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The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021

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Cancer Communications 2021年第8期41卷 747-795页

作者： Feng-Hua wang Xiao-Tian zhang Yuan-Fang li lei Tang Xiu-Juan Qu Jie-Er Ying Jun zhang ling-Yu Sun Rong-Bo lin Hong Qiu Chang wang Miao-Zhen Qiu Mu-yan Cai QiWu Hao liu Wen-long Guan Ai-Ping Zhou Yu-Jing zhang Tian-Shu liu Feng Bi Xiang-lin Yuan Sheng-Xiang Rao yan Xin Wei-Qi Sheng Hui-mian Xu Guo-Xin li Jia-fu Ji Zhi-Wei Zhou Han liang yan-Qiao zhang Jing Jin lin Shen Jin li Rui-Hua Xu Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China Department of Gastric Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001P.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310006P.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025P.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001P.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujian 350000P.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030P.R.China Cancer Center of The First Hospital of Jilin University ChangchunJilin 130021P.R.China Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Endoscopy Center Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuan

There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western *** Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it *** into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in *** 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric *** on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant *** the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant *** value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been *** the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided.

关键词： adjuvant chemotherapy Chinese Society of Clinical Oncology(CSCO) diagnosis gastric cancer immunotherapy neoadjuvant radiotherapy surgery targeted therapy

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Combined Modeling of Shear-Induced Cell Aggregation and Adhesion Dynamics Mediated by Receptor-ligand Interactions

Combined Modeling of Shear-Induced Cell Aggregation and Adhe...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Yu Du Shou-qin lü Yu-hong Cui yan zhang mian long Key laboratory of Microgravity(National Microgravity laboratory) Institute of MechanicsChinese Academy of Sciences Center of Biomechanics and Bioengineering Institute of MechanicsChinese Academy of Sciences Department of Mechanics Tianjin University

Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation,inflammatory cascade,and tumor metastasis, in which these cellular interactions are mainly mediated by dynamics and kinetics of underlying receptor-ligand *** the theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately,how to couple these two processes remains poorly understood. Here we developed a unified framework that couples cellular aggregation dynamics and ad-

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唐山市乐亭县附近海域表层海水与沉积物中重金属污染评价

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海洋技术学报 2024年第4期43卷 75-85页

作者：刘书锦岳奇李锋李长亮国家海洋技术中心唐山市港口实业集团有限公司

为分析人类活动对海洋环境的影响程度，评价潜在重金属污染风险，本文根据2022年5月和9月的调查监测数据对唐山市乐亭县附近海域的表层海水和沉积物中的铜（Cu）、铅（Pb）、锌（Zn）、镉（Cd）、汞（Hg）和砷（As）等重金属污染情况进... 详细信息

为分析人类活动对海洋环境的影响程度，评价潜在重金属污染风险，本文根据2022年5月和9月的调查监测数据对唐山市乐亭县附近海域的表层海水和沉积物中的铜（Cu）、铅（Pb）、锌（Zn）、镉（Cd）、汞（Hg）和砷（As）等重金属污染情况进行分析，表层海水的重金属污染分析采用单项污染物指数法进行分析，沉积物中的污染物采用潜在生态危害指数（Ecological Risk Index,ERI）进行分析。分析结果表明：对于表层海水而言，春季海水中的各重金属污染物浓度符合海水水质标准中的Ⅰ类海水水质的要求，秋季海水除Pb超标外，其余元素也均符合Ⅰ类海水水质要求，表层海水污染主要是由陆源污染物排放、远洋航运和渔船捕捞所致。调查海域表层沉积物的污染水平不高，对生态环境的危害较为轻微，污染类型为轻微污染。沉积物中的污染物防治需要重点关注Cd，秋季还需要注意防范Hg、Cd、Pb的潜在污染风险。

关键词：海水沉积物重金属污染潜在风险分析

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鞍钢10号3200m^(3)高炉降低焦比生产实践

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鞍钢技术 2024年第1期 51-54,58页

作者：李林春赵东明张延辉张海明杨长亮鞍钢股份有限公司炼铁总厂辽宁鞍山114021 鞍钢集团钢铁研究院辽宁鞍山114009

针对高炉焦比指标较高的问题,提出了采取提高原燃料质量、提高煤比、保证合理的炉型、优化装料制度和提高炉缸活跃性等措施。实践后,高炉入炉焦比降低16 kg/t,综合焦比降低18 kg/t,产量提升360 t/d,高炉长期稳定顺行,效果良好。

关键词：高炉炉型管理入炉焦比综合焦比稳定顺行

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肝动脉灌注化疗联合瑞戈非尼治疗结直肠癌肝转移患者的临床研究

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中国临床药理学杂志 2024年第2期40卷 185-189页

作者：彭涛杨沔金梁斌沈雷斌宁波市医疗中心李惠利医院结直肠肛肠外科浙江宁波315000

目的观察肝动脉灌注化疗(HAIC)联合瑞戈非尼治疗结直肠癌肝转移的近远期效果。方法入选结直肠癌肝转移患者作为研究对象,按队列法分为试验组和对照组。对照组采用mFOlFOX6的HAIC化疗方案,试验组在对照组的基础上第1~21 d联合口服瑞戈非... 详细信息

