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Radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun chang Yue chang Zhe chang xinyuan chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen xin Chen Xun Chen Xurong Chen ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of science and technology Faculty of Physics and Applied Computer ScienceKrakow anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing beijing Computational science research Center Beijing beijing Conveyi LTD Beijing beijing Glass research institute Co. LtdBeijing beijing institute of technology Beijing beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of mining and technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear research(DLNP JINR) Dubna East china University Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TDR)follows the Preliminary Conceptual design Report(Pre-CDR,2015)and the Conceptual design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-zhou Ren Yi-Wei yang yong-Hao Chen Rong Liu Bang-Jiao ye Jie Wen Hai-Rui Guo Zi-Jie han Qi-Ping Chen Zhong-Wei Wen Wei-Li Sun han Yi xing-yan Liu tao ye Jiang-Bo Bai Qi An Jie Bao Yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan chang-Qing Feng Ke-Qing Gao Xiao-Long Gao min-Hao Gu chang-Cai han Guo-Zhu He yong-Cheng He yang Hong Yi-Wei hu han-Xiong huang Xi-Ru huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang han-tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li yang Li Jie Liu Shu-Bin Liu Ze Long Guang-Yuan Luan chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Jia Sun Zhi-xin Tan Jing-Yu Tang xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun yang Li Yu tao Yu yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-yong Zhang Lu-Ping zhou Zhi-Hao zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source science Center Dongguan 523803China institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear science and technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest institute of Nuclear technology Xi’an 710024China University of Chinese academy of sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the china Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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基于工厂建设的可重用业务流程库技术研究

机电产品开发与创新 2011年第3期24卷 92-94页

作者：胡长艳周岩涛叶永韩新民机械科学研究总院北京100044

以业务流程库为研究对象,以国家科技支撑计划《建筑业信息化关键技术研究与应用》为项目依托,研究了构建企业业务流程库的关键技术。在分析了建立可重用的业务流程需求后,建构了重用度高的业务流程参考模型,并根据流程的事件流、控制流... 详细信息

以业务流程库为研究对象,以国家科技支撑计划《建筑业信息化关键技术研究与应用》为项目依托,研究了构建企业业务流程库的关键技术。在分析了建立可重用的业务流程需求后,建构了重用度高的业务流程参考模型,并根据流程的事件流、控制流和信息流对流程进行了粒度分级,研究了代表业务流程基本控制逻辑的业务流程样式,列举分析了典型的流程样式,并与数据仓库技术对比后,研究了业务流程库的特点及其分层实现架构,最后开发了工厂建设设计业务流程库原型系统。

关键词：业务流程库业务流程参考模型业务流程样式业务流程管理数据仓库

The first data release(DR1) of the LAMOST regular survey

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research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-xin Chen Li Chen Xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-xin Guo Zhan-Wen han Bo-Liang He Jin-Liang Hou yong-hui Hou Wen Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Zhi-Ying huo Lei Jia Fang-hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li chang-hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li xin-Nan Li yan Li Yin-Bi Li ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen huo-ming Shi Jing Song Yi-han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng xing Ling-Zhe Xu xin-Qi Xu yan Xu Tai-Sheng yan De-hua yang Hai-Feng yang hui-Qin yang ming yang Zheng-Qiu Yao yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang yong Zhang yan-Xia Zhang Zheng-Chao Zhang ming Zhao Fang zhou Xu zhou Jie Zhu yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing institute of Astronomical Optics & technology National Astronomical ObservatoriesChinese Academy of Sciences University of science and technology of china Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in china(INSCOC)Study:2021 update

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Journal of Nutritional Oncology 2022年第2期7卷 64-74页

