检索结果-南通市图书馆

Ultrasound-guided fine-needle aspiration/biopsy-based pancreatic organoids establishment:an alternative model for basic and preclinical research

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Gastroenterology Report 2023年第1期11卷 88-94页

作者： Sheng Chen Min Wang Lei Liu Guodong Wang Lei Wang changqing zhong Chao Gao Wei Wu Lianyong Li Department of Gastroenterology PLA Strategic Support Force Medical CenterBeijingP.R.China State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health PLA Strategic Support Force Medical CenterBeijingP.R.China Department of Medical Psychology PLA Strategic Support Force Medical CenterBeijingP.R.China Department of Otorhinolaryngology Head and Neck Surgery PLA Strategic Support Force Medical CenterBeijingP.R.China

Pancreatic ductal adenocarcinoma(PDAC),as one of the malignant cancers with the worst prognosis,is becoming the most urgent clinical *** to the lack of early diagnosis and curable therapeutic methods,it is critical to exploit proper models that can capture the overall attributes of the primary ***,organoid technology has emerged and flourished as a powerful tool to enable long-termculture of pancreatic tissues,including *** accumulating studies suggest,organoids can retain morphological,genetic,and behavioral traits,and have tremendous value in predicting the therapeutic response to conventional chemotherapy drugs or newfangled ***,this review comprehensively summarizes the tissue source including human fetal and adult pancreatic tissue to generate a pancreatic organoid as well as current organoids cultivate *** PDAC organoids can be established from a small number of samples derived from endoscopic ultrasound-guided fine-needle aspiration/biopsy(EUS-FNA/FNB),we also review the literature to date on EUS-FNA/FNBbased organoid constitution and its implementation in inquiring tumor behavior and evaluating therapeutic *** enabling the alignment of basic and clinical research platforms,the application of organoids would open up new avenues for drug discovery and maximally benefit translational medicine in the near future.

关键词： organoids pancreatic ductal adenocarcinoma ultrasound-guided fine-needle aspiration/biopsy review

Gastroesophageal reflux disease:recent innovations in endoscopic assessment and treatment

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Gastroenterology Report 2021年第5期9卷 383-391,I0001页

作者： Sheng Chen Feng Du changqing zhong Caifang Liu Xiaoying Wang Yan Chen Gang Wang Xiaopei Gao Lu Zhang Lianyong Li Wei Wu Department of Gastroenterology PLA Strategic Support Force Characteristic Medical CenterBeijingP.R.China State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health PLA Strategic Support Force Characteristic Medical CenterBeijingP.R.China Department of Internal Medicine The Hospital of the People’s Liberation Army 63650 CorpsMalanXinjiangP.R.China Department of Pediatrics The First Affiliated Hospital of Xi’an Medical UniversityXi’anShaanxiP.R.China Department of Otorhinolaryngology Head and Neck Surgery PLA Strategic Support Force Characteristic Medical CenterBeijingP.R.China

Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reﬂux disease(GERD).GERD,as one of the most prevalent gastrointestinal disorders in the world,has always been on the cutting edge of endoscopic interventions.A primary diagnosis of GERD is based on symptoms and an initial trial of proton-pump inhibitor(PPI)therapy,which is devoid of adequately instructive value for therapeutic *** and optional biopsies can be used to directly observe and determine the abnormal structural and pathophysiological damage in the *** emergence of minimally invasive endoscopic therapyﬁlls the gap between patients who are reluctant or insensitive to PPIs and candidates who are not indicated for surgical anti-reﬂux *** this review,we discuss the utility of endoscopy and biopsy in patients with persistent GERD-related manifestations after proper medical anti-reﬂux ***,we portray a landscape of four current endoscopic GERD therapies and clarify the merits and disadvantages of each *** research needs to concentrate on stratifying GERD patients based on personal conditions and elucidating the primary pathophysiology of GERD.

