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急诊科护理人员职业应激与应对策略研究

智慧健康 2024年第4期10卷 185-188页

作者：程明雪张琳张长敏山东大学齐鲁医院山东济南250000

目的探讨急诊科护理人员日常工作的压力源及影响因素。方法采取描述性方式选取2021年8月—2022年8月在本院急诊科工作的112名护士,发放问卷调查其一般资料、压力源量表、心理卫生评定量表、应对量表,以发现急诊护士心理问题,寻求有效应... 详细信息

目的探讨急诊科护理人员日常工作的压力源及影响因素。方法采取描述性方式选取2021年8月—2022年8月在本院急诊科工作的112名护士,发放问卷调查其一般资料、压力源量表、心理卫生评定量表、应对量表,以发现急诊护士心理问题,寻求有效应对策略。结果①急诊护士工作压力包括护理工作与专业、工作量与时间分配、工作环境与资源、患者护理以及管理与人际关系共五方面;②急诊护士由于压力过大易出现抑郁、强迫、焦虑、恐惧以及心理疾病;③针对急诊护士的心理问题,实施积极有效的应对策略后,发生不良心理问题情况明显降低,与实施应对策略前相比存在统计学差异(P<0.05)。结论采取合理有效的应对策略,能够有效减轻急诊护士压力,缓解由于应激源而产生的心理问题,促进身心健康;应积极采取有效应对策略,构建科室支持系统,以减轻压力,促进急诊护士健康发展。

关键词：急诊科职业应激心理问题负性情绪应对策略

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自噬在毛发再生中的作用

中国组织工程研究 2024年第7期28卷 1112-1117页

作者：黄雨馨梁文姿陈秀文倪娜赵颖琳林常敏汕头大学医学院广东省汕头市515041 汕头大学精神卫生中心广东省汕头市515065

背景:在生物医学界,自噬是一个快速发展的研究热点,许多研究人员正在积极探究多种疾病中自噬的分子调控机制,但是自噬在毛发生长中所起的作用仍存在许多未知。目的:综述目前自噬在毛发生长与再生中的研究进展及应用价值,了解自噬在毛发... 详细信息

背景:在生物医学界,自噬是一个快速发展的研究热点,许多研究人员正在积极探究多种疾病中自噬的分子调控机制,但是自噬在毛发生长中所起的作用仍存在许多未知。目的:综述目前自噬在毛发生长与再生中的研究进展及应用价值,了解自噬在毛发生长中的作用,以探究自噬在病理性脱发中的发病机制,为研究治疗脱发的药物提供新思路。方法:应用计算机在中国知网(CNKI)、PubMed数据库中,以“毛囊生长,毛发生长,毛发再生,自噬相关蛋白,自噬活性,自噬相关基因,自噬”或“hair growth,hair follicle,hair regeneration,autophagy”为检索词进行检索。查阅国内外近年来关于自噬、毛发生长和自噬在毛发生长中作用的研究进展进行总结,排除与文章主题内容不相符的文献,最终纳入78篇文献进行结果分析。结果与结论:(1)自噬是真核生物的正常代谢过程,具有复杂的分子机制和功能特性,既有利于细胞生存,又可促进细胞死亡。(2)脱发相关疾病与自噬活性的改变有关,且自噬活性可调控毛发生长周期;敲除或过表达自噬相关基因可改变毛发生长状态,已发现有多条自噬相关信号通路与毛囊生长有关;自噬的激活剂或抑制剂可用于治疗或预防脱发疾病。

关键词：毛囊毛发毛发再生毛囊再生毛囊生长周期自噬自噬活性自噬激活剂自噬抑制剂

揭阳市医务人员脱发现状及其相关因素调查分析

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汕头大学医学院学报 2024年第1期37卷 58-62页

作者：林晓升魏奕娜林常敏刘彩霞汕头大学医学院广东汕头515041 揭阳市人民医院广东揭阳522000

目的:探讨揭阳市医务人员脱发的现状及相关因素,为医务人员脱发的防治提供依据。方法:2021年4月—2023年4月选取揭阳市医务人员530名为研究对象,通过问卷收集基本信息,采用多因素logistic回归分析筛选脱发的相关因素。使用90项症状自评... 详细信息