作者： Hong Xia Xu Chun hua Song Liang Yu Yin chang Wang Zhen ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen hu Yi Ba Su Yi Li Zeng Ning Li Kun hua Wang Jing Wu Ying He Jia Jun yang Cong hua Xie Fu Xiang zhou xin Xia Song Gong yan Chen Wen Jun Ma Su Xia Luo Zi hua Chen Zhi Kang Chen ming hua Cong hu Ma Chun Ling zhou Wei Wang Qi Luo yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang hua Wu Jia xin Chen Yu Fang Lan zhou yong Dong Feng Rong Shao Tan tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu min Weng Qing hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu ming Liu Wei Li han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center of the first Hospital of Jilin University Changchun 130021Jilin China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Surgery The First Affiliated Hospital of SunYat-Sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Cancer HospitalHefei 230031AnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina Department of Clinical Nutrition The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006ZhejiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai Peo

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of *** Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in china(INSCOC study)since *** is an extension to the previous 2013-2020 study *** study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of *** and study design This is an observational,multi-centered,hospital-based prospective cohort *** collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital ***-up will be conducted for 1-20 years after *** primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of *** factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of

关键词： Cancer Malnutrition Nutritional status Nutritional assessment Survival Patient-Generated Subjective Global Assessment

柳氮磺吡啶在我国类风湿关节炎患者的用药现况调查

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北京大学学报（医学版） 2012年第2期44卷 188-194页

作者：刘田王秀茹安媛周云杉张晓盈段天骄朱佳鑫李晓峰王莉枝王彩虹王永福杨荣王国春卢昕朱平陈丽娜靳洪涛刘湘源孙琳陈海英崔刘福舒荣刘白鹭张卓莉李光韬李振彬杨静李俊芳贾彬张风肖陶杰梅韩淑玲林金盈韦美秋刘晓敏柯丹胡绍先叶丛杨岫岩李昊黄慈波高明赖蓓李兴福宋立军王轶王晓元穆荣苏茵栗占国北京大学人民医院风湿免疫科北京100044 北京大学首钢医院多顶街社区卫生中心全科山西医科大学第二医院风湿免疫科太原030001 包头医学院第一附属医院风湿免疫科包头014010 中日友好医院风湿免疫科北京100029 第四军医大学西京医院风湿免疫科西安710032 河北医科大学第二医院风湿免疫科石家庄050000 北京大学第三医院风湿免疫科北京100191 河北医科大学第三医院风湿免疫科石家庄050051 华北煤炭医学院附属开滦医院风湿免疫科唐山063000 北京大学第一医院风湿免疫科北京100034 白求恩国际和平医院风湿免疫科石家庄050082 河北邯郸中心医院风湿免疫科邯郸056001 河北省人民医院风湿免疫科石家庄050051 北京大学首钢医院风湿免疫科北京100144 广西壮族自治区人民医院风湿免疫科南宁530021 北京顺义区医院风湿免疫科北京101300 华中科技大学同济医学院附属同济医院风湿免疫科武汉430030 中山医科大学附属第一医院风湿免疫科广州510080 北京医院风湿免疫科北京100730 山东大学齐鲁医院风湿免疫科济南250012 兰州大学第二医院风湿免疫科兰州730030

目的:调查和分析类风湿关节炎(rheumatoid arthritis,RA)患者治疗中柳氮磺吡啶(sulphasalazine,SSZ)的使用及其不良反应发生情况。方法:采用流行病学现况调查的研究方法,对北京大学人民医院等全国21家三级甲等医院2009年7月至2010年12... 详细信息

