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Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve

Neural Regeneration Research 2019年第12期14卷 2199-2208页

作者： Zhong-yuan Zhang Jin Yang Zhen-Hai Fan Da-Li Wang yu-ying Wang Tao Zhang Li-Mei yu chang-yin yu Key Laboratory of Cell Engineering in Guizhou Province The Affiliated Hospital of Zunyi Medical University Zunyi Guizhou Province China Department of Thyroid and Breast Surgery Fifth People’s Hospital of Chengdu Chengdu Sichuan Province China The Team of Scientific and Technological Innovation Talents on The Basic and Clinical Research of Amniotic Membrane and Bone Marrow Stem Cells in Guizhou Province Zunyi Guizhou Province China Department of Burn and Plastic Surgery The Affiliated Hospital of Zunyi Medical University Zunyi Guizhou Province China Department of Neurology The Affiliated Hospital of Zunyi Medical University Zunyi Guizhou Province China

Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote the healing of a variety of tissues. In this study, the right common peroneal nerve underwent a 5-mm transection in rats. Epineural nerve repair was performed using 10/0 non-absorbable surgical suture. The repair site was wrapped with a two-layer amniotic membrane with α-cyanoacrylate rapid medical adhesive after suture. Hindlimb motor function was assessed using footprint analysis. Conduction velocity of the common peroneal nerve was calculated by neural electrical stimulation. The retrograde axoplasmic transport of the common peroneal nerve was observed using fast blue BB salt retrograde fluorescent staining. Hematoxylin- eosin staining was used to detect the pathological changes of the common peroneal nerve sputum. The mRNA expression of axon regeneration-related neurotrophic factors and inhibitors was measured using real-time polymerase chain reaction. The results showed that the amniotic membrane significantly improved the function of the injured nerve;the toe spread function rapidly recovered, the nerve conduction velocity was restored, and the number of fast blue BB salt particles were increased in the spinal cord. The amniotic membrane also increased the recovery rate of the tibialis anterior muscle and improved the tissue structure of the muscle. Meanwhile, mRNA expression of nerve growth factor, growth associated protein-43, collapsin response mediator protein-2, and brain-derived neurotrophic factor recovered to near-normal levels, while Lingo-1 mRNA expression decreased significantly in spinal cord tissues. mRNA expression of glial-derived neurotrophic factor did not change significantly. changes in mRNA levels were more significant in amniot

关键词： nerve regeneration human amniotic membrane axonal Schwann cells α-cyanoacrylate rapid medical adhesive neural suture tibial anterior muscle neuronal growth factor common peroneal nerve injury neural regeneration

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Schwannomatosis patient who was followed up for fifteen years:A case report

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World Journal of Clinical Cases 2022年第20期10卷 6981-6990页

作者： Kai Li Si-Jing Liu Huai-Bo Wang chang-yu yin Yong-Sheng Huang Wei-Tao Guo Department of Spine Surgery The Second Hospital affiliated to Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

BACKGROUND Schwannomatosis is a rare disease characterized by multiple schwannomas of the whole *** benign,schwannomatosis that occurs in important areas of the body,such as the brain and spinal canal,can cause considerable disability and *** disease is rare,frequent and relapsing,and this poses a diagnostic and therapeutic *** SUMMARY A 40-year-old male had multiple masses all over his body,starting at the age of *** years prior,he started to experience a progressive decrease in muscle strength in both lower limbs and developed urinary and defecation dysfunctions,and gradual *** month prior,the patient developed pain and numbness in his left *** patient had undergone five surgical procedures for this disease in our *** on the family history,imaging examinations,pathological biopsy and molecular biological examinations,the diagnosis of schwannomatosis was *** time,the patient was admitted to our hospital again for a 6th operation because of the pain and numbness in his left *** the operation,the patient's symptoms improved significantly;the patient recovered and was discharged from the *** the last telephone follow-up,the patient reported a poor general condition but was *** Here,we report a rare case of *** conducted 15 years of patient follow-up and treatment,and analyzed the timing of surgery and patient *** case will further extend our overall understanding of the diagnosis and treatment of this rare tumor.

关键词： Schwannomatosis Pathogenesis Clinical symptoms Diagnosis Treatment Case report

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Anxiety and depression among epilepsy patients in low-risk areas for COVID-19 in the northern part of Guizhou Province,China,during the COVID-19 pandemic

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Acta Epileptologica 2022年第2期5卷 78-87页

作者： Shen Wang Juan Yang Nian Wei Wenbo Lv Zhigang Jiang Hao Huang Jun Zhang Ping Xu chang yin yu Zucai Xu Department of Neurology Affliated Hospital of Zunyi Medical UniversityZunyi 563000China. Zunyi Medical University Zunyi 563000China.

