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Comparative quality of life study between endoscopic sphincterotomy and surgical choledochotomy

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World Journal of Gastroenterology 2014年第25期20卷 8237-8243页

作者： Feng Liu Xue Bai Guang-Feng duan Wen-Hua Tian Zhao-Shen Li Bin Song Department of Gastroenterology Changhai HospitalSecond Military Medical University Department of Health Services Management Second Military Medical University

AIM: To determine quality of life improvement in choledocholithiasis patients who underwent endoscopic sphincterotomy (EST) versus open choledochotomy (OCT).

关键词： Choledocholithiasis Cholelithotomy Endoscopic sphincterotomy Open choledochotomy Quality of life

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水利水电工程河道截流分类

武汉大学学报（工学版） 2011年第1期44卷 7-11页

作者：贺昌海段兴平王一博陈欢武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 中国长江三峡集团公司湖北宜昌443002

收集和分析了大量水利水电工程河道截流实际工程资料,应用系统分析与统计分析方法,对截流聚类指标进行了分析和筛选,确定采用截流流量、最大落差、最大断面平均流速和龙口最大水深4个指标进行聚类分析.应用系统聚类原理,基于SPSS数据分... 详细信息

收集和分析了大量水利水电工程河道截流实际工程资料,应用系统分析与统计分析方法,对截流聚类指标进行了分析和筛选,确定采用截流流量、最大落差、最大断面平均流速和龙口最大水深4个指标进行聚类分析.应用系统聚类原理,基于SPSS数据分析软件,对截流资料进行了聚类分析,结合工程经验,将河道截流分为5类,并定性描述了各类截流的特点、风险性质和截流难度,同时,对3个待判工程进行了判别分析,结果与理论和实践认识基本一致.该研究成果为深入研究河道截流风险决策奠定了基础,对截流规划、设计和施工具有参考意义.

关键词：聚类分析判别分析河道截流分类截流风险

A novel PIK3CD C896T mutation detected in bilateral sudden sensorineural hearing loss using next generation sequencing:An indication of primary immunodeficiency

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Journal of Otology 2016年第2期11卷 78-83页

作者： Jing Zou Xiangqiang duan Guiliang Zheng Zhen Zhao Shiyue Chen Pu Dai Hongliang Zheng Department of Otolaryngology-Head and Neck Surgery Center for Otolaryngology-Head & Neck Surgery of Chinese PLA Changhai Hospital Second Military Medical University Department of Radiology National Key Discipline Changhai Hospital Second Military Medical University Department of Otolaryngology-Head and Neck Surgery Chinese PLA General Hospital

Objective:To investigate immune-related genetic background in bilateral sudden sensorineural hearing loss (SSNHL). Case report and methods: The case is a 45-year-old man presenting with a 7-year history of bilateral profound SSNHL. Blood biochemical testing demonstrated increased levels of total cholesterol (5.88 mmol/L). Tests for hepatitis B showed a positive antibody against the hepatitis B core antigen. Complement C3 was below the normal value, and complement C4 and IgG were in the lower range of normal values. CT images showed a normal inner ear and vestibular aqueduct but round window membranous ossification on both sides. A total number of 232 immune-associated genes were sequenced using the next generation sequencing technique. Results: Mutations were detected in 5 genes, including the phosphoinositide 3-kinase catalytic subunit delta (PIK3CD), caspase recruitment domain-containing protein 9 (CARD9), complement factor H-related (CFHR2), immunoglobulin lambda-like polypeptide 1 Protein (IGLL1), and transmembrane channel-like gene family 8 (TMC8). In the PIK3CD gene, a C896T substitute in exon 7 was detected. This mutation causes primary immunodeficiency and is an autosomal dominant disease. Conclusion: The PIK3CD C896T mutation responsible for primary immunodeficiency may contribute to the onset of bilateral SSNHL with subsequent rapid progression.

关键词： Sudden sensorineural hearing loss Immunology Genetics Next generation sequencing

Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3433-3446页

作者： Yuran Qiu Yuanhao Wang Zongtao Chai duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji Department of Urology Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Cardiology Renji HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200120China Department of Plastic Surgery Changhai HospitalNaval Military Medical UniversityShanghai 200438China

RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded *** gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer *** a well-recognized target in malignancy,RAS has been intensively studied in the past *** the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS *** at several residues has been recently determined as regulators for wild-type and mutated RAS ***,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic *** this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated ***,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed.