关键词： gastroesophageal reﬂux disease endoscopy biopsy treatment

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基于价值链分析的图书馆品牌构建

图书情报知识 2006年第2期23卷 109-110页

作者：钟常青湘潭大学图书馆湘潭411105

本文运用价值链分析方法,分析了图书馆价值链的构成要素以及图书馆品牌价值贡献要素系统,提出了在图书馆品牌构建过程中的相关策略。

关键词：价值链品牌构建图书馆信息资源

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中文网络信息保存体系探讨

图书馆杂志 2008年第4期27卷 21-25页

作者：钟常青杨道玲湘潭大学图书馆湖南411105 武汉大学信息管理学院湖北430072

网络信息保存体系是一种解决与网络信息资源保存相关的一系列问题的整体方案。本文首先简要介绍了构建网络信息保存体系的背景与意义。然后作者提出,在建立中文网络信息资源保存战略体系时,应该从宏观上研究保存中的4个基本模块:保存目... 详细信息

网络信息保存体系是一种解决与网络信息资源保存相关的一系列问题的整体方案。本文首先简要介绍了构建网络信息保存体系的背景与意义。然后作者提出,在建立中文网络信息资源保存战略体系时,应该从宏观上研究保存中的4个基本模块:保存目的、保存主体、保存对象、保存方法。

关键词：网络信息长期保存体系

A comparative study on 3-D solar wind structure observed by Ulysses and MHD simulation

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Science Bulletin 2005年第07期50卷 672-678页

作者： FENG Xueshang, XIANG changqing, zhong Dingkun & FAN Quanlin SIGMA Weather Group, Key Laboratory of Space Weather Key Labo- ratory of Geospace Environment and Geodesy, Ministry of Education, Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100080, China SIGMA Weather Group Key Laboratory of Space Weather Key Labo- ratory of Geospace Environment and Geodesy Ministry of Education Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China

During Ulysses’ first rapid pole-to-pole transit from September 1994 to June 1995, its observations showed that middle- or high-speed solar winds covered all latitudes except those between ?20° and +20° near the ecliptic plane, where the velocity was 300―450 km/s. At poleward 40°, however, only fast solar winds at the speed of 700―870 km/s were observed. In addition, the transitions from low-speed wind to high-speed wind or vice versa were abrupt. In this paper, the large-scale structure of solar wind observed by Ulysses near solar minimum is simulated by using the three-dimensional numerical MHD model. The model com- bines TVD Lax-Friedrich scheme and MacCormack II scheme and decomposes the calculation region into two re- gions: one from 1 to 22 Rs and the other from 18 Rs to 1 AU. Based on the observations of the solar photospheric magnetic field and an addition of the volumetric heating to MHD equations, the large-scale solar wind structure mentioned above is reproduced by using the three-dimensional MHD model and the numerical results are roughly consistent with Ulysses’ observations. Our simulation shows that the initial magnetic field topology and the addition of volume heating may govern the bimodal structure of solar wind observed by Ulysses and also demonstrates that the three-dimensional MHD numerical model used here is efficient in modeling the large-scale solar wind structure.

关键词： Ulysses observation solar wind structure numerical simulation.

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基于皮格马利翁效应的图书馆员情绪管理

图书馆研究 2006年第2期36卷 105-106页

作者：钟常青湘潭大学图书馆

简要介绍了皮格马利翁效应,在此基础上将图书馆员划分为兴奋期、稳定期、抱怨期和阵亡期这四个不同的类型,分析了四种类型图书馆员的不同情绪特征,并有针对性地提出了具体的情绪管理措施。

关键词：皮格马利翁效应图书馆员情绪管理

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网络时代高校图书馆竞争情报服务发展探析

高校图书馆工作 2005年第6期25卷 70-72页

作者：钟常青湘潭大学湖南湘潭411105

本文论述了网络环境下公开信息对竞争情报发展的重要性,网络环境下高校图书馆信息服务工作的新特点,以及图书馆竞争情报服务工作的策略等方面的问题。参考文献7。

关键词：网络环境高校图书馆竞争情报服务策略

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藏民頭像(木刻八幅)

当代美术家 1985年第1期 22-23页

作者：鍾長靑不详

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線與力——木刻語言管窺

当代美术家 1985年第1期 16-18页

作者：鍾長靑不详

我們所說的力,是指物理的力和心理的力在藝術作品中對於審美主體的復合感覺。要說明線與力之間的種種聯繫'就應該對線條的功能有一個明確的概念。線條在藝術作品中的功能'可以歸納爲下列三個方面:(一)連接各物象形體'使那些支離破碎的... 详细信息

我們所說的力,是指物理的力和心理的力在藝術作品中對於審美主體的復合感覺。要說明線與力之間的種種聯繫'就應該對線條的功能有一個明確的概念。線條在藝術作品中的功能'可以歸納爲下列三個方面:(一)連接各物象形體'使那些支離破碎的物像富於整體感,這類線條,可以稱之爲外輪廓線;(二)分割面積,使面與面之間分切明顯,呈現出主結構脈絡,這類線條'可以稱之爲内結構法。

关键词：形體分切物像