目的观察肝动脉灌注化疗(HAIC)联合瑞戈非尼治疗结直肠癌肝转移的近远期效果。方法入选结直肠癌肝转移患者作为研究对象,按队列法分为试验组和对照组。对照组采用mFOlFOX6的HAIC化疗方案,试验组在对照组的基础上第1~21 d联合口服瑞戈非尼160 mg治疗,28 d为1个周期。治疗28 d后评价近期疗效,比较2组患者肿瘤标志物、肝功能、远期疗效、药物不良反应。结果试验组入组38例和对照组入组42例。试验组和对照组的客观缓解率分别为26.32%和9.52%,疾病控制率分别为71.05%和47.62%,治疗后,试验组和对照组的血清癌胚抗原水平分别为(10.06±2.33)和(14.67±3.50)μg·l^(-1),糖类抗原199水平分别为(41.39±10.25)和(62.19±15.38)kU·l^(-1),糖类抗原242水平分别为(8.67±2.12)和(13.04±3.17)kU·l^(-1),血清糖类抗原125水平分别为(36.52±9.18)和(45.22±9.01)kU·l^(-1),血清谷草转氨酶水平分别为(26.44±6.72)和(33.17±8.20)U·l^(-1),谷丙转氨酶水平分别为(22.98±5.78)和(30.89±7.62)U·l^(-1),中位无进展生存期分别为3.7和2.7个月,中位总生存期分别为11.7和9.4个月。试验组上述指标与对照组比较,在统计学上差异均有统计学意义(均P0.05)。结论HAIC联合瑞戈非尼治疗结直肠癌肝转移显著提高近期疗效,延长患者生存期,临床获益较好。

关键词：瑞戈非尼肝动脉灌注化疗结直肠癌肝转移疗效肿瘤标志物

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Molecular kinetics of cell aggregation and disaggregation under uniform shear flow:unequal-sized doublets

Molecular kinetics of cell aggregation and disaggregation un...

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2008年全国生物流变学与生物力学学术会议

作者： changliang fu,mian long(National Microgravity laboratory and Center for Biomechanics and Bioengineering, Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China)

Shear-induced cell aggregation and disaggregation,mediated by specific receptor-ligand interactions,play important roles in many biological and biophysical *** investigations have been performed to elucidate the shear rate and shear stress dependence of cell *** existing models based on population balance equation(PBE),however,have rarely dealt with the aggregation

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基于层次分析法的高原湖泊生态系统评价——以沙湖为例

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环境科学导刊 2024年第4期43卷 83-87页

作者：徐志鹏闵嵩傲朱翔汪龙眠谢磊刘明会汪金辉昆山市水利设计院有限公司江苏苏州215300 昆山市巴城镇建设局江苏苏州215300 生态环境部南京环境科学研究所江苏南京210042 河南省交通规划设计研究院股份有限公司河南郑州450046 上海交通大学环境科学与工程学院上海200240

基于国内外湖泊生态系统评价体系,提出了“3要素17指标”作为沙湖生态系统评价的指标体系。评价结果显示,沙湖生态系统评价体系中“整体功能”赋分较低,“社会影响”赋分较高,沙湖生态系统整体处于一般稳定状态。建议从控制黄河输水量... 详细信息

基于国内外湖泊生态系统评价体系,提出了“3要素17指标”作为沙湖生态系统评价的指标体系。评价结果显示,沙湖生态系统评价体系中“整体功能”赋分较低,“社会影响”赋分较高,沙湖生态系统整体处于一般稳定状态。建议从控制黄河输水量及水质、降低工农业污染、提高沙湖水质等方面开展湖泊生态整治,以期为沙湖生态治理、保护和修复提供理论支持。

关键词：层次分析法生态系统评价指标评价体系沙湖

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Ge/SiGe非对称耦合量子阱强度调制特性仿真

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量子电子学报 2024年第2期41卷 388-396页

作者：江佩璘张意黄强石浩天黄楚坤余林峰孙军强余长亮华中科技大学武汉光电国家研究中心湖北武汉430074 武汉飞思灵微电子技术有限公司湖北武汉430074

硅基光子学已被广泛认为是能实现片上光电子集成的有效平台,然而迄今为止,对硅基光源、探测器以及调制器等硅基有源器件的研究仍然具有一定的挑战性。为此,提出并仿真分析了一种可以用于实现硅基强度调制的Ge/SiGe非对称耦合量子阱结构... 详细信息