目的:调查和分析类风湿关节炎(rheumatoid arthritis,RA)患者治疗中柳氮磺吡啶(sulphasalazine,SSZ)的使用及其不良反应发生情况。方法:采用流行病学现况调查的研究方法,对北京大学人民医院等全国21家三级甲等医院2009年7月至2010年12月于风湿免疫科门诊及病房就诊的1 096例RA患者进行问卷调查,并详细记录患者的一般资料和临床特点,分析其中160例使用SSZ患者的临床特点、副作用发生情况、SSZ使用现况及联合用药种类和时间等数据。结果:160例患者使用SSZ治疗,使用比例为14.6%。该组患者男女之比为1∶7,平均发病年龄为(46.1±15.0)岁,平均病程为(9.9±7.8)年。SSZ平均用量为(1.87±0.52)g/d,平均用药时间为(26.3±14.6)月。所有患者仅有17%(27/160)使用SSZ单药治疗,其余患者均曾联合应用其他缓解病情抗风湿药(diseasemodifying antirheumatic drugs,DMARDs),其中甲氨蝶呤(methotrexate,MTX)是最常应用的联合治疗药物,占63.1%,平均联合使用MTX时间(28.2±12.3)月;其次为来氟米特(36.2%)和羟氯喹(18.1%);SSZ+MTX是最常见的联合治疗方案(36.2%)。应用SSZ患者的疗效指标优于未应用者。调查时有41.9%(67/160)的患者曾使用SSZ治疗,但因药物不良反应或其他原因而停药。有17.5%(28/160)的患者因不良反应停药,其中因胃肠道反应停药比率(8.8%)最高,其次为皮疹(3.8%)和肝功能异常(3.1%)。结论:与其他国家相比,SSZ在我国应用率偏低,且平均用量上较临床规范用量偏小。SSZ治疗RA不良反应程度较轻,在临床应用中相对比较安全。

关键词：柳氮磺吡啶关节炎,类风湿横断面研究

我国类风湿关节炎患者应用肿瘤坏死因子抑制剂现况调查

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北京大学学报（医学版） 2012年第2期44卷 182-187页

作者：王秀茹苏茵安媛周云杉张晓盈段天骄朱佳鑫李小峰王彩虹王莉枝王永福杨荣王国春卢昕朱平陈丽娜王轶王晓元靳洪涛刘金婷陈海英魏平王俊祥刘湘源孙琳崔刘福舒荣刘白鹭张卓莉李光韬李振彬杨静李俊芳贾彬张风肖陶杰梅林金盈韦美秋刘晓敏柯丹胡绍先叶丛韩淑玲杨岫岩李昊黄慈波高明赖蓓李兴福宋立军穆荣栗占国北京大学人民医院风湿免疫科北京100044 北京大学首钢医院多顶街社区卫生中心全科山西医科大学第二医院风湿免疫科太原030001 包头医学院第一附属医院风湿免疫科包头014010 中日友好医院风湿免疫科北京100029 第四军医大学西京医院风湿免疫科西安710032 兰州大学第二医院风湿免疫科兰州730030 河北医科大学第二医院风湿免疫科石家庄050000 河北医科大学第三医院风湿免疫科石家庄050051 北京大学第三医院风湿免疫科北京100191 华北煤炭医学院附属开滦医院风湿免疫科唐山063000 北京大学第一医院风湿免疫科北京100034 白求恩国际和平医院风湿免疫科石家庄050082 河北邯郸中心医院风湿免疫科邯郸056001 河北省人民医院风湿免疫科石家庄050051 广西壮族自治区人民医院风湿免疫科南宁530021 北京顺义区医院风湿免疫科北京101300 华中科技大学同济医学院附属同济医院风湿免疫科武汉430030 北京大学首钢医院风湿免疫科北京100144 中山医科大学附属第一医院风湿免疫科广州510080 北京医院风湿免疫科北京100730 山东大学齐鲁医院风湿免疫科济南250012

目的:了解我国类风湿关节炎(rheumatoid arthritis,RA)患者应用肿瘤坏死因子(tumor necrosis factor,TNF)抑制剂的现状以及影响其应用的因素。方法:采用多中心现况调查问卷调查的方法,记录入选者的一般情况和应用TNF抑制剂的情况,计算... 详细信息

