Cisplatin and paclitaxel co-delivery nanosystem for ovarian cancer chemotherapy
作者机构：Department of MedicineLeshan Vocational and Technical CollegeNo.1336Middle Section of Qingyijiang AvenueShizhong DistrictLeshan CitySichuan ProvinceChina Medical Imaging Key Laboratory of Sichuan Province and School of Medical ImagingNorth Sichuan Medical College55 Dongshun RoadGaoping DistrictNanchongSichuan ProvinceChina
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第3期
页 面：133-140页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：The work was supported by National Natural Science Foundation of China(81601490) the Key Project of Sichuan Education Department(16ZA0399) the Sichuan Science and Technology Program(2017JY0107,2016JY0172) the Leshan Science and Technology Bureau of China(17GZD041)
主 题：drug delivery ovarian cancer co-delivery nanosystem paclitaxel combination chemotherapy
摘 要：We have designed and developed an effective drug delivery system using biocompatible polymer of poly(ethylene glycol)-polyaspartic acid(mPEG-PAsp)for co-loading the chemotherapy drugs paclitaxel(PTX)and cisplatin(CP)in one *** study aimed to improve the anti-cancer effi-cacy of combinations of chemotherapy drugs and reduce their side ***-PAsp-(PTX/Pt)nano-micelles disperse well in aqueous solution and have a narrow size distribution(37.863.2 nm)in dynamic light scattering(DLS).Drug release profiles found that CP released at pH 5.5 was signifi-cantly faster than that at pH ***-PAsp-(PTX/Pt)nano-micelles displayed a significantly higher tumor inhibitory effect than mPEG-PAsp-PTX nano-micelles when the polymer concentrations reached 50 lg/*** data indicated that polymer micelles of mPEG-PAsp loaded with the combined drug exert synergistic anti-tumor efficacy on SKOV3 ovarian cells via different action *** from our studies suggested that mPEG-PAsp-(PTX/Pt)nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.
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