Combined Modeling of Shear-Induced Cell Aggregation and Adhesion Dynamics Mediated by Receptor-Ligand Interactions
作者单位：Key Laboratory of Microgravity(National Microgravity Laboratory)Institute of MechanicsChinese Academy of Sciences Center of Biomechanics and BioengineeringInstitute of MechanicsChinese Academy of Sciences Department of MechanicsTianjin University
会议名称：《第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议》
会议日期：2012年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by National Natural Science Foundation of China(No.11072251) National Key Basic Research Foundation of China(2011 CB710904) CAS Knowledge Innovation Program(KJCX2- YW-L08) Scientific Research Equipment Project(Y2010030)
摘 要：Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation,inflammatory cascade,and tumor metastasis, in which these cellular interactions are mainly mediated by dynamics and kinetics of underlying receptor-ligand *** the theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately,how to couple these two processes remains poorly understood. Here we developed a unified framework that couples cellular aggregation dynamics and ad-