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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

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Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao Ye Man Feng changhua Ji Wenzhong Zhou Fei Wang Lixiang Yu Shuya Huang Zhigang Yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is unknown.Methods: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to trastuzumab.Results: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft model.Conclusions: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance to trastuzumab. These findings support clinical

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

Size-effect on Ni electrocatalyst:The case of electrochemical benzyl alcohol oxidation

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Nano Research 2023年第1期16卷 202-208页

作者： Jian Zhong Yongli Shen Pei Zhu Shuang Yao changhua an Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials&Low-Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

The nanoparticles(NPs)of Ni with different sizes endows its distinctive physical and chemical properties,which represents a typical strategy for the development of high-performance catalysts.However,the size effect of metallic Ni-NPs on electrocatalytic performance remains ambiguous.Herein,the Ni-NPs with different sizes supported on nitrogen doped carbon(NC)has been synthesized by controlling the pyrolysis temperature,leading to the synthesis of Ni@NC-500(8.3 nm),Ni@NC-280(1.9 nm)and Ni@NC-200(1.0 nm).The electrooxidation of benzyl alcohol(BA)over these nanocatalysts shows the yield of benzoic acid was 99%,82%,55%on Ni@NC-280,Ni@NC-200 and Ni@NC-500,respectively.The experimental and theoretical simulation demonstrate that the difference in the adsorption strength of reactant molecules by Ni-NPs is responsible for their different performance,where the Ni@NC-280 exhibits an optimal adsorption configuration between Ni@NC-280 electrode and BA.This work provides a new angle for designing and synthesizing efficient electrocatalysts,which may be extended to the exploration of various promising electrocatalytic systems.

关键词： size effect electro-oxidation Ni nanoparticles benzyl alcohol

Study on Key Joining Technology and Test Method of Steel/Al Hybrid Structure Body-in-White

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Journal of Materials Science and Chemical Engineering 2024年第4期12卷 104-118页

作者： Lijun Han Fuyang Liu changhua Liu Planning Technology Center FAW-Volkswagen Automotive Co. Ltd. Changchun China

Green and low carbon promote the application and development of light-weight materials in body-in-white. Large-scale die-casting Al alloy (DCAA) and high-strength thermo-formed steel sheet (TFSS) have put forward higher requirements for the application of joining technology of high-strength steel/Al dissimilar materials. Taking the new die-casting Al alloy body as an example, this paper systematically studies the progress of the latest joining methods of steel/Al dissimilar material with combination of two-layer plate and three-layer plate. By analyzing the joining technologies such as FSPR, RES, FDS and SPR, the technology and process characteristics of steel/Al dissimilar material joining are studied, and the joining technical feasibility and realization means of different material combination of the body are analyzed. The conditions of material combination, material thickness, material strength, flange height, preformed holes and joint spacing for achieving high-quality joining are given. The FSPR joining technology is developed and tested in order to meet with the joining of parts with DCAA and TFSS, especially for the joining of three-layer plates with them. It finds the method and technical basis for the realization of high quality joining of dissimilar materials, provides the early conditions for the application of large DCAA and TFSS parts in body-in-white, and meets the design requirements of new energy body. .

关键词： Body-in-White Lightweight Die-Casting Al Alloy Thermo-Formed Steel Joining

Fabrication of N,S co-doped carbon immobilized high-density Co single atoms toward electro-oxidation of organic sulfides with water as feedstock

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Nano Research 2023年第5期16卷 6593-6600页