目的:探讨揭阳市医务人员脱发的现状及相关因素,为医务人员脱发的防治提供依据。方法:2021年4月—2023年4月选取揭阳市医务人员530名为研究对象,通过问卷收集基本信息,采用多因素logistic回归分析筛选脱发的相关因素。使用90项症状自评量表对研究对象进行心理评估并抽取血液进行血糖、血脂和血清皮质醇检测。结果:530名医务人员的脱发患病率为22.5%(119/530)。logistic回归分析显示,年龄(OR=0.89,95%CI:0.84~0.96)、加班次数≥7次/月(OR=11.14,95%CI:1.47~84.66)、睡眠时间6~<7 h/d(OR=22.79,95%CI:3.55~146.41)、睡眠时间≥8 h/d(OR=41.14,95%CI:4.66~363.47)、头发生长速度缓慢(OR=69.89,95%CI:24.43~199.95)是脱发的相关因素。脱发组90项症状自评量表的躯体化、抑郁和敌对3个因子的得分及血糖、胆固醇、甘油三酯和皮质醇4个血液指标值均高于非脱发组,差异有统计学意义(均P<0.05)。结论:揭阳市医务人员脱发患病率较高,年龄、加班、睡眠时间和头发生长速度是脱发的相关因素。

关键词：医务人员脱发相关因素 90项症状自评量表

Rational design of nanocarriers for mitochondria-targeted drug delivery

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Chinese Chemical Letters 2022年第9期33卷 4146-4156页

作者： Lihua Huang Zonghao Sun Qian Shen Zhongxi Huang Shuangxi Wang Naidi Yang Gongqiang Li Qiong Wu Wei Wang lin Li changmin Yu Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China Institute of Agro-product Safety and Nutrition Zhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China

Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable.Numerous studies have been conducted on the treatment of mitochondria-related diseases;however,further improvements are required to develop more effective drug delivery methods.Herein,we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers,and discuss the different strategies of available nanocarriers for targeting mitochondria.We also highlight the advantages and disadvantages of various carrier systems that are currently in use.Finally,perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.

关键词： Mitochondria target Mitochondria diseases Therapeutic drugs Nanocarriers

Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer

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Chinese Chemical Letters 2022年第4期33卷 1855-1860页

作者： Yongxin Liu Mengda Cao Zhongxi Huang changmin Yu Naidi Yang Qiong Wu Liang Shi Wenjie Duan Yi Zhu Jifu Wei lin Li Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Research Division of Clinical Pharmacology&Clinical Allergy Center the First Affiliated Hospital of Nanjing Medical UniversityDepartment of PharmacyJiangsu Institute of Cancer Research&the Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Pharmacy Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210044China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi’an 710072China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases.

关键词： Gold nanoparticles Magnetic nanocapturer IgE detection Ultrasensitive immunosensor Cancer

Older adults’social participation and social relationship and association with partner’s cognition:a latent profile analysis

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China Population and Development Studies 2023年第4期7卷 418-437页

作者： Yiyang Yuan changmin Peng Yan lin Shan Qu Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical School368 Plantation StreetWorcesterMA 01605USA Department of Gerontology John W.McCormack Graduate School of Public and Global StudiesUniversity of Massachusetts Boston100 Morrissey BoulevardBostonMA 02125USA

Older adults’social participation and social relationship may be affected by their partners’cognitive function.In 3,722 cognitively intact married/partnered Health and Retirement Study respondents,latent profile analysis identified three social participation profiles(Limited overall social participation(prevalence:69%);Frequent volunteer participation(10%);Frequent non-volunteer participation(21%)),and three social relationship profiles(Social support from all relationships(68%);Mixed social support and strain from all relationships(18%);Social strain from partner with support from other relationships(14%)).Spouse/partner’s cognition was not significantly associated with social participation profiles.Impaired cognition in spouses/partners increased older adults’likelihood of perceiving social strain from their partners with support from other relationships.Frequent volunteer and non-volunteer participation and perceiving social support from all relationships predicted better self-rated health and lower odds of depressive symptoms.These findings highlight the need of community programs that promote social connectedness for older adults living with cognitively impaired spouses/partners.