Background:This study was aimed to investigate whether patients with epilepsy(PWE)have higher depression and anxiety levels than the normal population in low-risk areas for coronavirus disease 2019(COVID-19)in the northern part of Guizhou Province,China,during the COVID-19 epidemic,to evaluate their knowledge on COVID-19,and to analyze related factors for the psychological distress of PWE at this special ***:The survey was conducted online from February 28,2020 to March 7,2020 via a *** from the outpatient clinic of epilepsy of the Aflited Hospital of Zunyi Medical University,and healthy people matched for age and sex,participated in this *** health was assessed via a generalized anxiety self-rating scale(GAD-7)and the self-rating depression scale(PHQ-9).The knowledge of COVID-19 in both groups was ***:There were no significant differences in the general demographics between the PWE and healthy control *** scores of PHQ-9(P0.05).PWE knew less about some of the prevention and control measures of COVID-19 than healthy ***:During the COVID-19 epidemic,excessive attention to the epidemic an

关键词： COVID-19 Epilepsy Anxiety Depression Knowledge of epidemic prevention and control

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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慢性脑低灌注大鼠海马CA1区VEGF和磷酸化tau蛋白的表达及意义

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中国老年学杂志 2008年第23期28卷 2292-2294页

作者：鲁远君余昌胤遵义医学院附属医院神经内科贵州遵义563003

目的观察慢性脑低灌注大鼠海马CA1区血管内皮生长因子(VEGF)和磷酸化tau蛋白的表达及意义。方法将SD大鼠随机分为正常对照组(对照组)、假手术组和模型组。采用永久性结扎双侧颈总动脉建立慢性脑低灌注模型(2VO);实验开始后1、2、3月,应... 详细信息

目的观察慢性脑低灌注大鼠海马CA1区血管内皮生长因子(VEGF)和磷酸化tau蛋白的表达及意义。方法将SD大鼠随机分为正常对照组(对照组)、假手术组和模型组。采用永久性结扎双侧颈总动脉建立慢性脑低灌注模型(2VO);实验开始后1、2、3月,应用免疫组织化学染色法检测海马CA1区VEGF和磷酸化tau蛋白的表达。结果与对照组和假手术组比较,模型组海马CA1区VEGF表达在1、2月时明显增高(P0.05)。磷酸化tau蛋白表达在1月时各组间差异无显著性(P>0.05);2和3月时,模型组表达较对照组和假手术组明显增高(P<0.05)。结论慢性脑低灌注时VEGF表达增高可能是一种自身保护机制,磷酸化tau蛋白参与了慢性脑低灌注认知功能损伤过程。

关键词：慢性脑低灌注血管内皮生长因子磷酸化tau蛋白海马大鼠

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Atypical Guillain-Barrésyndrome with positive anti-sulfatide,anti-GT1b,and anti-GT1a antibodies:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4372-4376页

作者： Fei-Fei Tan He-Xu Liu Xue-Yan Huang chang-yin yu Xiao-Yan Yang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND The role of diverse antibodies in mediating peripheral nerve injury in Guillain-Barrésyndrome(GBS)is becoming clearer,but positivity for multiple antibodies in one case is *** our knowledge,this is the first case involving GBS with positive anti-sulfatide,anti-GT1a,and anti-GT1b *** SUMMARY A 20-year-old female patient was admitted to the hospital due to weakness of limbs for 5 d,and deterioration of the weakness and muscle aches for 1 *** patient's limbs were weak,but the tendon reflexes in the part of the limbs were *** was no comorbid peripheral nociception or deep sensory *** was diagnosed with GBS and was discharged after receiving intravenous human immunoglobulin pulse *** In this article,the clinical manifestations,neurophysiological examination,and auxiliary examination findings of a GBS patient positive for multiple antibodies were analyzed to improve the identification of the disease by clinical physicians at an early stage.

关键词： Guillain-Barré Anti-sulfatide antibody Anti-GT1b antibody Anti-GT1a antibody Case report

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雷公藤多甙对慢性脑低灌注大鼠海马CA1区血管内皮生长因子和磷酸化tau蛋白表达的影响

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临床神经病学杂志 2010年第2期23卷 117-120页

作者：鲁远君余昌胤重庆市长寿区人民医院神经内科 401220 遵义医学院附属医院神经内科

目的探讨雷公藤多甙(TWP)对慢性脑低灌注大鼠海马CA1区血管内皮生长因子(VEGF)和磷酸化tau蛋白表达的影响。方法 105只SD大鼠随机分为正常对照组、TWP对照组、假手术组、低灌注模型组、生理盐水组、TWP低剂量组和TWP高剂量组。采用永久... 详细信息

