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Regenerative Biomaterials 2023年第1期10卷 194-204页

作者： Linrui Jiang Rong Zheng Ni Zeng changqiang wu Hongying Su Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China Sichuan Key Laboratory of Medical Imaging North Sichuan Medical CollegeNanchong 637000China

Polymeric micelles have long been considered as promising nanocarrier for hydrophobic drugs and imaging probes,due to their nanoscale particle size,biocompatibility and ability to loading reasonable amount of ***,a facile method for dextran micelles preparation was developed and their performance as carriers of superparamagnetic iron oxide(SPIO)nanocrystals was *** dextran(Dex-g-OA)was synthesized via the Schiff base reactions between oxidized dextran and oleylamine,and self-assembled in situ into nano-size micelles in the reaction *** self-assembling behaviors of the amphiphilic dextran were identified using fluorescence resonance energy transfer technique by detection the energy transfer signal between the fluorophore pairs,Cy5 and *** SPIO nanoparticles(Fe_(3)O_(4)NPs)were successfully loaded into the dextran micelles via the in situ self-assembly process,leading to a series of Fe_(3)O_(4)NPs-loaded micelle nanocomposites(Fe_(3)O_(4)@Dex-g-OA)with good biocompatibility,superparamagnetism and strongly enhanced T_(2)*** the magnetic field of 0.5 T,the Fe_(3)O_(4)@Dex-g-OA nanocomposite with particle size of 116.2±53.7 nm presented a higher T_(2)relaxivity of 327.9 mM_(re)^(-1)·s^(-1)·s^(−1).The prepared magnetic nanocomposites hold the promise to be used as contrast agents in magnetic resonance imaging.

关键词： micelle dextran superparamagnetic iron oxide magnetic resonance imaging Schiff base

Cisplatin and paclitaxel co-delivery nanosystem for ovarian cancer chemotherapy

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Regenerative Biomaterials 2021年第3期8卷 133-140页

作者： Qiaoying Wang changqiang wu Xiaoting Li Dixiao Yang Liangjun Shi Department of Medicine Leshan Vocational and Technical CollegeNo.1336Middle Section of Qingyijiang AvenueShizhong DistrictLeshan CitySichuan ProvinceChina Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging North Sichuan Medical College55 Dongshun RoadGaoping DistrictNanchongSichuan ProvinceChina

We have designed and developed an effective drug delivery system using biocompatible polymer of poly(ethylene glycol)-polyaspartic acid(mPEG-PAsp)for co-loading the chemotherapy drugs paclitaxel(PTX)and cisplatin(CP)in one *** study aimed to improve the anti-cancer effi-cacy of combinations of chemotherapy drugs and reduce their side ***-PAsp-(PTX/Pt)nano-micelles disperse well in aqueous solution and have a narrow size distribution(37.863.2 nm)in dynamic light scattering(DLS).Drug release profiles found that CP released at pH 5.5 was signifi-cantly faster than that at pH ***-PAsp-(PTX/Pt)nano-micelles displayed a significantly higher tumor inhibitory effect than mPEG-PAsp-PTX nano-micelles when the polymer concentrations reached 50 lg/*** data indicated that polymer micelles of mPEG-PAsp loaded with the combined drug exert synergistic anti-tumor efficacy on SKOV3 ovarian cells via different action *** from our studies suggested that mPEG-PAsp-(PTX/Pt)nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.

关键词： drug delivery ovarian cancer co-delivery nanosystem paclitaxel combination chemotherapy

Ultra-small superparamagnetic iron oxide nanoparticles for intra-articular targeting of cartilage in early osteoarthritis

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Regenerative Biomaterials 2023年第1期10卷 1111-1121页

作者： Jun wu changqiang wu Zhongyuan Cai Haojie Gu Li Liu Chunchao Xia Su Lui Qiyong Gong Bin Song Hua Ai Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu 610207China Medical Imaging Key Laboratory of Sichuan Province School of Medical ImagingNorth Sichuan Medical CollegeNanchong 637000China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and ImmunologyNHCResearch Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610064China Department of Radiology West China Xiamen Hospital of Sichuan UniversityFujianXiamen 361000China Department of Radiology Sanya People’s HospitalHainanSanya 572000China

Early diagnosis of osteoarthritis(OA)is critical for effective cartilage ***,lack of blood vessels in articular cartilage poses a barrier to contrast agent delivery and subsequent diagnostic *** address this challenge,we proposed to develop ultra-small superparamagnetic iron oxide nanoparticles(SPIONs,4 nm)that can penetrate into the matrix of articular cartilage,and further modified with the peptide ligand WYRGRL(particle size,5.9 nm),which allows SPIONs to bind to type II collagen in the cartilage matrix and increase the retention of *** II collagen in the cartilage matrix is gradually lost with the progression of OA,consequently,the binding of peptide-modified ultra-small SPIONs to type II collagen in the OA cartilage matrix is less,thus presenting different magnetic resonance(MR)signals in OA group from the normal *** introducing the AND logical operation,damaged cartilage can be differentiated from the surrounding normal tissue on T1 and T2 AND logical map of MR images,and this was also verified in histology ***,this work provides an effective strategy for delivering nanosized imaging agents to articular cartilage,which could potentially be used to diagnosis joint-related diseases such as osteoarthritis.