关键词： RAS Phosphorylation Undruggable Protein kinases Allostery

A tunable genome editing system of the prime editor mediated by dihydrofolate reductase

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Journal of Genetics and Genomics 2023年第3期50卷 204-207页

作者： Shu Liu Xiaoyue duan Feng Peng Yafang Wang Yang Liu Xiaoling Wan Jingfa Zhang Xiaosa Li Xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Ophthalmology Shanghai Changhai HospitalShanghai 200043China Shanghai Key Laboratory of Ocular Fundus Diseases 100 Haining RoadShanghai 200080China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(CRISPR/Cas)system was discovered in bacteria and archaea as an adaptive immunity system to protect against exogenous DNA(Barrangou et al.,2007).This system has been developed into a powerful gene editing tool for eukaryotic genome manipulation that has therapeutic opportunities against hereditary diseases(Cong et al.,2013),especially monogenic diseases.

关键词： CRISPR/Cas genome system

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青藏高原自然资源综合观测体系构建探讨

草业科学 2022年第12期39卷 2645-2658页

作者：杨斌谭昌海赵阳刚何晓波段阳海张浔浔中国地质调查局应用地质研究中心四川成都610036 自然资源要素耦合过程与效应重点实验室北京100055 中国科学院西北生态环境资源研究院冰冻圈科学国家重点实验室甘肃兰州730000

青藏高原是我国的国家安全屏障、生态安全屏障、亚洲水塔、水土和生态资源储备基地。高原的“山水林田湖草沙冰”等自然资源和生态环境在我国具有特殊重要的地位。开展该区域的自然资源调查监测与评价是国家制定高原生态脆弱区环境保护... 详细信息

青藏高原是我国的国家安全屏障、生态安全屏障、亚洲水塔、水土和生态资源储备基地。高原的“山水林田湖草沙冰”等自然资源和生态环境在我国具有特殊重要的地位。开展该区域的自然资源调查监测与评价是国家制定高原生态脆弱区环境保护政策以及优化资源配置的基础和关键。综合观测体系是开展野外综合观测研究的前提,是实现野外台站目标的保证。基于“两统”“两分”的总体设计,从青藏高原的重要性和特殊性出发,结合当前观测的复杂性和稀缺性特征,明确主要自然资源观测对象,构建综合观测体系,确保野外观测站点观测对象清楚、观测指标清晰、站点层级明确、台站管理顺畅、观测数据规范、准确、连续,更好服务自然资源统一管理。同时,可为今后自然资源野外观测研究示范推广奠定基础。

关键词：青藏高原自然资源生态环境观测体系构建示范两统两分

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华北陆块南、北缘铅锌矿床成矿特征对比

矿床地质 2008年第3期27卷 383-398页

作者：段士刚薛春纪燕长海刘国印宋要武张德会中国地质大学地质过程与矿产资源国家重点实验室河南省地质调查院河南郑州450007

华北陆块北缘是中国重要铅锌成矿带,对其南缘地区铅锌矿的勘查近年进展明显,对比南、北缘成矿地质环境和矿床地质特征,有助于南缘地区铅锌找矿方向的进一步明确。对比分析表明,华北陆块南、北缘地质特征相似:南、北缘印支期铅锌成矿作... 详细信息

华北陆块北缘是中国重要铅锌成矿带,对其南缘地区铅锌矿的勘查近年进展明显,对比南、北缘成矿地质环境和矿床地质特征,有助于南缘地区铅锌找矿方向的进一步明确。对比分析表明,华北陆块南、北缘地质特征相似:南、北缘印支期铅锌成矿作用都不太发育,均在燕山期铅锌成矿明显;以与岩浆作用有关的接触交代、热液充填和变质热液成矿以及对早先形成的矿床或矿源层的变质改造作用为主,出现斑岩型、矽卡岩型、热液脉型及蚀变岩型等矿床类型;南、北缘铅锌矿都有由"层控"向"岩控"变化的趋势,成矿元素组合也由简单变得复杂。但华北陆块南、北缘不同的地质时代成矿的主导作用有所不同:北缘有太古宙VMS型矿床,而南缘发现的都是中元古代以来的矿床;北缘主要是元古宙和燕山期成矿作用,特别是中元古代Sedex型成矿作用更为显著,形成多个大型-超大型铅锌矿床,而南缘的成矿作用主要发生在古生代和燕山晚期,矿床规模多为中、小型,研究程度相对较低。栾川断裂以北的裂谷系中碳酸盐岩台地沉积有寻找MVT矿床的前景,宽坪岩群分布区可以作为今后寻找Sedex型铅锌矿床的重要地区。