目的探讨雷公藤多甙(TWP)对慢性脑低灌注大鼠海马CA1区血管内皮生长因子(VEGF)和磷酸化tau蛋白表达的影响。方法 105只SD大鼠随机分为正常对照组、TWP对照组、假手术组、低灌注模型组、生理盐水组、TWP低剂量组和TWP高剂量组。采用永久性结扎双侧颈总动脉建立慢性脑低灌注模型;TWP低、高剂量组及生理盐水组分别予以TWP 10 mg/(kg.d)、30 mg/(kg.d)及生理盐水连续灌胃;TWP对照组予以TWP 30 mg/(kg.d)连续灌胃。用免疫组化染色法测定实验开始后1个月、2个月和3个月时各组大鼠海马CA1区VEGF和磷酸化tau蛋白的表达。结果 1个月、2个月时,生理盐水组和低灌注模型组海马CA1区VEGF表达较正常对照组、TWP对照组和假手术组明显增高(均P<0.05),TWP高、低剂量组VEGF表达较生理盐水组和低灌注模型组明显增高(均P<0.05);3个月时各组间表达差异无统计学意义。1个月时各组间磷酸化tau蛋白表达差异无统计学意义;2个月、3个月时,TWP高、低剂量组磷酸化tau蛋白表达水平较正常对照组、TWP对照组和假手术组明显增高(均P<0.05),较生理盐水组和低灌注模型组明显降低(均P<0.05)。结论 TWP能促进慢性脑低灌注大鼠海马CA1区VEGF表达,抑制磷酸化tau蛋白表达。

关键词：慢性脑低灌注血管内皮生长因子磷酸化tau蛋白雷公藤多甙海马

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Facile synthesis of high capacity P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2) cathode material for sodium-ion batteries

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Transactions of Nonferrous Metals Society of China 2021年第7期31卷 2074-2080页

作者： Mu-lan QIN chang-yu yin Wen XU Yang LIU Jun-hao WEN Bin SHEN Wei-gang WANG Wan-min LIU Hunan Provincial Key Laboratory of Environmental Catalysis&Waste Recycling College of Materials and Chemical EngineeringHunan Institute of EngineeringXiangtan 411104China

P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2) was synthesized by a facile sol−gel method,and the effect of calcination temperature on the structure,morphology and electrochemical performance of samples was *** results show that the sample obtained at 900℃ is pure P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2) phase with good crystallization,which consists of hexagon plate-shaped particles with the size and thickness of 2−4μm and 200−400 nm,*** sample exhibits an initial specific discharge capacity of 243 mA·h/g at a current density of 26 mA/g with good cycling *** high specific capacity indicates that P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2) is a promising cathode material for sodiumion batteries.

关键词： sodium-ion battery cathode material Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2) electrochemical performance sol−gel method

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大鼠实验性变态反应性脑脊髓炎CD_4^+/CD_8^+改变及细胞间黏附分子1表达的意义

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中国现代医学杂志 2007年第8期17卷 914-916页

作者：余昌胤郑和忠遵义医学院附属医院神经科贵州遵义563003

目的探讨急性实验性变态反应性脑脊髓炎(EAE)大鼠外周血CD4+/CD8+和脑及脊髓ICAM-1的表达及意义。方法采用豚鼠髓鞘蛋白匀浆和福氏完全佐剂注射诱发大鼠EAE模型,分别注射生理盐水/福氏佐剂、左旋咪唑作为对照,注射后16d时取材,采用Loye... 详细信息

目的探讨急性实验性变态反应性脑脊髓炎(EAE)大鼠外周血CD4+/CD8+和脑及脊髓ICAM-1的表达及意义。方法采用豚鼠髓鞘蛋白匀浆和福氏完全佐剂注射诱发大鼠EAE模型,分别注射生理盐水/福氏佐剂、左旋咪唑作为对照,注射后16d时取材,采用Loyez氏髓鞘染色法和免疫组化法观察脑和脊髓髓鞘改变及ICAM-1表达,流式细胞仪检测外周血CD4+/CD8+改变,并与对照组比较。结果正常组、NS/CFA组和LMS对照组髓鞘结构未见异常;模型组髓鞘染色见髓鞘结构疏松、部分髓鞘脱失。EAE大鼠脑和脊髓中I-CAM-1主要表达于血管内皮细胞,其面密度为(5.08!0.39),显著高于对照组(P<0.05)。结论EAE大鼠存在外周血CD4+/CD8+比值及脑和脊髓ICAM-1表达异常,CD4+/CD8+比值增高和ICAM-1表达异常在EAE的发生过程中发挥重要作用。

关键词：急性实验性变态反应性脑脊髓炎细胞间黏附分子1-1 CD4+/CD8+

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