硅基光子学已被广泛认为是能实现片上光电子集成的有效平台,然而迄今为止,对硅基光源、探测器以及调制器等硅基有源器件的研究仍然具有一定的挑战性。为此,提出并仿真分析了一种可以用于实现硅基强度调制的Ge/SiGe非对称耦合量子阱结构。首先,利用8带k·p理论模型对耦合量子阱的能带结构和电子波函数进行了仿真计算;然后,详细分析了外加电场强度在0 kV/cm至60 kV/cm范围内,非对称耦合量子阱对TE和TM偏振模式的传输光的光吸收谱随外加电场强度的变化。仿真结果表明,对于TE偏振模式的传输光,在无外加电场强度条件下,非对称耦合量子阱的第一个吸收带边约在1449 nm处;而在30 kV/cm外加电场下,该量子阱的吸收带边相比于无外加电场情况向长波方向移动约22 nm,比相同外加电压下的普通量子阱显著。本工作所提出的Ge/SiGe非对称耦合量子阱结构是一种有望实现更低工作电压、更高速和更低损耗硅基强度调制器的结构。

关键词：光电子学强度调制量子限制斯塔克效应 Ge/SiGe量子阱非对称耦合量子阱

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High Thermal Stable Polyimide Resins Derived from Phenylethynyl-endcapped Fluorenyl Oligoimides with low Melt Viscosities

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Chinese Journal of Polymer Science 2016年第8期34卷 933-948页

作者： Wei Chen mian Ji 杨士勇 laboratory of Advanced Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

To improve the processability and thermal stability of polyimide, a series of novel phenylethynyl-endcapped oligoimides （PEPA-oligoimides） with calculated molecular weights （M_nC） were successfully prepared from thermal imidization of 4,4＇-（9-fluorenylidene） dianiline （BAFl） as fluorenyl diamine, 4,4＇-oxy-diphthalic anhydride （ODPA） as aromatic dianhydride and 4-phenylethynylphthalic anhydride （4-PEPA） acted as reactive end-capping reagent at elevated temperatures. Experiment results indicated that the oligoimides were the mixtures of PEPA-endcapped oligomers with different degrees of polymerization characterized by MAlDI-TOF mass spectra. The influence of chemical structures on the melt processabilities of the oligoimides, the thermal, dielectric and mechanical properties of the thermoset resins was studied. The typical oligoimide resin owned minimum melt viscosity of 0.2 Pa＇s at around 310 ℃and wide melting processing window, suitable for resin transfer molding （RTM）. Besides, its corresponding thermal-cured polyimide resin possessed glass transition temperature （T_g） as high as 514 ℃. The dielectric constants of polyimide resins decreased from 3.15 to 2.80 by reducing the M_nC. The mechanical properties of the polyimide neat resins were improved gradually with increasing M_nC. Finally, the carbon fiber/polyimide （C_f/PI） composite laminates showed excellent mechanical strength retention rate at 350 ℃, might be long-term served at extremely high temperature in aerospace and aviation field.

关键词： Polyimide Fluorene Proccessability Thermal stability Composite.

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A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer

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Cancer Communications 2018年第1期38卷 254-262页

作者： Wei wang Zhe Sun Jing-Yu Deng Xiao-long Qi Xing-Yu Feng Cheng Fang Xing-Hua Ma Zhen-Ning wang Han liang Hui-mian Xu Zhi-Wei Zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng East RoadGuangzhou 510060GuangdongP.R.China Department of Surgical Oncology The First Affiliated Hospital of China Medical UniversityShenyang 110000LiaoningP.R.China Department of Gastric Cancer Surgery Tianjin Medical University Cancer HospitalTianjin 300000P.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515GuangdongP.R.China Department of Gastroenterology Surgery Guangdong General HospitalGuangzhou 510030GuangdongP.R.China Department of Preventive Medicine School of Public HealthSun Yat-sen UniversityGuangzhou 510275GuangdongP.R.China

Background:Few studies have shown nomograms that may predict disease-specific survival(DSS)probability after curative D2 gastrectomy for advanced gastric cancer(AGC),particularly among Chinese *** study sought to develop an elaborative nomogram that predicts long-term DSS for AGC in Chinese ***:A retrospective study was conducted on 6753 AGC patients undergoing D2 gastrectomy between January 1,2000 and December 31,2012 from three large medical hospitals in *** assigned patients from Sun Yat-sen University Cancer Center to the training set,and patients from the First Affiliated Hospital of China Medical University and Tianjin Medical University Cancer Hospital to two separate external validation sets.A multivariate survival analysis was performed using Cox proportional hazards regression model in a training set,and a nomogram was ***’s C-index was used to evaluate discrimination and calibration plots were used to validate similarities between survival probabilities predicted by the nomogram model and actual survival rates in two validation ***:The multivariate Cox regression model identified age,tumor size,location,lauren classification,lymphatic/venous invasion,depth of invasion,and metastatic lymph node ratio as covariates associated with *** the training set,the nomogram exhibited superior discrimination power compared with the 8th American Joint Com-mittee on Cancer TNM classification(Harrell’s C-index,0.82 vs.0.74;Plidation sets,the nomogram’s discrimination power was also excellent relative to TNM classification(C-index,0.83 vs.0.75 and 0.81 vs.0.74,respec-tively;Plibration,the nomogram produced survival predictions that corresponded closely with actual survival ***:The established nomogram was able to predict 3-,5-,and 10-year DSS probabilities for AGC *** revealed that this nomogram exhibited excellent discrimination and calibrat

关键词： Advanced gastric cancer Disease-specific survival Prognostic nomogram

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