关键词：地质学华北陆块南缘和北缘铅锌矿床成矿特征对比找矿方向豫西南

低蛋白日粮调整TSAA水平对肉鸡生长和氮代谢的影响

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饲料工业 2015年第2期36卷 10-14页

作者：段晓翔张丽明陈洪影廖先东周长海吉林大学动物科学学院吉林长春130062

试验旨在研究在玉米-豆粕型低蛋白日粮中添加不同含硫氨基酸水平（TSAA）对AA肉鸡生长和氮代谢影响。300只体重接近的8日龄AA肉鸡随机分为5个处理组,每个处理组设置4个重复。肉鸡的饲养按照NRC标准分为生长期（8-21日龄）和育肥期（22-4... 详细信息

试验旨在研究在玉米-豆粕型低蛋白日粮中添加不同含硫氨基酸水平（TSAA）对AA肉鸡生长和氮代谢影响。300只体重接近的8日龄AA肉鸡随机分为5个处理组,每个处理组设置4个重复。肉鸡的饲养按照NRC标准分为生长期（8-21日龄）和育肥期（22-42日龄）。对照组（前期CP23%、ME 13.20 MJ/kg、TSAA为0.90%;后期CP 20%、ME 13.45 MJ/kg、TSAA为0.72%）为正常蛋白、正常氨基酸水平,其余4个试验组为低蛋白组（前期CP 21%、ME 13.21 MJ/kg;后期CP 18%、ME13.42 MJ/kg）,粗蛋白含量比饲养标准降低2%。4个试验组TSAA水平分别为0.80%、0.90%、1.00%、1.10%（生长期）和0.62%、0.72%、0.82%、0.92%（育肥期）。结果显示：在试验结束时,0.92%的TSAA低蛋白日粮组肉鸡生长最快,平均体重达到2.55 kg,并且相比0.62%TSAA水平呈现显著性差异（P〈0.05）;在整个饲养阶段,低蛋白日粮组不同程度降低了肉鸡采食量,改善了料肉比（P〈0.05）,增加了饲料利用率;在42日龄时,不同处理组对肉鸡血清中Ca2＋和总蛋白无显著影响（P〉0.05）,低蛋白日粮组可以在不同程度上降低肉鸡尿素氮和尿酸的含量（P〈0.05）;在生长期,当低蛋白日粮中TSAA水平为0.80%时,可以显著降低肉鸡氮的消化率（P〈0.05）,但是对氮的排泄量无明显影响（P〉0.05）,在育肥期,低蛋白日粮各组可以降低肉鸡氮的排泄量（P〈0.05）,但对排泄率和消化率无明显影响（P〉0.05）。综上所述,低蛋白日粮调整TSAA水平不仅可以降低育肥期肉鸡氮的排泄,而且当TSAA水平为0.72%时,可以促进肉鸡生长,使肉鸡出栏重达到正常蛋白组,并且可以降低料肉比,增加饲料利用率。

关键词：低蛋白日粮肉鸡 TSAA 氮代谢

Relapse of a cardiac tumor from myxoma to low-grade malignant myofibroblastic sarcoma: malignant transformation or metachronous lesion?

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Journal of Medical Colleges of PLA(China) 2010年第1期25卷 50-53页

作者： duan Lian Xu Zhiyun Li Zhigang Department of Thoracic and Cardiovascular Surgery Changhai Hospital Shanghai 200433 China

A 47-year-old woman, who had undergone cardiac myxoma removal surgery six years ago, was readmitted due to a 2-week history of chest distress, and dyspnea with the change of body position. Both the examinations and the surgery confirmed a cardiac tumor relapse. Histology demonstrated that the mass resected in surgery had a pathologic change from myxoma to a low-grade malignant myofibroblastic sarcoma. The patient received heart transplantation 2 years later due to tumor recurrence, and finally died of cerebral hemorrhage.

关键词： Neoplasm Myxoma Malignant myofibroblastic sarcoma