目的:了解我国类风湿关节炎(rheumatoid arthritis,RA)患者应用肿瘤坏死因子(tumor necrosis factor,TNF)抑制剂的现状以及影响其应用的因素。方法:采用多中心现况调查问卷调查的方法,记录入选者的一般情况和应用TNF抑制剂的情况,计算患者应用TNF抑制剂的费用,分析我国TNF抑制剂的应用现状及影响其应用的相关因素。结果:2009年7月至2010年11月期间,共有全国范围内的21家大型医院风湿免疫科就诊的1 095位RA患者完成问卷,其中112位患者应用了TNF抑制剂(infliximab,商品名类克或etanercept,商品名益赛普)进行治疗,占总研究人群的10.2%(其中益赛普81例,占7.4%;类克26例,占2.4%;两种制剂都用过者5例,占0.5%)。应用类克疗程1%,益赛普疗程25.0%。应用类克疗程1.1、0.5、0.1,益赛普的相应评分分别为1.3、1.0、0.3。应用类克疗程24 525.0、69 300.0、96 800.0元,益赛普的费用分别为7 394.8、9 158.6、54 910.9元。应用类克疗程158.9元,益赛普分别为2 158.4、288.5、180.1元。出现过敏和感染的比例在应用益赛普者均为3.5%,在应用类克者均为6.5%。Logistic回归分析显示,受教育程度是影响TNF抑制剂应用的主要相关因素。结论:在我国大型医院就诊的RA患者中约有10%应用过TNF抑制剂,其病情随应用TNF抑制剂的疗程延长而减轻,治疗总费用随用药疗程延长而增加,但间接经济损失随疗程延长而减少,主要不良反应为过敏和感染,受教育程度是影响其应用的主要相关因素。

关键词：关节炎,类风湿肿瘤坏死因子问卷调查药费支出

全国多中心类风湿关节炎冠心病危险因素的现况调查

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北京大学学报（医学版） 2012年第2期44卷 176-181页

作者：李春王秀茹唐熠达安媛周云杉郭时伟张晓盈段天骄朱佳鑫李晓峰王莉枝王彩虹王永福杨荣王国春卢昕朱平陈丽娜靳洪涛刘金婷刘湘源孙琳陈海英魏平王俊祥崔刘福舒荣刘白鹭张卓莉李光韬李振彬杨静李俊芳贾彬张风肖陶杰梅韩淑玲林金盈韦美秋刘晓敏柯丹胡绍先叶丛杨岫岩李昊黄慈波高明赖蓓李兴福宋立军王轶王晓元穆荣苏茵栗占国北京大学人民医院风湿免疫科北京100044 北京大学首钢医院多顶街社区卫生中心全科中国医学科学院北京协和医学院阜外心血管病医院心内科北京100037 山西医科大学第二医院风湿免疫科太原030001 包头医学院第一附属医院风湿免疫科包头014010 中日友好医院风湿免疫科北京100029 第四军医大学西京医院风湿免疫科西安710032 河北医科大学第二医院风湿免疫科石家庄050000 北京大学第三医院风湿免疫科北京100191 河北医科大学第三医院风湿免疫科石家庄050051 华北煤炭医学院附属开滦医院风湿免疫科唐山063000 北京大学第一医院风湿免疫科北京100034 白求恩国际和平医院风湿免疫科石家庄050082 河北邯郸中心医院风湿免疫科邯郸056001 河北省人民医院风湿免疫科石家庄050051 北京大学首钢医院风湿免疫科北京100144 广西壮族自治区人民医院风湿免疫科南宁530021 北京顺义区医院风湿免疫科北京101300 华中科技大学同济医学院附属同济医院风湿免疫科武汉430030 中山医科大学附属第一医院风湿免疫科广州510080 北京医院风湿免疫科北京100730 山东大学齐鲁医院风湿免疫科济南250012 兰州大学第二医院风湿免疫科兰州730030

目的:了解我国类风湿关节炎(rheumatoid arthritis,RA)患者冠心病(coronary artery disease,CAD)的患病情况并评估其发生的危险因素。方法:调查RA患者冠心病相关的临床资料,包括冠心病的患病情况、冠心病传统危险因素[糖尿病、高血压、... 详细信息