关键词： early osteoarthritis magnetic resonance imaging superparamagnetic iron oxide collagen type II targeting peptide

Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation

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Regenerative Biomaterials 2016年第4期3卷 223-229页

作者： Jiuju Du Wencheng Zhu Li Yang changqiang wu Bingbing Lin Jun wu Rongrong Jin Taipeng Shen Hua Ai National Engineering Research Center for Biomaterials Department of Radiology West China HospitalSichuan UniversityChengdu610065P.R.China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031P.R.China School of Medical Imaging North Sichuan Medical CollegeNanchong637000P.R.China

Superparamagnetic iron oxide(SPIO)nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their *** covered with amphiphilic alkyl-polyethyleneimine(PEI),the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery carriers and cell tracking ***,the positively charged amines of PEI can also cause cytotoxicity and restricts their further *** this study,we used lactose to modify amphiphilic low molecular weight polyethylenimine(C_(12-)PEI_(2K))at different lactosylation *** was found that the N-alkyl-PEI-lactobionic acid wrapped SPIO nanocomposites show better cell viability without compromising their labelling efficacy as well as MR imaging capability in RAW 264.7 cells,comparing to the unsubstituted ***,we found the PEI induced cell autophagy can be reduced via lactose modification,indicating the increased cell viability might rely on down-regulating ***,our findings provide a new approach to overcome the toxicity of PEI wrapped SPIO nanocomposites by lactose modification.

关键词： SPIO polyethyleneimine lactosylation MRI RAW 264.7 autophagy

Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy

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Regenerative Biomaterials 2023年第1期10卷 678-689页

作者： Liang Du Wei Chen Jie Zhong Shuang Yan Chenwu Yang Yu Pu Jiang Zhu Tianwu Chen Xiaoming Zhang changqiang wu Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000PR China

Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in *** particular,the method combination of nanophotothermal agents and magnetic resonance imaging(MRI)shows great promise for biomedical therapeutic ***,a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide(SPIO)and ferric ion(SPIO@PAsp-DAFe/PEG)was developed for MRI-guided near-infrared photothermal therapy(PTT).SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility,had a diameter of 57.8±7.8 nm in dynamic light scattering,negatively charged surface(zeta potential=−11 mV),exhibited good stability and outstanding photothermal conversion efficiency(35.4%)and produced superior magnetic resonance enhanced *** the experiment with tumor-bearing mice,the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for *** the use of MRI-guided near-infrared therapy,the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects,confirming their great potential as effective MRI/PTT therapeutic agents.

关键词： dopamine superparamagnetic iron oxide nanocomposites magnetic resonance imaging photothermal therapy

Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes

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Science Bulletin 2015年第14期60卷 1272-1280页

作者： Bingbing Lin Hongying Su Rongrong Jin Danyang Li changqiang wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai National Engineering Research Center for Biomaterials Sichuan University Department of Chemical Engineering Kunming University of Science and Technology School of Engineering and Materials Science Queen Mary University of London Department of Radiology West China Hospital Sichuan University

Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles （SPIO） was prepared for drug delivery and magnetic resonance imaging （MRI）. Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L^-1. Doxorubicin （DOX） and a cluster of the manganese-doped iron oxide nanoparticles （Mn-SPIO） nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplat- lk）rm for the delivery of anticancer drug DOX with a loading content （DLC） of 16 %. Confocal laser scanning microscopy reveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with flee ***. Under a 3.0-T MRI scanner, Mn-SPIO/ DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation （T2） rate is also significantly higher than that of the control cells （33.9 versus 2.3 s^-1）. Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability.