作者： Pei Zhu Wen-Xiong Shi Ying Wang Zhi-Ming Zhang Lina Li changhua an Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion Tianjin Key Laboratory of Advanced Functional Porous MaterialsInstitute for New Energy Materials&Low-Carbon TechnologiesTianjin University of TechnologyTianjin 300384China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Development of high-density single atoms site(SAs)electrocatalysts is highly desirable due to their extraordinary catalytic performance.However,their synthesis is still challenging and their anticorrosion capacities in electrolyte(particularly in acidic electrolyte)are unsatisfying.Herein,we have constructed N,S co-doped carbon to anchor~10 wt.%Co SAs(Co-SAs/NSC)via a novel polymerization–sulfurization–pyrolysis strategy toward selective electro-oxidation of thioethers in acidic solution.The asobtained Co SAs has a coordination geometry of Co-S_(2)N_(4),exhibiting excellent electrocatalytic activity and robust stability.At a low potential of 1.40 V vs.reversible hydrogen electrode(RHE),the conversion rate of thioethers over Co-SAs/NSC reaches 99.7%with 100%selectivity and 100%Faraday efficiency(FE)for producing sulfoxide,which is higher than the commercial Pt electrode and the reported state-of-the-art catalysts.Theoretical calculations and experiments reveal that the Co-S_(2)N_(4)structure endows the outstanding electro-oxidation activity of Co SAs through significantly promoting desorption of the products.This work presents a convenient strategy to build high-performance SAs catalysts for the resourceful use of sulfur-containing pollutants.

关键词： single-atom cobalt high density selective oxidation electrocatalysis

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“两个结合”赋能思想政治教育的理路构建

思想战线 2024年第3期50卷 152-161页

作者：彭长华江南大学马克思主义学院江苏无锡214122

在庆祝中国共产党成立100周年大会上,习近平总书记提出“两个结合”的重要论断。“两个结合”对马克思主义中国化百年实践的经验总结,丰富了马克思主义中国化的科学内涵,为新时代思想政治教育提供了方法论指引。“两个结合”进一步明确... 详细信息

在庆祝中国共产党成立100周年大会上,习近平总书记提出“两个结合”的重要论断。“两个结合”对马克思主义中国化百年实践的经验总结,丰富了马克思主义中国化的科学内涵,为新时代思想政治教育提供了方法论指引。“两个结合”进一步明确了思想政治教育的理论支撑、具体实际、文化之蕴。以“两个结合”的方法论重塑思想政治教育的理论逻辑、实践逻辑与历史逻辑以破解思想政治教育的现实困境,用“两个结合”价值内涵赋能思想政治教育;以“两个结合”的理论特质,推进思想政治教育内容与形式的统一;以“两个结合”的实践能动,激发思想政治教育的动力之源;以“两个结合”的历史主动,激发思想政治教育在培“根”铸“魂”中坚定文化自信,以此提升思想政治教育成效。

关键词：思想政治教育思想政治理论课 “两个结合” 践行理路

Shaped gold and silver nanoparticles

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Frontiers of Materials Science 2011年第1期5卷 1-24页

作者： Yugang SUN changhua an Center for Nanoscale Materials Argonne National Laboratory 9700 Cass Avenue Argonne IL 60439 USA State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical Engineering China University of Petroleum Qingdao 266555 China

Advance in the synthesis of shaped nanoparticles made of gold and silver is reviewed in this article. This review starts with a new angle by analyzing the relationship between the geometrical symmetry of a nanoparticle shape and its internal crystalline structures. According to the relationship, the nanoparticles with well-defined shapes are classified into three categories： nanoparticles with single crystallinity, nanoparticles with angular twins, and nanoparticles with parallel twins. Discussion and analysis on the classical methods for the synthesis of shaped nanoparticles in each category are also included and personal perspectives on the future research directions in the synthesis of shaped metal nanoparticles are briefly sum marized. This review is expected to provide a guideline in designing the strategy for the synthesis of shaped nanoparticles and analyzing the corresponding growth mechanism.

关键词： shaped nanoparticles geometric symmetry internal crystalline structure multiple twins gold silver

公私益界分下生态环境侵害惩罚性赔偿的适用研究

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河南师范大学学报（哲学社会科学版） 2024年第2期51卷 60-67页

作者：麻昌华张靖晗中南财经政法大学法学院湖北武汉430073

在生态环境侵害领域,我国存在并行的三种制度,分别是私益类的一般环境侵权制度和公益类的生态环境损害赔偿制度以及环境民事公益诉讼制度。借助于对环境权本质的探讨,公益类的生态环境侵害问题亦有在民法体系中寻求解决路径的合理性。... 详细信息