目的:了解我国类风湿关节炎(rheumatoid arthritis,RA)患者冠心病(coronary artery disease,CAD)的患病情况并评估其发生的危险因素。方法:调查RA患者冠心病相关的临床资料,包括冠心病的患病情况、冠心病传统危险因素[糖尿病、高血压、高血脂、吸烟及体重指数(Bmi)]及RA临床表现[关节肿胀、疼痛、畸形数目,皮下结节数目,动态红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、类风湿因子(rheumatoid factor,RF)等]、关节功能状态评分及用药情况。对冠心病组及非冠心病组的危险因素、临床特点及用药情况等方面进行单因素比较及多因素Logistic回归分析。结果:共调查21家医院的960例RA患者,其中女性779人,男性181人,女∶男=4.3∶1,平均年龄(52.7±13.9)岁(11.0～86.0岁)。RA患者冠心病的患病率为3.5%(34/960),其中合并超重和肥胖者占35.1%(377/960)、吸烟者占12.3%(118/960)、高血压者占17.0%(163/960)、糖尿病者占7.7%(74/960)、高胆固醇血症者占0.4%(4/960)、脑血管病者占3.0%(29/960)。冠心病组与非冠心病组相比,年龄高[(64.7±9.3)岁vs.(52.3±14.0)岁,P1]、皮下结节数目多(14.7%vs.3.1%,P=0.005)、肺间质病变发生率高(17.6%vs.7.0%,P=0.034)、羟氯喹(hydroxychloroquine,HCQ)使用比例低(5.9%vs.22.6%,P=0.021)、糖尿病及高血压患病率高(29.4%vs.7.0%,P1;38.2%vs.16.2%,P=0.001),而受检时关节畸形数目、RF水平及糖皮质激素的使用、高胆固醇血症患病率及Bmi与冠心病发生无关。经多元Logistic回归分析,高龄、合并糖尿病及高血压为RA合并冠心病的独立危险因素,使用HCQ为RA合并冠心病的保护因素。结论:RA患者冠心病的患病率为3.5%。高龄、合并糖尿病及高血压为其独立危险因素,合并使用HCQ为其保护因素。

关键词：关节炎,类风湿冠心病危险因素患病率

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2017年上海市细菌耐药性监测

中国感染与化疗杂志 2019年第2期19卷 113-127页

作者：杨洋郭燕朱德妹胡付品汪复蒋晓飞刘云王靖王敏周军王传清王爱敏应春妹高晶方毅张景皓袁轶群王峰沈芳胡娟喻靓张菁李华茵黄声雷胡海清刘耀婷汤瑾吴琼刘庆中汤荣张泓王春孙康德虞中敏钟政荣瞿跃红潘秋辉黄卫春孙景勇韩立中李丽周敏李敏张灏旻卫颖珏杨海慧孙晴徐伟红刘瑛陈峰张莉钱敏健龚炜朱学源王蓉吴唯一魏取好唐群力林勇翁丽贞刘兴晖沈振华汪瑞忠房华范惠清邓卫平张立朱卿戴俊华康向东唐之俭曲浩刘军彭敬红吴亚洲尧荣凤李志兰别立翰胡骏胡晓波乔昀张珏陶建敏严丽张雯雁叶杨芹袁应华刘妍侯伟伟江涟李娜邢晓宇李妮娅刘淮玉赵芳饶桂华吴文娟何丽华奚卫赵新宇袁艳玲解新复旦大学附属华山医院上海长海医院东方肝胆外科医院复旦大学附属儿科医院复旦大学附属妇产科医院复旦大学附属华东医院复旦大学附属金山医院复旦大学附属上海市第五人民医院复旦大学附属肿瘤医院复旦大学附属中山医院上海长征医院上海交通大学附属第六人民医院上海交通大学附属第一人民医院上海交通大学附属儿童医院上海交通大学医学院附属第九人民医院上海交通大学医学院附属第三人民医院上海交通大学医学院附属儿童医学中心上海交通大学医学院附属瑞金医院上海交通大学医学院附属瑞金医院北院上海交通大学医学院附属仁济医院(浦东) 上海交通大学医学院附属仁济医院(浦西) 上海交通大学医学院附属同仁医院(仙霞路院区) 上海交通大学医学院附属新华医院上海市崇明区中心医院上海市第八人民医院上海市第二人民医院上海市奉贤区中心医院上海市静安区中心医院上海市浦东新区公利医院上海市浦东新区人民医院上海市浦东医院上海市普陀区人民医院上海市普陀区中心医院上海市青浦区中心医院上海市松江区中心医院上海市杨浦区中心医院上海中医药大学附属第七人民医院上海中医药大学附属龙华医院上海中医药大学附属曙光医院上海中医药大学附属岳阳中西医结合医院同济大学附属东方医院同济大学附属第十人民医院同济大学附属同济医院中国人民解放军第四五五医院上海交通大学附属第六人民医院东院上海市闵行区中心医院同济大学附属东方医院南院上海交通大学医学院附属仁济医院南院上海市第一人民医院宝山分院