关键词： Cognitive impairment Social participation Social relationship Latent profile analysis Self-rated health Depressive symptoms

Recent progress in small molecule fluorescent probes for nitroreductase

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Chinese Chemical Letters 2018年第10期29卷 1451-1455页

作者： Wenjing Qin Chenchen Xu Yanfei Zhao changmin Yu Sheng Shen lin Li Wei Huang Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech)Nanjing 211816 China Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing 210008 China

Nitroreductase（NTR） is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia,which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply, can result in NTR overexpression. Using either nicotinamide adenine dinucleotide（NADH） or nicotinamide adenine dinucleotide phosphate（NADPH） as a source of reducing equivalents, NTR can catalyze the reduction of nitroaromatic compounds to the corresponding amines.Based on this reduction mechanism, NTR can be applied not only in the bioremediation and degradation of organic nitrogen compounds, but also in the development of NTR-targeted fluorescent probes to detect the hypoxic status of cancer cells. This review aims to provide a summary of the progress in fluorescent probes for NTR in recent years and elucidate the main fluorescent mechanisms that have been applied to design probes.

关键词： Probe Fluorescence Nitroreductase Small molecule probes

Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes

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Chinese Chemical Letters 2020年第3期31卷 759-763页

作者： Hong Wang Jing Wei Chonghua Zhang Yuan Zhang Yubin Zhang lin Li changmin Yu Peisheng Zhang Jian Chen Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education Hunan Provincial Key Laboratory of Controllable Preparationand Functional Application of Fine PolymersHunan Provincial Key Lab of Advanced Materials for New Energy Storage and ConversionHunan Province College KeyLaboratory of QSAR/QSPRSchool of Chemistry and Chemical EngineeringHunan University of Science and TechnologyXiangtan 411201China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211800China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

Direct,in situ selective detection of intracellular formaldehyde(FA)is of great significance for understanding its function in FA-related diseases.Herein,red carbon dots(RCD)are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA.Upon addition of FA,the-NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water.In addition,the nanoprobes exhibit outsta nding photo stability,rapid response(<1 min),high sensitivity(~9.9μmol/L)and excellent selectivity toward FA over other aldehyde group compounds.Notably,owing to the good cell-membrane permeability and biocompatibility,as well as the large two-photon absorption cross-section,the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation.Moreover,RCD could stain the tissue of zebrafishes at depths interval of up to 240μm under two-photon excitation.This research implied that RCD are promising tools for directly and in situ imaging FA in vivo,thus providing critical insights into FA-related pathophysiological processes.

关键词： Carbon dots(CDs) Two-photon excitation Formaldehyde(FA) Intracellular imaging Zebrafishes

Mitochondria-targeted fluorescent probe based on vibration-induced emission for real-time monitoring mitophagy-specific viscosity dynamic

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Chinese Chemical Letters 2020年第11期31卷 2897-2902页

作者： Shuangxi Wang Bicong Zhou Na Wang changmin Yu Naidi Yang Jian Chen Qiong Wu Chengwu Zhang lin Li Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&•Institute of Advanced Materials(1AM) Nanjing Tech University(NanjingTech)Nanjing 211800China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi'an 710072China Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers Hunan University of Science and TechnologyXiangtan 411201China

Directly monitoring mitophagy-specific viscosity dynamic in living cells is of great significance but remains challenging.Herein,this study reported a novel mitochondria-targeted fluorescent probe DPACDY based on vibration-induced emission(VIE)for monitoring viscosity changes during mitochondrial autophagy.This probe contained N,N’-diphenyl-dihydrodibenzo[a,c]phenazine(DPAC)as the VIE core and two positively charged pyridinium moieties for mitochondria anchoring.As the ambient viscosity increased,the vibration of DPAC-DY could be hindered,and subsequently resulting in the enhancement of fluorescence emission.In vitro and intracellular experiments indicated that the probe DPAC-DY showed highly sensitive response to viscosity due to VIE mechanism.Importantly,by virtue of this probe,in situ and real-time visualization of the specific viscosity dynamics during the mitochondrial autophagy process was achieved.Thus,this work provides a novel strategy for VIE-based viscosity response sensors applied to specific organelles and offers a platform for in-depth study of mitochondrial viscosity-related diseases.

关键词： Vibration-induced emission Autophagy Viscosity Fluorescence detection