhou Hospital Affiliated Hospital of Medical SchoolNanjing UniversitySuzhou 215153Jiangsu ProvinceChina Suzhou CASENS Co.Ltd. Suzhou 215163China Ji Hua Laboratory Foshan 528000China Department of Clinical Laboratory The Second Hospital of Shandong UniversityJinan 250033ShandongChina

Objective and Impact Statement:We describe an electroenzymatic mediator(EM)sensor based on an electroenzymatic assembly peak separation strategy,which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease(CVD)metabolites in 5μl of plasma under one *** work has substantial implications toward improving the efficiency of chronic CVD ***:Monitoring CVD of metabolites is strongly associated with disease *** and time-consuming detection in hospitals is unfavorable for chronic CVD ***:The EM was flexibly designed by the cross-linking of electron mediators and enzymes,and 3 EM layers with different characteristics were assembled on one *** were transferred under tunable potential;3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite ***:In this study,the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 *** linear correlation between the sensor and clinical was greater than 0.980 for 242 patients,and the consistency of risk assessment was 94.6%.Conclusion:Metabolites could be expanded by the EM,and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment.

关键词： flex linking consuming

Reshaping the Cortical Connectivity Gradient by Long-Term Cognitive Training During Development

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Neuroscience Bulletin 2024年第1期40卷 50-64页

作者： Tianyong Xu Yunying Wu Yi zhang Xi-Nian Zuo Feiyan Chen changsong Zhou Bio-X Laboratory School of PhysicsZhejiang UniversityHangzhou 310027China Qiushi Academy for Advanced Studies Zhejiang UniversityHangzhou 310027China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Cognitive Neuroscience and Learning Bejing Normal UniversityBeijing 100875China Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China Zhejiang Province Key Laboratory of Quantum Technology and Devices Zhejiang UniversityHangzhou 310027China Department of Physics Centre for Nonlinear Studies and Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems(Hong Kong)Institute of Computational and Theoretical StudiesHong Kong Baptist UniversityHong Kong 999077China

The organization of the brain follows a topologi-cal hierarchy that changes dynamically during ***,it remains unknown whether and how cognitive training administered over multiple years during develop-ment can modify this hierarchical *** measuring the brain and behavior of school children who had carried out abacus-based mental calculation(AMC)training for five years(starting from 7 years to 12 years old)in pre-training and post-training,we revealed the reshaping effect of long-term AMC intervention during development on the brain hierarchical *** observed the development-induced emergence of the default network,AMC training-promoted shifting,and regional changes in cortical ***,the training-induced gradient changes were located in visual and somatomotor areas in association with the visuospatial/motor-imagery *** found that gradient-based features can predict the math ability within *** findings provide novel insights into the dynamic nature of network recruitment impacted by long-term cognitive training during development.

关键词： Connectivity gradient Cognitive training Development Neural plasticity Abacus-based mental calculation

Clinicopathological significance and immunotherapeutic outcome of claudin 18.2 expression in advanced gastric cancer:A retrospective study

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Chinese Journal of Cancer Research 2024年第1期36卷 78-89页

作者： changsong Qi Xiaoyi Chong Ting Zhou Mingyang Ma Jifang Gong Miao zhang Jian Li Jun Xiao Xiaohui Peng Zhen Liu Zonghai Li Lin Shen Xiaotian zhang State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China CARsgen Therapeutics Co. LtdShanghai 200231China CARsgen Life Sciences Co. LtdShanghai 200131China

Objective: Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive(CLDN18.2-positive) gastric cancer(GC) vary in different clinical studies, making it difficult to optimize antiCLDN18.2 therapy. We conducted a retrospective analysis to explore the association of CLDN18.2 expression with clinicopathological characteristics and immunotherapeutic outcomes in ***: A total of 536 advanced GC patients from 2019 to 2021 in the CT041-CG4006 and CT041-ST-01clinical trials were included in the analysis. CLDN18.2 expression on ≥40% of tumor cells(2+, 40%) and CLDN18.2 expression on ≥70% of tumor cells(2+, 70%) were considered the two levels of positively expressed GC. The clinicopathological characteristics and immunotherapy outcomes of GC patients were analyzed according to CLDN18.2 expression ***: CLDN18.2 was expressed in 57.6%(cut-off: 2+, 40%) and 48.9%(cut-off: 2+, 70%) of *** death-ligand 1(PD-L1) and CLDN18.2 were co-expressed in 19.8% [combined positive score(CPS)≥1, CLDN18.2(cut-off: 2+, 40%)] and 17.2% [CPS≥5, CLDN18.2(cut-off: 2+, 70%)] of ***18.2 expression positively correlated with younger age, female sex, non-gastroesophageal junction(nonGEJ), and diffuse phenotype(P<0.001). HER2 and PD-L1 expression were significantly lower in CLDN18.2-positive GC(both P<0.05). Uterine adnexa metastasis(P<0.001) was more frequent and liver metastasis(P<0.001)was less common in CLDN18.2-positive GC. Overall survival and immunotherapy-related progression-free survival(ir PFS) were inferior in the CLDN18.2-positive ***: CLDN18.2-positive GC is associated with poor prognosis and worse immunotherapeutic outcomes. The combination of anti-CLDN18.2 therapy, anti-PD-L1/PD-1 therapy, and chemotherapy for GC requires further investigation.

关键词： Gastric cancer claudin18.2 CT041 PD-L1 immunotherapy

Integrated microdevice with a windmill-like hole array for the clog-free,efficient,and self-mixing enrichment of circulating tumor cells

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Microsystems & Nanoengineering 2022年第1期8卷 291-304页

作者： Hao Li Jinze Li Zhiqi zhang Zhen Guo changsong zhang Zixu Wang Qiuquan Guo Chao Li Chuanyu Li Jia Yao Anran Zheng Jingyi Xu Qingxue Gao Wei zhang Lianqun Zhou School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China260026 HefeiChina CAS Key Lab of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of Sciences215163 SuzhouChina Ji Hua Laboratory 528000 FoshanChina Department of Laboratory Medicine The Affiliated Suzhou Science and Technology Town HospitalNanjing Medical University215153 SuzhouChina Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China518000 ShenzhenChina Suzhou CASENS Co. Ltd215163 SuzhouChina Jinan Guoke Medical Technology Development Co. Ltd250001 JinanChina

Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive *** the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further ***,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and *** by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater *** addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the *** the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of *** white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and *** to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses.

关键词： logging free aggregation