目的了解2017年上海市细菌耐药性监测结果。方法采用纸片扩散法或自动化仪器法对上海市49所医院的临床分离菌进行药敏试验。包括30所三级医院(含3所儿童医院)和19所二级医院。采用美国临床和实验室标准化协会(CLSI)2017年版标准判断结... 详细信息

目的了解2017年上海市细菌耐药性监测结果。方法采用纸片扩散法或自动化仪器法对上海市49所医院的临床分离菌进行药敏试验。包括30所三级医院(含3所儿童医院)和19所二级医院。采用美国临床和实验室标准化协会(CLSI)2017年版标准判断结果。结果共获134078株临床分离菌,其中革兰阳性菌40243株,占30.0%;革兰阴性菌93835株,占70.0%。二级医院和三级医院菌株分别占29.0%和71.0%。在二、三级医院中革兰阳性菌和革兰阴性菌各为25.4%和74.6%、31.9%和68.1%。MRSA和MRCNS在各自菌种中的检出率分别为49.1%和79.7%。二级医院、三级医院的MRSA和MRCNS检出率分别为53.2%和72.1%、47.7%和82.2%。葡萄球菌属中未发现万古霉素耐药株。1041株儿童非脑膜炎肺炎链球菌分离株中青霉素敏感(PSSP)、中介(PISP)和耐药株(PRSP)分别占84.3%、7.8%和7.9%;330株成人分离株PSSP、PISP和PRSP分别为89.4%、4.2%和6.4%。检出5株(0.1%)万古霉素耐药粪肠球菌、64株(1.2%)万古霉素耐药屎肠球菌,经过PCR测序确认的菌株中主要为vanA基因型。大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌中ESBL的检出率分别为54.9%、35.1%和47.6%。上述产ESBL菌株在二级医院和三级医院的检出率分别为53.7%、31.5%、44.0%和55.5%、37.0%、50.0%。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感,对亚胺培南和美罗培南的总耐药率分别为11.1%和11.0%,二级医院、三级医院分别为9.0%和9.2%、12.2%和11.9%,碳青霉烯类耐药肠杆菌科细菌(CRE)的检出率为11.9%,其中73.4%是肺炎克雷伯菌。鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌和大肠埃希菌中出现对大多数测试药物耐药而仅对1～2种抗菌药物敏感的广泛耐药株,二级医院和三级医院分别为64株、357株、7株、25株和412株、1129株、38株、45株。结论目前主要临床分离菌对于常用抗菌药物的耐药性仍甚为严重,尤其是多重耐药的革兰阴性杆菌,对人类健康构成严重威胁,需引起高度重视并采取有效措施防治耐药菌感染。

关键词：细菌耐药性监测碳青霉烯类耐药广泛耐药菌