在生态环境侵害领域,我国存在并行的三种制度,分别是私益类的一般环境侵权制度和公益类的生态环境损害赔偿制度以及环境民事公益诉讼制度。借助于对环境权本质的探讨,公益类的生态环境侵害问题亦有在民法体系中寻求解决路径的合理性。而惩罚性赔偿作为具备多重功能的民事法律制度,能够助力生态环境侵害制度体系实现其特殊的生态功能及社会效果。同时基于对其适用于公益类案件中理论争议的回应,惩罚性赔偿应作为公私益生态环境侵害问题中的共同规则。但公私益生态环境侵害案件的差异不可忽视,确有必要在公私益区分下对惩罚性赔偿的适用要件进行不同解释,以合理限制公益类生态环境侵害惩罚性赔偿的适用。具体而言,相较于私益类生态环境侵害,公益类生态环境侵害惩罚性赔偿的行为加重要件应采狭义理解;主观加重要件不应纳入“重大过失”。在结果加重要件上,无论公益类还是私益类,都应重新审视对“严重后果”的要求。

关键词：生态环境侵害惩罚性赔偿公益私益适用研究

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从出土医学文献看《黄帝内经》中的经脉系统

中华中医药杂志 2024年第1期39卷 82-86页

作者：何仙童柳长华成都中医药大学成都610000

中医学元典《黄帝内经》自诞生以来,上下五千年,相关研究著作、论文可谓层出不穷,其作为后世经脉医学之祖,源远流长。然而经脉的起源与流派是多元化的,至今流传最广,成为权威学说的理论便是《灵枢·经脉》所形成的十二经脉系统“阴阳相... 详细信息

中医学元典《黄帝内经》自诞生以来,上下五千年,相关研究著作、论文可谓层出不穷,其作为后世经脉医学之祖,源远流长。然而经脉的起源与流派是多元化的,至今流传最广,成为权威学说的理论便是《灵枢·经脉》所形成的十二经脉系统“阴阳相贯,如环无端”。而其他流派的经脉系统或因为社会、政治、文化等因素失传而埋没于历史的长河中。文章从出土医学文献的角度,结合传世的《黄帝内经》文本,试图梳理《黄帝内经》秦汉时期所蕴含的数种经脉系统,如阴脉阳脉系统、六脉系统、十脉系统、十一脉系统等,为经脉医学的传承和创新提供借鉴。

关键词：《黄帝内经》经脉系统出土文献考证

Surface-tuning nanoporous AuCu_(3) engineering syngas proportion by electrochemical conversion of CO_(2)

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Nano Research 2021年第11期14卷 3907-3912页

作者： Chao An Yongli Shen Wenxiu Yan Linxiu Dai changhua an Life and Health Institute Tianjin Key Laboratory of Organic Solar Cells and Photochemical ConversionSchool of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin300384China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

The direct electrochemical conversion of CO_(2) to syngas with controllable composition remains challenging. In this work, driven by concentration gradient, a simple air-heating aided strategy has been developed to adjust surface composition of the self-supporting nanoporous AuCu_(3) alloy. According to Fick First Law, the interior Cu atoms of the AuCu_(3) alloy with Au-rich surface gradually segregated outwards during heating, realizing Cu-rich surface eventually. Correspondingly, the competing electrocatalytic CO_(2) reduction (ECR) to CO and hydrogen evolution reactions (HER) were tactfully balanced on these alloy surfaces, thus achieving proportion-tunable syngas (CO/H2). Density functional theory (DFT) calculations on the Gibbs free energy change of the COOH* and H* (ΔGCOOH*, ΔGH*) on the alloy surfaces were conducted, which are generally considered as the selectivity descriptors for CO and H2 products, respectively. It shows ΔGCOOH* gradually increases in contrast to the decreased ΔGH* with more Cu on the surface, suggesting H2 is more favored over Cu sites, which is consistent with the declining CO/H2 ratio observed in the experiments. This study reveals that the surface composition controls ECR activity of nanoporous AuCu_(3) alloy, providing an alternative way to the syngas production with desirable proportion.

关键词： AuCu3 surface segregation CO2 reduction syngas