关键词： Dextran micelle - Drug delivery systemSuperparamagnetic iron oxide Multifunctionalnanoparticles Magnetic resonance imaging

MRI-guided photothermal/photodynamic immune activation combined with PD-1 inhibitor for the multimodal combination therapy of melanoma and metastases

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Regenerative Biomaterials 2024年第4期3卷 38-51页

作者： changqiang wu Wei Chen Shuang Yan Jie Zhong Liang Du Chenwu Yang Yu Pu Yang Li Jiafu Lin Mei Zeng Xiaoming Zhang Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging North Sichuan Medical CollegeNanchong 637000P.R.China Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu 610106P.R.China Institute of Basic Medicine and Forensic Medicine North Sichuan Medical College and Institute of Rheumatology and ImmunologyThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China

Non-invasive image-guided precise photothermal/photodynamic therapy(PTT/PDT)has been proven to be an effective local treatment modality but incompetent against ***,the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor ***,a magnetic resonance imaging(MRI)-visualized PTT/PDT agent(SIDP NMs)was constructed,and the efficacy of its multimodal combination with a programmed cell death 1(PD-1)inhibitor in the treatment of melanoma and metastases was *** to the hydrophobic encapsulation of indocyanine green within the micellar core,SIDP NMs exhibited excellent photothermal/photodynamic properties and stability under an 808 nm near-infrared *** vitro cell experiments showed that SIDP NMs had a good killing *** incubating with B16-F10 cells for 24 h and irradiating with an 808-nm laser for 10 min,cell viability decreased *** resonance imaging experiments in melanoma-bearing mice have shown that the dynamic distribution of SIDP NMs in tumor tissue could be monitored by T2WI and T2-MAP non-invasively due to the presence of superparamagnetic iron oxide nanocrystal in SIDP *** the 808 nm laser was irradiated at the maximum focusing time point shown by MRI,the temperature of the tumor area rapidly increased from 32℃to 60.7℃in 5 *** mouse melanoma ablation and distant tumor immunotherapy studies,SIDP NMs provided excellent MRI-guided PTT/PDT results and,when combined with PD-1 inhibitor,have great potential to cure primary tumors and eradicate metastases.

关键词： photothermal therapy photodynamic therapy immunotherapy magnetic resonance imaging multimodal treatment

Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes

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Chinese Science Bulletin 2012年第31期57卷 4012-4018页

作者： WANG Dan SU HongYing LIU yanHong wu changqiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan University Chengdu 610041China

Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo.

关键词：荧光成像纳米粒子聚阳离子近红外多模态磁铁矿两亲性超顺磁性氧化铁

聚天冬氨酸-多巴胺接枝聚合物-铁(Ⅲ)配合物用于磁共振可视化光热治疗剂

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生物医学工程学杂志 2022年第2期39卷 398-404页

作者：杜亮卢福麟吴昌强川北医学院医学影像四川省重点实验室四川南充637000

为探究聚天冬氨酸-多巴胺接枝聚合物(PAsp-g-DA)螯合三价铁离子(Fe^(3+))用于磁共振可视化光热治疗的潜力,本实验通过聚琥珀酰亚胺(PSI)氨解反应获得共价接枝多巴胺和聚乙二醇的聚天冬氨酸接枝共聚物(PAsp-g-DA/PEG),然后将其与Fe^(3+)... 详细信息

为探究聚天冬氨酸-多巴胺接枝聚合物(PAsp-g-DA)螯合三价铁离子(Fe^(3+))用于磁共振可视化光热治疗的潜力,本实验通过聚琥珀酰亚胺(PSI)氨解反应获得共价接枝多巴胺和聚乙二醇的聚天冬氨酸接枝共聚物(PAsp-g-DA/PEG),然后将其与Fe^(3+)在水溶液中螯合,通过808 nm波长光热转换、体外弛豫效率和体内磁共振成像检测其光热转换和磁共振对比增强效果。结果显示,聚合物铁配合物具有较好的近红外光吸收及光热转换能力,同时具有良好的磁共振增强效果,在不同场强下具有良好的纵向弛豫效能。综上所述,本研究提供了一种新型的磁共振可视化光热治疗剂,为相关领域的研究提供了新的研究思路。

关键词：磁共振成像光热转换可视化治疗

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意志、道德意志、善良意志

学术交流 2010年第12期 8-12页

作者：易小明吴昌强中南大学应用伦理学研究中心长沙410000 吉首大学哲学研究所湖南吉首416000

意志是以自由为存在前提的,其策动的行为处于善恶之间;道德意志是道德活动中的意志,是意志中指向善的那一部分,其行为以善为指向;善良意志是道德意志中的纯粹利他部分,它是道德意志的一种特殊状态,其行为以"善本身"为目的。从道德动机... 详细信息

意志是以自由为存在前提的,其策动的行为处于善恶之间;道德意志是道德活动中的意志,是意志中指向善的那一部分,其行为以善为指向;善良意志是道德意志中的纯粹利他部分,它是道德意志的一种特殊状态,其行为以"善本身"为目的。从道德动机的角度来看,从意志到道德意志再到善良意志,表现为人的道德属性不断增强的发展过程,既不能将意志等同于道德意志,也不能将道德意志等同于善良意志。因此,厘清三者的各自内涵,既是道德理论探讨的需要,也是道德实践的需要。

关键词：意志道德意志善良意志